CLEFT RR- New App to Calculate Recurrence Risk in Cleft Lip and Palate

Abstract Background: The impact of the birth of a child with cleft lip and palate generates a concern in the family related to care and the child's future. The opportunity to clarify the recurrence risk arouses high interest in families and adult individuals born with orofacial clefts and it contributes to decisions regarding family planning. Results: The purpose is to present the Cleft Recurrence Risk (Cleft RR), which aims to facilitate health professionals to quickly calculate the recurrence risk considering the ancestry, cleft type, sex, and family history. After defining parameters the application development follows the steps: development, prototyping , and documentation. The validation of the calculated data was performed by comparing the results of 100 cases undergoing genetic counseling at the cleft lip and palate treatment center obtained by the manual method. The results were obtained by the mobile app method; the data were submitted to the Bland-Altman statistics and a high concordance was found. Conclusions: The mobile app for use by healthcare professionals proved to be simple to use, easy to apply, and provided accurate results. Cleft RR is an App for smartphones developed for genetic counseling in cleft lip and palate, supplementary use by health professionals, and should not replace professional performance.