Seed proteins mining for development, nutrition and germination using comparative proteomics analysis in quinoa（Chenopodium quinoa willd.)

Seed proteins mining for development, nutrition and germination using comparative proteomics analysis in quinoa（Chenopodium quinoa willd.) | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Seed proteins mining for development, nutrition and germination using comparative proteomics analysis in quinoa（Chenopodium quinoa willd.) Suxia Xu, Qingyun Huang, Ziyang Li, Yijin Huang, Chunsong Lin, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-19485/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Recently quinoa( Chenopodium quinoa willd., 2n=4x=36)raises worldwide popularity with its totally nutrition, stress-tolerance, which leads quinoa to a strategic global food from an Andean native crop. However, seed pre-harvest sprouting, saponin contents e.c., restrict greatly quinoa production and popularity. In the study, we successfully used a combinational proteomics of TMT labeling and parallel reaction monitoring (PRM) to assess proteome changes relating to seed maturation conversion in quinoa to help accelerate genetic improvement for quinoa. Results In total, 6,097 proteins were identified and 4,770 proteins were quantified. Of them, 581 were differential expressed proteins (DEPs). Based on PRM data, seventeen DEPs were identified and quantified, including thirteen down-regulated proteins and four up-regulated proteins. Seventeen DEPs involved in oleanane-type saponins bio-synthesis (β-amyrin 28-oxidase), seed generation (β-Amylase), seed dormancy (late embryogenesis abundant proteins, Cyprosin), seed nutrition (globulin seed storage proteins), accumulation of sugars under seed desiccation (EARLY-RESPONSIVE TO DEHYDRATION 7 protein), pre-harvest sprouting (seed biotin-containing protein SBP65, ABA-inducible protein PHV A1), and enzymes related promoting seed maturation (bifunctional purple acid phosphatase 26), and pigment biosynthesis (3-O-glucosyltransferase). Conclusions We present the high-quality proteomics analysis of quinoa assessing proteome changes during seed maturation conversion. Our results summarize a valuable proteome profiles characterizing quinoa seed maturation. The DEPs are candidate for the functional analyses of proteins regulating seed maturation conversion in quinoa, which provide an important first step towards the genetic improvement of quinoa. Plant Molecular Biology and Genetics DEP maturation Proteomes Quinoa Figures Figure 1 Figure 2 Figure 3 Figure 4 Background Quinoa, ( Chenopodium quinoa Willd., 2n = 4x = 36) a tetraploid native crop that has offered strong subsistence, nutrition, and medicine for Andean indigenous cultures for 8,000 years ( Schlick and Bubenheim, 1996 ; Bhargava et al., 2006 ). Quinoa contains outstanding protein content, possesses a balanced amino acid profile compared to common cereal grains, similar to the biological value of protein in milk (Oelke et al., 1992 ; Wu et al., 2014). It overcomes cereals in the level of lipids, proteins, dietary fibers, vitamins B1, B2, B6, C, E and minerals (Wu et al., 2014). In addition to presenting high nutritional quality, it is also noteworthy that quinoa is gluten-free, suitable food products for people with celiac disease (Zevallos et al., 2014 ; Wu, 2016 ). Also, quinoa have high salt tolerance and can grow under extremely dry conditions (Ruiz et al., 2016 ; Walters et al., 2016). Particular adaptations of this species to certain geographical areas gave rise to different ecotype in adaptations to rainfall areas with precipitation of 2000 mm per year to extremely drought stress of 150 mm per year (Fuentes et al., 2012 ). Quinoa has the potential to provide a drought/salt tolerant, nutritious alternative staple food. However, so far, quinoa supply is much insufficient, especially many people are suffering starvation or malnutrition in the world (FAO, 2014). Despite its agronomic potential, quinoa is still an underutilized crop with the objective of enhancing global food security for a growing world population (Massawe et al. 2016 ). Probably all theses aspects were taken into account by the FAO when it included quinoa in the list of most promising crops for world food security and human nutrition in future (FAO, 2006). Nutrition accumulation is common concern in quinoa production. Quinoa nutrition is characterized with seed storage proteins, carbohydrate, starch, saponins, vitamins, minerals, i.e (Wu et al., 2014). Of them, seed storage proteins are mainly responsible for seed germination (Aloisi et al., 2016 ), also make quinoa nutritious. Additionally, quinoa has some unpleasant traits, such as pre-harvest sprouting, unpalatable bitterness of seed coat (Lopes et al., 2019 ). Pre-harvest sprouting is one big problem in quinoa production, which bugs farmers a lot (Lintschinger et al., 1997 ; Lopes et al., 2019 ). It would facilitate genetic improvement to pre-harvest sprouting during seed maturation, if pre-harvest sprouting related proteins could be identified (Burrieza et al., 2019 ). Quinoa seeds contain a mixture of triterpene glycosides called saponins (David et al., 2017 ). Saponins are another problem in quinoa production. Although saponins may be beneficial for plant growth (Kuljanabhagavad, et al., 2009), they impart bitterness to the grain (Fiallos-Jurado et al., 2016 ), and they must be removed before human consumption. To explore saponins biosynthesis proteins during seed maturation can help modify grain flavor in future quinoa production. Thus, it is much helpful to explore these typical proteins above during seed maturation to accelerate the genetic improvement of quinoa. Proteomics is an efficient tool to help find reliable proteins markers. (David et al., 2017 ). Fortunately, a high quality genome sequence for quinoa was published. Building on this, here we successfully used a combinational proteomics of TMT and parallel reaction monitoring (PRM) (Peterson et al., 2012) to assess proteome changes relating to seed maturation conversion in Chenopodium quinoa Willd. to help accelerate genetic improvement for quinoa. Results Morphological comparison between two developing stages Morphological indexes were measured such as plant height, inflorescence diameter, hundred-grain weight, grain diameter, grain thickness and colors (leaves color, leaf axil color, stem streaks color, inflorescence color, palea color and episperm color) (see Table 1). At morphological level, palea/episperm color and hundred-grain weight showed sharp difference between two developing stages. Grains of 72 days after sewing is in the eve of seed maturation conversion, and grains 84 days after sewing were mature seeds, edible and dry. Profile of proteome in quinoa We performed a comparative proteomics analysis for seed development, nutrition and germination in two developing stages of maturity conversion by using TMT labeling, HPLC fractionation and LC-MS/MS analysis. Totally 6097 proteins were identified and 4770 were quantifiable, based on 17,362 unique peptides. A quantitative Yellow_1 vs Yellow_2 ratio higher than 1.5 was considered to indicate up-regulation and a quantitative ratio of less than 0.5 was regarded as down-regulation indication. 1,226 proteins were identified as differential- expressed proteins (DEPs) between the two stages. Of them, 675 proteins were up-regulated and 551 were down-regulated (Table 2) (Supplementary Table S1). Supplementary Table S1 showed the MS basic information of DEPs identified. Pearson's Correlation Coefficient was calculated to test the repeatability. The result showed good repeatability was obtained (Table 3 & Figure 2A). Based on the Fisher's exact test, hierarchical clustering heat maps were made to illustrate the changing amounts of DEPs from each of the pooled samples (Figure 2B & Supplementary Tables S2, 3, 4, 5). Based on different protein functional classification (such as: GO, Domain, Pathway, Complex), all the categories were collated and filtered with a corrected p-value < 0.05. For each category, a two-tailed Fisher’s exact test was employed to test the enrichment of the DEPs against all identified proteins. The GO enrichment analysis indicated that the enrichment levels of the up-regulated proteins were high while the enrichment levels of the down-regulated proteins were relatively low as shown in Table 5. Most of the identified DEPs appeared to be involved in the molecular function (43.7%), biological process (39.2%) and cellular component (17.1%) ((see Figure 2C&D, Table 4, 5, & Supplementary Table S6). The up-regulated proteins mainly grouped in the cell component, molecular function and biological process categories, involving in organelle membrane and membrane-enclosed lumen, mitochondrial/membrane binding, adenyl ribonucleotide/adenyl nucleotide binding, ATP- or NTP-dependent helicase activity, and nucleobase-containing compound metabolic process. Supplementary Tables S8 presented the number of DEPs associated with each level GO term according to the GO annotation information of the identified proteins. The KEGG pathway enrichment analysis showed that the up-regulated proteins were mainly enriched in pathway entries related to phenylpanoid biosynthesis including ubiquonone biosynthesis, flavonoid biosynthesis, and/or stilbenoid, diarylheptanoid, gingerol biosynthesis, ribosome, cutin, suberine and wax biosynthesis. Besides, upregulated proteins were mainly enriched in pathway related to photosynthesis proteins. Down-regulated proteins were mainly enriched in glycolysis/ gluconeogenesis, ribosomal proteins, plant hormone signal transduction, proteins processing in endoplasmic reticulum and plant pathogen interaction (Figure 3). Subcellular prediction was performed to illustrate the subcellular localization of these DEPs, as shown in Table 6. Most of the up-regulated proteins were localized in the chloroplast (39.0%), cytoplasm (29.0%) and nucleus (12.0%), while the most of the down-regulated proteins were distributed in the cytoplasm (33.0%), chloroplast (29.0%), and nucleus (19.0%). The percentage of proteins located in extracellular, vacuolar membrane, and cytoskeleton was similar between down- and up-regulated proteins. The percentage of up-regulated proteins localized in the chloroplast and plasma membrane was higher than that of down-regulated proteins, while a higher percentage of down-regulated proteins were in cytoplasm and nucleus. In addition, one down-regulated protein localized to the peroxisome, and one localized to the golgi apparatus. PRM assay results TMT assays identified 4770 peptides, and 581 were identified as DEPs between the two seed developing stages. Those DEPs had predicted annotations related to saponins metabolism, pre-harvest sprouting, ubiquitous proteins accumulation, and ABA signaling pathways, likely involving in conferring stage Ⅰto stage Ⅱ. To confirm the TMT results, a total of 19 peptides were selected for validation using PRM, based on their functional significance, and finally 17 peptides were validated (see Table 7). The high consistency between PRM and TMT quantification results lends confidence to the TMT data. By combining DEPs with their enriched KEGG pathways, we outlined the metabolism characteristic in the maturity development in quinoa. The DEP, AUR62017037-RA, annotated as ABA-inducible protein PHV A1, was identified as down-regulated proteins in Yellow_1/Yellow_2 (see Table 7). Similarly, the DEP, AUR62014945-RA, annotated as β-amylase, showed down-regulation trend during seed maturity in Yellow_1/Yellow_2 (see Table 7). The six DEPs, AUR62002139-RA, AUR62015569-RA and AUR62024716-RA, AUR62003182-RA, AUR62006523-RA, AUR62025011-RA, were annotated as globulin seed storage protein (see Table 7). They were identified as down-regulated proteins. With seeds maturity approaching, these proteins were increasingly expressed. The main component of seed storage proteins is 11S or 13 S globulin in quinoa. The DEP, AUR62025699-RA, annotated as β-amyrin 28-oxidase, descended gradually with seeds maturity (see Table 7). The enzyme was essential for oleanane-type saponin biosynthesis. It indicated that saponins biosynthesis decreased with seeds maturity. Two DEPs, AUR62004613-RA and AUR62022650-RA, belonged to that family of late embryogenesis abundant protein (LEA). Two proteins, AUR62037387-RA and AUR62042308-RA, were identified as seed biotin-containing protein SBP65. A DEP, AUR62013047-RA, was a protein EARLY-RESPONSIVE TO DEHYDRATION 7 located in chloroplastic membrane. Four up-regulation DEPs, a β-amyrin 28-oxidase, a 3-O-glucosyltransferase, a bifunctional purple acid phosphatase 26 and a cyprosin were identified. Disccussion Quinoa is an excellent crop with balanced nutrition and wide adaptations. However, despite its agronomic potential, quinoa is still an underutilized crop with the objective of enhancing global food security for a growing world population. So far quinoa production suffers a lot of problems such as bitterness of saponins, seed maturity consistency, pre-harvest sprouting, nutrition accumulation, and so on, that provide genetic improvement aims. Seed development experienced nutrition accumulation, seed desiccation, pigment biosynthesis, seed dormancy preparation, saponins biosynthesis, and so on. We chose the stages from 72 days to 84 days after sewing for investigation of typical proteins involving in these biology progress using proteomics and PRM. Seventeen typical DEPs during seed maturity conversion were validated and showed obvious dynamic. The DEP, AUR62025699-RA, was annotated as β-amyrin 28-oxidase, a saponin bio-synthesis enzyme. Quinoa contains 2 to 5% saponins, producing an undesirable bitter flavor, found in the external layers of the seeds or leaves (Medina-Meza et al., 2016 ). According to their saponin content, quinoa varieties have been classified as “sweet” (free or less than 0.11 g/100 g DW) and “bitter” varieties (more than 0.11 g/100 g DW) (Vega-Galvez et al., 2010 ). Given the associated bitterness and toxicity of saponins, quinoa is treated to reduce saponin levels by washing, dehulling, or thermal processing(Gomez-Caravaca et al., 2014 ; Medina-Meza et al., 2016 ). The process is costly and water-intensive, also can reduce the nutritional value of the seeds (Zurita-Silva et al., 2004). Thus, the development of saponin-free lines is a major breeding objective in quinoa (Zurita-Silva et al., 2014 ). Oleanane-type triterpenes are the major saponin components in quinoa (Medina-Meza et al., 2016 ). The enzyme, β-amyrin 28-oxidase, is essential for oleanane-type saponin biosynthesis (Han et al., 2013 , Jo et al., 2017 ). In the study, expression of the enzyme, β-amyrin 28-oxidase, indicated increasing trend with seed maturity. β-amylases (BAM) are key enzymes of plastidial starch degradation. In the study, the enzyme AUR62014945-RA down-regulated with the maturity in Yellow_1/Yellow_2. It indicated that an amylase inhibitor prevents the function of β-amylases, AUR62014945-RA, i.e. the premature hydrolysis of stored starch during seed development (Mundy et al., 1985). The protein AUR62017037-RA, ABA-inducible protein PHV A1, maybe exert a role of an amylase inhibitor in quinoa. ABA-inducible protein PHV A1 inhibited seed germination in aleurone layers during barley maturity (Hong et al., 1988 ). Pre-harvest sprouting occurred frequently in quinoa production (Fig. 4 ), and made farmers suffered a lot. The function of ABA-inducible protein PHV A1 is under investigation. The six DEPs, AUR62002139-RA, AUR62015569-RA, AUR62024716-RA, AUR62003182-RA, AUR62006523-RA, AUR62025011-RA, were annotated as 13S globulin seed storage protein 1 and 11 globulin seed storage protein 2. Of them, three DEPs (AUR62003182-RA, AUR62006523-RA, AUR62025011-RA) were vicilin-like seed storage protein, and three DEPs (AUR62002139-RA, AUR62015569-RA, AUR62024716-RA) were legumin-like seed storage protein. The legumin-like proteins (both 11S and/or 13S) were generally much more abundant in quinoa seeds than the vicilin-like proteins (Burrieza et al., 2019 ). Proteins in quinoa seeds are mainly stored in the embryonic tissue also containing lipid, ash, fiber and saponin while the perisperm is rich in starch (Maldonado and Otegui, 1998; Ando et al., 2002). Of the total protein in mature seeds of quinoa, 37% proteins are 11S-type globulin called chenopodin, and 35% of the seed protein are 2S albumin (Dakhili et al., 2019 ). 11S globulin was the predominant component of quinoa seed storage proteins (Stevens et al., 2006, Dakhili et al., 2019 ). Accumulation of these proteins indicated approaching maturation. The main component of duckwheat and sweet beet were seed storage proteins, 13S globulin (Aloisi, et al., 2016 , Burrieza et al., 2019 , Zhou et al., 2019 ). Quinoa seeds have main storage proteins including globulins, (legumins and vicilins), with rich lysine, methionine and cysteine than common cereals and legumes (Ruales & Nair, 1992, Burrieza et al. 2019 ). These globulins were active peptides, reported as the antibacterial, antidiabetic, antihypertensive, chemo-preventive, anti-tumoral and antioxidant activities (Hu et al. 2017 , Vilcacundo et al. 2017 , 2018 ). These can be used as a functional ingredient in the food industry (Bendevis & Jacobsen, 2015, Zhou et al. 2019 ). The DEPs, AUR62037387-RA, AUR62042308-RA, were annotated as seed biotin-containing protein SBP65 (seed biotinylated protein of 65 kDa of apparent molecular mass). The proteins are biotin-dependent carboxylases, exerting key roles in basic metabolism in most plants (Dehaye et al., 1997 ). The biotinylated proteins, devoid of any carboxylase activity, were characterized with many physiological and molecular features with late embryo genesis-abundant (LEA) proteins in pea (Dehaye et al., 1997 ). These peculiar proteins, localized to the cytosol of embryonic cells, perhaps behave as a scavenger or a sink, of free biotin, during late stages of embryo development and is rapidly degraded during germination (Duval et al., 1994, Dehaye et al., 1997 ,Wang et al., 2012 ), while the essential role for biotin maybe exerts in seedling establishment from immature embryos. In fact, ABA can induce the expression of the proteins (Dehaye et al., 1997 ). The report indicated that the expression of the proteins increased with the seed maturity. Quinoa potentially evolved a nice mechanism to prevent from pre-harvest sprouting. Further investigation would help prevent from pre-harvest sprouting in quinoa. The report helps understand the function of these proteins in the embryo development of higher plants. The proteins, AUR62022650-RA and AUR62004613-RA, annotated as late embryogenesis abundant (LEA) proteins. LEA proteins were involved in ABA-mediated stress responses (Galau et al., 1986 ). Seeds can suffered desiccation during the maturation phase by the accumulation of high levels of LEA proteins (Avelange-Macherel et al., 2015, Saucedo et al., 2017 ). It was thought that LEAs have been evolutionarily selection to adopt diversified conditions driven by variations in their cellular environment (Mariana et al., 2019 ). Two LEAs, AUR62022650-RA and AUR62004613-RA, were accumulated highly, as well as increasing accumulation of 11S globulins and 2S albumin, consistent with increasingly seed desiccation during the maturation phase of quinoa. The DEP,AUR62028163-RA༌was annotated as protein EARLY-RESPONSIVE TO DEHYDRATION 7. The organelle localization of the DEP has been identified in chloroplast. Early responsive to dehydration (ERD) genes are rapidly induced to respond to dehydration and various other abiotic stresses in plasma, mitochondria and chloroplast membranes (Archana et al., 2012). The ERD protein maybe play a role as a putative sugar transporter as accumulation of sugars increased upon drought (Rizhsky et al., 2004 , Pertl-Obermeyer et al., 2016 ). ABA maybe involved in induction of the protein ((Yamada et al., 2010 ). Similarly, the protein was induced by seeds suffering the loss of cellular water during the maturation phase. It was not well known that ERDs were expressed earlier than LEAs or not. Its detailed function is under investigation. The DEP, AUR62028163-RA, was annotated as an anthocyanidin 3-O-glucosyltransferase 7. So far, anthocyanins and betalains never coexist in the same plant species. Interestingly lots of research indicated that genes responsible for anthocyanins biosynthesis were identified in betalain-accumulation plants (Xu et al. 2015 , 2016). It is supposed that both betacyanin and anthocyanin metabolisms coexisted in earlier plants and maybe get separated with evolution (Shibendu et al., 2013). Betacyanins are the major pigments present in quinoa. The terminal glycosylation of the aglycone betanidin transfers betanidin to batanins in the biosynthesis pathway of betacyanins (Isayenkova et al., 2006 , Das et al., 2013 ). The similarity of the 3-O-glucosyltransferase, the DEP, AUR62028163-RA, in quinoa to that of anthocyanin 3-O-glucosyltransferase indicates the coexistence of both the pathways of pigment biosynthesis. The protein, AUR62028163-RA, up-regulated the transfer of glucose from UDP-glucose to betalains. It indicated that betalains accumulation in seeds decreased as quinoa seeds approached maturation. Color changes are also regarded as the typical sighs of maturity. The DEP, AUR62013288-RA, was annotated as a bifunctional purple acid phosphatase 26 (PAP). PAPs are key phosphate (Pi)-metabolizing enzymes, help plants with Pi availability and absorption as they are mostly exposed to suboptimal environmental conditions for this vital element (Mohammad et al., 2018 ). Seeds development is a Pi-consuming phase, and then Pi starvation often occurs. The DEP, AUR62013288-RA, decreased as seeds maturation ends. The enzymes can also be regarded as typical proteins during maturation phase of seeds. The last DEP, AUR62023656-RA, was identified as an up-regulated cyprosin. It indicated that the DEP encoded decreased with seed maturation. Cyprosin, a member of aspartic proteinases family, is involved in the process of dormancy, viability and germination of seeds (Milisavljevicet al., 2008, Janek et al., 2016 , Shen et al., 2018 ). Seed dormancy, an evolutional strategy, prevents from seeds germination during seed storage, or in stress conditions. The process from dormancy to generation includes three stages: the primary dormancy acquirement with seed maturation, gradual loss of seed dormancy in a subsequent period of seed storage (so-called after-ripening), and finally approach into a non-dormant state (Graeber et al., 2012 ; Ne´e et al., 2017a ). Pre-harvest sprouting is cut-short dormancy or dormancy-loss and abnormal generation, which is a severe problem in quinoa production. It is possible the aspartic proteinases, AUR62023656-RA, promotes seed dormancy. Further investigation of the protein could help find the solution to pre-harvest sprouting. For an early maturation accession, timely harvest seemed to be very crucial to obtain plump grains with nice color, on which the yield depends. Untimely harvest would result in both harms: delayed harvest brings about grains exposing to continuous rainwater and early harvest results in poor grain plumpness. In subtropical areas, timely harvest could get the second benefit as a result that spring rains is the great enemy for quinoa harvest. Spring rain in subtropical areas always goes on for two or three weeks, which almost cover whole harvest season. Pre-harvest sprouting in quinoa causes poor grain quality and results in significant reductions in yield, leading to significant economic losses. In the past four years, quinoa culture in Xiamen experienced twice three-week spring-rains, respectively in 2016 and 2019 when maturity was closing. Bad grains were collected exposing to continuous spring rains. However, early harvest directly lead to grains with poor plumpness based on morphological index. Conclusions Seed maturation conversion is an essential stage in plant life, especially for seed economic crops such as quinoa. Proteomics analysis of quinoa assessed proteome changes during seed maturation conversion. Thirteen down-regulated DEPs and four up-regulated DEPs showed dynamic of oleanane-type saponins bio-synthesis, seed generation, seed dormancy, related enzymes such as β-Amylase, ABA-inducible protein PHV A1, seed storage proteins, LEAs, cyprosin, PAP, and so on. The work enhances our understanding of the biological and physiological characteristics of seed maturation in quinoa, and an important first step towards the genetic improvement of quinoa. Methods Materials Experiments were conducted at Fujian Institute of Subtropical Botany’s Quinoa Garden, which is located in Xiamen, China (118°04′04″, latitude 24°26′46″, annual average temperature 22°C), at an elevation of 63 m above sea level. The site receives an average rainfall of 1200 mm/year. The accession PI596293, was obtained from Plant Germplasm Quarantine Center, USDA. accession PI596293, named COLORADO 407D, is a native ecotype from Colorado., the United states, and is early maturing. COLORADO 407D was characterized with a central axis and secondary and tertiary axes, the large, amaranthiform, compact and glomerous inflorescences, large, yellow, sweet seeds. It was sewed in Oct 26, 2017, eared Dec 10 and harvested on Jan 26, 2018. Inflorescence was collected in both developing stages, respectively. The first stage (Stage I) was 72 days after sewing, and the second stage (Stage II) was 84 days after sewing. Grains of 72 days after sewing is in the eve of seed maturation conversion, and grains 84 days after sewing were mature seeds, edible and dry. Protein Extraction Whole inflorescence was collected, quickly frozen in liquid nitrogen, and then stored at -80°C. The sample was grinded by liquid nitrogen into cell powder and then transferred to a 5-mL centrifuge tube. After that, four volumes of lysis buffer (8 M urea, 1% Triton-100, 10 mM dithiothreitol, and 1% Protease Inhibitor Cocktail) was added to the cell powder, followed by sonication three times on ice using a high intensity ultrasonic processor (Scientz). The remaining debris was removed by centrifugation at 20,000 g at 4 °C for 10 min. Finally, the protein was precipitated with cold 20% TCA for 2 h at -20 °C. After centrifugation at 12,000g 4 °C for 10 min, the supernatant was discarded. The remaining precipitate was washed with cold acetone for three times. The protein was redissolved in 8 M urea and the protein concentration was determined with BCA kit according to the manufacturer’s instructions. Trypsin Digestion For digestion, the protein solution was reduced with 5 mM dithiothreitol for 30 min at 56 °C and alkylated with 11 mM iodoacetamide for 15 min at room temperature in darkness. The protein sample was then diluted to urea concentration less than 2M. Finally, trypsin was added at 1:50 trypsin-to-protein mass ratio for the first digestion overnight at 37°C and 1:100 trypsin-to-protein mass ratio for a second 4 h-digestion. TMT Labeling Peptide was desalted using Strata X C18 SPE column (Phenomenex) and vacuum-dried after trypsin digestion. According to the manufacturer’s TMT kit protocol, Peptide was reconstituted and processed in 0.5 M TEAB . Briefly, thawed and reconstituted in acetonitrile, then one unit of TMT reagent incubated the peptide mixtures for 2 h at room temperature and pooled, desalted and dried by vacuum centrifugation. HPLC Fractionation The tryptic peptides were digested into fractions by high pH reverse-phase HPLC using Agilent 300Extend C18 column (5 μm particles, 4.6 mm ID, 250 mm length). Then, peptides were first separated with a gradient of 8% to 32% acetonitrile (pH 9.0) over 60 min into 60 fractions. Finally, the peptides were fractionated into 18 fractions and dried using vacuum centrifuging. LC-MS/MS Analysis Peptides were dissolved in 0.1% formic acid (solvent A) before the tryptic peptides loaded onto a home-made reversed-phase analytical column (15-cm length, 75 μm i.d.). The gradient was consisted of an increase from 6% to 23% solvent B (0.1% formic acid in 90% acetonitrile) over 38 min, 23% to 35% in 14 min and adding to 80% in 4 min then holding at 80% for the last 4 min, all at a constant flow rate of 400 nL/min on an EASY-nLC 1000 UPLC system. The peptides were subjected to NSI source followed by tandem mass spectrometry (MS/MS) in Q ExactiveTM Plus (Thermo) coupled online to the UPLC. The electrospray voltage applied was 2.0 kV. The m/z scan range was 300 to 1000 for full scan, and intact peptides were detected in the Orbitrap at a resolution of 35,000. Peptides were then selected for MS/MS using NCE setting as 27 and the fragments were detected in the Orbitrap at a resolution of 17,500. A data-independent procedure that alternated between one MS scan followed by 20 MS/MS scans. Automatic gain control (AGC) was set at 3E6 for full MS and 1E5 for MS/MS. The maximum IT was set at 20 ms for full MS and auto for MS/MS. The isolation window for MS/MS was set at 2.0 m/z. Database Search The obtained MS/MS data were processed using Maxquant search engine (v.1.5.2.8). Tandem mass spectra were searched against quinoa database concatenated with reverse decoy database. The mass tolerance for precursor ions was set as 20 ppm in First search and 5 ppm in Main search,and the mass tolerance for fragment ions was set as 0.02 Da. Trypsin/P was specified as cleavage enzyme allowing up to 2 missing cleavages. Carbamidomethyl on Cys was specified as fixed modification and oxidation on Met was specified as variable modifications. FDR was adjusted to 40. Bioinformatics analysis Proteome data was annotated, subcellular Localized and functional enrichment analyzed. Go annotation proteome was derived from the UniProt-GOA database (www. http://www.ebi.ac.uk/GOA/). Then proteins were classified by Gene Ontology annotation based on three categories: biological process, cellular component. Identified proteins domain functional description were annotated by InterProScan (a sequence analysis application) based on protein sequence alignment method, and the InterPro domain database was used. Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to annotate protein pathway. Also, we used wolfpsort, a subcellular localization predication soft to predict subcellular localization. An updated version of PSORT/PSORT II for the prediction of eukaryotic sequences and molecular function. A corrected p-value < 0.05 is considered significant. The resulting MS data were processed using Skyline (v.3.6). Enzyme was set as Trypsin [KR/P], Max missed cleavage set as 0. The peptide length was set as 7-25, Variable modification was set as Carbamidomethyl on Cys and oxidation on Met, and maxvariable modifications was set as 3. Transition settings: precursor charges were set as 2, 3, ion charges were set as 1, ion types were set as b, y. The productions were set as from ion 3 to last ion, the ion match tolerance was set as 0.02 Da. PRM validation for Targeted MS Analysis To determine the reliability sequencing results, original proteins samples were applied to the same LC-MS system used above. According to results from the above assessment, a total of 19 peptides were selected and added to the inclusion list for the PRM assay detection. Full details referenced Hashimoto et al. (2019). Acknowledgement This work was supported by the Xiamen Science & Techno lodge Project (Grant No. 2016S0974, 2016-2019) and the National Natural Science Foundation of China (Grant No. 31 372 093). 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Consent for publication The manuscript is based on Consent for publication Availability of data and material The submission includes all data and material, and are available. The supporting data has been uploaded with submission, which can be accessed. Competing interests The manuscript has not any Competing interests . Funding All funding for the studies are listed in the manuscript, together with the names of the principal funding recipients. Authors' contributions SX X: designed the research, preparing manuscript and acquire Funding; QY H: analyze data,materials collecting; ZY L: pictures preparation, manuscript modifying; H YJ: treatment; L CS: data curation; H EM: methodology; L FC : Software. All authors have read and approved the manuscript . Acknowledgement All funding for the studies in the manuscript, together with the names of people who provided any help for the work, must be listed in the Acknowledgement. Tables Table 1 Morphological characteristics of plant in two developing stages Stage Mean Plant height (cm) Mean diameter of inflorescence (cm) Mean height of inflorescence (cm) Leaves color Leaf axil color Stem streaks Color Stage Ⅰ 111.2 5.4 30.5 green green green Stage Ⅱ 107.1 5.6 32.0 Green Green Green Stage Mean grain diameter (mm) Mean grain thickness (mm) Mean hundred-grain weight (g) Palea color Episperm color Days after sewing Stage Ⅰ 2.2 1.1 0.22 green orange 72 Stage Ⅱ 2.5 1.4 0.38 yellow orange 84 Table 2. DEPs summary (Filtered with threshold value of expression fold change and P value 1.2 fold change >1.3 fold change >1.5 fold change >2.0 Yellow_1/Yellow_2 up-regulated 1263 1042 675 287 down-regulated 1013 824 551 294 Table 3 Pearson's correlation of quantification Yellow_1_1 Yellow_1_2 Yellow_1_3 Yellow_2_1 Yellow_2_2 Yellow_2_3 Yellow_1_1 1 0.78 0.9 -0.73 -0.74 -0.79 Yellow_1_2 0.78 1 0.73 -0.74 -0.74 -0.68 Yellow_1_3 0.9 0.73 1 -0.7 -0.72 -0.79 Yellow_2_1 -0.73 -0.74 -0.7 1 0.89 0.84 Yellow_2_2 -0.74 -0.74 -0.72 0.89 1 0.84 Yellow_2_3 -0.79 -0.68 -0.79 0.84 0.84 1 Table 4 GO distribution of up-regulate proteins(Yellow_1-vs-Yellow_2) GO Terms Level 1 GO Terms Level 2 No. of Protein Percent % Biological Process metabolic process 140 47.0 single-organism process 81 cellular process 78 response to stimulus 16 biological regulation 8 cellular component organization or biogenesis 6 localization 5 other 3 Cellular Component cell 36 14.3 membrane 27 macromolecular complex 18 organelle 12 supramolecular complex 5 extracellular region 5 Molecular Function catalytic activity 152 38.7 binding 101 antioxidant activity 8 electron carrier activity 7 molecular function regulator 5 structural molecule activity 3 other 2 Table 5: GO distribution of down-regulate proteins(Yellow_1-vs-Yellow_2) GO Terms Level 1 GO Terms Level 2 No. of Protein Percent % Biological Process metabolic process 91 31.4 cellular process 66 single-organism process 32 response to stimulus 10 localization 7 cellular component organization or biogenesis 7 developmental process 3 multicellular organismal process 3 biological regulation 3 other 2 Cellular Component cell 51 19.9 organelle 43 macromolecular complex 35 extracellular region 7 membrane 6 Molecular Function catalytic activity 78 48.7 binding 71 structural molecule activity 35 nutrient reservoir activity 12 antioxidant activity 3 molecular function regulator 3 other 3 Table 6 Sub-cell location of DEPs (Yellow_1-vs-Yellow_2) Subcellular Location Number of up-regulate proteins (% of total) Number of down-regulate proteins (% of total) chloroplast 111(39) 84(29) cytoplasm 85(29) 97(33) nucleus 36(12) 56(19) plasma membrane 19(7) 9(3) extracellular 15(5) 17(6) vacuolar membrane 8(3) 6(2) mitochondria 6(2) 12(4) cytoskeleton 5(2) 6(2) endoplasmic reticulum 2(1) 4(2) Golgi apparatus 0 1(0) peroxisome 0 1(0) cytoplasm 0 1(0) Total 287 294 Table 7 Identified DEPs in two developing stages using PRM Proteins codes Protein description Regulated Type Yellow_1/Yellow_2 Ratio (PRM) a Yellow_1/Yellow_2 Ratio (TMT) a AUR62017037-RA ABA-inducible protein PHV A1 [Vitis vinifera] Down 0.09 0.134 AUR62014945-RA beta-amylase [Beta vulgaris subsp. vulgaris] down 0.01 0.08 AUR62002139-RA 13S globulin seed storage protein 1 [Beta vulgaris subsp. vulgaris] down 0.48 0.29 AUR62015569-RA 13S globulin seed storage protein 1 [Beta vulgaris subsp. vulgaris] down 0.34 0.30 AUR62024716-RA 11S globulin seed storage protein 2 isoform X2 [Beta vulgaris subsp. vulgaris] down 0.36 0.32 AUR62003182-RA vicilin-like seed storage protein At2g18540 [Beta vulgaris subsp. vulgaris] down 0.40 0.33 AUR62006523-RA vicilin-like seed storage protein At2g28490 isoform X2 [Beta vulgaris subsp. vulgaris] down 0.37 0.28 AUR62025011-RA vicilin-like seed storage protein At2g28490 isoform X2 [Beta vulgaris subsp. vulgaris] down 0.36 0.25 AUR62037387-RA seed biotin-containing protein SBP65 [Beta vulgaris subsp. vulgaris] down 0.09 0.20 AUR62042308-RA seed biotin-containing protein SBP65 [Beta vulgaris subsp. vulgaris] down 0.07 0.16 AUR62022650-RA late embryogenesis abundant protein (LEA) family protein [Medicago truncatula] down 0.39 0.20 AUR62004613-RA late embryogenesis abundant protein (LEA) family protein [Medicago truncatula] down 0.18 0.15 AUR62013047-RA "protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic [Beta vulgaris subsp. vulgaris]" down 0.09 0.129 AUR62025699-RA β -amyrin 28-oxidase [Beta vulgaris subsp. vulgaris] Up 3.93 2.05 AUR62028163-RA anthocyanidin 3-O-glucosyltransferase 7 [Beta vulgaris subsp. vulgaris] Up 7.46 3.188 AUR62013288-RA bifunctional purple acid phosphatase 26 [Beta vulgaris subsp. vulgaris] Up 5.13 2.97 AUR62023656-RA cyprosin [Beta vulgaris subsp. vulgaris] Up 9.50 3.158 a All results were signifificant at p< 0.05. Abbreviations ABA, abscisic acid; AGC, automatic gain control; BAM, β-Amylase; BCA, bicinchoninic acid; COG/KOG, Clusters of Orthologous Groups/Eukaryotic Orthologous Groups; DEPs, differential expressed proteins; ERD, early responsive to dehydration; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; LEA, late embryogenesis abundant proteins; PRM, parallel reaction monitoring; TEAB, Triethylamonium bicarbonat; TMT, Tandem Mass Tag; UDP, Uridinediphosphate; UGT, UDP-glycosyltransferase. Supplementary Files SupplementaryTableS8ProteinGOTermsLevel2Classify.xlsx SupplementaryTableS9KEGGpathwayenrichment.xlsx SupplementaryTableS2Yellow1vsYellow2Q1annot.xlsx SupplementaryTableS10ProteinSubcellularClassify.xlsx SupplementaryTableS1Yellow1vsYellow2Qallproteinlist.xls SupplementaryTableS11PRM1Result.xlsx SupplementaryTableS7Proteindomainenrichment.xlsx SupplementaryTableS3Yellow1vsYellow2Q2annot.xlsx SupplementaryTableS4Yellow1vsYellow2Q3annot.xlsx SupplementaryTableS5Yellow1vsYellow2Q4annot.xlsx SupplementaryTableS6allproteinpathwayenrichment.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-19485","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":446174,"identity":"d7c9ac99-1701-437d-9f06-df0b3c8cc2c3","order_by":1,"name":"Suxia Xu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAvUlEQVRIiWNgGAWjYBAC++PNBwwSKv7J8ROv58yxhIIPZw4YSzYQreVGjsHHmW0HEg0OEKuDseeM4WbetjsJxseTNzD8qNhGWAsze1uxMc+5Z3lmZ54VAPXfJqyFjefwNmOeMuZiM6ALmRnbiNDCI5Fg/puHjTlx8wxitUhIpBgYzmg7nLhBglgtBjzHEgw+nEkzlgD65SBRfjFgB0eljRx/e/LGBz8qiNCCBBKIjxqEFlJ1jIJRMApGwQgBANM6Q85E1NdyAAAAAElFTkSuQmCC","orcid":"","institution":"Fujian Institute of Subtropical Botany","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Suxia","middleName":"","lastName":"Xu","suffix":""},{"id":446175,"identity":"03e5f8fc-0a19-4a80-843c-4526a9da4237","order_by":2,"name":"Qingyun Huang","email":"","orcid":"","institution":"Fujian Institute of Subtropical Botany","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qingyun","middleName":"","lastName":"Huang","suffix":""},{"id":446176,"identity":"fe09022b-4117-40e5-aa05-feddd81270f5","order_by":3,"name":"Ziyang Li","email":"","orcid":"","institution":"Northeast Agricultural University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ziyang","middleName":"","lastName":"Li","suffix":""},{"id":446177,"identity":"07bc90a1-00f6-484b-9649-e93d986c7ee8","order_by":4,"name":"Yijin Huang","email":"","orcid":"","institution":"Xiamen University and Fujian Medical University Affiliated First Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yijin","middleName":"","lastName":"Huang","suffix":""},{"id":446178,"identity":"7768f3b7-7493-4cbf-a80c-37dc1bdb93d8","order_by":5,"name":"Chunsong Lin","email":"","orcid":"","institution":"Fujian Institute of Subtropical Botany","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chunsong","middleName":"","lastName":"Lin","suffix":""},{"id":446179,"identity":"42b63459-bf45-4949-9bf1-647915704103","order_by":6,"name":"Enming He","email":"","orcid":"","institution":"Fujian Institute of Subtropical Botany","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Enming","middleName":"","lastName":"He","suffix":""},{"id":446180,"identity":"17ef7306-28c2-4872-82fd-c03b5b5daa41","order_by":7,"name":"Fucong Lin","email":"","orcid":"","institution":"Fujian Institute of Subtropical Botany","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Fucong","middleName":"","lastName":"Lin","suffix":""}],"badges":[],"createdAt":"2020-03-25 16:56:38","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-19485/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-19485/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":746925,"identity":"c5958fdd-3ee3-4301-a597-da96c60a124e","added_by":"auto","created_at":"2020-03-27 21:15:44","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":2599632,"visible":true,"origin":"","legend":"Materials in the study. A is in Stage I and B is in Stage II.","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Figure 1.jpg"},{"id":746927,"identity":"7ff88079-a63c-4e24-b40d-a5c9daa9b6cf","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":362634,"visible":true,"origin":"","legend":"Quantitative identification and annotation of up- and down-regulated proteins by TMT labeling. (A) Pearson's correlation coeffificients calculated from three biological replicates for each biotype/treatment. (B) Numbers of DEPs based on difference fold in Yellow_1-vs-Yellow_2. (C) GO classification of the up-regulated DEPs in Yellow_1-vs-Yellow_2. (D) GO classification of the down-regulated DEPs in Yellow_1-vs-Yellow_2.","description":"","filename":"Figure2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Figure 2.jpg"},{"id":746929,"identity":"9cda22f2-ef1b-40fd-8ee0-d4a19c487007","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":131801,"visible":true,"origin":"","legend":"KEGG pathways of up-regulated proteins (A,red) and down-regulated proteins (B, green).","description":"","filename":"Figure3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Figure 3.jpg"},{"id":746931,"identity":"739569dd-7e75-4e49-9873-e21b619248bf","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":3800796,"visible":true,"origin":"","legend":"Pre-harvest sprouting in quinoa","description":"","filename":"Figure4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Figure 4.jpg"},{"id":13496345,"identity":"4ee3f068-87bb-4f9f-8f1a-4b1e1f9169bf","added_by":"auto","created_at":"2021-09-16 22:48:58","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":902913,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/a531b1f6-512f-4541-a5b3-49cea899e502.pdf"},{"id":746933,"identity":"30f02baa-4bca-4af5-a586-31cdf41b5a5a","added_by":"auto","created_at":"2020-03-27 21:15:46","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":6438,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS8ProteinGOTermsLevel2Classify.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S8 -Protein_GO_Terms_Level2_Classify.xlsx"},{"id":746934,"identity":"d8ae747a-c5a4-41c3-a673-9dc1a84baf4a","added_by":"auto","created_at":"2020-03-27 21:15:46","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":44466,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS9KEGGpathwayenrichment.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S9-KEGG_pathway_enrichment.xlsx"},{"id":746935,"identity":"531b0817-0764-48e3-82bf-552bf12121a6","added_by":"auto","created_at":"2020-03-27 21:15:46","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":63639,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS2Yellow1vsYellow2Q1annot.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S2-Yellow_1vsYellow_2_Q1_annot.xlsx"},{"id":746936,"identity":"48564ef8-f063-4b7a-b052-4ba07e825fd7","added_by":"auto","created_at":"2020-03-27 21:15:46","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":5875,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS10ProteinSubcellularClassify.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S10-Protein_Subcellular_Classify.xlsx"},{"id":746937,"identity":"59262624-44bb-4a83-a1e1-8adc8d7d533c","added_by":"auto","created_at":"2020-03-27 21:15:46","extension":"xls","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":739366,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS1Yellow1vsYellow2Qallproteinlist.xls","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S1-Yellow_1vsYellow_2_Qall_protein_list.xls"},{"id":746938,"identity":"68ff3d21-ff11-4552-9c3d-1d8296208fad","added_by":"auto","created_at":"2020-03-27 21:15:46","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":20462,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS11PRM1Result.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S11-PRM1_Result.xlsx"},{"id":746926,"identity":"fcabc28b-1a8b-46d2-a9c7-cb37349e3f2f","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":101171,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS7Proteindomainenrichment.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S 7-Protein domain enrichment.xlsx"},{"id":746928,"identity":"50d9c577-2493-4e20-b3d6-900123df4bcb","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":69670,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS3Yellow1vsYellow2Q2annot.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S3-Yellow_1vsYellow_2_Q2_annot.xlsx"},{"id":746930,"identity":"a9e93f1f-f648-42c2-86f3-1985b061d4a3","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":105617,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS4Yellow1vsYellow2Q3annot.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S4-Yellow_1vsYellow_2_Q3_annot.xlsx"},{"id":746932,"identity":"92bf24e3-887c-45d4-a4ae-06eadc738cf6","added_by":"auto","created_at":"2020-03-27 21:15:45","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":73886,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS5Yellow1vsYellow2Q4annot.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S5-Yellow_1vsYellow_2_Q4_annot.xlsx"},{"id":746924,"identity":"edea8f28-92ec-4d30-8830-c0bc9f8df47b","added_by":"auto","created_at":"2020-03-27 21:15:44","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":5712,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS6allproteinpathwayenrichment.pdf","url":"https://assets-eu.researchsquare.com/files/rs-19485/v1/Supplementary Table S6-all_protein_pathway_enrichment.pdf"}],"financialInterests":"","formattedTitle":"Seed proteins mining for development, nutrition and germination using comparative proteomics analysis in quinoa（Chenopodium quinoa willd.)","fulltext":[{"header":"Background","content":" \u003cp\u003eQuinoa, (\u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eChenopodium quinoa\u003c/span\u003e Willd., 2n\u0026thinsp;=\u0026thinsp;4x\u0026thinsp;=\u0026thinsp;36) a tetraploid native crop that has offered strong subsistence, nutrition, and medicine for Andean indigenous cultures for 8,000\u0026nbsp;years ( Schlick and Bubenheim, \u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e1996\u003c/span\u003e; Bhargava et al., \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2006\u003c/span\u003e). Quinoa contains outstanding protein content, possesses a balanced amino acid profile compared to common cereal grains, similar to the biological value of protein in milk (Oelke et al., \u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e1992\u003c/span\u003e; Wu et al., 2014). It overcomes cereals in the level of lipids, proteins, dietary fibers, vitamins B1, B2, B6, C, E and minerals (Wu et al., 2014). In addition to presenting high nutritional quality, it is also noteworthy that quinoa is gluten-free, suitable food products for people with celiac disease (Zevallos et al., \u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e2014\u003c/span\u003e; Wu, \u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). Also, quinoa have high salt tolerance and can grow under extremely dry conditions (Ruiz et al., \u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e2016\u003c/span\u003e; Walters et al., 2016). Particular adaptations of this species to certain geographical areas gave rise to different ecotype in adaptations to rainfall areas with precipitation of 2000\u0026nbsp;mm per year to extremely drought stress of 150\u0026nbsp;mm per year (Fuentes et al., \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e2012\u003c/span\u003e). Quinoa has the potential to provide a drought/salt tolerant, nutritious alternative staple food. However, so far, quinoa supply is much insufficient, especially many people are suffering starvation or malnutrition in the world (FAO, 2014). Despite its agronomic potential, quinoa is still an underutilized crop with the objective of enhancing global food security for a growing world population (Massawe et al. \u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). Probably all theses aspects were taken into account by the FAO when it included quinoa in the list of most promising crops for world food security and human nutrition in future (FAO, 2006).\u003c/p\u003e \u003cp\u003eNutrition accumulation is common concern in quinoa production. Quinoa nutrition is characterized with seed storage proteins, carbohydrate, starch, saponins, vitamins, minerals, i.e (Wu et al., 2014). Of them, seed storage proteins are mainly responsible for seed germination (Aloisi et al., \u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e2016\u003c/span\u003e), also make quinoa nutritious. Additionally, quinoa has some unpleasant traits, such as pre-harvest sprouting, unpalatable bitterness of seed coat (Lopes et al., \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Pre-harvest sprouting is one big problem in quinoa production, which bugs farmers a lot (Lintschinger et al., \u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e1997\u003c/span\u003e; Lopes et al., \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). It would facilitate genetic improvement to pre-harvest sprouting during seed maturation, if pre-harvest sprouting related proteins could be identified (Burrieza et al., \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Quinoa seeds contain a mixture of triterpene glycosides called saponins (David et al., \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2017\u003c/span\u003e). Saponins are another problem in quinoa production. Although saponins may be beneficial for plant growth (Kuljanabhagavad, et al., 2009), they impart bitterness to the grain (Fiallos-Jurado et al., \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e2016\u003c/span\u003e), and they must be removed before human consumption. To explore saponins biosynthesis proteins during seed maturation can help modify grain flavor in future quinoa production.\u003c/p\u003e \u003cp\u003eThus, it is much helpful to explore these typical proteins above during seed maturation to accelerate the genetic improvement of quinoa. Proteomics is an efficient tool to help find reliable proteins markers. (David et al., \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e2017\u003c/span\u003e). Fortunately, a high quality genome sequence for quinoa was published. Building on this, here we successfully used a combinational proteomics of TMT and parallel reaction monitoring (PRM) (Peterson et al., 2012) to assess proteome changes relating to seed maturation conversion in \u003cspan type=\"Italic\" class=\"Italic\" name=\"Emphasis\"\u003eChenopodium quinoa\u003c/span\u003e Willd. to help accelerate genetic improvement for quinoa.\u003c/p\u003e "},{"header":"Results","content":" \u003cp\u003e\u003cstrong\u003eMorphological comparison between two developing stages \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMorphological indexes were measured such as plant height, inflorescence diameter, hundred-grain weight, grain diameter, grain thickness and colors (leaves color, leaf axil color, stem streaks color, inflorescence color, palea color and episperm color) (see Table 1). At morphological level, palea/episperm color and hundred-grain weight showed sharp difference between two developing stages. Grains of 72 days after sewing is in the eve of seed maturation conversion, and grains 84 days after sewing were mature seeds, edible and dry.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eProfile of proteome in quinoa\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe performed a comparative proteomics analysis for seed development, nutrition and germination in two developing stages of maturity conversion by using TMT labeling, HPLC fractionation and LC-MS/MS analysis. Totally 6097 proteins were identified and 4770 were quantifiable, based on 17,362 unique peptides. A quantitative Yellow_1 vs Yellow_2 ratio higher than 1.5 was considered to indicate up-regulation and a quantitative ratio of less than 0.5 was regarded as\u0026nbsp; down-regulation indication. 1,226 proteins were identified as differential- expressed proteins (DEPs) between the two stages. Of them, 675 proteins were up-regulated and 551 were down-regulated (Table 2) (Supplementary Table S1). Supplementary Table S1 showed the MS basic information of DEPs identified. Pearson's Correlation Coefficient was calculated to test the repeatability. The result showed good repeatability was obtained (Table 3 \u0026amp; Figure 2A). Based on the Fisher's exact test,\u003c/p\u003e\n\u003cp\u003ehierarchical clustering heat maps were made to illustrate the changing amounts of DEPs from each of the pooled samples (Figure 2B \u0026amp; Supplementary Tables S2, 3, 4, 5).\u003c/p\u003e\n\u003cp\u003eBased on different protein functional classification (such as: GO, Domain, Pathway, Complex), all the categories were collated and filtered with a corrected p-value \u0026lt; 0.05. For each category, a two-tailed Fisher\u0026rsquo;s exact test was employed to test the enrichment of the DEPs against all identified proteins. The GO enrichment analysis indicated that the enrichment levels of the up-regulated proteins were high while the enrichment levels of the down-regulated proteins were relatively low as shown in Table 5. Most of the identified DEPs appeared to be involved in the molecular function (43.7%), biological process (39.2%) and cellular component (17.1%) ((see Figure 2C\u0026amp;D, Table 4, 5, \u0026amp; Supplementary Table S6). The up-regulated proteins mainly grouped in the cell component, molecular function and biological process categories, involving in organelle membrane and membrane-enclosed lumen, mitochondrial/membrane binding, adenyl ribonucleotide/adenyl nucleotide binding, ATP- or NTP-dependent helicase activity, and nucleobase-containing compound metabolic process. Supplementary Tables S8 presented the number of DEPs associated with each level GO term according to the GO annotation information of the identified proteins.\u003c/p\u003e\n\u003cp\u003eThe KEGG pathway enrichment analysis showed that the up-regulated proteins were mainly enriched in pathway entries related to phenylpanoid biosynthesis including ubiquonone biosynthesis, flavonoid biosynthesis, and/or stilbenoid, diarylheptanoid, gingerol biosynthesis, ribosome, cutin, suberine and wax biosynthesis. Besides, upregulated proteins were mainly enriched in pathway related to photosynthesis proteins. Down-regulated proteins were mainly enriched in glycolysis/ gluconeogenesis, ribosomal proteins, plant hormone signal transduction, proteins processing in endoplasmic reticulum and plant pathogen interaction (Figure 3).\u003c/p\u003e\n\u003cp\u003eSubcellular prediction was performed to illustrate the subcellular localization of these DEPs, as shown in Table 6. Most of the up-regulated proteins were localized in the chloroplast (39.0%), cytoplasm (29.0%) and nucleus (12.0%), while the most of the down-regulated proteins were distributed in the cytoplasm (33.0%), chloroplast (29.0%), and nucleus (19.0%). The percentage of proteins located in extracellular, vacuolar membrane, and cytoskeleton was similar between down- and up-regulated proteins. The percentage of up-regulated proteins localized in the chloroplast and plasma membrane was higher than that of down-regulated proteins, while a higher percentage of down-regulated proteins were in cytoplasm and nucleus. In addition, one down-regulated protein localized to the peroxisome, and one localized to the golgi apparatus.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePRM assay results\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTMT assays identified 4770 peptides, and 581 were identified as DEPs between the two seed developing stages. Those DEPs had predicted annotations related to saponins metabolism, pre-harvest sprouting, ubiquitous proteins accumulation, and ABA signaling pathways, likely involving in conferring stage Ⅰto stage Ⅱ. To confirm the TMT results, a total of 19 peptides were selected for validation using PRM, based on their functional significance, and finally 17 peptides were validated (see Table 7). The high consistency between PRM and TMT quantification results lends confidence to the TMT data. By combining DEPs with their enriched KEGG pathways, we outlined the metabolism characteristic in the maturity development in quinoa.\u003c/p\u003e\n\u003cp\u003eThe DEP, AUR62017037-RA, annotated as ABA-inducible protein PHV A1, was identified as down-regulated proteins in Yellow_1/Yellow_2 (see Table 7). Similarly, the DEP, AUR62014945-RA, annotated as \u0026beta;-amylase, showed down-regulation trend during seed maturity in Yellow_1/Yellow_2 (see Table 7). The six DEPs, AUR62002139-RA, AUR62015569-RA and AUR62024716-RA, AUR62003182-RA, AUR62006523-RA, AUR62025011-RA, were annotated as globulin seed storage protein (see Table 7). They were identified as down-regulated proteins. With seeds maturity approaching, these proteins were increasingly expressed. The main component of seed\u0026nbsp;storage\u0026nbsp;proteins\u0026nbsp;is\u0026nbsp;11S\u0026nbsp;or 13 S globulin in quinoa.\u003c/p\u003e\n\u003cp\u003eThe DEP, AUR62025699-RA, annotated as \u0026beta;-amyrin 28-oxidase, descended gradually with seeds maturity (see Table 7). The enzyme was essential for oleanane-type saponin biosynthesis. It indicated that saponins biosynthesis decreased with seeds maturity. \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTwo DEPs, AUR62004613-RA and AUR62022650-RA, belonged to that family of late embryogenesis abundant protein (LEA). Two proteins, AUR62037387-RA and AUR62042308-RA, were identified as seed biotin-containing protein SBP65. A DEP, AUR62013047-RA, was a protein EARLY-RESPONSIVE TO DEHYDRATION 7 located in chloroplastic membrane. Four up-regulation DEPs, a \u0026beta;-amyrin 28-oxidase, a 3-O-glucosyltransferase, a bifunctional purple acid phosphatase 26 and a cyprosin were identified.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Disccussion","content":" \u003cp\u003eQuinoa is an excellent crop with balanced nutrition and wide adaptations. However, despite its agronomic potential, quinoa is still an underutilized crop with the objective of enhancing global food security for a growing world population. So far quinoa production suffers a lot of problems such as bitterness of saponins, seed maturity consistency, pre-harvest sprouting, nutrition accumulation, and so on, that provide genetic improvement aims. Seed development experienced nutrition accumulation, seed desiccation, pigment biosynthesis, seed dormancy preparation, saponins biosynthesis, and so on. We chose the stages from 72 days to 84 days after sewing for investigation of typical proteins involving in these biology progress using proteomics and PRM. Seventeen typical DEPs during seed maturity conversion were validated and showed obvious dynamic.\u003c/p\u003e \u003cp\u003eThe DEP, AUR62025699-RA, was annotated as β-amyrin 28-oxidase, a saponin bio-synthesis enzyme. Quinoa contains 2 to 5% saponins, producing an undesirable bitter flavor, found in the external layers of the seeds or leaves (Medina-Meza et al., \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). According to their saponin content, quinoa varieties have been classified as \u0026ldquo;sweet\u0026rdquo; (free or less than 0.11\u0026nbsp;g/100\u0026nbsp;g DW) and \u0026ldquo;bitter\u0026rdquo; varieties (more than 0.11\u0026nbsp;g/100\u0026nbsp;g DW) (Vega-Galvez et al., \u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e2010\u003c/span\u003e). Given the associated bitterness and toxicity of saponins, quinoa is treated to reduce saponin levels by washing, dehulling, or thermal processing(Gomez-Caravaca et al., \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e2014\u003c/span\u003e; Medina-Meza et al., \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). The process is costly and water-intensive, also can reduce the nutritional value of the seeds (Zurita-Silva et al., 2004). Thus, the development of saponin-free lines is a major breeding objective in quinoa (Zurita-Silva et al., \u003cspan citationid=\"CR54\" class=\"CitationRef\"\u003e2014\u003c/span\u003e). Oleanane-type triterpenes are the major saponin components in quinoa (Medina-Meza et al., \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). The enzyme, β-amyrin 28-oxidase, is essential for oleanane-type saponin biosynthesis (Han et al., \u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e2013\u003c/span\u003e, Jo et al., \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e2017\u003c/span\u003e). In the study, expression of the enzyme, β-amyrin 28-oxidase, indicated increasing trend with seed maturity.\u003c/p\u003e \u003cp\u003eβ-amylases (BAM) are key enzymes of plastidial starch degradation. In the study, the enzyme AUR62014945-RA down-regulated with the maturity in Yellow_1/Yellow_2. It indicated that an amylase inhibitor prevents the function of β-amylases,\u003c/p\u003e \u003cp\u003eAUR62014945-RA, i.e. the premature hydrolysis of stored starch during seed development (Mundy et al., 1985). The protein AUR62017037-RA, ABA-inducible protein PHV A1, maybe exert a role of an amylase inhibitor in quinoa. ABA-inducible protein PHV A1 inhibited seed germination in aleurone layers during barley maturity (Hong et al., \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e1988\u003c/span\u003e). Pre-harvest sprouting occurred frequently in quinoa production (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e), and made farmers suffered a lot. The function of ABA-inducible protein PHV A1 is under investigation.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003eThe six DEPs, AUR62002139-RA, AUR62015569-RA, AUR62024716-RA, AUR62003182-RA, AUR62006523-RA, AUR62025011-RA, were annotated as 13S globulin seed storage protein 1 and 11 globulin seed storage protein 2. Of them, three DEPs (AUR62003182-RA, AUR62006523-RA, AUR62025011-RA) were vicilin-like seed storage protein, and three DEPs (AUR62002139-RA, AUR62015569-RA, AUR62024716-RA) were legumin-like seed storage protein. The legumin-like proteins (both 11S and/or 13S) were generally much more abundant in quinoa seeds than the vicilin-like proteins (Burrieza et al., \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Proteins in quinoa seeds are mainly stored in the embryonic tissue also containing lipid, ash, fiber and saponin while the perisperm is rich in starch (Maldonado and Otegui, 1998; Ando et al., 2002). Of the total protein in mature seeds of quinoa, 37% proteins are 11S-type globulin called chenopodin, and 35% of the seed protein are 2S albumin (Dakhili et al., \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). 11S globulin was the predominant component of quinoa seed storage proteins (Stevens et al., 2006, Dakhili et al., \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Accumulation of these proteins indicated approaching maturation. The main component of duckwheat and sweet beet were seed storage proteins, 13S globulin (Aloisi, et al., \u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e2016\u003c/span\u003e, Burrieza et al., \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e, Zhou et al., \u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Quinoa seeds have main storage proteins including globulins, (legumins and vicilins), with rich lysine, methionine and cysteine than common cereals and legumes (Ruales \u0026amp; Nair, 1992, Burrieza et al. \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). These globulins were active peptides, reported as the antibacterial, antidiabetic, antihypertensive, chemo-preventive, anti-tumoral and antioxidant activities (Hu et al. \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e2017\u003c/span\u003e, Vilcacundo et al. \u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e2017\u003c/span\u003e, \u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e2018\u003c/span\u003e). These can be used as a functional ingredient in the food industry (Bendevis \u0026amp; Jacobsen, 2015, Zhou et al. \u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e2019\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eThe DEPs, AUR62037387-RA, AUR62042308-RA, were annotated as seed biotin-containing protein SBP65 (seed biotinylated protein of 65\u0026nbsp;kDa of apparent molecular mass). The proteins are biotin-dependent carboxylases, exerting key roles in basic metabolism in most plants (Dehaye et al., \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e1997\u003c/span\u003e). The biotinylated proteins, devoid of any carboxylase activity, were characterized with many physiological and molecular features with late embryo genesis-abundant (LEA) proteins in pea (Dehaye et al., \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e1997\u003c/span\u003e). These peculiar proteins, localized to the cytosol of embryonic cells, perhaps behave as a scavenger or a sink, of free biotin, during late stages of embryo development and is rapidly degraded during germination (Duval et al., 1994, Dehaye et al., \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e1997\u003c/span\u003e,Wang et al., \u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e2012\u003c/span\u003e), while the essential role for biotin maybe exerts in seedling establishment from immature embryos. In fact, ABA can induce the expression of the proteins (Dehaye et al., \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e1997\u003c/span\u003e). The report indicated that the expression of the proteins increased with the seed maturity. Quinoa potentially evolved a nice mechanism to prevent from pre-harvest sprouting. Further investigation would help prevent from pre-harvest sprouting in quinoa. The report helps understand the function of these proteins in the embryo development of higher plants.\u003c/p\u003e \u003cp\u003eThe proteins, AUR62022650-RA and AUR62004613-RA, annotated as late embryogenesis abundant (LEA) proteins. LEA proteins were involved in ABA-mediated stress responses (Galau et al., \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e1986\u003c/span\u003e). Seeds can suffered desiccation during the maturation phase by the accumulation of high levels of LEA proteins (Avelange-Macherel et al., 2015, Saucedo et al., \u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e2017\u003c/span\u003e). It was thought that LEAs have been evolutionarily selection to adopt diversified conditions driven by variations in their cellular environment (Mariana et al., \u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e2019\u003c/span\u003e). Two LEAs, AUR62022650-RA and AUR62004613-RA, were accumulated highly, as well as increasing accumulation of 11S globulins and 2S albumin, consistent with increasingly seed desiccation during the maturation phase of quinoa.\u003c/p\u003e \u003cp\u003eThe DEP,AUR62028163-RA༌was annotated as protein EARLY-RESPONSIVE TO DEHYDRATION 7. The organelle localization of the DEP has been identified in chloroplast. Early responsive to dehydration (ERD) genes are rapidly induced to respond to dehydration and various other abiotic stresses in plasma, mitochondria and chloroplast membranes (Archana et al., 2012). The ERD protein maybe play a role as a putative sugar transporter as accumulation of sugars increased upon drought (Rizhsky et al., \u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e2004\u003c/span\u003e, Pertl-Obermeyer et al., \u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e2016\u003c/span\u003e). ABA maybe involved in induction of the protein ((Yamada et al., \u003cspan citationid=\"CR51\" class=\"CitationRef\"\u003e2010\u003c/span\u003e). Similarly, the protein was induced by seeds suffering the loss of cellular water during the maturation phase. It was not well known that ERDs were expressed earlier than LEAs or not. Its detailed function is under investigation.\u003c/p\u003e \u003cp\u003eThe DEP, AUR62028163-RA, was annotated as an anthocyanidin 3-O-glucosyltransferase 7. So far, anthocyanins and betalains never coexist in the same plant species. Interestingly lots of research indicated that genes responsible for anthocyanins biosynthesis were identified in betalain-accumulation plants (Xu et al. \u003cspan citationid=\"CR50\" class=\"CitationRef\"\u003e2015\u003c/span\u003e, 2016). It is supposed that both betacyanin and anthocyanin metabolisms coexisted in earlier plants and maybe get separated with evolution (Shibendu et al., 2013). Betacyanins are the major pigments present in quinoa. The terminal glycosylation of the aglycone betanidin transfers betanidin to batanins in the biosynthesis pathway of betacyanins (Isayenkova et al., \u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e2006\u003c/span\u003e, Das et al., \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e2013\u003c/span\u003e). The similarity of the 3-O-glucosyltransferase, the DEP, AUR62028163-RA, in quinoa to that of anthocyanin 3-O-glucosyltransferase indicates the coexistence of both the pathways of pigment biosynthesis. The protein, AUR62028163-RA, up-regulated the transfer of glucose from UDP-glucose to betalains. It indicated that betalains accumulation in seeds decreased as quinoa seeds approached maturation. Color changes are also regarded as the typical sighs of maturity.\u003c/p\u003e \u003cp\u003eThe DEP, AUR62013288-RA, was annotated as a bifunctional purple acid phosphatase 26 (PAP). PAPs are key phosphate (Pi)-metabolizing enzymes, help plants with Pi availability and absorption as they are mostly exposed to suboptimal environmental conditions for this vital element (Mohammad et al., \u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e2018\u003c/span\u003e). Seeds development is a Pi-consuming phase, and then Pi starvation often occurs. The DEP, AUR62013288-RA, decreased as seeds maturation ends. The enzymes can also be regarded as typical proteins during maturation phase of seeds.\u003c/p\u003e \u003cp\u003eThe last DEP, AUR62023656-RA, was identified as an up-regulated cyprosin. It indicated that the DEP encoded decreased with seed maturation. Cyprosin, a member of aspartic proteinases family, is involved in the process of dormancy, viability and germination of seeds (Milisavljevicet al., 2008, Janek et al., \u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e2016\u003c/span\u003e, Shen et al., \u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e2018\u003c/span\u003e). Seed dormancy, an evolutional strategy, prevents from seeds germination during seed storage, or in stress conditions. The process from dormancy to generation includes three stages: the primary dormancy acquirement with seed maturation, gradual loss of seed dormancy in a subsequent period of seed storage (so-called after-ripening), and finally approach into a non-dormant state (Graeber et al., \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e2012\u003c/span\u003e; Ne\u0026acute;e et al., \u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e2017a\u003c/span\u003e). Pre-harvest sprouting is cut-short dormancy or dormancy-loss and abnormal generation, which is a severe problem in quinoa production. It is possible the aspartic proteinases, AUR62023656-RA, promotes seed dormancy. Further investigation of the protein could help find the solution to pre-harvest sprouting.\u003c/p\u003e \u003cp\u003eFor an early maturation accession, timely harvest seemed to be very crucial to obtain plump grains with nice color, on which the yield depends. Untimely harvest would result in both harms: delayed harvest brings about grains exposing to continuous rainwater and early harvest results in poor grain plumpness. In subtropical areas, timely harvest could get the second benefit as a result that spring rains is the great enemy for quinoa harvest. Spring rain in subtropical areas always goes on for two or three weeks, which almost cover whole harvest season. Pre-harvest sprouting in quinoa causes poor grain quality and results in significant reductions in yield, leading to significant economic losses.\u003c/p\u003e \u003cp\u003eIn the past four years, quinoa culture in Xiamen experienced twice three-week spring-rains, respectively in 2016 and 2019 when maturity was closing. Bad grains were collected exposing to continuous spring rains. However, early harvest directly lead to grains with poor plumpness based on morphological index.\u003c/p\u003e "},{"header":"Conclusions","content":" \u003cp\u003eSeed maturation conversion is an essential stage in plant life, especially for seed economic crops such as quinoa. Proteomics analysis of quinoa assessed proteome changes during seed maturation conversion. Thirteen down-regulated DEPs and four up-regulated DEPs showed dynamic of oleanane-type saponins bio-synthesis, seed generation, seed dormancy, related enzymes such as β-Amylase, ABA-inducible protein PHV A1, seed storage proteins, LEAs, cyprosin, PAP, and so on. The work enhances our understanding of the biological and physiological characteristics of seed maturation in quinoa, and an important first step towards the genetic improvement of quinoa.\u003c/p\u003e "},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eMaterials \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eExperiments were conducted at Fujian Institute of Subtropical Botany\u0026rsquo;s Quinoa Garden, which is located in Xiamen, China (118\u0026deg;04\u0026prime;04\u0026Prime;, latitude 24\u0026deg;26\u0026prime;46\u0026Prime;, annual average temperature 22\u0026deg;C), at an elevation of 63 m above sea level. The site receives an average rainfall of 1200 mm/year.\u003c/p\u003e\n\u003cp\u003eThe accession PI596293, was obtained from Plant Germplasm Quarantine Center, USDA. accession PI596293, named COLORADO 407D, is a native ecotype from Colorado., the United states, and is early maturing. COLORADO 407D was characterized with a central axis and secondary and tertiary axes, the large, amaranthiform, compact and glomerous inflorescences, large, yellow, sweet seeds. It was sewed in Oct 26, 2017, eared Dec 10 and harvested on Jan 26, 2018. Inflorescence was collected in both developing stages, respectively. The first stage (Stage I) was 72 days after sewing, and the second stage (Stage II) was 84 days after sewing. Grains of 72 days after sewing is in the eve of seed maturation conversion, and grains 84 days after sewing were mature seeds, edible and dry.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtein Extraction \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWhole inflorescence was collected, quickly frozen in liquid nitrogen, and then stored at -80\u0026deg;C. The sample was grinded by liquid nitrogen into cell powder and then transferred to a 5-mL centrifuge tube. After that, four volumes of lysis buffer (8 M urea, 1% Triton-100, 10 mM dithiothreitol, and 1% Protease Inhibitor Cocktail) was added to the cell powder, followed by sonication three times on ice using a high intensity ultrasonic processor (Scientz). The remaining debris was removed by centrifugation at 20,000 g at 4 \u0026deg;C for 10 min. Finally, the protein was precipitated with cold 20% TCA for 2 h at -20 \u0026deg;C. After centrifugation at 12,000g 4 \u0026deg;C for 10 min, the supernatant was discarded. The remaining precipitate was washed with cold acetone for three times. The protein was redissolved in 8 M urea and the protein concentration was determined with BCA kit according to the manufacturer\u0026rsquo;s instructions.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrypsin Digestion\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFor digestion, the protein solution was reduced with 5 mM dithiothreitol for 30 min at 56 \u0026deg;C and alkylated with 11 mM iodoacetamide for 15 min at room temperature in darkness. The protein sample was then diluted to urea concentration less than 2M. Finally, trypsin was added at 1:50 trypsin-to-protein mass ratio for the first digestion overnight at 37\u0026deg;C and 1:100 trypsin-to-protein mass ratio for a second 4 h-digestion.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTMT Labeling\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePeptide was desalted using Strata X C18 SPE column (Phenomenex) and vacuum-dried after trypsin digestion. According to the manufacturer\u0026rsquo;s TMT kit protocol, Peptide was reconstituted and processed in 0.5 M TEAB . Briefly, thawed and reconstituted in acetonitrile, then one unit of TMT reagent incubated the peptide mixtures for 2 h at room temperature and pooled, desalted and dried by vacuum centrifugation.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eHPLC Fractionation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe tryptic peptides were digested into fractions by high pH reverse-phase HPLC using Agilent 300Extend C18 column (5 \u0026mu;m particles, 4.6 mm ID, 250 mm length). Then, peptides were first separated with a gradient of 8% to 32% acetonitrile (pH 9.0) over 60 min into 60 fractions. Finally, the peptides were fractionated into 18 fractions and dried using vacuum centrifuging.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLC-MS/MS Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePeptides were dissolved in 0.1% formic acid (solvent A) before the tryptic peptides loaded onto a home-made reversed-phase analytical column (15-cm length, 75 \u0026mu;m i.d.). The gradient was consisted of an increase from 6% to 23% solvent B (0.1% formic acid in 90% acetonitrile) over 38 min, 23% to 35% in 14 min and adding to 80% in 4 min then holding at 80% for the last 4 min, all at a constant flow rate of 400 nL/min on an EASY-nLC 1000 UPLC system. The peptides were subjected to NSI source followed by tandem mass spectrometry (MS/MS) in Q ExactiveTM Plus (Thermo) coupled online to the UPLC. The electrospray voltage applied was 2.0 kV. The m/z scan range was 300 to 1000 for full scan, and intact peptides were detected in the Orbitrap at a resolution of 35,000. Peptides were then selected for MS/MS using NCE setting as 27 and the fragments were detected in the Orbitrap at a resolution of 17,500. A data-independent procedure that alternated between one MS scan followed by 20 MS/MS scans. Automatic gain control (AGC) was set at 3E6 for full MS and 1E5 for MS/MS. The maximum IT was set at 20 ms for full MS and auto for MS/MS. The isolation window for MS/MS was set at 2.0 m/z.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDatabase Search\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe obtained MS/MS data were processed using Maxquant search engine (v.1.5.2.8). Tandem mass spectra were searched against quinoa database concatenated with reverse decoy database. The mass tolerance for precursor ions was set as 20 ppm in First search and 5 ppm in Main search,and the mass tolerance for fragment ions was set as 0.02 Da. Trypsin/P was specified as cleavage enzyme allowing up to 2 missing cleavages. Carbamidomethyl on Cys was specified as fixed modification and oxidation on Met was specified as variable modifications. FDR was adjusted to \u0026lt; 1% and minimum score for peptides was set \u0026gt; 40.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioinformatics analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eProteome data was annotated, subcellular Localized and functional enrichment analyzed. Go annotation proteome was derived from the UniProt-GOA database (www. http://www.ebi.ac.uk/GOA/). Then proteins were classified by Gene Ontology annotation based on three categories: biological process, cellular component. Identified proteins domain functional description were annotated by InterProScan (a sequence analysis application) based on protein sequence alignment method, and the InterPro domain database was used. Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to annotate protein pathway. Also, we used wolfpsort, a subcellular localization predication soft to predict subcellular localization. An updated version of PSORT/PSORT II for the prediction of eukaryotic sequences and molecular function. A corrected p-value \u0026lt; 0.05 is considered significant.\u003c/p\u003e\n\u003cp\u003eThe resulting MS data were processed using Skyline (v.3.6). Enzyme was set as Trypsin [KR/P], Max missed cleavage set as 0. The peptide length was set as 7-25, Variable modification was set as Carbamidomethyl on Cys and oxidation on Met, and maxvariable modifications was set as 3. Transition settings: precursor charges were set as 2, 3, ion charges were set as 1, ion types were set as b, y. The productions were set as from ion 3 to last ion, the ion match tolerance was set as 0.02 Da.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePRM validation for Targeted MS Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo determine the reliability sequencing results, original proteins samples were applied to the same LC-MS system used above. According to results from the above assessment, a total of 19 peptides were selected and added to the inclusion list for the PRM assay detection. Full details referenced Hashimoto et al. (2019).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Acknowledgement ","content":"\u003cp\u003eThis work was supported by the Xiamen Science \u0026amp; Techno lodge Project (Grant No. 2016S0974, 2016-2019) and the National Natural Science Foundation of China (Grant No. 31\u0026thinsp;372\u0026thinsp;093).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003eAloisi, I., Parrotta, L., Ruiz, K.B., Landi, C., Bini, L., Cai, G., Biondi, S., Del Duca, S., 2016. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/27242857\"\u003eNew Insight into\u0026ensp;Quinoa\u0026ensp;Seed\u0026ensp;Quality under Salinity: Changes in Proteomic and Amino Acid Profiles, Phenolic Content, and Antioxidant Activity of\u0026ensp;Protein\u0026ensp;Extracts.\u003c/a\u003e Front Plant Sci., 18(7):656\u003c/p\u003e\n\u003cp\u003eBhargava, A., Schuka, S., Ohri, D., 2006. Chenopodium quinoa \u0026ndash; an Indian perspective. Ind. Crops Products, 23(1):73-87.\u003c/p\u003e\n\u003cp\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Burrieza%20HP%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31151615\"\u003eBurrieza, H.P\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Rizzo%20AJ%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31151615\"\u003eRizzo, A.J\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Moura%20Vale%20E%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31151615\"\u003eMoura Vale, E\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Silveira%20V%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31151615\"\u003eSilveira, V\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Maldonado%20S%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31151615\"\u003eMaldonado, S\u003c/a\u003e., 2019. Shotgun proteomic analysis of quinoa\u0026nbsp;seeds\u0026nbsp;reveals novel lysine-rich\u0026nbsp;seed\u0026nbsp;storage\u0026nbsp;globulins. \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/31151615\"\u003eFood Chem.\u003c/a\u003e, 293:299-306.\u003c/p\u003e\n\u003cp\u003e\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Dakhili%20S%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31323439\"\u003eDakhili, S\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Abdolalizadeh%20L%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31323439\"\u003eAbdolalizadeh, L\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Hosseini%20SM%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31323439\"\u003eHosseini, S.M\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Shojaee-Aliabadi%20S%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31323439\"\u003eShojaee-Aliabadi, S\u003c/a\u003e.,\u0026nbsp;\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Mirmoghtadaie%20L%5bAuthor%5d\u0026amp;cauthor=true\u0026amp;cauthor_uid=31323439\"\u003eMirmoghtadaie, L\u003c/a\u003e.,2019.\u003c/p\u003e\n\u003cp\u003eQuinoa\u0026nbsp;protein: Composition, structure and functional properties.\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=13S+globulin+seed+storage+protein+1+quinoa\"\u003eTheor. 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Breed., 34:13\u0026ndash;30.\u003c/p\u003e\n\n"},{"header":"Declarations ","content":"\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eEthics approval and consent to participate\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eThe manuscript is based on \u003c/em\u003e\u003cem\u003eEthics approval and consent to\u003c/em\u003e \u003cem\u003eparticipate\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eConsent for publication\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eThe manuscript is based on \u003c/em\u003e\u003cem\u003eConsent for publication\u003c/em\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eAvailability of data and material\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eThe submission includes all data and material, and are available. \u003c/em\u003e\u003cem\u003eThe supporting data has been uploaded with submission, which can be accessed.\u003c/em\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eCompeting interests\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eThe manuscript has not any \u003c/em\u003e\u003cem\u003eCompeting interests\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eFunding\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eAll funding for the studies are listed in the manuscript, together with the names of the principal funding recipients.\u003c/em\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cem\u003eAuthors' contributions\u003c/em\u003e\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eSX X: designed the research, preparing manuscript and acquire Funding; QY H: analyze data,materials collecting; ZY L: pictures preparation, manuscript modifying; H YJ: treatment; L CS: data curation; H EM: methodology; L FC : Software.\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eAll authors have read and approved the manuscript\u003c/em\u003e\u003cem\u003e.\u003c/em\u003e\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003eAcknowledgement\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003e\u003cem\u003eAll funding for the studies in the manuscript, together with the names of people who provided any help for the work, must be listed in the Acknowledgement.\u003c/em\u003e\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: 10px; line-height: 150%; color: rgb(0, 0, 0); font-family: Verdana, Geneva, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 1 Morphological characteristics of plant in two developing stages\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\n \u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:33.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"9.205020920502092%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStage\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:61.3pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.15481171548117%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMean Plant height (cm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.899581589958158%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMean diameter of inflorescence (cm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.1pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.10878661087866%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMean height of inflorescence\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e(cm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.75pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"10.878661087866108%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eLeaves color\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.4pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.271966527196653%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eLeaf axil color\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.5pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.481171548117155%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStem streaks Color\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:33.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"9.205020920502092%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStage\u0026nbsp;Ⅰ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:61.3pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.15481171548117%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e111.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.899581589958158%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.10878661087866%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e30.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"10.878661087866108%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003egreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.271966527196653%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003egreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.481171548117155%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003egreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:33.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"9.205020920502092%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStage\u0026nbsp;Ⅱ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:61.3pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.15481171548117%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e107.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.899581589958158%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.10878661087866%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e32.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"10.878661087866108%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.271966527196653%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.481171548117155%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:33.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"9.205020920502092%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStage\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:61.3pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.15481171548117%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMean grain diameter (mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.899581589958158%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMean grain thickness (mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.10878661087866%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMean hundred-grain weight (g)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"10.878661087866108%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ePalea color\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.271966527196653%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eEpisperm color\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.481171548117155%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eDays after sewing\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:33.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"9.205020920502092%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStage\u0026nbsp;Ⅰ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:61.3pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.15481171548117%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e2.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.899581589958158%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.1pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.10878661087866%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"10.878661087866108%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003egreen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.4pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.271966527196653%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eorange\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.5pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.481171548117155%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:33.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"9.205020920502092%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eStage\u0026nbsp;Ⅱ\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:61.3pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.15481171548117%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.899581589958158%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.1pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.10878661087866%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.38\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"10.878661087866108%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eyellow\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.271966527196653%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eorange\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:55.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.481171548117155%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 2. DEPs summary (Filtered with threshold value of expression fold change and P value \u0026lt; 0.05)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left:-5.95pt;border-collapse:collapse;border:none;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.103986135181977%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eCompare group\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.75pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.197573656845755%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eRegulated type\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.75pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.038128249566725%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003efold change \u0026gt;1.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.944540727902947%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003efold change \u0026gt;1.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.0in;border-top:solid windowtext 1.0pt;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:none;padding: 0in 5.4pt 0in 5.4pt;\" width=\"16.63778162911612%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003efold change \u0026gt;1.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:64.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.077989601386482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003efold change \u0026gt;2.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 87pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.103986135181977%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_1/Yellow_2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:78.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.197573656845755%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eup-regulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.75pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.038128249566725%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1263\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.944540727902947%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1042\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.0in;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"16.63778162911612%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e675\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:64.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"15.077989601386482%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e287\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:78.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"22.7765726681128%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003edown-regulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.75pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"17.570498915401302%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1013\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:69.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"19.95661605206074%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e824\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:1.0in;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"20.824295010845987%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e551\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:64.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"18.872017353579174%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e294\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 3 Pearson's correlation of quantification\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 60.85pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_1_1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_1_2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_1_3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_2_1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_2_2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_2_3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:60.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_1_1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:60.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eYellow_2_3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.85pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e-0.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:60.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;\" width=\"14.285714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 4 GO distribution of up-regulate proteins(Yellow_1-vs-Yellow_2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\n \u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.35pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"23.19859402460457%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGO Terms Level 1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 197.3pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"46.22144112478032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGO Terms Level 2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eNo. of Protein\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ePercent %\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"8\" style=\"width:99.35pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"23.19859402460457%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eBiological Process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 197.3pt;border: none;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"46.22144112478032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emetabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;border: none;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e140\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"8\" style=\"width:64.95pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e47.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003esingle-organism process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e81\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecellular process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eresponse to stimulus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ebiological regulation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecellular component organization or biogenesis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003elocalization\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eother\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"6\" style=\"width:99.35pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"23.19859402460457%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eCellular Component\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"46.22144112478032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecell\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"6\" style=\"width:64.95pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e14.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emembrane\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emacromolecular complex\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eorganelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003esupramolecular complex\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eextracellular region\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"7\" style=\"width:99.35pt;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"23.19859402460457%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMolecular Function\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"46.22144112478032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecatalytic activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e152\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"7\" style=\"width:64.95pt;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.289982425307556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e38.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ebinding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e101\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eantioxidant activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eelectron carrier activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emolecular function regulator\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003estructural molecule activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 197.3pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"75.14285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eother\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.95pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"24.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTable 5: GO distribution of down-regulate proteins(Yellow_1-vs-Yellow_2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cdiv align=\"center\" style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\n \u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.35pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"20.035149384885763%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGO Terms Level 1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.2pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"45.69420035149385%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGO Terms Level 2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"18.27768014059754%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eNo. of Protein\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:68.0pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\" width=\"15.992970123022847%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ePercent %\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width:85.35pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"20.035149384885763%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eBiological Process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.2pt;border: none;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"45.69420035149385%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emetabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;border: none;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"18.27768014059754%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e91\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"10\" style=\"width:68.0pt;border:none;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.992970123022847%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e31.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecellular process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003esingle-organism process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eresponse to stimulus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e10\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003elocalization\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecellular component organization or biogenesis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003edevelopmental process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emulticellular organismal process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ebiological regulation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eother\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"5\" style=\"width:85.35pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"20.035149384885763%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eCellular Component\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"45.69420035149385%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecell\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"18.27768014059754%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"5\" style=\"width:68.0pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.992970123022847%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e19.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eorganelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emacromolecular complex\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eextracellular region\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emembrane\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"7\" style=\"width:85.35pt;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"20.035149384885763%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eMolecular Function\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"45.69420035149385%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecatalytic activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"18.27768014059754%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"7\" style=\"width:68.0pt;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.0pt;\" width=\"15.992970123022847%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e48.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ebinding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003estructural molecule activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003enutrient reservoir activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eantioxidant activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emolecular function regulator\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 195.2pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"71.42857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eother\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 78.1pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 5.4pt;height: 15pt;vertical-align: bottom;\" valign=\"bottom\" width=\"28.571428571428573%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:15.6pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 6 Sub-cell location of DEPs (Yellow_1-vs-Yellow_2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 49.1pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eSubcellular Location\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 49.1pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eNumber of up-regulate proteins (% of total)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 5.4pt;height: 49.1pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eNumber of down-regulate\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eproteins (% of total)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003echloroplast\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e111(39)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e84(29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecytoplasm\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e85(29)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e97(33)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003enucleus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e36(12)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e56(19)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eplasma membrane\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e19(7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e9(3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eextracellular\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e15(5)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e17(6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003evacuolar membrane\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e8(3)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e6(2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003emitochondria\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e6(2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e12(4)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecytoskeleton\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e5(2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e6(2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eendoplasmic reticulum\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e2(1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e4(2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eGolgi apparatus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eperoxisome\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003ecytoplasm\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e1(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.75pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"23.214285714285715%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003eTotal\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 162.5pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.75%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e287\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 159.8pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"38.035714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e294\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:15.6pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:15.6pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:15.6pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:15.6pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:25.0pt;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:15.6pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTable 7 Identified DEPs\u0026nbsp;in two developing stages\u0026nbsp;using PRM\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;\" width=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0.75pt 0.75pt 0in;height: 28.5pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eProteins codes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 149.3pt;border-top: 1pt solid black;border-left: none;border-bottom: 1pt solid black;border-right: none;padding: 0.75pt 0.75pt 0in;height: 28.5pt;vertical-align: bottom;\" valign=\"bottom\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eProtein description\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.4pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:.75pt .75pt 0in .75pt;height:28.5pt;\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRegulated Type\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.25pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:.75pt .75pt 0in .75pt;height:28.5pt;\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYellow_1/Yellow_2 Ratio (PRM) \u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:76.15pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:.75pt .75pt 0in .75pt;height:28.5pt;\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eYellow_1/Yellow_2 Ratio (TMT)\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62017037-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eABA-inducible protein PHV A1 [Vitis vinifera]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.4pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:76.15pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.134\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62014945-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ebeta-amylase [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62002139-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13S globulin seed storage protein 1 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62015569-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13S globulin seed storage protein 1 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62024716-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11S globulin seed storage protein 2 isoform X2 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62003182-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003evicilin-like seed storage protein At2g18540 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62006523-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003evicilin-like seed storage protein At2g28490 isoform X2 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62025011-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003evicilin-like seed storage protein At2g28490 isoform X2 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62037387-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eseed biotin-containing protein SBP65 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62042308-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eseed biotin-containing protein SBP65 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62022650-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003elate embryogenesis abundant protein (LEA) family protein [Medicago truncatula]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.39\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62004613-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003elate embryogenesis abundant protein (LEA) family protein [Medicago truncatula]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62013047-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\"protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic [Beta vulgaris subsp. vulgaris]\"\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.4pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003edown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:76.15pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.129\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62025699-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"background: white;\"\u003eβ\u003c/span\u003e-amyrin 28-oxidase [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.4pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:68.55pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62028163-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eanthocyanidin 3-O-glucosyltransferase 7 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.4pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e7.46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:76.15pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.188\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62013288-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ebifunctional purple acid phosphatase 26 [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.4pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.15pt;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:bottom;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.97\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 68.55pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"15.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAUR62023656-RA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:149.3pt;border:none;border-bottom:solid black 1.0pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"34.79020979020979%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ecyprosin [Beta vulgaris subsp. vulgaris]\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.4pt;border:none;border-bottom:solid black 1.0pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"11.538461538461538%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eUp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.25pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1pt solid black;padding: 0.75pt 0.75pt 0in;height: 14.25pt;vertical-align: top;\" valign=\"top\" width=\"19.93006993006993%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9.50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:76.15pt;border:none;border-bottom:solid black 1.0pt;padding:.75pt .75pt 0in .75pt;height:14.25pt;\" width=\"17.832167832167833%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:right;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;vertical-align:middle;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.158\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size: \n 10px;\"\u003e\u003cspan style=\"font-family: \n Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003csup\u003ea\u003c/sup\u003e\u0026nbsp;All results were signifificant at\u0026nbsp;p\u0026lt;\u0026nbsp;0.05.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;line-height:150%;\"\u003e\u003cspan style=\"font-size: 10px; line-height: 150%; color: rgb(0, 0, 0); font-family: Verdana, Geneva, sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"},{"header":"Abbreviations ","content":"\u003cp\u003eABA, abscisic acid;\u003c/p\u003e\n\u003cp\u003eAGC, automatic gain control;\u003c/p\u003e\n\u003cp\u003eBAM, \u0026beta;-Amylase;\u003c/p\u003e\n\u003cp\u003eBCA, bicinchoninic acid;\u003c/p\u003e\n\u003cp\u003eCOG/KOG, Clusters of Orthologous Groups/Eukaryotic Orthologous Groups;\u003c/p\u003e\n\u003cp\u003eDEPs, differential expressed proteins;\u003c/p\u003e\n\u003cp\u003eERD, early responsive to dehydration;\u003c/p\u003e\n\u003cp\u003eGO, Gene Ontology;\u003c/p\u003e\n\u003cp\u003eKEGG, Kyoto Encyclopedia of Genes and Genomes;\u003c/p\u003e\n\u003cp\u003eLEA, late embryogenesis abundant proteins;\u003c/p\u003e\n\u003cp\u003ePRM, parallel reaction monitoring;\u003c/p\u003e\n\u003cp\u003eTEAB, Triethylamonium bicarbonat;\u003c/p\u003e\n\u003cp\u003eTMT, Tandem Mass Tag;\u003c/p\u003e\n\u003cp\u003eUDP, Uridinediphosphate;\u003c/p\u003e\n\u003cp\u003eUGT, UDP-glycosyltransferase.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"DEP, maturation, Proteomes, Quinoa ","lastPublishedDoi":"10.21203/rs.3.rs-19485/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-19485/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground Recently quinoa( Chenopodium quinoa willd., 2n=4x=36)raises worldwide popularity with its totally nutrition, stress-tolerance, which leads quinoa to a strategic global food from an Andean native crop. However, seed pre-harvest sprouting, saponin contents e.c., restrict greatly quinoa production and popularity. In the study, we successfully used a combinational proteomics of TMT labeling and parallel reaction monitoring (PRM) to assess proteome changes relating to seed maturation conversion in quinoa to help accelerate genetic improvement for quinoa. \u003c/p\u003e\u003cp\u003eResults In total, 6,097 proteins were identified and 4,770 proteins were quantified. Of them, 581 were differential expressed proteins (DEPs). Based on PRM data, seventeen DEPs were identified and quantified, including thirteen down-regulated proteins and four up-regulated proteins. Seventeen DEPs involved in oleanane-type saponins bio-synthesis (β-amyrin 28-oxidase), seed generation (β-Amylase), seed dormancy (late embryogenesis abundant proteins, Cyprosin), seed nutrition (globulin seed storage proteins), accumulation of sugars under seed desiccation (EARLY-RESPONSIVE TO DEHYDRATION 7 protein), pre-harvest sprouting (seed biotin-containing protein SBP65, ABA-inducible protein PHV A1), and enzymes related promoting seed maturation (bifunctional purple acid phosphatase 26), and pigment biosynthesis (3-O-glucosyltransferase). \u003c/p\u003e\u003cp\u003eConclusions We present the high-quality proteomics analysis of quinoa assessing proteome changes during seed maturation conversion. Our results summarize a valuable proteome profiles characterizing quinoa seed maturation. The DEPs are candidate for the functional analyses of proteins regulating seed maturation conversion in quinoa, which provide an important first step towards the genetic improvement of quinoa.\u003c/p\u003e","manuscriptTitle":"Seed proteins mining for development, nutrition and germination using comparative proteomics analysis in quinoa（Chenopodium quinoa willd.)","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-03-27 21:15:40","doi":"10.21203/rs.3.rs-19485/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3cdd7ade-60f3-4f2a-9364-d54860122d5d","owner":[],"postedDate":"March 27th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":75777,"name":"Plant Molecular Biology and Genetics"}],"tags":[],"updatedAt":"2020-08-26T18:48:49+00:00","versionOfRecord":[],"versionCreatedAt":"2020-03-27 21:15:40","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-19485","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-19485","identity":"rs-19485","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}