68 Ga-FAPI-04 Versus 18 F-FDG PET/CT in a Case of Xanthogranulomatous Cholecystitis.

Xie Y, Lin X, Yue Chen
Clinical nuclear medicine · 2025 · doi:10.1097/rlu.0000000000005984 · PMID:40829135
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Abstract

Xanthogranulomatous cholecystitis (XGC) is an uncommon inflammatory disease of the gallbladder. We report a case of XGC with elevated activity of 18 F-FDG and 68 Ga-FAPI (fibroblast activating protein inhibitor), which mimics malignancy. Our case suggests that XGS should be considered in the differential diagnosis of cancer-like gallbladder lesions with increased 68 Ga-FAPI uptake.
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Xanthogranulomatous cholecystitis (XGC) is an uncommon inflammatory disease of the gallbladder. We report a case of XGC with elevated activity of 18F-FDG and 68Ga-FAPI (fibroblast activating protein inhibitor), which mimics malignancy. Our case suggests that XGS should be considered in the differential diagnosis of cancer-like gallbladder lesions with increased 68Ga-FAPI uptake. 68Ga-FAPI-04 Versus 18F-FDG PET/CT in a Case of Xanthogranulomatous Cholecystitis Plain Language SummaryXanthogranulomatous cholecystitis (XGC) is a rare gallbladder inflammation that can resemble cancer due to high uptake of imaging tracers like 18F-FDG and 68Ga-FAPI. This case study highlights the importance of considering XGC when diagnosing gallbladder lesions that show increased 68Ga-FAPI activity, as it can mimic malignancy. Recognizing XGC in such scenarios can prevent misdiagnosis and ensure appropriate treatment. Text is machine generated and may contain inaccuracies. FAQ

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