WITHDRAWN: Bibliometric Analysis of Research Trends and Future Development Directions in Bile Acids and Primary Biliary Cholangitis

preprint OA: closed
Full text JSON View at publisher

Abstract

Abstract This study aims to analyze the evolution of research interest and key focus areas in bile acids and primary biliary cholangitis (PBC) within the global medical community. Based on 1,246 articles related to bile acids and PBC published between 1980 and 2024, retrieved from the Web of Science Core Collection database, we conducted a visual analysis using VOSviewer software. The analysis covered metrics including annual publication output, citation frequency, average citations per article, journal names and their impact factors, contributing countries/regions, institutions, and authors.Statistical results showed that research in this field involved 52 countries worldwide. Among these, 190 institutions participated in no fewer than 4 international collaborative projects, with the University of California, Davis (USA), University of Birmingham (UK), and Medical University of Vienna (Austria) being the most active. Among 167 authors who had published at least 5 internationally co-authored papers, Erik M. Gershwin had the highest co-authorship frequency. The core journals with the highest total link strength were Hepatology, Gastroenterology, and Journal of Hepatology.From the perspective of citation hotspots, "primary biliary cholangitis" formed a knowledge cluster with high academic influence. Since 2010, keywords such as "ursodeoxycholic acid dosage", "farnesoid X receptor", "mouse experiment", "biochemical reaction", "activation", "obeticholic acid", "primary biliary cholangitis", and "cirrhosis" have frequently appeared, reflecting the latest research trends in PBC.This bibliometric analysis of bile acids and PBC highlights research trends, influential studies, and collaborative networks. It further summarizes key academic contributions and provides a basis for identifying future research directions.
Full text 9,653 characters · extracted from preprint-html · click to expand
WITHDRAWN: Bibliometric Analysis of Research Trends and Future Development Directions in Bile Acids and Primary Biliary Cholangitis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article WITHDRAWN: Bibliometric Analysis of Research Trends and Future Development Directions in Bile Acids and Primary Biliary Cholangitis Qi Gao, jing cheng, Pan Li, zhenhua Ma This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7787327/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Full Text The authors have withdrawn this preprint from Research Square. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7787327","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":544090258,"identity":"15be9634-d239-4f2a-9299-5361c0f139f9","order_by":0,"name":"Qi Gao","email":"","orcid":"","institution":"北华大学","correspondingAuthor":false,"prefix":"","firstName":"Qi","middleName":"","lastName":"Gao","suffix":""},{"id":544090261,"identity":"69dc4b5a-a309-48c3-9251-066d4a64106c","order_by":1,"name":"jing cheng","email":"","orcid":"","institution":"北华大学","correspondingAuthor":false,"prefix":"","firstName":"jing","middleName":"","lastName":"cheng","suffix":""},{"id":544090262,"identity":"984b2326-48fc-434d-b6a6-297cc35a357d","order_by":2,"name":"Pan Li","email":"","orcid":"","institution":"北华大学","correspondingAuthor":false,"prefix":"","firstName":"Pan","middleName":"","lastName":"Li","suffix":""},{"id":544090263,"identity":"f72eb9aa-3d8c-4dba-93cc-06c203094889","order_by":3,"name":"zhenhua Ma","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7klEQVRIiWNgGAWjYHACNiA+wMDAzHz8x4cKCTl+4rWwsyVIzjhjYSzZQLQWfh4Dad62isQNhLToth9/9uDjjjuJ/c08Bsa88yQYNzAwP3x0A48WszMJ6YYzzzxLnHGYrSBx7jYJZnMGNmPjHHxaDiQcA7rncGLDYeYNB95uk2CzbOBhk8ar5fzDNum/QC3zDzMYNvDOkeAxOEBIy41kNmlGoJYNh1mMGXkbJCSI0PKMTbK37bDxxsNsaYwzjkkYSDYT8sv59GcSP9sOy847f/gYw4eauvp+9uaHj/FpwQKYSVM+CkbBKBgFowALAACKkFHLzJR9mQAAAABJRU5ErkJggg==","orcid":"","institution":"北华大学","correspondingAuthor":true,"prefix":"","firstName":"zhenhua","middleName":"","lastName":"Ma","suffix":""}],"badges":[],"createdAt":"2025-10-06 01:53:22","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.3.rs-7787327/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-7787327/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.","failedWorkflow":false,"files":[{"id":95818751,"identity":"284300a9-6c61-47e7-9b55-737d771a9070","added_by":"auto","created_at":"2025-11-13 10:32:35","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":155961,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7787327/v2/ce0aaeb2-7b2d-4919-a372-4c84bc81a1bd.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"WITHDRAWN: Bibliometric Analysis of Research Trends and Future Development Directions in Bile Acids and Primary Biliary Cholangitis","fulltext":[{"header":"Full Text","content":"The authors have withdrawn this preprint from Research Square."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":true,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":true,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-7787327/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7787327/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.","manuscriptTitle":"WITHDRAWN: Bibliometric Analysis of Research Trends and Future Development Directions in Bile Acids and Primary Biliary Cholangitis","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2025-11-12 17:23:15","doi":"10.21203/rs.3.rs-7787327/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2025-10-27 14:11:43","doi":"10.21203/rs.3.rs-7787327/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"94fc32c3-9b22-45e4-8a15-8ea206c66b70","owner":[],"postedDate":"November 12th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-11-12T17:23:15+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-12 17:23:15","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-7787327","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7787327","identity":"rs-7787327","version":["v2"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00