Does Dexamphetamine Cause Addiction? A Narrative Review

Dexamphetamine (DEX) is widely used in treatments, but concerns persist about its potential for addiction. This review aimed to assess the risks of DEX dependence by examining existing literature. Originally planned as a systematic review, it was adjusted due to a lack of qualifying studies. Of seven cohort and case studies reviewed, only four poorly documented cases of possible DEX addiction were found. Commonly cited papers on prescription amphetamine addiction did not hold up to scrutiny. Overall, the evidence that DEX is addictive is limited and inconclusive, highlighting the need for more rigorous research to clarify its true addiction risk.