ВИЗНАЧЕННЯ ОСОБЛИВОСТЕЙ ГЕНОТИПІВ У ЖІНОК З ГЕНІТАЛЬНИМ ЕНДОМЕТРІОЗОМ ТА ФІБРОЗНО-КІСТОЗНОЮ МАСТОПАТІЄЮ ТА ЇХ РОЛЬ У ТЯЖКОСТІ ПЕРЕБІГУ ЗАХВОРЮВАННЯ

Л. М. Маланчук, V. M. Martinyuk
In: Medical Informatics and Engineering · 2015 · doi:10.11603/mie.1996-1960.2015.3.5006 · W2256624761
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This study investigated the role of deletion variants of GSTT1, GSTM1, and p53 genes in the development of endometriosis and fibrosis-cystic mastitis in women.

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The paper investigated genetic polymorphisms in women with genital endometriosis and fibrous-cystic mastitis, focusing on deletion variants of GSTT1, GSTM1, and p53 and their role in disease severity. It describes screening women for carriage of these alleles in relation to susceptibility to developing the disorders, based on the broader concept that detoxification system genes (glutathione S-transferases) and the onco-gene p53 are polymorphic and associated with risk. A stated limitation is that the study frames conclusions around genetic carriage screening without detailing the specific analytic methods or effect sizes in the provided text. This paper is centrally about endometriosis — it studies GSTT1, GSTM1, and p53 deletion variants as factors linked to endometriosis development and severity in women with concomitant fibrous-cystic mastitis.

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Abstract

The scientific work is devoted to the urgent problem of our time - dishormonal disease of the female reproductive system, namely endometriosis and fibrosis-cystic mastitis. During the last years there has been a steady increase in the dual pathology of genital and breast diseases. According to statistics dishormonal frequency of breast diseases in the population of the female population suffering from various gynecological diseases varies between 76-98 %. It is known that the risk of this disease is closely associated with some alleles detoxification system, glutathione family - S- transferase and proonkogenom p 53, characterized by significant polymorphism. The article presents the results of research on the role of deletion variants of genes GSTT1, GSTM1 and p 53 in the development of endometriosis and fibrosis-cystic mastitis. Screening populations on carriage of alleles reveals women who are likely to develop these diseases and choose the most effective tactics of medical treatment in the event of the disease.
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DETERMINATION OF GENOTYPE CHARACTERISTICS IN WOMEN WITH ENDOMETRIOSIS AND FIBROUS-CYSTIC MASTITIS AND THEIR ROLE IN DISEASE SEVERITY DOI: https://doi.org/10.11603/mie.1996-1960.2015.3.5006Abstract The scientific work is devoted to the urgent problem of our time - dishormonal disease of the female reproductive system, namely endometriosis and fibrosis-cystic mastitis. During the last years there has been a steady increase in the dual pathology of genital and breast diseases. According to statistics dishormonal frequency of breast diseases in the population of the female population suffering from various gynecological diseases varies between 76-98 %. It is known that the risk of this disease is closely associated with some alleles detoxification system, glutathione family - S- transferase and proonkogenom p 53, characterized by significant polymorphism. The article presents the results of research on the role of deletion variants of genes GSTT1, GSTM1 and p 53 in the development of endometriosis and fibrosis-cystic mastitis. Screening populations on carriage of alleles reveals women who are likely to develop these diseases and choose the most effective tactics of medical treatment in the event of the disease.References Голубева О. В. Клинико-генетический анализ ге-нитального эндометриоза: эндометриомы яичников и аденомиоза : автореф. дис. на соискание науч. степени канд. мед. наук / О. В. Голубева. - М., 2007. - 24 с. Генетические факторы предрасположенности к аде-номиозу / О. В. Голубева, Т. Э. Иващенко, В. С. Баранов, 3. К. Айламазян // Журнал акушерства и женских болезней. - 2007. - Т. LVI, № 2. - С. 25-39. Запорожан В. М. Генетична схильність до ендометріозу: від теоретичних моделей до практичного генетичного моніторингу / В. М. Запорожан, О. В. Михайленко // Одеський медичний журнал. - 2009. - № 2 (112). -С. 46-48. Лобанова О. Т. Генетические и иммунологические аспекты внутреннего эндометриоза : автореф. дисс. на соискание научной степени канд. мед. наук: спец. 14. 01. 01 М., 2003. - 22 с. Рожковска Н. М. Генетичні поліморфізми та функціональний стан рецепторного апарату ендометрія при ендометріозі / Наталія Рожковська, Кристина Кротенко // Педіатрія, акушерство та гінекологія. - 2012. - Т. 74, № 1. - С. 97-99 Adenomyosis: epidemiological factors. / P. Vercellini, P. Vigano, E. Somigliana // Best Pract Res Clin Obstet Gynaecol. - 2006. - Vol. 20 ( 4 ) - P. 465 - 477. Glutathione-S-transferase PI gene polymorphism and susceptibility to endometriosis / D. Ertunc, M. Aban, E. C. Ток^ al.] // Hum Reprod. - 2005. № 20(8). -Р. 2157-2161. McLeod B. S. Epidemiology of endometriosis: an assessment of risk factors / B. S. McLeod, M. G. Retzloff // Clin. Obstet. Gynecol. - 2010 - Vol. 53 (2) - P. 389-396. Downloads Published How to Cite Issue Section License Journal Medical Informatics and Engineering allows the author(s) to hold the copyright without registration The majority of Medical Informatics and Engineering Open Access journals publish open access articles under the terms of the Creative Commons Attribution (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The remaining journals offer a choice of licenses. This journal is available through Creative Commons (CC) License CC-BY 4.0 Accepted 2015-10-20 Published 2015-10-20

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