[Expression and significance of p63, aromatase P450 and steroidogenic factor-1 in endometrial polyp].

OBJECTIVE: To investigate the expression and signification of p63, aromatase P450 (P450 arom) and steroidogenic factor-1 (SF-1) in endometrial polyp, and to explore its role in the pathogenesis of endometrial polyp. METHODS: Specimen were collected from hysteroscopic resection, pathologically confirmed endometrial polyp specimens of 30 cases of endometrial polyp and the adjoining endometrium around endometrial polyp in 20 cases, endometrial tissue of normal control group of 25 patients. Immunohistochemistry SP method and real- time PCR technology were used to detect the three groups in the expression of p63, P450 arom and SF- 1 protein and gene. RESULTS: P450arom gene (0.274 ± 0.082) and protein (1.2 ± 1.1) expression in endometrial polyp was significantly higher than the adjoining endometrium and normal endometrium (P < 0.05); the expression of SF- 1 protein (1.1 ± 0.8) and p63 protein (0.8 ± 0.5) were also higher in the endometrial polyp than the other two control groups (P < 0.05); while the expression of SF-1 mRNA (0.105 ± 0.049 versus 0.053 ± 0.043) and p63 mRNA (0.261 ± 0.052 versus 0.180 ± 0.018) in endometrial polyp had no significant difference between endometrial polyp and the adjoining endometrial (P > 0.05). CONCLUSION: p63, P450 arom and SF-1 may play a role in the formation of endometrial polyp.