Dyskinesia-hyperpyrexia syndrome in Parkinson’s disease may benefit from GPi deep brain stimulation: a case report

Introduction: Dyskinesia-hyperpyrexia syndrome (DHS) is a rare but life-threatening complication in Parkinson’s disease (PD). Its prevention and treatment are clinical challenges. Case presentation: We herein present a case of a female PD patient who experienced recurrent episodes of DHS and levodopa-induced dyskinesia. The complications were alleviated after bilateral globus pallidus internus (GPi) deep brain stimulation (DBS). Conclusion Our report provides evidence that GPi DBS may reduce the susceptibility to DHS. More evidences are warranted to validate this hypothesis.