Prostaglandin F2 synthesis and metabolism by luteal phase endometrium in vitro

John R. Brumsted, Jane Chapitis, Jeffrey L. Deaton, Daniel H. Riddick, Mark Gibson
In: Fertility and Sterility · 1989 · vol. 52(5) , pp. 769–773 · doi:10.1016/s0015-0282(16)61029-4 · PMID:2806618 · W2418627284
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This study investigated prostaglandin F2 synthesis and metabolism within the endometrium during the luteal phase of the menstrual cycle in an in vitro setting.

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Abstract

Differences in prostaglandin (PG) F2 alpha synthesis and degradation were sought between early luteal endometrium (histology day 15 to 22, n = 6) and late luteal endometrium (histology day 23 to 28, n = 6). In addition, alterations in PGF2 alpha synthesis and degradation in response to 17 beta-estradiol (E2) and progesterone (P) were examined to clarify the mechanism of steroid modulation of endometrial PG production (n = 12). Endometrium was maintained in tissue culture and the concentration of PGF2 alpha and 13,14 dehydro-15 keto F2 alpha (DHKF2 alpha) was determined in spent media by radioimmunoassay. Prostaglandin F2 alpha and DHKF2 alpha output from luteal endometrium exposed to P and E2 + P were both significantly reduced when compared with no addition or E2 treatments. This implies that the modulation of PGF2 alpha output by P in vitro is secondary to altered synthesis. There was an increase in PGF2 alpha output from late luteal endometrium when compared with early luteal endometrium in the P and E2 + P treatments, but DHKF2 alpha remained unchanged. These data imply that the temporal increase in PGF2 alpha output is the result of alterations in both PG synthesis and catabolism.

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