Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin

Dorota Popiolek, Asok Kumar, Khush Mittal
In: Gynecologic Oncology · 2004 · vol. 96(1) , pp. 249–253 · doi:10.1016/j.ygyno.2004.09.040 · PMID:15589611 · W1965796043
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This paper describes a rare case of large cell variant small cell carcinoma with hypercalcemia, originating in the peritoneum.

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Abstract

BackgroundLarge cell variant of small cell carcinoma hypercalcemic type (SCC-HT) is extremely rare. All reported cases involved an ovary, and one with primary peritoneal origin has not been described. Also, convincing neuroendocrine granules have not been illustrated.CaseA 35-year-old woman underwent an exploratory laparotomy for leiomyomas. Intraoperative impression of peritoneal carcinomatosis was confirmed on frozen section. TAH/BSO, debulking/omentectomy followed. The tumor was present on the pelvic/abdominal peritoneum. The normal-sized ovaries were free of tumor grossly. The tumor had features of large cell variant of SCC-HT, described in the ovary. Furthermore, unequivocal neuroendocrine granules were present. The patient received standard chemotherapy for SCC. At 22 months she is NED.ConclusionSCC-HT should be considered in the differential diagnosis of primary neoplasms of the peritoneum.

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