The use of gnrh agonists in the treatment of endometriomas with or without drainage

Alı Haberal, H. Çelikkanat, Mustafa Uğur, Gülnur Özakşit, Nuran Sevimli Kuslu Cicek, P. Möröy, Sertaç Batıoğlu
1995 · vol. 8(4) , pp. 175–178 · W3001314590
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This prospective study found that surgical drainage combined with GnRH agonist therapy significantly improved endometrioma resolution rates compared to GnRH agonist monotherapy in women with endometriomas.

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This prospective study evaluated the efficacy of GnRH agonist therapy in managing endometriomas larger than 3 cm, comparing outcomes between patients who underwent cyst drainage followed by six months of ovarian suppression and those receiving medical therapy alone. The results demonstrated that the group undergoing surgical drainage combined with postoperative GnRH-a treatment achieved a 100% rate of decreased ovarian adenomyosis fibrosis scores and a 36.8% complete resolution rate. In contrast, the group treated solely with GnRH agonists showed only a 17.6% response rate, indicating significantly inferior clinical outcomes compared to the combined approach. This paper is centrally about endometriosis — specifically the comparative effectiveness of surgical drainage versus medical management for endometriomas.

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Abstract

In order to assess the effectiveness of GnRH-agonist (GnRH-a) therapy in the treatment of endometriomas, with or without surgical intervention, 26 women with laparoscopically proven endometriomas, greater than 3 cm diameter were recruited to the study.Fourteen women who had 19 endometriomas (5 of them were bilaterally), had drainage of endometrioma at the initial laparoscopy. After the procedure, they had ovarian suppression with GnRH-a therapy for 6 months.The second group which consisted of 12 women, had 17 endometriomas. No surgical procedure was performed. They received only GnRH-A therapy for 6 months. At the second -look laparoscopy, the rates of decrease in ovarian AFS scores of endometriomas and complete resolution were found as 100% and 36.8% respectively, in the first group, In the second group the response was only 17.6% (p<0.0001).In this prospective study we found that drainage of the cyst (surgical therapy) combined with the postoperative GnRH-a suppression is a better treatment modality for endometriomas. Than the use of GnRH-a (medical therapy) alone.
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Abstract

In order to assess the effectiveness of GnRH-agonist (GnRH-a) therapy in the treatment of endometriomas, with or without surgical intervention, 26 women with laparoscopically proven endometriomas, greater than 3 cm diameter were recruited to the study. Fourteen women who had 19 endometriomas (5 of them were bilaterally), had drainage of endometrioma at the initial laparoscopy. After the procedure, they had ovarian suppression with GnRH-a therapy for 6 months. The second group which consisted of 12 women, had 17 endometriomas. No surgical procedure was performed. They received only GnRH-A therapy for 6 months. At the second -look laparoscopy, the rates of decrease in ovarian AFS scores of endometriomas and complete resolution were found as 100% and 36.8% respectively, in the first group, In the second group the response was only 17.6% (p<0.0001). In this prospective study we found that drainage of the cyst (surgical therapy) combined with the postoperative GnRH-a suppression is a better treatment modality for endometriomas. Than the use of GnRH-a (medical therapy) alone.

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References - Meldrum DR, Chang RJ, Lu J, Vale W, River J, Judd ML. Medical oopherectomy using a long-acting GnRh agonist - a possible new approach to the treatment of endometriosis. J Clin Endocrinol Metab 1982;54:81-85. Details Primary Language English Subjects Clinical Sciences Journal Section Research Article Authors A. Haberal This is me Türkiye H. Çelikkanat This is me Türkiye M. Uğur This is me Türkiye G. Özakşit This is me Türkiye N. Çiçek This is me Türkiye P. Moröy This is me Türkiye S. Batıoğlu This is me Türkiye Publication Date October 1, 1995 Submission Date November 10, 2016 Acceptance Date August 1, 1995 Published in Issue Year 1995 Volume: 8 Number: 4

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endometrioma

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