A Clinical study of CA15-3 and some other Hematological Parameters in Diagnosis of Breast Cancer patients in Al-Amal Hospital/Iraq

Abstract Background Breast cancer encompasses various subtypes of tumors with distinct molecular characteristics, with distinct molecular and cellular origins and clinical behaviors. Most of them are the origin of ductal or lobular epithelial tumors. Globally, it is the most common malignant disease of women diagnosed every year and the second leading cause of death in women worldwide. The aim of this study was to evaluate CA15-3 and hematological parameters as useful markers to distinguish between patients with breast cancer and healthy individuals. Methods The case-control study took place at Al-Amal National Hospital in Baghdad Governorate, Iraq, over the course of three months, from mid-November to the end of February. It involved drawing sixty blood samples, divided into two groups. 100 women with instances of breast cancer made up the first group (A), while 50 healthy women made up the control group in the second group (B). Every study participant gave their authorized consent. The blood samples were collected from each woman included in this study for the estimation of CA15.3 using Cobas e411, and hematological parameters were analyzed using the Sysmex KX-550TM automated hematology analyzer system. Result The difference between the BC patients and the control group was significant in Ca15-3 (P ≤ 0.01). Also, there was a moderate difference between the two groups in WBC, RBC and PLT parameters (P ≤ 0.05). Meanwhile, the two groups had a minimal difference in LYM parameter (P ≤ 0.05). On the other hand, there was no significant difference between the BC patients and the control group in Hb, PCV, NEUT, Mono, EOSi, and basophil counts (P ≤ 0.05).