Coagulation Status in Women With Missed Abortion

Coagulation Status in Women With Missed Abortion | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Coagulation Status in Women With Missed Abortion Shuo Yang, Dandan Chen, Junxiong Wang, Rui Qiao, Liyan Cui This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-171135/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Missed abortion is a special type of spontaneous miscarriage, as well as a complex and multifactorial reproductive health problem that affects people all over the world. The purpose of this study was to assess the status of coagulation function in a large series of reproductive-age women diagnosed as missed abortion. Likewise, we want to explore the association between coagulation and missed abortions, in order to evaluate whether they could be used as early predictive factors for missed abortions. Methods: A total of 11182 women who suffered from missed abortion from Peking University Third Hospital and 5298 healthy age –matched early pregnancy women were enrolled in our study. Coagulation function test (prothrombin time, activated partial thromboplastin time), fibrinolysis status detection (fibrinogen, D-Dimer), anticoagulation function tests (protein C, protein S and antithrombin III) and lupus anticoagulants (LAC) were examined on an automated coagulation analyzer. In addition, platelet counts were detected by automated hematology analyzer. Platelet aggregation (PAgT) were tested by light transmission aggregometry (LTA). All tests were taken according to standard operating procedures of the instruments. Results: Compared with healthy pregnancy, the level of D-Dimer and platelet count were higher, and the antithrombin III (AT-III) activity was lower(P<0.05). 13.1% patients with missed abortion were positive for LAC, and platelet aggregation was increased in 47.4% patients. There were no significant differences in the levels of PT, aPTT, TT, fibrinogen, protein C and protein S between the patients with missed abortion and healthy pregnancy. Moreover, multivariate logistic regression analysis showed that D-Dimer, dRVVT-R, AT-III and PAgT had significant predictive value for missed abortion. Conclusion: These findings provide evidence of hypercoagulability in patients with missed abortion. Lupus anticoagulant, PAgT and D-Dimer were the strongest predictors of missed abortion. These data suggest that treatment of the lupus anticoagulant and antiplatelet aggregation could be considered in missed abortion. Maternal & Fetal Medicine miss abortion coagulation anticoagulation lupus anticoagulant platelet aggregation hypercoagulability Figures Figure 1 Figure 2 Figure 3 Figure 4 Full Text Tables Table 1 Characteristics of the normal pregnancy women and patients with missed abortion Characteristics Normal pregnancy Patients with missed abortion P Number 5298 11182 / Age(years) 33.20±7.43 33.00±4.38 0.59 Glucose (mmol/L) 4.86±0.50 4.67±0.52 0.18 Alanine aminotransferase (U/L) 14.33±9.25 16.05±6.93 0.91 Aspartate aminotransferase (U/L) 16.73±4.84 17.54±3.62 0.33 Urea (mmol/L) 3.36±0.29 3.66±0.85 0.61 Creatinine (μmol/L) 57.69±7.20 61.65±5.90 0.19 Uric acid (μmol/L) 215.93±53.04 235.32±49.51 0.99 Table 2 Comparison of various coagulation and platelet related parameters between the normal pregnancy women and Women with Missed Abortion Analytes Pregnancy (n=5298) Missed abortion (n=11182) Pregnancy 2.5th–97.5th P APTT (s) 30.76±2.86 30.99±3.63 26.4-41.9 0.684 PT (s) 10.75±0.36 10.92±0.64 9.7-12.5 0.528 TT (s) 14.04±0.70 14.24±1.49 11.7-17.0 0.503 Fibrinogen (g/L) 2.99±0.39 3.076±0.64 2.37-4.44 0.533 D-Dimer (μg/mL) 0.10±0.04 0.14±0.05 0.01-0.31 0.021 AT-III (%) 109.15±6.18 99.32±13.08 72-120 0.000 PC (%) 97.77±23.09 111.71±21.19 29-150 0.005 fPS (%) 74.50±24.29 75.65±23.45 21-143 0.122 dRVVT-R 0.96±0.07 1.028±0.10 0.92-1.11 0.000 PAgT (%) 78.31±8.66 87.70±12.48 52.7-91 0.001 PLT (×10 12 ) 212.77±47.59 239.53±59.76 148-312 0.009 Table 3 Multivariate logistic regression of variables predicting missed abortion Analytes OR（95%CI） P D-Dimer 51.35（40.34-62.97） 0.041 AT-III 0.90（0.82-0.97） 0.019 PC 1.07（1.02-1.12） 0.002 dRVVT-R 73.28（55.49-90.02） 0.003 PAgT 81.04（60.96-98.10） 0.002 PLT 1.02（0.80-1.23） 0.504 Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-171135","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":10840193,"identity":"1e47c59d-3cbd-49af-8e92-7220f492a4f8","order_by":0,"name":"Shuo Yang","email":"","orcid":"","institution":"Peking University Third Hospital","correspondingAuthor":false,"prefix":"","firstName":"Shuo","middleName":"","lastName":"Yang","suffix":""},{"id":10840194,"identity":"0a63b9b5-1439-48ad-bb5c-81e2296fbd1e","order_by":1,"name":"Dandan Chen","email":"","orcid":"","institution":"Beijing Obstetrics and Gynecology Hospital","correspondingAuthor":false,"prefix":"","firstName":"Dandan","middleName":"","lastName":"Chen","suffix":""},{"id":10840195,"identity":"a0cf9f9b-b703-4d1a-acd9-d9dca6812aee","order_by":2,"name":"Junxiong Wang","email":"","orcid":"","institution":"Beijing Friendship Hospital","correspondingAuthor":false,"prefix":"","firstName":"Junxiong","middleName":"","lastName":"Wang","suffix":""},{"id":10840196,"identity":"14071a0a-65de-4e2a-aadb-af77abf87a2f","order_by":3,"name":"Rui Qiao","email":"","orcid":"","institution":"Peking University Third Hospital","correspondingAuthor":false,"prefix":"","firstName":"Rui","middleName":"","lastName":"Qiao","suffix":""},{"id":10840197,"identity":"3b737ece-9da2-4e6b-a063-c46e1fdd9e77","order_by":4,"name":"Liyan Cui","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAsElEQVRIiWNgGAWjYDACdsYGIGnDw8/fQKwWZrCWNBnJGQeI1gImD9sYNCQQqYO/mblN4ueO8zwGDAcYP3zMIUKLxGHGNsneM7d5zJkbmCVnbiNCiwEzY5sEb9ttHsuGA2zMvMRqkfzbdo7H4EACCVqkedsOkKAF6Jdma9m2ZB7JGQebifMLf3v7w5tv2+zs+fmbD374SIwWIGCRgNDgOCUOMH8gWukoGAWjYBSMTAAAQQkxW4Ih3skAAAAASUVORK5CYII=","orcid":"","institution":"Peking University Third Hospital","correspondingAuthor":true,"prefix":"","firstName":"Liyan","middleName":"","lastName":"Cui","suffix":""}],"badges":[],"createdAt":"2021-01-28 08:59:31","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-171135/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-171135/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":5838802,"identity":"efadd992-5f64-48d8-a25f-02b749daabd5","added_by":"auto","created_at":"2021-02-10 19:43:30","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":40532,"visible":true,"origin":"","legend":"Selection of patients of the study ","description":"","filename":"Fig01.png","url":"https://assets-eu.researchsquare.com/files/rs-171135/v1/865bc133731eb09ef3567653.png"},{"id":5839073,"identity":"6ef3b276-db3f-49c3-99b6-a49060a03787","added_by":"auto","created_at":"2021-02-10 19:46:30","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":120172,"visible":true,"origin":"","legend":"Coagulation function screening tests (aPTT, PT, TT, fibrinogen, D-Dimer ) in patients with missed abortion and healthy pregnant women\n*P \u003c 0.05 between the patients with missed abortion and healthy pregnant women","description":"","filename":"Fig02.png","url":"https://assets-eu.researchsquare.com/files/rs-171135/v1/f37d239cdcfa1e62fdbbb974.png"},{"id":5839074,"identity":"f2ecf018-2415-4295-9999-04ffe3d9d216","added_by":"auto","created_at":"2021-02-10 19:46:30","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":137132,"visible":true,"origin":"","legend":"Changes in anticoagulation function, platelet aggregation and platelet counts in patients with missed abortion compared with healthy pregnant women\n*P \u003c 0.05 between the patients with missed abortion and healthy pregnant women","description":"","filename":"Fig03.png","url":"https://assets-eu.researchsquare.com/files/rs-171135/v1/5e4663d9f8667c14092609b2.png"},{"id":5838804,"identity":"1ff53992-00f5-4c39-9bdc-a386d67dc85f","added_by":"auto","created_at":"2021-02-10 19:43:30","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":42332,"visible":true,"origin":"","legend":"Distribution of D-Dimer, AT-III，dRVVT-R，PAgT，and platelet counts in patients with missed abortion according to the reference intervals established by early pregnant women. ","description":"","filename":"Fig04.png","url":"https://assets-eu.researchsquare.com/files/rs-171135/v1/b86f342b98eb6033347279d7.png"},{"id":13582884,"identity":"6a53ee33-2031-4ddd-9f15-94c004ed4a3c","added_by":"auto","created_at":"2021-09-17 04:32:55","extension":"pdf","order_by":5,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":537018,"visible":true,"origin":"","legend":"","description":"","filename":"ysCoagulationStatusinWomenwithMissedAbortion11.pdf","url":"https://assets-eu.researchsquare.com/files/rs-171135/v1_covered.pdf"},{"id":5839298,"identity":"8e10aecc-7f2a-4b0a-9a60-32dd301d4a6c","added_by":"auto","created_at":"2021-02-10 19:49:32","extension":"pdf","order_by":5,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":680923,"visible":true,"origin":"","legend":"","description":"","filename":"ysCoagulationStatusinWomenwithMissedAbortion11.pdf","url":"https://assets-eu.researchsquare.com/files/rs-171135/v1_stamped.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"\u003cp\u003eCoagulation Status in Women With Missed Abortion\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"\u003cp\u003eThis preprint is available for \u003ca href='/article/rs-171135/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003eTable 1\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCharacteristics of the normal pregnancy women and patients with missed abortion\u003c/p\u003e\n\u003ctable border=\"1\" width=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eCharacteristics\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003eNormal pregnancy\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003ePatients with\u003c/p\u003e\n\u003cp\u003emissed abortion\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e\u003cem\u003eP\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eNumber\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e5298\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e11182\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e/\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eAge(years)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e33.20\u0026plusmn;7.43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e33.00\u0026plusmn;4.38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.59\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eGlucose (mmol/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e4.86\u0026plusmn;0.50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e4.67\u0026plusmn;0.52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.18\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eAlanine aminotransferase (U/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e14.33\u0026plusmn;9.25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e16.05\u0026plusmn;6.93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.91\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eAspartate aminotransferase (U/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e16.73\u0026plusmn;4.84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e17.54\u0026plusmn;3.62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.33\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eUrea (mmol/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e3.36\u0026plusmn;0.29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e3.66\u0026plusmn;0.85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.61\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eCreatinine (\u0026mu;mol/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e57.69\u0026plusmn;7.20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e61.65\u0026plusmn;5.90\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.19\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"208\"\u003e\n\u003cp\u003eUric acid (\u0026mu;mol/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e215.93\u0026plusmn;53.04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"132\"\u003e\n\u003cp\u003e235.32\u0026plusmn;49.51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"95\"\u003e\n\u003cp\u003e0.99\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr /\u003eTable 2\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eComparison of various coagulation and platelet related parameters between the normal pregnancy women and Women with Missed Abortion\u003c/p\u003e\n\u003ctable border=\"1\" width=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003eAnalytes\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003ePregnancy\u003c/p\u003e\n\u003cp\u003e(n=5298)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003eMissed abortion\u003c/p\u003e\n\u003cp\u003e(n=11182)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003ePregnancy\u003c/p\u003e\n\u003cp\u003e2.5th\u0026ndash;97.5th\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e\u003cem\u003eP\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003eAPTT (s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e30.76\u0026plusmn;2.86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e30.99\u0026plusmn;3.63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e26.4-41.9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.684\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003ePT (s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e10.75\u0026plusmn;0.36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e10.92\u0026plusmn;0.64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e9.7-12.5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.528\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003eTT (s)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e14.04\u0026plusmn;0.70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e14.24\u0026plusmn;1.49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e11.7-17.0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.503\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003eFibrinogen (g/L)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e2.99\u0026plusmn;0.39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e3.076\u0026plusmn;0.64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e2.37-4.44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.533\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003eD-Dimer (\u0026mu;g/mL)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e0.10\u0026plusmn;0.04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e0.14\u0026plusmn;0.05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e0.01-0.31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.021\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003eAT-III (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e109.15\u0026plusmn;6.18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e99.32\u0026plusmn;13.08\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e72-120\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.000\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003ePC (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e97.77\u0026plusmn;23.09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e111.71\u0026plusmn;21.19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e29-150\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.005\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003efPS (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e74.50\u0026plusmn;24.29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e75.65\u0026plusmn;23.45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e21-143\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.122\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003edRVVT-R\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e0.96\u0026plusmn;0.07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e1.028\u0026plusmn;0.10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e0.92-1.11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.000\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003ePAgT (%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e78.31\u0026plusmn;8.66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e87.70\u0026plusmn;12.48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e52.7-91\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"123\"\u003e\n\u003cp\u003ePLT (\u0026times;10\u003csup\u003e12\u003c/sup\u003e)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"142\"\u003e\n\u003cp\u003e212.77\u0026plusmn;47.59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"146\"\u003e\n\u003cp\u003e239.53\u0026plusmn;59.76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"115\"\u003e\n\u003cp\u003e148-312\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"34\"\u003e\n\u003cp\u003e0.009\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr /\u003eTable 3\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMultivariate logistic regression of variables predicting missed abortion\u003c/p\u003e\n\u003ctable border=\"1\" width=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003eAnalytes\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003eOR（95%CI）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e\u003cem\u003eP\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003eD-Dimer\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003e51.35（40.34-62.97）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e0.041\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003eAT-III\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003e0.90（0.82-0.97）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e0.019\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003ePC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003e1.07（1.02-1.12）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003edRVVT-R\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003e73.28（55.49-90.02）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e0.003\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003ePAgT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003e81.04（60.96-98.10）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"178\"\u003e\n\u003cp\u003ePLT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"207\"\u003e\n\u003cp\u003e1.02（0.80-1.23）\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd width=\"109\"\u003e\n\u003cp\u003e0.504\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"miss abortion, coagulation, anticoagulation, lupus anticoagulant, platelet aggregation, hypercoagulability","lastPublishedDoi":"10.21203/rs.3.rs-171135/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-171135/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Missed abortion is a special type of spontaneous miscarriage, as well as a complex and multifactorial reproductive health problem that affects people all over the world. The purpose of this study was to assess the status of coagulation function in a large series of reproductive-age women diagnosed as missed abortion. Likewise, we want to explore the association between coagulation and missed abortions, in order to evaluate whether they could be used as early predictive factors for missed abortions.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e A total of 11182 women who suffered from missed abortion from Peking University Third Hospital and 5298 healthy age –matched early pregnancy women were enrolled in our study. Coagulation function test (prothrombin time, activated partial thromboplastin time), fibrinolysis status detection (fibrinogen, D-Dimer), anticoagulation function tests (protein C, protein S and antithrombin III) and lupus anticoagulants (LAC) were examined on an automated coagulation analyzer. In addition, platelet counts were detected by automated hematology analyzer. Platelet aggregation (PAgT) were tested by light transmission aggregometry (LTA). All tests were taken according to standard operating procedures of the instruments.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eCompared with healthy pregnancy, the level of D-Dimer and platelet count were higher, and the antithrombin III (AT-III) activity was lower(P\u0026lt;0.05). 13.1% patients with missed abortion were positive for LAC, and platelet aggregation was increased in 47.4% patients. There were no significant differences in the levels of PT, aPTT, TT, fibrinogen, protein C and protein S between the patients with missed abortion and healthy pregnancy. Moreover, multivariate logistic regression analysis showed that D-Dimer, dRVVT-R, AT-III and PAgT had significant predictive value for missed abortion.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eThese findings provide evidence of hypercoagulability in patients with missed abortion. Lupus anticoagulant, PAgT and D-Dimer were the strongest predictors of missed abortion. These data suggest that treatment of the lupus anticoagulant and antiplatelet aggregation could be considered in missed abortion.\u003c/p\u003e","manuscriptTitle":"Coagulation Status in Women With Missed Abortion","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-02-10 19:43:28","doi":"10.21203/rs.3.rs-171135/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"8b988fd5-8afd-49dd-88af-ac14fbef3b13","owner":[],"postedDate":"February 10th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":2354432,"name":"Maternal \u0026 Fetal Medicine"}],"tags":[],"updatedAt":"2021-02-10T19:43:29+00:00","versionOfRecord":[],"versionCreatedAt":"2021-02-10 19:43:28","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-171135","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-171135","identity":"rs-171135","version":["v1"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}