The Diagnostic Value Of Soluble CD93 In Chinese Patients With Type 2 Diabetic Nephropathy

Objective: Our aim was to explore the diagnostic value of serum soluble cluster of differentiation 93 (sCD93) for diabetic nephropathy (DN) in chinese patients. Methods: : 130 patients with type 2 diabetes mellitus (T2DM) and 30 healthy individuals were enrolled. Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum sCD93 concentration. And renal function and blood lipid-related index in serum or urine were detected using the routine assays. A receiver operating characteristic (ROC) curve was exployed to evaluate the diagnostic efficacy of integrated indicators. Results: The eGFR, ACR ( P < 0.05) and the prevalence of DN ( P < 0.05) were significantly different between the H-sCD93 group and the L-sCD93 group. The serum sCD93 concentration was correlated with the ACR (r = 0.191, P = 0.029) and eGFR (r = -0.509, P = 0.000). In all albuminuria subgroups, the serum sCD93 concentration increased with the increase in the ACR ( P < 0.05). Pairwise comparisons between subgroups indicated that the serum sCD93 concentrations from the N-ACR and M-ACR groups were lower than that in the L-ACR group (P 0.05). The levels of serum sCD93, NGAL and Cr in DN group were significantly higher than those in DM group ( P <0.05). On the basis of the ROC curve, the best AUC area value was 0.942 from sCD93+NGAL+Cr triple test. Conclusion: sCD93 was a independent predictor for DN in chinese patients, and integration analysis of sCD93, NGAL and Cr has better diagnostic efficacy.