On a general definition of the set of native conformations for globular polypeptides

Here we question the generality of the conventional definition of a native conformation –as the 3-dimensional conformation of an entire globular polypeptide molecule. Although considered common knowledge, and thus not explicitly stated in modern writings, this definition of native conformations has a history as old as the protein folding problem. We attempt a more applicable definition that better correlates with functional activity and thus may be a more suitable substitute for the current convention.