Multi-trait colocalisation using MystraColoc : improved performance, deeper insights

Multi-trait colocalisation is a vital tool to make sense of the large amounts of GWAS data available on platforms like Mystra. It identifies genetic association signals that cluster together, allowing us to infer which gene might be causal for a trait and also which constellation of biological effects might be affected by modulating that gene. Multi-trait colocalisation is a challenging computational problem. Here, we introduce MystraColoc , a Bayesian algorithm for multi-trait colocalisation that works across hundreds or even thousands of GWAS datasets. We illustrate its power both via a worked example at the HDAC9 - TWIST1 locus, and via a simulation study that demonstrates its superior clustering performance compared to alternative methods.