Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors

Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors Beibei Zhang, Lei Zhang, Yili Ren, Chenkai Xu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7179250/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Aims: This study investigated the occurrence of arrhythmias in patients with malignant tumors and coronary heart disease (CHD) during antitumor drug treatment. Methods: 109 patients with malignant tumors undergoing antitumor treatment at Zhejiang Hospital from January 2023 to January 2024 were analyzed. All patients underwent 12-lead ECG before and after each chemotherapy cycle. The primary endpoint was the occurrence of new arrhythmias recorded through ECG. Univariate and multivariate logistic regression analysis were performed to recognize the risk factors. Results: Atrial arrhythmias occurred in 13 cases (11.93%). The incidence of atrial arrhythmias was significantly higher in the CHD group compared to the non-CHD group (27.27% vs 1.54%; P < 0.001). Multivariate logistic regression analysis indicated that smoking (P = 0.009), ischemic heart disease (P = 0.006), and left ventricular ejection fraction < 50% (P = 0.014) increased the risk of developing arrhythmias after antitumor treatment. Conclusion: Atrial arrhythmias are more common in cancer patients with CHD when undergoing antitumor treatment. A history of smoking, ischemic heart disease, and reduced left ventricular ejection fraction increases the risk of atrial arrhythmias after antitumor therapy. Atrial arrhythmias Coronary heart disease Antitumor treatment risk factors Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7179250","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":501065672,"identity":"32e69797-3ec9-4448-8057-e83c68d02533","order_by":0,"name":"Beibei Zhang","email":"","orcid":"","institution":"Zhejiang Hospital","correspondingAuthor":false,"prefix":"","firstName":"Beibei","middleName":"","lastName":"Zhang","suffix":""},{"id":501065673,"identity":"2b6d2abf-83fb-410a-a439-582a3e7de1fc","order_by":1,"name":"Lei Zhang","email":"","orcid":"","institution":"Affiliated Hospital of Shaoxing University","correspondingAuthor":false,"prefix":"","firstName":"Lei","middleName":"","lastName":"Zhang","suffix":""},{"id":501065674,"identity":"f7a3cb6e-ff02-48bf-abd0-2bca384d9f98","order_by":2,"name":"Yili Ren","email":"","orcid":"","institution":"Affiliated Hospital of Shaoxing University Geriatrics II","correspondingAuthor":false,"prefix":"","firstName":"Yili","middleName":"","lastName":"Ren","suffix":""},{"id":501065675,"identity":"f217a59a-d86a-4de4-9b20-22a4e507fd07","order_by":3,"name":"Chenkai Xu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA3ElEQVRIie3RoQ7CMBCA4ZIlnelS2yWEZ2gyS8KrtGaOBFkxMTLSCcBP8BA4wLUs2UzxCAQYFAIckg0L2YZD9Nf3ibsDwGb7yyBQdzFEo6Q3PTMRdSI9nZlwQN0koWdTdCJO7sl9QFEp/cvMaQe0LFiOjOIbwqXgMQQ4nbNG4i9CpVfixHcZl0e+7QNiDutGgokbq5u58vhYEwMBJeNmAmviyfxNJlw67QQTqHRFAmq0BJ1ItQt7H9lPpwlhpkCtu1QXC+71K7HjXh5PEQ1wumwmH6Hfxm02m832tReczlVgVnzV2gAAAABJRU5ErkJggg==","orcid":"","institution":"Zhejiang Hospital","correspondingAuthor":true,"prefix":"","firstName":"Chenkai","middleName":"","lastName":"Xu","suffix":""}],"badges":[],"createdAt":"2025-07-21 15:53:25","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7179250/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7179250/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":104403243,"identity":"88cc9c83-dca7-4f58-a7ed-d8bec6bca05b","added_by":"auto","created_at":"2026-03-11 12:17:50","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":328114,"visible":true,"origin":"","legend":"","description":"","filename":"ManuscriptZhangetal..pdf","url":"https://assets-eu.researchsquare.com/files/rs-7179250/v1_covered_4993ebf9-2dc5-4725-8c3d-0b6a0331a1cd.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Atrial arrhythmias, Coronary heart disease, Antitumor treatment, risk factors","lastPublishedDoi":"10.21203/rs.3.rs-7179250/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7179250/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eAims: \u003c/strong\u003eThis study investigated the occurrence of arrhythmias in patients with malignant tumors and coronary heart disease (CHD) during antitumor drug treatment.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e 109 patients with malignant tumors undergoing antitumor treatment at Zhejiang Hospital from January 2023 to January 2024 were analyzed. All patients underwent 12-lead ECG before and after each chemotherapy cycle. The primary endpoint was the occurrence of new arrhythmias recorded through ECG. Univariate and multivariate logistic regression analysis were performed to recognize the risk factors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Atrial arrhythmias occurred in 13 cases (11.93%). The incidence of atrial arrhythmias was significantly higher in the CHD group compared to the non-CHD group (27.27% vs 1.54%; P \u0026lt; 0.001). Multivariate logistic regression analysis indicated that smoking (P = 0.009), ischemic heart disease (P = 0.006), and left ventricular ejection fraction \u0026lt; 50% (P = 0.014) increased the risk of developing arrhythmias after antitumor treatment.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Atrial arrhythmias are more common in cancer patients with CHD when undergoing antitumor treatment. 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