Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence

Abstract Bladder cancer is the most prevalent cancer of the urinary system, but its pathogenesis is still poorly understood. Several reports have suggested that gene damage repair is highly correlated with tumor development and drug resistance, in which homologous recombination repair gene Rad54L, seems to play an important role, through yet unclear mechanisms. Therefore, this study stratified cancer patients by Rad54L expression in bladder cancer tissue, and high Rad54L expression was associated with a poor prognosis. Mechanistically, we demonstrate that high Rad54L expression promotes abnormal bladder tumor cell proliferation by changing the cell cycle and cell senescence. In addition, this study also suggests that Rad54L may be associated with p53, p21, and pRB in bladder cancer tissue. In summary, this study exposes Rad54L as potential a prognostic biomarker and precision treatment target in bladder cancer.