Design and Synthesis of Pyrene Containing Unusual α-Amino Acid Derivatives
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Abstract
We report here, constrained α-amino acid derivatives containing pyrene ring by using ethyl isocyanoacetate as a glycine equivalent. The required starting precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene 14 was prepared starting with commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride 15 in a three step sequence.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00