Modification of oestrogen signalling pathways influences cough induced by citric acid but not capsaicin in the animal model of both sexes

Tomáš Buday, Alireza Matloobi, Lucia Kopcova, Mariana Brozmanová, Miroslav Sterusky, Jana Plevková
In: Respiratory Physiology & Neurobiology · 2023 · vol. 312 , pp. 104039 · doi:10.1016/j.resp.2023.104039 · PMID:36842728 · W4321769419
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-15 ⓘ

In guinea pigs, estrogen depletion via fulvestrant or danazol increased citric acid-induced cough in females but not males, indicating that this cough pathway is estrogen-dependent while capsaicin-induced cough remains resistant to hypoestrogenic states.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

To clarify the role of oestrogen signalling and the role of oestrogen receptor alpha (ERα) in the cough pathways we performed a study in which coughing was observed in both sexes animal models after the treatment by selective ERα degrader fulvestrant (ICI 182-780) and inhibitor of oestrogen synthesis danazol. Degradation of ERα with the normal plasma oestrogen levels induced by fulvestrant, significantly augments the cough response of female but not male guinea pigs. These changes were observed in citric acid-induced cough. Female guinea pigs responded with an increased count of cough expulsions per challenge time and we also detected shorter cough latency. The capsaicin-induced cough did not change. A similar response was observed after danazol treatment, which decreased the plasma oestrogen level. Our results indicate that the transient receptor potential vanilloid-1 (TRPV1) channel-mediated cough is resistant to the hypoestrous state, while the citric acid-mediated cough is oestrogen-dependent and hypersensitive during the hypoestrous state.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (39)

Source provenance

openalex
last seen: 2026-05-14T06:08:44.784461+00:00
unpaywall
last seen: 2026-09-06T06:31:40.515551+00:00
License: CC0 · commercial use OK