Effect of Different in Vitro Fertilization Treatment Protocols on Infertile Women with Adenomyosis

Objective To investigate the effect of different in vitro fertilization ( IVF) treatment protocols on infertile women with adenomyosis. Methods Sixty-four infertile women with adenomyosis who had IVF treatment cycles from January 2006 to June 2009 were retrospectively analyzed. According to administration of long course gonadotropin-releasing hormone agonist ( GnRH-a) and the start time of gonadotropin ( Gn) ,all participants were divided into three groups:the first group with ultra-long term protocol,the second group with long or short term protocol after administration of long course GnRH-a and the third group with routine long term protocol. Results There were no differences among the three groups with regard to days of Gn administration,amounts of Gn administration,numbers of retrieved oocytes,prevalence of poor response and miscarriage ( P 0. 05). The cancelation rates of the three groups were 20. 0% 、7. 7% and 30. 0% respectively. There were significant differences in cancelation rates among the groups ( χ2 = 5. 74,P 0. 05) ,and the cancelation rate in the second group was significantly lower than the other groups ( χ2 = 7. 21,P 0. 05). The ongoing pregnancy rates of the groups were 23. 0% 、37. 0% and 15. 3% respectively. There were significant differences in ongoing pregnancy rates among three groups ( χ2 =11. 31,P 0. 05) ,and the ongoing pregnancy rate in the second group was significantly higher than the other groups ( χ2 =8. 52,P 0. 05). Conclusion Compared with the ultra-long term and routine long term protocol of IVF treatment in infertile woman with adenomyosis,the ongoing pregnancy rate might be higher and the cancelation rate might be lower in the long or short term protocol after administration of long course GnRH-a.