Comparison of effects of Leuprorelin and Marvelon in on endometriosis after laparoscopic surgery

Objective To compare the effects of Leuprorelin and Marvelon on endometriosis(EM)after laparoscopic surgery.Methods Patients with EM were enrolled and divided into laparoscopic surgery group(CON group),laparoscopic surgery combined with Marvelon group(MAR group),and laparoscopic surgery group combined with Leuprorelin group(LEU group),according to the therapeutic methods.The effective rates,recurernce rates,pregnancy rates and adverse reactions of the three groups were compared.The levels of CA125 and MMP-9were detected by ELISA before treatment,4weeks and 12 weeks after treatment respectively,and the results were analyzed.Results Comparing with CON group,the effective rates and the pregnancy rates of EM patients inⅠ+Ⅱ and Ⅲ+Ⅳ stages in MAR group and LEU group were significantly higher,and the recurrence rates were significantly lower(P0.05).Comparing with MAR group,the effective rates and the pregnancy rates of EM patients inⅢ+Ⅳ stage of LEU group were significantly higher(P0.05),and the recurrence rate was significantly lower(P0.05).There was no marked difference of incidences of irregular vaginal bleeding,liver and kidney function abnormalities,and weight abnormity of CON group,MAR group,and LEU group(P0.05).The incidences of menopausal symptoms of LEU group patients were significantly higher than those of MAR group and CON group(P0.05).The concentrations of CA125 and MMP-9in LEU group were significantly lower than MAR group after 4-week and 12-week treatment(P0.05).Conclusion With regard to the drug treated after laparoscopic surgery,Leuprorelin is suitable for EM patients in Ⅲ+Ⅳ stage,while Marvelon is suitable for EM patients in Ⅰ+Ⅱ stage.