Genomic Characterization of the Comamonas kerstersii Isolated from Diarrheal Patients in Bangladesh

2025 · doi:10.22541/au.172115040.03950879/v2
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This study performed whole genome sequencing of three *Comamonas kerstersii* strains from diarrheal patients in Bangladesh, identifying clonal relationships, seven AMR genes, virulence factors, phage regions, and an IncQ1 plasmid.

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Abstract

This study marks the first identification and genomic characterization of Comamonas kerstersii isolates from diarrheal patients in Bangladesh. C. kerstersii is a gram-negative opportunistic bacterium that has also been reported in several clinical samples, including urine, blood, stool, peritoneal liquid, and sputum. We carried out the whole genome sequencing of three C. kerstersii isolates with the aim of analyzing genomic features in 3 different strains isolated from Bangladesh for the first time. Phylogenetic analysis suggests that these three strains share a clonal relationship. Seven AMR genes, aph(6)-Id, aph(3”)-Ib, mph(E), mph(F), msr(E), sul2, and tet(A), have been observed in all the strains. We identified several virulence factors, including copper homeostasis genes, type IV pili, and type VI secretion system. Phage regions and IncQ1 plasmid were also detected. These initial findings highlight the need for extensive genomic surveillance of C. kerstersii in different diarrheal patients, along with investigating their genotype-phenotype correlation to understand the molecular pathogenesis in detail.
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Abstract

This study marks the first identification and genomic characterization of Comamonas kerstersii isolates from diarrheal patients in Bangladesh. C. kerstersii is a gram-negative opportunistic bacterium that has also been reported in several clinical samples, including urine, blood, stool, peritoneal liquid, and sputum. We carried out the whole genome sequencing of three C. kerstersii isolates with the aim of analyzing genomic features in 3 different strains isolated from Bangladesh for the first time. Phylogenetic analysis suggests that these three strains share a clonal relationship. Seven AMR genes, aph(6)-Id, aph(3”)-Ib, mph(E), mph(F), msr(E), sul2, and tet(A), have been observed in all the strains. We identified several virulence factors, including copper homeostasis genes, type IV pili, and type VI secretion system. Phage regions and IncQ1 plasmid were also detected. These initial findings highlight the need for extensive genomic surveillance of C. kerstersii in different diarrheal patients, along with investigating their genotype-phenotype correlation to understand the molecular pathogenesis in detail. Supplementary Material File (manuscript.docx) - Download - 179.10 KB Information & Authors Information Peer review timeline Published PLOS One Version of Record10 Apr 2026Published Copyright This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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Authors Metrics & Citations Metrics Article Usage 364views 175downloads Citations Download citation Noshin Ibnat Rib, Fariza Shams, Fahad Khan, et al. Genomic Characterization of the Comamonas kerstersii Isolated from Diarrheal Patients in Bangladesh. Authorea. 11 December 2025. DOI: https://doi.org/10.22541/au.172115040.03950879/v2 DOI: https://doi.org/10.22541/au.172115040.03950879/v2 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.

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