Rubinstain -taybi Syndrome: An Unusual Case Report

Rubinstain -taybi Syndrome: An Unusual Case Report | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Rubinstain -taybi Syndrome: An Unusual Case Report Dr Sudipa, Dr Pramod G V, Dr Shivaprasad S., Dr Ashok L. This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8583928/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract RUBINSTAIN -TAYBI SYNDROME is an unusual genetic disorder which affects many systems of the body, characterized by growth and developmental delays, distinctive craniofacial features & intellectual disability. A 12- year- old girl reported in the department of oral medicine and radiology with a chief complaint of decayed teeth. Patient was medically challenged. Extraoral features revealed distinctive cranio-facial appearance with broad thumbs and halluces and intraoral features observed were talon cusp in the maxillary central incisors, narrow maxillary arch, carious teeth and plaque accumulation. Considering the history, clinical characteristics and radiographic investigations, patient diagnosed as chronic irreversible pulpitis w.r.t 11.21.36.42,46. Chronic generalized marginal gingivitis with RUBINSTAIN -TAYBI SYNDROME type I. For effective management and good health of the patient, preventive and curative dental procedure and treatment plan had been taken. As an oral physician, understanding RUBINSTAIN -TAYBI SYNDROME is crucial because it requires a multidisciplinary approach to manage the oral health issues associated with it. Early intervention and continuous support are essential to maintaining the well-being of affected individuals. Medical Genetics Dentistry Pediatrics Broad Thumb-Hallux Syndrome Microdeletion Talon Cusps RSTS Fluorescence In-Situ Hybridization (FISH). Full Text Additional Declarations Authors are declared that there were no conflicts of interest and the parents of the patients have given their consent to the clinical and radiographic images to be published as a case. The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8583928","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":573416767,"identity":"e0c9742b-94b1-4d56-a94c-38b300484046","order_by":0,"name":"Dr Sudipa","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCUlEQVRIiWNgGAWjYDACCQYGZiDF2AbEDz8Y2IDYjQeI1cJsLFGRBmI3EKelgYGBTYLnzGGwIF4t8tHNhz8X/Dks2yfd/NhAsu283dr2w0BbamyicWkxvHMsTXpm22HjNpljhg8K224nbzuTCNRyLC23AZeWGTlmzLwNhxPbJBKMgbbcTjY7ANTC2HAYnxbjzzx/QFrSv0nwtp1LNjv/EL8WeYkcA2keNpCWHDOg9w/Ymd0gYIuBRFqaNG9bOtAvZ4qBgZycYHYDaEsCHr/Iz0g+DHSYtez82e0bgVFpZ292Pv3hgw81NrhtOQBjSUCoRLDKBBzKwbbAzYJqscejeBSMglEwCkYoAAARqGZmHLKjkgAAAABJRU5ErkJggg==","orcid":"","institution":"BAPUJI DENTAL COLLEGE AND HOSPITAL","correspondingAuthor":true,"prefix":"Dr","firstName":"","middleName":"","lastName":"Sudipa","suffix":""},{"id":573421766,"identity":"c7fc43c3-5b04-48d4-8e7c-429678902cfc","order_by":1,"name":"Dr Pramod G V","email":"","orcid":"","institution":"BAPUJI DENTAL COLLEGE AND HOSPITAL","correspondingAuthor":false,"prefix":"Dr","firstName":"Pramod","middleName":"G","lastName":"V","suffix":""},{"id":573421767,"identity":"da8a0544-5319-4697-a93a-36e996d8d311","order_by":2,"name":"Dr Shivaprasad S.","email":"","orcid":"","institution":"BAPUJI DENTAL COLLEGE AND HOSPITAL","correspondingAuthor":false,"prefix":"Dr","firstName":"Shivaprasad","middleName":"","lastName":"S.","suffix":""},{"id":573421768,"identity":"a6aefc06-9544-4068-8b13-9bb0a3a32380","order_by":3,"name":"Dr Ashok L.","email":"","orcid":"","institution":"BAPUJI DENTAL COLLEGE AND HOSPITAL","correspondingAuthor":false,"prefix":"Dr","firstName":"Ashok","middleName":"","lastName":"L.","suffix":""}],"badges":[],"createdAt":"2026-01-12 16:37:24","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":true,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-8583928/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8583928/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":100422058,"identity":"b51196c6-d106-4c58-8503-5eb13febf40f","added_by":"auto","created_at":"2026-01-16 14:05:23","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":400132,"visible":true,"origin":"","legend":"","description":"","filename":"RUBINSTAINcorrected2Copy.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8583928/v1_covered_c6c17ba2-78a3-4c6a-b9d5-f29991ebcd65.pdf"}],"financialInterests":"\u003cp\u003eAuthors are declared that there were no conflicts of interest and the parents of the patients have given their consent to the clinical and radiographic images to be published as a case.\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e","formattedTitle":"\u003cp\u003eRubinstain -taybi Syndrome: An Unusual Case Report\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Broad Thumb-Hallux Syndrome, Microdeletion, Talon Cusps, RSTS, Fluorescence In-Situ Hybridization (FISH). ","lastPublishedDoi":"10.21203/rs.3.rs-8583928/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8583928/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eRUBINSTAIN -TAYBI SYNDROME is an unusual genetic disorder which affects many \u0026nbsp;systems of the body, characterized by growth and developmental delays, distinctive \u0026nbsp;craniofacial features \u0026amp; intellectual disability. \u0026nbsp;A 12- year- old girl reported in the department of oral medicine and radiology with a chief \u0026nbsp;complaint of decayed teeth. Patient was medically challenged. Extraoral features revealed \u0026nbsp;distinctive cranio-facial appearance with broad thumbs and halluces and intraoral features \u0026nbsp;observed were talon cusp in the maxillary central incisors, narrow maxillary arch, carious teeth \u0026nbsp;and plaque accumulation. 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