Premenstrual Psychosis In A Patient With Polycystic Ovary Syndrome: A Case Report

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This case report details a 28-year-old female with schizoaffective disorder and PCOS who experienced distinct premenstrual psychotic episodes, including delusions of pregnancy, which resolved post-menstruation.

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This case report describes a 28-year-old woman with a long-standing schizoaffective disorder who was later diagnosed with polycystic ovary syndrome (PCOS) and then experienced distinct psychotic episodes that coincided acutely with her premenstrual period. During these episodes, she had delusions of pregnancy, and symptoms were reported to near-resolve with the end of menstruation. The authors frame the presentation as an atypical, cyclic pattern of psychosis with potential implications for pathogenesis, but the report is limited to a single patient and does not establish causality. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Abstract Periodic psychosis in relation to the menstrual cycle phases has been reported but its pathogenesis not yet known. We report a case of a 28 year old female with schizoaffective disorder since 18 years old. She was diagnosed with polycystic ovary syndrome (PCOS) 3 years later and was noted to have distinct psychotic episodes that coincided acutely with her premenstrual period. Peculiarly she exhibited delusions of pregnancy during her psychotic episodes. This was followed by near resolution with the end of menstruation. This case sheds light on this atypical presentation of psychosis in female patients as well as its potential aetiology.
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We report a case of a 28 year old female with schizoaffective disorder since 18 years old. She was diagnosed with polycystic ovary syndrome (PCOS) 3 years later and was noted to have distinct psychotic episodes that coincided acutely with her premenstrual period. Peculiarly she exhibited delusions of pregnancy during her psychotic episodes. This was followed by near resolution with the end of menstruation. This case sheds light on this atypical presentation of psychosis in female patients as well as its potential aetiology. Psychiatry Periodic psychosis menstrual cycle premenstrual female estrogen Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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