Effect of Different Doses and Courses of Mifepristone in the Treatment of Rats′ Endometriosis

Objective To investigate the effect of different dosages and different treatment methods of mifepristone in rat′s endometriosis(EMs). Methods A total of 79 rats were selected to establishment of models of EMs,and were randomly divided into high-dose group[dosages of 2.604 mg/(kg·d)], low-dose group[dosages of 1.041 mg/(kg·d)],control group(placebo of 1 mL peanut oil)to determine the drugs effects of the ectopic lesions reduce by medication. There were 7 rats died during treatment period. According to different courses of treatment 20 days,30 days and 40 days, 72 rats were divided into 9 sub-groups to determine the effectiveness of treatment. Results After treatment of mifepristone, ectopic lesions of EMs were significantly reduced than those before treatment in low-dose group and high-dose group (P0.05);in low-dose group and high-dose group there were significance difference than those in control group (P0.05); however, curative effects of mifepristone between low-dose group and high-dose group (P=0.662) or different courses of treatment 20 days,30 days and 40 days subgroups had no statistically significant difference (P=0.559, 0.145, 0.057). Conclusions Mifepristone could inhibit the growth of EMs ectopic lesions. There was no statistically significant difference to treatment models of EMs rats by medication dosages of 2.604 mg/(kg·d),1.041 mg/(kg·d) or different courses of treatment by medication 20 days,30 days and 40 days subgroups.