Ultrasound assessment of the endometric in postmenopausal asymptomatic women using hormonal substitutions

Anna Chalkidou, Αnastasia Bothou, A Koukoulomati, Konstantinos Nikolettos, Nikos Nikolettos, P Tsikouras
In: Geburtshilfe und Frauenheilkunde · 2022 · vol. 82(10) , pp. e56 · doi:10.1055/s-0042-1756775 · W4307688890
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study aimed to use ultrasound to detect endometrial pathology in asymptomatic postmenopausal women undergoing hormone replacement therapy with Timbolone.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This retrospective study evaluated endometrial thickness in 850 asymptomatic postmenopausal women (48–58 years; 2–3 years since menopause) undergoing annual preventive gynecologic examinations while using hormone substitutions, comparing Timbolone versus MF11RCE-yalouronic acid with transvaginal ultrasound. Endometrial thickness ≤6 mm was treated as normal, and women with thickness >6 mm were referred for diagnostic fractional abrasion combined with hysteroscopy. The authors reported that 33.6% had thickness <6 mm, 12.26% were between 5–7 mm, and 4.13% were ≥8 mm, and they found no statistically significant difference in thickness between the hormone groups. The study’s limitation is that it focused on thickness measurements and comparative ultrasound outcomes without providing detailed diagnostic pathology results in the provided text. Relevance to endometriosis: the paper is not centrally about endometriosis or adenomyosis; it was included in the corpus via a keyword match related to endometrial assessment in endometrial pathology risk contexts.

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Abstract

Aim The observed steady increase in morbidity, mortality and incidence of endometrial cancer has aroused the interest of many researchers to find methods for early diagnosis of endometrial neoplasms. The purpose of this study is the early detection of endometrial pathology in postmenopausal women (PMW) without clinical symptoms with hormone replacement therapy (Timbolone, MF11RCE-yalouronyc acid).
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Material and methods

In a retrospective study conducted at the University Obstetrics and Gynecology Clinic of Democritus University of Thrace, in Greece, 850 PMW examined from 01.01.2007 to 31.12.2019 in the context of annual preventive gynecological examinations without previous pathology. Their age ranged between 48 and 58 years, with an average time of established menopause between 2 and 3 years. We considered endometrial thickness as a normal limit ≤6mm. In all cases where the thickness of the endometrium was greater than 6mm we performed diagnostic fractional abrasion in combination with hysteroscopy. Resuts After measurements of the thickness of the endometrium in the consortium of the above women with the help of transvaginal ultrasound was found in 702 women (33.6%) endometrial thickness <6mm in (Group A). In 92 women (12.26%) ranged between 5-7 mm (Group B), in 34 cases (4.13%) endometrial thickness greater than or equal to 8mm was found (Group C).

Conclusion

There was no statistically significant difference in endometrial thickness between groups of Timbolone and MF11RCE-yalouronic acid. However, in cases of endometrial ultrasound thickness > 6 mm of asymptomatic PMW, to exclude the possibility of pathology, we recommend endometrium hysteroscopic biopsy Publication History Article published online: 11 October 2022 © 2022. Thieme. All rights reserved. Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, Germany

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