Observation of female fetuses HOXA10 gene aberrant methylation in pregnant women suffering from endometriosis

Objective To detect the endometriosis susceptibility gene of HOXA10 promoter region aberrant methylation in pregnant women with endometriosis and normal pregnant women,and to analyze the family heredity of endometriosis.Methods Specimens were collected from January 2010 to December 2012 hospitalized in Zhujiang Hospital of Southern Medical University,which included fifteen female fetus cord blood specimens of pregnant woman with endometriosis and twenty-six female fetus cord blood specimens of normal pregnant woman.The HOXA10 aberrant methylation in two groups were detected by methylation specific polymerase chain reaction(MSP) and bisulfite salt modified sequencing(BSP).Results The fetal cord blood HOXA10 methylation rate in pregnant women with endometriosis was higher than that in normal pregnant women,with statistically significant difference(all P0.05).Conclusion As in the epigenetics,endometriosis may have family heredity.