Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin

Dorota A Popiolek, Dorota Popiolek, Asok Kumar, Asok R Kumar, Khush Mittal
Gynecologic Oncology · 2004 · vol. 96(1) , pp. 249–253 · doi:10.1016/j.ygyno.2004.09.040 · PMID:15589611 · W1965796043
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This paper describes a rare case of large cell variant small cell carcinoma with hypercalcemia, originating in the peritoneum.

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Abstract

BACKGROUND: Large cell variant of small cell carcinoma hypercalcemic type (SCC-HT) is extremely rare. All reported cases involved an ovary, and one with primary peritoneal origin has not been described. Also, convincing neuroendocrine granules have not been illustrated. CASE: A 35-year-old woman underwent an exploratory laparotomy for leiomyomas. Intraoperative impression of peritoneal carcinomatosis was confirmed on frozen section. TAH/BSO, debulking/omentectomy followed. The tumor was present on the pelvic/abdominal peritoneum. The normal-sized ovaries were free of tumor grossly. The tumor had features of large cell variant of SCC-HT, described in the ovary. Furthermore, unequivocal neuroendocrine granules were present. The patient received standard chemotherapy for SCC. At 22 months she is NED. CONCLUSION: SCC-HT should be considered in the differential diagnosis of primary neoplasms of the peritoneum.

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MeSH descriptors

Carcinoma, Small Cell Hypercalcemia Peritoneal Neoplasms Adult Carcinoma, Small Cell Carcinoma, Small Cell Carcinoma, Small Cell Carcinoma, Small Cell Female Humans Hypercalcemia Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms Peritoneal Neoplasms

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