Effects of Different Pore Structures on Loading and Sustained-Release of MMC by Hollow Mesoporous Fe(0)@mSiO2

Effects of Different Pore Structures on Loading and Sustained-Release of MMC by Hollow Mesoporous Fe(0)@mSiO2 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Effects of Different Pore Structures on Loading and Sustained-Release of MMC by Hollow Mesoporous Fe(0)@mSiO2 Ziling Chang, Mengyang Dong, Huafei Li, Yuxiang Yang, Hongming Yuan, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1500266/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 7 You are reading this latest preprint version Abstract Herein, we developed the dual-function template method to fabricate hollow magnetic nano-spheres (denoted as HMFe-Si-Cn, n=16, 18) with a mesoporous shell and hollow interior structure using alkyl chain trimethoxysilane templating. The shorter chain template directed formation of HMFe-Si-C16 with size of 119 nm, having disordered inkbottle type mesopores and saturation magnetization of 50.01 emu/g higher than that of HMFe-Si-C18 with cylindrical type mesopores. By contrast, Mitomycin C (MMC) loading efficiency of HMFe-Si-C16 was higher owing to the fact that the pore size, surface area, and pore volume of HMFe-Si-C16 were larger than those of HMFe-Si-C18. Besides, MMC loaded HMFe-Si-Cn hollow spheres showed a clear pH-dependent drug release behavior, having a higher release rate in acidic environments of pH 5.7. For the pH 5.7 and 7.4 release, the release kinetic for HMFe-Si-C16-MMC composites follows pseudo-first-order attributable to its special pore structure. For this reason the inner cavity of HMFe-Si-C16 could be labeled with radioisotope 99Tcm to study the magnetic targeting distribution of HMFe-Si-C16 in vivo, and its cytotoxicity against in vitro HeLa cells was also studied. These results indicate the potential of HMFe-Si-C16 in the magnetic targeted drug delivery system. hollow magnetic nano-spheres particle size mitomycin C sustained-release targeting label Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Major revision 21 Apr, 2022 Reviews received at journal 08 Apr, 2022 Reviewers agreed at journal 07 Apr, 2022 Reviewers invited by journal 06 Apr, 2022 Editor assigned by journal 04 Apr, 2022 Submission checks completed at journal 04 Apr, 2022 First submitted to journal 29 Mar, 2022 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1500266","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":96637369,"identity":"0d9b682b-25ef-4640-997d-1df63646188e","order_by":0,"name":"Ziling Chang","email":"","orcid":"","institution":"East China University of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ziling","middleName":"","lastName":"Chang","suffix":""},{"id":96637370,"identity":"59a4b264-c42d-4870-99e0-73f6f08803a7","order_by":1,"name":"Mengyang Dong","email":"","orcid":"","institution":"East China University of Science and Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mengyang","middleName":"","lastName":"Dong","suffix":""},{"id":96637371,"identity":"8f5acedf-b428-4032-b54d-c857f4556fd8","order_by":2,"name":"Huafei Li","email":"","orcid":"","institution":"Shanghai University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Huafei","middleName":"","lastName":"Li","suffix":""},{"id":96637372,"identity":"68649380-8e06-4cf1-893f-57b9a0c82d30","order_by":3,"name":"Yuxiang Yang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3klEQVRIiWNgGAWjYPACGxiDmWgtaSCCsYEULYdJ0GJwI8fwc8Gv83L8M9KfP2CosE5sYD97AL+WM2eMpWf23TaWAOptYDiTntjAk5eAX8vxHgNp3p7biRskchgbGNsOJzZI8Bjg13KYx/g3b8+5+g0S6Q8bGP8Ro+V4j5k0z48DCQYSCYYNjA1EaJE8c6zMmrch2XDGmTeGMxKOpRu38eTg18J3I3nzbZ4/dvL87ekPPnyosZbtZz+DX4vCAQ4DBsY2KC8BiNnwqgcC+Qb2BwwMfwgpGwWjYBSMghENAJgRSEgjbOhwAAAAAElFTkSuQmCC","orcid":"","institution":"East China University of Science and Technology","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Yuxiang","middleName":"","lastName":"Yang","suffix":""},{"id":96637373,"identity":"f4e472f1-784e-4cbd-8f3d-5fe2149fe970","order_by":4,"name":"Hongming Yuan","email":"","orcid":"","institution":"Jilin University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hongming","middleName":"","lastName":"Yuan","suffix":""},{"id":96637374,"identity":"b386272f-6690-49d7-ab65-3030531bcfd8","order_by":5,"name":"Chaoying Ni","email":"","orcid":"","institution":"University of Delaware","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chaoying","middleName":"","lastName":"Ni","suffix":""}],"badges":[],"createdAt":"2022-03-29 06:59:27","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1500266/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1500266/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":20119855,"identity":"0e0f53f6-9035-4794-9b7c-86b38d0a194c","added_by":"auto","created_at":"2022-04-08 14:28:09","extension":"pdf","order_by":32,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1455974,"visible":true,"origin":"","legend":"","description":"","filename":"fabricatedhmnps3.23.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1500266/v1_covered.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Effects of Different Pore Structures on Loading and Sustained-Release of MMC by Hollow Mesoporous Fe(0)@mSiO2","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-1500266/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-porous-materials","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jopo","sideBox":"Learn more about [Journal of Porous Materials](http://link.springer.com/journal/10934)","snPcode":"10934","submissionUrl":"https://submission.nature.com/new-submission/10934/3","title":"Journal of Porous Materials","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"hollow magnetic nano-spheres, particle size, mitomycin C, sustained-release, targeting label","lastPublishedDoi":"10.21203/rs.3.rs-1500266/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1500266/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Herein, we developed the dual-function template method to fabricate hollow magnetic nano-spheres (denoted as HMFe-Si-Cn, n=16, 18) with a mesoporous shell and hollow interior structure using alkyl chain trimethoxysilane templating. The shorter chain template directed formation of HMFe-Si-C16 with size of 119 nm, having disordered inkbottle type mesopores and saturation magnetization of 50.01 emu/g higher than that of HMFe-Si-C18 with cylindrical type mesopores. By contrast, Mitomycin C (MMC) loading efficiency of HMFe-Si-C16 was higher owing to the fact that the pore size, surface area, and pore volume of HMFe-Si-C16 were larger than those of HMFe-Si-C18. Besides, MMC loaded HMFe-Si-Cn hollow spheres showed a clear pH-dependent drug release behavior, having a higher release rate in acidic environments of pH 5.7. For the pH 5.7 and 7.4 release, the release kinetic for HMFe-Si-C16-MMC composites follows pseudo-first-order attributable to its special pore structure. For this reason the inner cavity of HMFe-Si-C16 could be labeled with radioisotope 99Tcm to study the magnetic targeting distribution of HMFe-Si-C16 in vivo, and its cytotoxicity against in vitro HeLa cells was also studied. These results indicate the potential of HMFe-Si-C16 in the magnetic targeted drug delivery system.\n","manuscriptTitle":"Effects of Different Pore Structures on Loading and Sustained-Release of MMC by Hollow Mesoporous Fe(0)@mSiO2","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-04-08 14:27:56","doi":"10.21203/rs.3.rs-1500266/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2022-04-21T12:10:37+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2022-04-08T06:30:48+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"af634429-ae92-4322-8a0e-9a702d6fef3f","date":"2022-04-07T05:45:11+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2022-04-06T14:52:01+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2022-04-04T06:44:02+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2022-04-04T06:44:01+00:00","index":"","fulltext":""},{"type":"submitted","content":"Journal of Porous Materials","date":"2022-03-29T06:58:49+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"journal-of-porous-materials","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jopo","sideBox":"Learn more about [Journal of Porous Materials](http://link.springer.com/journal/10934)","snPcode":"10934","submissionUrl":"https://submission.nature.com/new-submission/10934/3","title":"Journal of Porous Materials","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"9fb146fa-1455-41a0-b5fb-061d898edb25","owner":[],"postedDate":"April 8th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2022-05-15T11:14:07+00:00","versionOfRecord":[],"versionCreatedAt":"2022-04-08 14:27:56","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1500266","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1500266","identity":"rs-1500266","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}