Efficacy of Non-Ablative Radiofrequency on Sexual Function in Postmenopausal Women. A Randomized Clinical Trial

Efficacy of Non-Ablative Radiofrequency on Sexual Function in Postmenopausal Women. A Randomized Clinical Trial | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 5 June 2025 V1 Latest version Share on Efficacy of Non-Ablative Radiofrequency on Sexual Function in Postmenopausal Women. A Randomized Clinical Trial Authors : Claudia Andrea Quezada-Bascuñán , Asunción Ferri-Morales 0000-0001-5638-4718 [email protected] , Vicente Martinez-Vizcaino , Cristina Gallego-Gómez , Ana Torres-Costoso , and Cristina Lirio-Romero Authors Info & Affiliations https://doi.org/10.22541/au.174912503.32735535/v1 258 views 158 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objective: To evaluate the efficacy of non-ablative capacitive–resistive monopolar radiofrequency (CRMRF) on sexual function and vaginal health in postmenopausal women with genitourinary syndrome of menopause (GSM). Design: double-blind, randomised, controlled clinical trial. Setting: University of Castilla-La Mancha, Spain Population: Sixty-three postmenopausal women with symptoms of GSM Methods: Participants were randomly allocated to receive six weekly sessions of CRMRF (n=32) or sham treatment (n=31). Assessments were conducted at baseline (T0), posttreatment (T1), and at 12-week follow-up (T2) Main Outcome Measures: Sexual function was assessed using the Female Sexual Function Index (FSFI), and vaginal health was assessed via the Vaginal Health Index (VHI). The vaginal maturation index and estrogenic status were also assessed via vaginal cytology. Results: Compared with the CG, the intervention group presented greater improvements in FSFI scores at both T1 (4.41, p <0.001) and T2 (3.19, p =0.005). The domain with the greatest improvement at T1 was dyspareunia (∆pain: 2.13, p <0.001 in the IG), with no significant change in the CG. The VHI score increased after treatment (4.74, p <0.001) and at follow-up (6.90, p <0.001). No significant changes were observed in estrogenic status. No adverse events were reported. Conclusion: CRMRF significantly improves sexual function and vaginal health in women with GSM, with both within-group and between-group differences, particularly in the reduction of dyspareunia. The benefits appear to be independent of the vaginal maturation index, supporting CRMRF as a safe and effective non-hormonal therapy for GSM. Supplementary Material File (figures_captions.docx) Download 15.24 KB File (manuscript.docx) Download 95.43 KB File (table.docx) Download 20.12 KB Information & Authors Information Version history V1 Version 1 05 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords genitourinary medicine gynaecology: in the elderly menopause menopause: hrt regimens pelvic pain psychosexual medicine Authors Affiliations Claudia Andrea Quezada-Bascuñán Universidad de Castilla-La Mancha - Campus de Toledo View all articles by this author Asunción Ferri-Morales 0000-0001-5638-4718 [email protected] Universidad de Castilla-La Mancha - Campus de Toledo View all articles by this author Vicente Martinez-Vizcaino Universidad de Castilla-La Mancha - Campus de Cuenca View all articles by this author Cristina Gallego-Gómez Universidad de Castilla-La Mancha - Campus de Toledo View all articles by this author Ana Torres-Costoso Universidad de Castilla-La Mancha - Campus de Toledo View all articles by this author Cristina Lirio-Romero Universidad de Castilla-La Mancha - Campus de Toledo View all articles by this author Metrics & Citations Metrics Article Usage 258 views 158 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Claudia Andrea Quezada-Bascuñán, Asunción Ferri-Morales, Vicente Martinez-Vizcaino, et al. Efficacy of Non-Ablative Radiofrequency on Sexual Function in Postmenopausal Women. A Randomized Clinical Trial. Authorea . 05 June 2025. DOI: https://doi.org/10.22541/au.174912503.32735535/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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