Effect of Hydroalcoholic Extracts of Capsella Bursa-Pastoris on Heavy Menstrual Bleeding: A Randomized Clinical Trial

Mahdis Naafe, Nourossadat Kariman, Zohreh Keshavarz, Nasim Khademi, Faraz Mojab, Abolfazl Mohammadbeigi
In: The Journal of Alternative and Complementary Medicine · 2018 · vol. 24(7) , pp. 694–700 · doi:10.1089/acm.2017.0267 · PMID:29641247 · W2802462215
article OA: closed CC0 ⤵ 2 in-corpus citations
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This randomized clinical trial found that hydroalcoholic extracts of Capsella bursa-pastoris, when combined with mefenamic acid, significantly reduced heavy menstrual bleeding compared to mefenamic acid alone.

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Abstract

OBJECTIVES: Heavy menstrual bleeding (HMB) is one of the leading causes of low quality of life and iron deficiency anemia in women. This study aimed to determine the effect of hydroalcoholic extracts of Capsella bursa-pastoris on HMB. DESIGN: This study is a triple-blinded, randomized clinical trial. SETTING: The study was conducted in gynecology clinics affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran. SUBJECTS: Our patients affected to a complaint of HMB. After obtaining a complete medical history of the women and filling out the demographic forms, the participants were assigned randomly into the experimental (n = 42) and control groups (n = 42). INTERVENTION: The eligible participants were given a pictorial blood loss assessment chart (PBLAC) to confirm HMB during the menstrual cycle. The experimental group received two capsules of mefenamic acid (500 mg) every 8 h and two Capsella bursa-pastoris capsules every 12 h. The intervention started from the first day of menstruation to the end of this period up to 7 days for two consecutive cycles. In the control group, the patients received mefenamic acid and placebo instead of Capsella bursa-pastoris capsules. OUTCOME MEASUREMENTS: The PBLAC score and number of bleeding days, incidence of any possible problems, as well as participant satisfaction were measured. The data were analyzed using t-test, Chi-square, repeated-measures ANOVA, and ANCOVA tests in PASW Statistics ver. 18. RESULTS: After the intervention, there was observed significant decrease in the amount of menstrual bleeding in both groups. However, the mean decrease in the amount of bleeding was significantly more in the Capsella bursa-pastoris group (p < 0/001). CONCLUSION: Compared with control group, hydroalcoholic extracts of Capsella bursa-pastoris capsule appeared to be effective in reducing menstrual bleeding in this study. Further research regarding the efficacy and safety of Capsella bursa-pastoris is required.

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