A Comparative Study of the Impact of Chronic Pelvic Pain on Quality of Life in Women With and Without Endometriosis [34A]

INTRODUCTION: Few studies have examined the differing natural histories and quality of life in women with endometriosis-associated chronic pelvic pain (EACPP) versus other chronic pelvic pain (OCPP) in the years following surgery. In this study, we compared pain and quality of life scores in women with EACPP vs OCPP after surgery. METHODS: Women with CPP who had gynecologic surgery at the Cleveland Clinic between 2008 and 2010 with surgically confirmed endometriosis versus other CPP without endometriosis completed the EHP-30 and PROMIS validated quality of life questionnaires. Demographics and scores were compared between EACPP (N=84) versus OCPP (N=105) groups. RESULTS: Significant differences in racial demographics were seen between the two groups, with more African American patients in the OCPP group. The EACPP group had lower current disability than the OCPP group (3.6% vs 13.5%, P=.019). No significant difference was found in EHP-30 scores between groups. The PROMIS Global Health survey revealed no significant difference in Global Physical scores, however, the EACPP group had a lower mean Global Mental score compared to the OCPP group (12.5±3.4 vs 13.6±3.6, P=.057), a finding which approached significance. In exploratory regression models, higher age and higher Global Physical score were associated with lower EHP-30 scores (better health status) across all quality of life scales. CONCLUSION: Reported pain and quality of life are similar between women with EACPP vs OCPP. However, racial representation and disability status are different between groups. Furthermore, multivariable regression models indicated that higher age and physical health ratings may be associated with better quality of life.