Serum HE4 is more suitable as a biomarker than CA125 in Chinese women with benign gynecologic disorders

Y Zhang, Yan Zhang, C Qiao, Chen Qiao, Chunxia Qiao, Longjiang Li, Lian Li, Xiaocheng Zhao, Xuye Zhao, Yali Li, Yun Li
African health sciences · 2015 · vol. 14(4) , pp. 913 · doi:10.4314/ahs.v14i4.20 · PMID:25834501 · W1544353423
article OA: diamond CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found serum HE4 levels were less elevated than CA125 in Chinese women with benign gynecologic disorders, suggesting HE4 is a more suitable biomarker.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: This study measured the human epididymis protein 4 (HE4) and CA125 levels in Chinese women with benign gynecological disorders. MATERIAL AND METHODS: Sera were obtained from Chinese women prior to surgery for a pelvic mass and HE4 and CA125 levels were determined. The proportions of patients with HE4 and CA125 levels were compared. RESULTS: There were 68 Chinese women with benign diseases. HE4 levels were less elevated than CA125 (1% V.S. 29%, P<0.001). The significant difference was observed in patients with endometriosis/endometriomas in which HE4 was not elevated patients and CA125 was elevated in 53% (P<0.001). Serum HE4 level was not elevated in patients with cystadenoma (0% V.S. 23%, P<0.001) and in patients with germ cell tumors (0% V.S. 5%, P<0.001). CONCLUSION: HE4 was less elevated and more suitable as a biomarker than CA125 in chinese women with benign disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Asian People Biomarkers, Tumor CA-125 Antigen Genital Diseases, Female Membrane Proteins Proteins Adult Asian People Biomarkers, Tumor CA-125 Antigen CA-125 Antigen Female Genital Diseases, Female Genital Diseases, Female Genital Diseases, Female Humans Membrane Proteins Membrane Proteins Middle Aged Predictive Value of Tests

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

Cited by (1)

References (33)

Cited by (1)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:17:58.238279+00:00
License: CC0 · commercial use OK