Sleep and Risk of Peptic Ulcer Disease: a cross-sectional study

Abstract BACKGROUND & AIMS：The association between sleep duration and gastrointestinal disorders has been investigated extensively, but the specific link with peptic ulcer disease (PUD), including gastric ulcer (GU) and duodenal ulcer (DU), has not been thoroughly examined. Our objective was to assess the relationship between sleep duration and the occurrence of PUD, GU, and DU. METHODS: We undertook a cross-sectional analysis involving 4,860 individuals from the Wuwei cohort. Participants' daily sleep duration was assessed by inquiring about the number of hours slept per day. Odds ratios and 95% confidence intervals were calculated using binary logistic regression. RESULTS: In age- and sex-adjusted logistic regression analyses, those who slept > 9h were less likely to develop GU compared to those who slept 7-9h. (OR = 0.67, 95% CI= 0.55-0.80) , but had an increased risk of developing DU (OR = 1.39, 95% CI=1.10-1.77).This result remains significant in Model 2. CONCLUSIONS: Prolonged sleep associated with gastric ulcer and duodenal ulcer disease