THE EFFECT OF INDOMETHACIN ON SPONTANEOUS ACTIVITY IN THE ISOLATED HUMAN MYOMETRIUM AND ON THE RESPONSE TO OXYTOCIN AND PROSTAGLANDIN

D. B. Garrioch
In: BJOG: An International Journal of Obstetrics & Gynaecology · 1978 · vol. 85(1) , pp. 47–52 · doi:10.1111/j.1471-0528.1978.tb15825.x · W2017754546
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

Indomethacin abolished spontaneous activity in human myometrial strips and blunted oxytocin but not prostaglandin responses, with the latter's effect dependent on activity level.

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Abstract

Summary The spontaneous activity of human myometrial strips obtained during the proliferative and secretory phases of the menstrual cycle and during the early and late stages of pregnancy was studied. Both prostaglandin F 2α (PGF 2α ) and oxytocin caused contractions which were superimposed on a low level of spontaneous activity but only PGF 2α was seen to affect high levels of activity. Spontaneous contiactions were ultimately abolished by the addition of indomethacin. The strips remained responsive to PGF 2α but not to oxytocin.

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last seen: 2026-06-10T17:14:06.276822+00:00
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