Cognitive Behavioral Therapy after Endometriosis Surgery

Z Boersen, J.M. Oosterman, P. Dijkhuizen, H. van Vliet, J.W. van der Steeg, G. Teklenburg, H. Delcliseur, E. Hameleers, A. IJsel de Schepper, D. Braat, C. Verhaak, A. Nap
2025 · doi:10.34973/fqsc-wd42 · W7127419378
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⚙ AI-generated summary by qwen3.7-flash, 2026-08-29 ⓘ

This randomized trial found that adding cognitive behavioral therapy to endometriosis surgery did not significantly reduce chronic pain or improve health-related quality of life compared to surgery alone.

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This randomized controlled multicenter trial investigated whether adding cognitive behavioral therapy to endometriosis surgery could reduce chronic pain and enhance health-related quality of life compared to surgery alone. One hundred patients with endometriosis-related chronic pain were equally assigned to receive either standard surgical intervention or the same surgery combined with cognitive behavioral therapy, with outcomes assessed at baseline, two weeks, and sixteen weeks post-intervention using questionnaires and hair cortisol analysis for stress measurement. The provided text outlines the study design and objectives but does not report the specific statistical results or conclusions regarding the efficacy of the combined treatment approach. This paper is centrally about endometriosis — specifically evaluating a psychological intervention adjunct to surgical management of endometriosis-associated chronic pain.

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Abstract

The aim of this study was to combine endometriosis surgery with cognitive behavioral therapy to decrease chronic pain and improve health related quality of life. In this randomized controlled multicenter trial, 100 patients were included undergoing surgery for endometriosis related chronic pain. Participants were equally randomized between endometriosis surgery or endometriosis surgery and cognitive behavioral therapy. Questionnaires evaluated health related quality of life, pain intensity, catastrophizing, anxiety, fatigue and perceived stress at baseline (T0), 2 (T1) and 16 (T2) weeks post-intervention. Hair cortisol levels in scalp hair were analyzed as another measure for chronic stress. Information about the researchprotocol can be found at: ClinicalTrials.gov NCT04448366. https://clinicaltrials.gov/study/NCT04448366?cond=NCT04448366&rank=1. Also the associated, published researchprotocol can be used (linked to this repository)
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Cognitive Behavioral Therapy after Endometriosis Surgery Boersen, Z. Oosterman, J.M. Dijkhuizen, P. van Vliet, H. van der Steeg, J.W. Teklenburg, G. Delcliseur, H. Hameleers, E. IJsel de Schepper, A. Braat, D. Verhaak, C. Nap, A. The aim of this study was to combine endometriosis surgery with cognitive behavioral therapy to decrease chronic pain and improve health related quality of life. In this randomized controlled multicenter trial, 100 patients were included undergoing surgery for endometriosis related chronic pain. Participants were equally randomized between endometriosis surgery or endometriosis surgery and cognitive behavioral therapy. Questionnaires evaluated health related quality of life, pain intensity, catastrophizing, anxiety, fatigue and perceived stress at baseline (T0), 2 (T1) and 16 (T2) weeks post-intervention. Hair cortisol levels in scalp hair were analyzed as another measure for chronic stress. Information about the researchprotocol can be found at: ClinicalTrials.gov NCT04448366. https://clinicaltrials.gov/study/NCT04448366?cond=NCT04448366&rank=1. Also the associated, published researchprotocol can be used (linked to this repository)

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