Aspects of Pathogen Inactivation via Absorption of Short-Pulse UV- C Irradiation for Advanced Decontamination Strategies

Aspects of Pathogen Inactivation via Absorption of Short-Pulse UV- C Irradiation for Advanced Decontamination Strategies | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Short Report Aspects of Pathogen Inactivation via Absorption of Short-Pulse UV- C Irradiation for Advanced Decontamination Strategies Ion Munteanu, Nicolae Enachi, Ciobanu Nellu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7011699/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 18 Oct, 2025 Read the published version in Photochemical & Photobiological Sciences → Version 1 posted 7 You are reading this latest preprint version Abstract The inactivation of pathogens using ultraviolet (UV) radiation has become a critical research focus following the COVID-19 pandemic, underscoring the need for advanced decontamination strategies against viruses, bacteria, and other pathogens. This study proposes the use of short pulses of UV-C radiation (220–280 nm) as an effective method for pathogen inactivation. Our primary objective is to evaluate the decontamination efficacy of pulsed UV-C radiation by varying the time intervals between pulses while maintaining constant pulse energy, and to analyze the resulting absorption spectra of a yeast solution across different irradiation durations. The research addresses two main components: (1) a theoretical model examining the effects of short UV-C pulses on biomolecules during radiation propagation, and (2) practical applications for pathogen diagnosis, treatment, and inactivation, with significant implications for ontogenetic and public health outcomes. UV-C radiation short pulses biomolecules absorbance spectrum ultraviolet germicidal irradiation Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 18 Oct, 2025 Read the published version in Photochemical & Photobiological Sciences → Version 1 posted Editorial decision: Revision requested 31 Aug, 2025 Reviews received at journal 01 Aug, 2025 Reviewers agreed at journal 23 Jul, 2025 Reviewers invited by journal 08 Jul, 2025 Editor assigned by journal 04 Jul, 2025 Submission checks completed at journal 03 Jul, 2025 First submitted to journal 30 Jun, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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