Three-Step Synthesis of (E)-1-(2-(Pyridin-2-yl)benzo[d]thiazol-6-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as a Potential Ligand for Transition Metals

In the present study, (E)-1-(2-(pyridin-2-yl)benzo[d]thiazol-6-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (4) was designed and synthesized via a three-step reaction sequence. Initially, 6-acetylbenzo[d]thiazol-2(3H)-one (1) was hydrolyzed to the corresponding 5-acetyl-2-aminothiophenol 2 and then cyclized with pyridine-2-carbaldehyde. The final product was synthesized by a base-catalyzed aldol condensation of 1-(2-(pyridin-2-yl)benzo[d]thiazol-6-yl)ethan-1-one (3) and 3,4,5-trimethoxybenzaldehyde and was comprehensively characterized.