Peculiarities of management of patients in menopause from the point of view of a family doctor

In: Medicine of Ukraine · 2024 · pp. 13–17 · doi:10.37987/1997-9894.2024.4-5(280-281).316273 · W4404976483
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This paper reviews the management of menopausal patients from the perspective of a family physician, focusing on alternatives to hormone therapy. It highlights the use of phytotherapeutic complexes, specifically Menomedin-M, for women with contraindications to hormonal treatment. The text describes the composition and therapeutic effects of this plant-based supplement in alleviating climacteric syndrome symptoms. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Menopause is a difficult period in a woman’s life when her body needs support. In cases where hormonal therapy is contraindicated, which is not uncommon, it is necessary to resort to prescribing herbal preparations, which are quite effective and at the same time have no contraindications. One of these drugs is Menomedin®-M, which can be prescribed by both obstetrician-gynecologists and general practitioners. The composition, mechanism of action, therapeutic effects and results of clinical studies of plant components of Menomedin®-M ensure the effectiveness of prescribing this phytocomplex for women with climacteric syndrome
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Особливості ведення пацієнток у менопаузі з погляду сімейного лікаря DOI: https://doi.org/10.37987/1997-9894.2024.4-5(280-281).316273Ключові слова: менопауза, гормональний статус, остеопороз, фітотерапія, корекціяАнотація Менопауза – це складний період у житті жінки, коли її організм потребує підтримки. У випадках, коли гормональна терапія протипоказана, що не є рідкістю, потрібно вдаватися до призначення фітотерапевтичних комплексів, які є доволі ефективними і водночас не мають протипоказань. Одним із таких фітотерапевтичних комплексів є Меномедін®-М, який можуть призначати і лікарі акушери-гінекологи, і лікарі загальної практики. Склад, механізм дії, терапевтичні ефекти та результати клінічних досліджень рослинних компонентів препарату Меномедін®-М забезпечують ефективність призначення цього фітокомплексу жінкам із клімактеричним синдромом. Посилання Менопаузальні порушення та інші розлади в перименопаузальному періоді // Клінічна настанова, заснована на доказах. – Київ, 2022. – 130 с. – Режим доступу: https://www.dec.gov.ua/wpcontent/uploads/2022/06/2022_01_13_kn_menopauz_rozlady.pdf Наказ МОЗ України від 17.06.2022 № 1039 «Про затвердження Уніфікованого клінічного протоколу первинної, вторинної (спеціалізованої), третинної (високоспеціалізованої) медичної допомоги «Менопаузальні порушення та інші розлади в перименопаузальному періоді». – Режим доступу: https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-17062022--1039-pro-zatverdzhennja-unifikovanogo-klinichnogo-protokolu-pervinnoi-vtorinnoispecializovanoi-tretinnoi-visokospecializovanoi-medichnoi Benefits of Black Cohosh (Cimicifuga racemosa) for Women Health: An UpClose and In-Depth Review / Sradhanjali Mohapatra, Ashif Iqubal and other. // Pharmaceuticals (Basel). – 2022. – Vol. 15 (3). – Р. 278. Wuttke W. 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Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women / W. Wuttke, C. Gorkow, D. Seidlová-Wuttke // Menopause. – 2006. – Vol. 13. – P. 185–196. Efficacy of Cimicifuga racemose on climacteric complaints: A randomized study versus low-dose transdermal estradiol / R. E. Nappi, B. Malavasi, B Brundu., F. Facchinetti // Gynecol. Endocrinol. – 2005. – Vol. 20. – P. 30–35. The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells / M. Szmyd, V. Lloyd, K Hallman. [et al.] // Breast Cancer Targets Ther. – 2018. – Vol. 10. – P. 1–11. Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats / Anees Ahmed Syed, Mohammad Irshad Reza, Pragati Singh, Athar Husain, Shailesh Dadge, Jiaur R. Gayen // Experimental Gerontology. – 2022. – Vol. 159. – P. 111681. The Use of a Stem and Leaf Aqueous Extract of Cissus quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndrome in Overweight / Participants Robert Nash, Boris Azantsa, Dieudonne Kuate, Harrinder Singh, Julius Oben // The journal of alternative and complementary medicine. – 2019. – Vol. 25, Nо. 1. – Р. 98–106. Role of Cissus quadrangularis in the Management of Osteoporosis: An Overview / Jaspreet Kaur and other // Crit Rev Ther Drug Carrier Syst. – 2021. – Vol. 38 (5). – P. 27–51. Clinical evaluation of Cissus quadrangularis as osteogenic agent in maxillofacial fracture: A pilot study / Hemal R. and oher // Ayu. – 2015. – Vol. 36 (2). – P. 169–173. Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts. Duenpim Parisuthiman and oher. In Vitro Cell Dev Biol Anim. – 2009. – Vol. 45 (3–4). – P. 194–200. Cissus quadrangularis (Hadjod) Inhibits RANKL-Induced Osteoclastogenesis and Augments Bone Health in an Estrogen-Deficient Preclinical Model of Osteoporosis Via Modulating the Host Osteoimmune System / Zaffar Azam and other // Cells. – 2023. – Vol. 12 (2). – P. 216. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Julius E. Oben, Judith L. Ngondi, Claudia N. Momo, Gabriel A. Agbor // Lipids Health Dis. – 2008. – Vol. 7. – P. 12. Estrogenic activity of standardized extract of Angelica sinensis. Clara Circosta, Rita De Pasquale and other // Phytotherapy Research. – 2006. – Vol. 20 (8). – P. 665–669.

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