Comparison between therapeutic effects of mifepristone and danazol on endometriosis patients with infertility after laparoscopic operation

Objective To observe the therapeutic and side effects of mifepristone and danazol on endometriosis patients with infertility after laparoscopic operation and the influences on pregnancy and relapse rates after withdrawal. Methods 98 cases of endometriosis patients with infertility confirmed by laparoscopy were randomly divided into 2 groups. The mifepristone group (n =48) were given mifepristone 10 mg/d and the danazol group were given danazol 400 mg/d for 3 months. The clinical symptoms, signs and the side effects as well as the pregnancy and relapse rates after withdrawal were observed and compared. Results The clinical symptoms and signs were significantly improved during treatment in both groups. Side effects including body weight gain, liver function impairment and vaginal irregular bleeding were occurred less in mifepristone group than in those of danazol group. The average time of menstruous restoration was earlier in mifepristone group than in that of danazol group. There were no significant differences in pregnancy and relapse rates after withdrawal within two years between two groups. Conclusion Either mifepristone or danazol could control the symptoms of endometriosis patients and improve the pregnancy rate of those complicated with infertility. However mifepristone has the advantage of fewer side effects than dannazol and promise to be an ideal drug for endometriosis patients after laparoscopic operation.