Development of a Custom NGS Panel for the Determination of Bladder Cancer Risk

Development of a Custom NGS Panel for the Determination of Bladder Cancer Risk | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Development of a Custom NGS Panel for the Determination of Bladder Cancer Risk Imen Hemissi, SAMI BOUSETTA, Hamza Dallali, Faycel Hellal, Geoffroy Durand, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-840773/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Backgound Bladder cancer (BCa) is a heterogeneous disease caused by the interaction between environmental and genetic risk factors. The objective of this study was to design a panel that evaluates the role of some selected variants in BCa susceptibility. We are also interested in studying the interaction between environmental and genetic risk factors. Methods The case/controls cohort was composed with 249 BCa cases and 255 controls. The designed Bladder cancer hereditary panel (BCHP) is composed of 139 selected variants. These variants were genotyped by an amplification-based targeted Next-Generation Sequencing (NGS) on the Ion Torrent Proton sequencer (Life Technologies, Ion Torrent technology). Results We have found that rs162555, rs2228000, rs10936599, rs710521, rs3752645, rs804276, rs4639, rs4881400 and rs288980 were significantly associated with decreased risk of bladder cancer. However the homozygous genotypes for VPS37C (rs7104333, A/A), MPG (rs1013358, C/C) genes or the heterozygous genotype for ARNT gene (rs1889740, rs2228099, rs2256355, rs2864873), GSTA4 (rs17614751) and APOBR/IL27 (rs17855750) were significantly associated with increased risk of bladder cancer development compared to reference group (OR=2.53, 2.34, 1.99, 2.00, 2.00, 1.47, 1.96 and 2.27 respectively). We have also found that non–smokers patients harboring heterozygous genotypes for ARNT/rs2864873 (A>G), ARNT/ rs1889740 (C>T) or GSTA4/rs17614751 (G to A) were respectively at 2.775, 3.069 and 6.608 –folds increased risk of Bca development compared to non-smokers controls with wild genotypes. Moreover the ARNT CT (rs1889740), ARNT CG (rs2228099), ARNT TC (rs2864873) and GSS GA genotypes were associated with an increased risk of BCa even in absence of professional risk factors. Finally the decision-tree analysis produced a three major BCa class. These three classes were essentially characterized by an intensity of tobacco use more than 20 pack years (PY) and the CYP1A2 (rs762551) genotype. Conclusions The determined association between genetic variations in BCa and environmental factors, as well as the effect of studied pathway SNPs in comparison with environmental exposition may provide urologists additional genetic information that may help for clinical assessment and treatment decisions. Nevertheless, the underlying mechanisms through which these genes or SNPs affect the clinical behavior of BCas require further studies. Molecular Biology Bladder cancer NGS Panel SNP tobacco Tunisia Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Highlight In this study we determined the effect of studied pathway SNPs in comparison with environmental exposition using Next-Generation Sequencing (NGS). We have found that homozygous minor genotype or heterozygous genotype for rs1889740 C/T, rs2228099 C/G, rs2256355 T/C, rs2864873 A/G in ARNT gene (Aryl hydrocarbon receptor nuclear translocator) were significantly associated to increased risk of bladder cancer even in the absence of tobacco risk factors, or professional risk factors. Finally we noticed the importance of tobacco status and the CYP1A2 (rs762551) genotype in the stratification of Tunisian BCa patients. Background Bladder cancer (BCa) is a common malignancy of the urinary tract and the ninth most frequent cancer in the world, affecting nearly 3.4 million people with 430 000 new cases diagnosed in 2012 and 165 000 deaths per year (2% of all the cases)[ 1 ]. In the few last years, the incidence of BCa was higher in developed countries and some African countries, with an increase in the aggressiveness of the disease and the mortality rate [ 2 ]. According to the Cancer Registry of the north of Tunisia (1999–2003), BCa is the most frequent urological cancer in Tunisia in men and in 2018 it became the second malignant tumor with an age-standardized incidence rates of 17.7 and 2.0 per 100 000 in men in women respectively[ 3 ]. In 2018, the number of new BCa cases was 1323 [ 4 ]. The mean age at diagnosis is 65.9 years, without sex significant difference. At the time of diagnosis, non-muscle-invasive BCa (NMIBC) represents the majority of BCa whereas muscle-invasive BCa (MIBC) represents around 25% of bladder tumors with a 5-year survival rate ranging from 35–70%. NMIBC is usually associated with a favorable prognosis but it is characterized by a variable rate of recurrence and progression depending on tumor characteristics. MIBC is, however, initially aggressive and given the associated high risk of developing a metastatic disease requires a radical treatment when still localized[ 5 ]. BCa is a heterogeneous disease associated with many risk factors. The most known risk factor is tobacco smoking, which accounts for the occurrence of up 50% of BCa [ 6 ]. Occupational exposure to chemicals, genetic factors, and other environmental factors such as dietary factors, lifestyle, medical condition, fluid intake, also contribute to BCa carcinogenesis, although the evidence of the role of some of these risk factors is still inconclusive [ 6 , 7 ]. Most carcinogens undergo activation by Phase I enzymes, mostly through oxidation reactions, and detoxification by Phase II enzymes, which is the case for aromatic and heterocyclic amines, well-known BCa carcinogens present in smoking and occupational exposure [ 8 ]. Therefore, early studies evaluated whether candidate genetic variants in such metabolic pathways could modify the risk of BCa induced by the above-mentioned carcinogens. For example, the deletion of xenobiotic metabolism gene " GSTM1 and/or GSTT1 " characterized as GSTM1- and GSTT1-null genotypes have been shown to be BCa susceptibility loci in several studies [ 9 , 10 ]. Moreover, N-acetyltransferase 2 ( NAT2 ) and Glutathione-s-transferase M1 (GSTM1) variants were the first described genes showing a gene-smoking interaction associated with increased risk of BCa[ 11 ]. Hypothetically the deficiency in xenobiotic metabolizing pathway could result in the accumulation of somatic mutations which should be corrected by DNA-repair pathways. There are five major important DNA-repair pathways consisting of more than 130 genes: nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), double-strand break repair (DSBR) and transcription-coupled repair (TCR) [ 12 – 14 ]. Among these pathways, NER is the most important DNA repair mechanism responsible for various types of DNA damage consisting of oxidative DNA damage, bulky adducts cross-links, alkylating damage, and thymidine dimmers[ 15 ]. Deficient DNA repair capacity is known to be a cancer-predisposing factor. Indeed the presence of some single nucleotide polymorphisms (SNP) in DNA repair genes can impair the function of the repair enzymes, thus reducing DNA Repair Capacity (DRC) and inducing genetic instability [ 16 ]. In addition others studies have reported a significant association between variations in gene encoded for cell cycle and/or inflammatory response proteins and bladder development and/or prognosis[ 17 ]. All of this reported information highlights the complexity of the mechanisms implicated in the etiology of BCa which warrants further investigation. The goal of this case-control study was to evaluate the implication a selected SNP panel in BCa development of the Tunisian population. We developed an amplification-based targeted Next-Generation Sequencing (NGS) assay to simultaneously genotype 139 polymorphisms in 97 genes, selected according to their eventual implications in the etiology and the prognosis BCa such as those located in genes encoded for enzymes implicated in xenobiotic metabolism, DNA repair, treatment response, and inflammatory reaction process. The design of the panel was done, after consulting published data and available databases (dbSNP, UCSC Genome Browser, and GWAS). Methods Study population A case-control study was conducted in the Urology department of Charles Nicolle Hospital in Tunis (Tunisia) and the Laboratory of Protein Engineering and Bioactive Molecules (LIP-MB 11ES24) of the National Institute of Applied Sciences and Technology of Tunis (INSAT), in collaboration with the Genetic Cancer Susceptibility group (GCS group) of the International Agency for Research on Cancer in Lyon (IARC/WHO). Recruitment was carried out after the agreement of the ethics committee of the Charles Nicolle Hospital and approved by an Ethics Committee (IEC Project No. 17–35) and an MTA (MATERIAL TRANSFER AGREEMENT MTA/ 2017 / IMP / GCS)/ 0356) from IARC. This study was performed on a cohort of 504 cases (249 BCa patients and 255 controls). A total of 255 control cases, randomly selected from healthy volunteer cases enrolled in the Biochemistry Department, were matched to those of the BCa patients group according to the age range (64.28 ± 11.54), sex, and geographic origin. Epidemiological, clinical and anatomopathological data of BCa patients were collected from the medical records of the urology department and the histological reports from the pathology department of the Charles Nicolle Hospital in Tunis ( Table 1 ). Epidemiological data (age, sex, smoking status) and pathological data (grade, stage, histological type, type, and follow-up of treatment) were recorded and made available for the study ( Table 1 ) . Histological reviews of the tumors were performed confirmed by a trained pathologist in urological oncology. The BCa tumors of the 249 patients were classified as 45 Specimens of High-Grade (HG) NMIBC, 119 specimens of Low-Grade (LG) NMIBC, and 66 specimens of MIBC. Table 1: Clinical and Epidemiological characteristics of bladder cancer patients Clinical and epidemiological parameters Bladder cancer patients Controls Samples sizes Male Female 249 224 (89.96%) 25 (10.04%) 255 196 (76.86%) 59 (23.14%) Mean Age at diagnosis (years) 68.18 ± 12.80 64.28 ± 11.54 Smoking status Smokers 199 (79.91%) 138 (54.12%) Non smokers 27 (10.84%) 117 (45.88%) ND 23 (9.25%) 0 (00.00%) Number of pack/years < 20 PY 31 (15.58%) 70 (50.72%) ≥ 20 PY 168 (84.42%) 68 (49.28%) Exposure to professional risk factors (farmer, painter, building, chemical factory…) Not exposed 119 (47.80%) 225 (88.24%) Exposed 83 (33.33%) 30 (11.76%) ND 47 (18.87%) 0 (00.00%) TNM classification LG NMIBC 119 (47.80%) - HG NMIBC 45 (18.07%) - MIBC ND 66 (27.50%) 19 (07.63%) - ND: Not Determined; PY: Packet per Year; LG: Low Grade; HG: Haut Grade; MIBC: Muscle Invasive Bladder Cancer; NMIBC: Non-Muscle Invasive Bladder Cancer Biological Samples And Dna Extraction Peripheral blood samples were collected into tubes with ethylene diamine tetra-acetic acid EDTA (PH 8). Genomic DNA was extracted from leukocytes using a phenol /chloroform procedure. First, the integrity of the genomic DNA was visualized by electrophoresis on a 1% agarose gel stained with ethidium bromide. In a second step, DNA samples were quantified by Nanodrop and Qubit (High Sensitivity HS / Broad Rang BR) and were dried with the speedvac (Eppendorf™ Vacufuge™ Concentrator) to be normalized into 6*96-well plates. Panel Design We have selected a panel of 139 polymorphisms from 97 genes. These SNP were selected according to their eventual implications in poor-prognosis BCa such as those affecting the xenobiotic metabolism, DNA repair, treatment response, and inflammatory reaction. The design of the panel was done, after consulting published data and available databases (dbSNP, UCSC Genome Browser, and GWAS). In a second step, the implication of the SNPs selected in our SNP panel in BCa susceptibility was confirmed by the following tools: Kyoto Encyclopedia of Genes and Genomes (KEGG) available on the website https://www.genome.jp/kegg/pathway.html [ 18 , 19 ], Panther classification system available on the website ( http://pantherdb.org/tools/gxIdsList.do?list=upload_1&organism=Homo%20sapiens )[ 20 ], STRING database available on the website https://string-db.org/ ,AmiGO2[ 21 ], Reactome Pathway Database[ 22 ] and GWAS [ 23 ].In addition, we constructed candidate pathways based on our defined panel consisting of 97 genes. The pathways were defined according to the STRING protein–protein interaction networks. A complete list of the studied variants was summarized in Table 2 . Pathways and protein-protein interaction, in which the studied genes were implicated, were presented and described in Fig. 2 . Table 2 A comprehensive list of all regions targeted by the Tunisian bladder cancer hereditary panel and Allelic Association (BCHP panel) CHR SNP GENES VARIATION Reference variant Mutated variant Major allele /Minor allele Major.allele.freq Allelic Association p-value.log-additive OR 95% CI 1 rs2020902 CASP9 splice_region_variant,intron_variant A G A/G 82,5 0,873 0,97 0.7–1.35 1 rs2647396 BCL10 intron_variant C T T/C 65,3 0,685 1,05 0.81–1.37 1 rs560018 GSTM4 intron_variant T C T/C 82,8 0,938 0,99 0.72–1.36 1 rs11101992 GSTM5 intron_variant,non_coding_transcript_variant A C A/C 65,9 0,596 1,07 0,83 − 1,39 1 rs4970774 GSTM5 intron_variant,non_coding_transcript_variant A C C/A 50,1 0,754 1,04 0,81 − 1,33 1 rs4970776 GSTM5 intron_variant,non_coding_transcript_variant T A T/A 53,3 0,87 1,02 0,8 − 1,3 1 rs1571858 GSTM3 intron_variant C T C/T 75,9 0,888 1,02 0,76 − 1,37 1 rs15864 EPS8L3 3_prime_UTR_variant G C G/C 81,6 0,947 0,99 0,71 − 1,37 1 rs3136701 CD2 downstream_gene_variant G C C/G 52,8 0,79 0,97 0,76 − 1,23 1 rs1889740 ARNT intron_variant C T C/T 57,8 0,207 1,17 0,92 − 1,5 1 rs2228099 ARNT synonymous_variant C G C/G 57,4 0,203 1,18 0,92 − 1,51 1 rs1027699 ARNT intron_variant T C T/C 64,8 0,937 1,01 0,78 − 1,3 1 rs2256355 ARNT intron_variant T C T/C 56,7 0,181 1,18 0,92 − 1,52 1 rs2864873 ARNT intron_variant A G A/G 64,1 0,78 1,04 0,8 − 1,34 1 rs763110 FASLG upstream_gene_variant C T T/C 58,6 0,998 1 0,78 − 1,28 1 rs228001 ASTN1 intron_variant,non_coding_transcript_variant C A C/A 96 0,937 1,03 0,54 − 1,96 1 rs1800890 IL10 upstream_gene_variant A T A/T 74,9 0,886 0,98 0,74 − 1,3 1 rs2854461 EPHX1 intron_variant C A C/A 73,8 0,223 1,19 0,9 − 1,57 1 rs1051740 EPHX1 missense_variant T C T/C 72,5 0,66 1,06 0,81 − 1,4 1 rs2260863 EPHX1 intron_variant G C C/G 64,9 0,89 1,02 0,8 − 1,3 1 rs1805410 PARP1 intron_variant T C T/C 82,7 0,432 0,88 0,65 − 1,2 2 rs391835 AC012593.1/CCR2 intron_variant,non_coding_transcript_variant G A A/G 53,5 0,93 0,99 0,77 − 1,26 2 rs1056836 CYP1B1/RMDN2 downstream_gene_variant G C C/G 56,1 0,618 1,06 0,84 − 1,34 2 rs162555 CYP1B1 upstream_gene_variant T C T/C 76,1 0,017 0,7 0,52 − 0,94 2 rs3771171 IL18R1 intron_variant T C T/C 80 0,165 0,8 0,59 − 1,1 2 rs11892031 UGT1A10 intron_variant A C A/C 90,6 0,213 0,77 0,51 − 1,17 3 rs2228000 XPC missense_variant G A G/A 81,5 0,024 0,69 0,5 − 0,96 3 rs1050450 RHOA downstream_gene_variant G A G/A 74,6 0,953 1,01 0,81 − 1,25 3 rs10936599 ACTRT3 upstream_gene_variant C T C/T 85,2 0,004 0,6 0,42 − 0,85 3 rs710459 MASP1 downstream_gene_variant G A G/A 71,6 0,968 0,99 0,76 − 1,29 3 rs710521 TP63 regulatory_region_variant T C T/C 76,7 0,035 0,73 0,54 − 0,98 4 rs798766 TACC3 intron_variant T C C/T 69,7 0,836 0,98 0,77 − 1,24 4 rs4073 IL8 upstream_gene_variant A T A/T 55,3 0,83 0,97 0,77 − 1,23 4 rs2227306 IL8 intron_variant C T C/T 68,5 0,428 0,9 0,7 − 1,16 4 rs3804099 TLR2 synonymous_variant T C T/C 53 0,259 0,87 0,68 − 1,11 4 rs3087455 CASP3 intron_variant T G T/G 65 0,4 0,9 0,69 − 1,16 5 rs34847072 AHRR 3_prime_UTR_variant G C G/C 82,9 0,106 0,77 0,56 − 1,06 5 rs401681 TERT/CLPTM1L intron_variant C T T/C 53,8 0,415 0,9 0,69 − 1,16 5 rs2070874 IL4 5_prime_UTR_variant C T C/T 80,9 0,455 1,13 0,82 − 1,55 6 rs4510656 CDKAL1 intron_variant C A C/A 61,9 0,103 0,81 0,63 − 1,04 6 rs451774 GPX5 3_prime_UTR_variant A G A/G 60,5 0,377 0,89 0,68 − 1,15 6 rs8193036 IL17A upstream_gene_variant C T T/C 74,3 0,9 0,98 0,76 − 1,27 6 rs2275913 IL17A upstream_gene_variant G A G/A 79,8 0,207 1,21 0,9 − 1,64 6 rs2180314 GSTA2 missense_variant C G G/C 54,9 0,398 0,9 0,7 − 1,15 6 rs2144698 GSTA2 intron_variant T G G/T 79,5 0,679 1,06 0,79 − 1,43 6 rs17614751 GSTA4 downstream_gene_variant G A G/A 95,4 0,029 2,14 1,14 − 3,99 6 rs367836 GSTA4 downstream_gene_variant G T T/G 59,7 0,764 1,04 0,81 − 1,32 6 rs150126 MAP3K7 intron_variant C T T/C 74,9 0,999 1 0,76 − 1,31 6 rs4880 SOD2 missense_variant A G A/G 53 0,406 1,11 0,87 − 1,4 7 rs1062492 SNX8 downstream_gene_variant C T C/T 79,8 0,234 0,83 0,62 − 1,13 7 rs2017000 EGFR intron_variant A G A/G 74,5 0,139 0,82 0,63 − 1,07 7 rs1140475 EGFR synonymous_variant T C C/T 92,3 0,59 1,12 0,73 − 1,73 7 rs2293347 EGFR synonymous_variant C T C/T 96 0,698 1,13 0,61 − 2,09 7 rs1045642 ABCB1 synonymous_variant A G G/A 69,1 0,12 1,24 0,95 − 1,62 7 rs1858923 ABCB1 intron_variant A G A/G 61,8 0,611 1,07 0,82 − 1,39 7 rs2740574 CYP3A4 upstream_gene_variant C T T/C 79,4 0,129 0,79 0,58 − 1,07 7 rs11773597 CYP3A4 upstream_gene_variant G C G/C 92,3 0,247 1,28 0,81 − 2,04 7 rs3752645 PRKAR2B intron_variant G A G/A 90,9 0,023 0,6 0,39 − 0,94 8 rs804276 NEIL2 upstream_gene_variant G A G/A 67,4 0,03 0,75 0,58 − 0,97 8 rs8191604 NEIL2 intron_variant T G T/G 69,3 0,409 1,11 0,86 − 1,44 8 rs1874546 NEIL2 intron_variant C G C/G 85,2 0,769 0,95 0,66 − 1,35 8 rs4639 NEIL2 3_prime_UTR_variant A G A/G 65,4 0,009 0,72 0,56 − 0,92 8 rs1961456 NAT2 intron_variant A G A/G 76,8 0,952 1,01 0,75 − 1,36 8 rs1799929 NAT2 synonymous_variant C T C/T 54,3 0,374 1,12 0,88 − 1,42 8 rs1799930 NAT2 missense_variant G A G/A 70,9 0,17 0,82 0,63 − 1,09 8 rs1799931 NAT2 missense_variant G A G/A 97,3 0,814 1,09 0,54 − 2,19 8 rs12674710 NAT2 downstream_gene_variant A C A/C 89,8 0,538 0,88 0,58 − 1,33 8 rs1495741 NAT2 regulatory_region_variant G A A/G 79,6 0,509 1,11 0,82 − 1,51 8 rs13278062 TNFRSF10A upstream_gene_variant G T G/T 55,7 0,633 0,94 0,74 − 1,2 8 rs1126452 EPHX2 synonymous_variant A C A/C 69,9 0,325 1,14 0,88 − 1,49 8 rs3136717 POLB intron_variant C T T/C 71,6 0,439 1,11 0,85 − 1,45 8 rs17226566 LY96 intron_variant T C T/C 84,3 0,611 0,92 0,66 − 1,27 8 rs9642880 CASC11 intron_variant,non_coding_transcript_variant G T T/G 50,3 0,405 1,11 0,87 − 1,43 8 rs2294008 PSCA 5_prime_UTR_variant C T T/C 54,4 0,426 0,9 0,7 − 1,16 10 rs1937845 AKR1C3 5_prime_UTR_variant A G G/A 52,8 0,886 0,98 0,77 − 1,25 10 rs3763676 AKR1C3 5_prime_UTR_variant A G A/G 72 0,289 1,16 0,88 − 1,52 10 rs12529 AKR1C3 missense_variant C G G/C 52,8 0,886 0,98 0,77 − 1,25 10 rs1937843 AKR1C3 intron_variant A G A/G 72 0,289 1,16 0,88 − 1,52 10 rs4881400 AKR1C3 intron_variant T G T/G 76,5 0,029 0,73 0,55 − 0,97 10 rs12775701 AKR1C3 intron_variant A G G/A 59,3 0,665 1,06 0,83 − 1,35 10 rs2475377 CYP2C9 intergenic_variant C T C/T 87,3 0,283 1,22 0,85 − 1,76 10 rs9332197 CYP2C9 intron_variant T C T/C 98,2 0,132 2,1 0,78 − 5,69 10 rs12357751 BLNK intron_variant C T C/T 73,5 0,66 1,06 0,81 − 1,41 10 rs3789928 BLNK intron_variant G C G/C 52,8 0,057 0,79 0,61 − 1,01 10 rs2031920 CYP2E1 upstream_gene_variant C T C/T 97,9 0,249 1,34 0,58 − 3,13 10 rs915908 CYP2E1 intron_variant G A G/A 84,5 0,869 1,03 0,73 − 1,46 11 rs7104333 VPS37C downstream_gene_variant G A G/A 52,5 0 1,58 1,24 − 2,02 11 rs625978 GSTP1 regulatory_region_variant C T C/T 61,5 0,73 0,96 0,74 − 1,23 11 rs1695 GSTP1 missense_variant A G A/G 62,5 0,376 0,89 0,69 − 1,15 12 rs3213427 CD4 3_prime_UTR_variant T C T/C 64,2 0,761 0,96 0,75 − 1,24 12 rs11046349 AICDA 3_prime_UTR_variant T G/A T/G 73,6 0,283 1,16 0,88 − 1,54 12 rs10878176 TBK1 intron_variant G C G/C 71,9 0,807 0,97 0,74 − 1,26 12 rs1866074 TDG intron_variant A G A/G 59,4 0,247 0,86 0,67 − 1,11 12 rs3890995 UNG upstream_gene_variant T C T/C 81,4 0,796 1,04 0,76 − 1,43 12 rs4765621 SCARB1 intron_variant C T C/T 51,6 0,155 0,83 0,65 − 1,07 13 rs1050112 PARP4 missense_variant G T G/T 50,6 0,164 0,85 0,68 − 1,07 13 rs13428 PARP4 missense_variant C G C/G 58,8 0,131 0,85 0,69 − 1,05 13 rs17655 ERCC5 missense_variant G C G/C 67,7 0,887 0,98 0,75 − 1,28 14 rs2228026 TEP1 synonymous_variant A G A/G 94,4 0,475 0,83 0,49 − 1,4 14 rs1130409 OSGEP upstream_gene_variant T G T/G 53,8 0,978 1 0,79 − 1,26 14 rs696 NFKBIA 3_prime_UTR_variant C T C/T 52,5 0,236 1,16 0,91 − 1,49 14 rs10133290 CHURC1 downstream_gene_variant A C A/C 72,7 0,797 0,96 0,74 − 1,27 14 rs7101 FOS 5_prime_UTR_variant C T T/C 81,8 0,698 0,94 0,69 − 1,29 14 rs861539 KLC1 intron_variant G A G/A 60,8 0,985 1 0,78 − 1,27 15 rs1048943 CYP1A1 missense_variant T C T/C 96,7 0,587 0,86 0,44 − 1,68 15 rs2472299 CYP1A1 intergenic_variant A G G/A 58,6 0,601 0,93 0,72 − 1,21 15 rs762551 CYP1A2 intron_variant C A A/C 57,6 0,901 0,98 0,76 − 1,27 15 rs976072 POLG downstream_gene_variant A G A/G 71,1 0,393 1,12 0,86 − 1,47 16 rs1013358 MPG intron_variant C T T/C 68,1 0,01 1,4 1,08 − 1,81 16 rs1799801 ERCC4 synonymous_variant T C T/C 67,7 0,044 1,31 1,01–1,71 16 rs17855750 APOBR/IL27 downstream_gene_variant A C A/C 96,1 0,021 2,37 1,18 − 4,74 16 rs153109 IL27 upstream_gene_variant T C T/C 75,6 0,632 1,07 0,81 − 1,4 16 rs1800566 NQO1 missense_variant G A G/A 73,8 0,507 1,1 0,83 − 1,46 16 rs689452 NQO1 intron_variant C G G/C 86,1 0,61 1,1 0,77 − 1,56 16 rs899729 IL17C upstream_gene_variant C A C/A 67,3 0,598 1,07 0,83 − 1,39 17 rs4791489 MAP2K4 downstream_gene_variant C T C/T 74,7 0,251 0,85 0,64 − 1,12 17 rs4796030 LIG3 3_prime_UTR_variant A C C/A 52,6 0,525 0,92 0,73 − 1,18 17 rs2333227 MPO upstream_gene_variant C T C/T 68,7 0,275 0,86 0,66 − 1,12 17 rs7209435 MAP3K3 intron_variant T C T/C 64,5 0,09 0,8 0,62 − 1,04 17 rs11655650 BIRC5 intron_variant C T C/T 56,9 0,485 1,09 0,85 − 1,39 18 rs288980 ROCK1 intron_variant T C C/T 71,4 0,03 0,75 0,57 − 0,97 18 rs10775480 SLC14A1 intron_variant T C C/T 61 0,363 1,13 0,87 − 1,46 18 rs10853535 SLC14A1 intron_variant C T T/C 61,3 0,479 1,1 0,85 − 1,43 18 rs723279 SOCS6 intron_variant G A G/A 69,1 0,963 1,01 0,77 − 1,31 19 rs3746162 SBNO2 intron_variant C T C/T 77,5 0,392 1,13 0,85 − 1,51 19 rs5498 ICAM5 upstream_gene_variant A G A/G 62,8 0,664 0,94 0,73 − 1,23 19 rs25487 XRCC1 missense_variant T C C/T 56,7 0,969 1 0,83 − 1,2 19 rs1799782 XRCC1 missense_variant G A G/A 94,3 0,765 0,93 0,56 − 1,53 19 rs13181 ERCC2 downstream_gene_variant T G T/G 65,9 0,092 0,8 0,62 − 1,04 20 rs7265992 GSS intron_variant G A G/A 90,4 0,148 0,74 0,49 − 1,12 20 rs6088662 GSS upstream_gene_variant T G T/G 69,9 0,091 0,8 0,61 − 1,04 20 rs7260770 GSS intergenic_variant G A G/A 88,6 0,046 1,48 1–2,19 21 rs2173962 AP000253.1 downstream_gene_variant T C T/C 96,6 0,943 1,03 0,51 − 2,06 21 rs2839488 TFF1 intron_variant G C G/C 50,4 0,904 1,02 0,8 − 1,29 22 rs4633 COMT synonymous_variant,NMD_transcript_variant C T C/T 57,9 0,152 0,84 0,65 − 1,07 22 rs4680 COMT missense_variant,NMD_transcript_variant G A G/A 58 0,081 0,8 0,63 − 1,03 22 rs1006771 DDTL 3_prime_UTR_variant G T T/G 74,3 0,177 1,22 0,91 − 1,64 22 rs1014971 GSTT2 regulatory_region_variant C T T/C 69,1 0,526 0,92 0,7 − 1,2 22 rs5751222 CYP2D6 downstream_gene_variant T A T/A 87,7 0,823 0,96 0,68 − 1,36 Chr: Chromosome; SNP: Single Nucleotide Polymorphism ; P: P value for Fisher Test; OR: Odds ratio; 95% CI: Confidence Interval Snp Genotyping SNP genotyping was performed by NGS on the Ion Torrent Proton sequencer (Life Technologies, Ion Torrent technology). The GeneRead DNAseq Panel PCR Kit V2 (Qiagen) was used for the amplification of the targeted SNPs. The Gene Readprimers provided in different three pools. The samples were all re-quantified by Picogreen (using Fluoroscan) and normalized to 5ng/ul and 20 ng of each sample was plated into 3 daughter plates for the analysis of each group of primers. A validated in-house protocol was used to perform multiplex PCRs in 10 µL reaction volumes, containing 20 ng DNA, 60 nM of each primer pool and 0.73 µL of HotStarTaq enzyme. Amplification was carried out in a 96-well format plates using the standard conditions recommended by Qiagen: 15 min at 95°C and 22 cycles of 15 s at 95°C and 4 min at 60°C and 10 min at 72°C. Amplification products from the same sample were pooled purified using paramagnetic Serapure beads at 1.8X and quantified with the Qubit DNA high-sensitivity assay kit (Invitrogen Corporation). Barcoded libraries were prepared from 10ul of purified products and as previously described [ 24 ]. For template preparation, the barcoded libraries were pooled in equimolar concentrations and 7 µL of 100 pM was subsequently used for emulsion PCR (emPCR) using the Ion Torrent Template Ion PI Hi-Q OT2 200 kit on the Ion OneTouch2 Instrument (Thermo Fisher Scientific). The sequencing reaction was performed on an Ion Proton System using Life Technologies' Ion PI™ Chip Kit v3 and Ion PI™ Hi-Q™ Sequencing 200 Kit (Thermoscience Fisher Scientific) ( Fig. 3 ). Bioinformatics Analyses Primary analyses were done using the Torrent_Suite 5.6.0 and included signal processing, base calling, reads alignment to the human genome reference 19 (Genome Reference Consortium GRCh37), quality control of mapping and coverage analysis, and variant calling. Subsequently, a list of detected sequence variants, including SNPs and small insertions/deletions, was imported into (Thermo Fisher Scientific) for annotation. The GeneRead data analysis workflow runs the GATK Variant Annotator program using the TVC output to populate the INFO field in the VCF file with the parameters necessary for downstream filtering. The INFO field of the GATK Unified Genotyper output already contains all the necessary parameters. Alignments were visually verified with the Integrative Genomics Viewer (IGV) v2.3. A combination of SnpEff v4.3, SnpSift v4.3 were used for annotation and filtration, and PLINK and in-house algorithms (R packages …) were used for analysis. QC filtered variants were then merged, annotated, and filtered using various databases including, ClinVar ( http://www.ncbi.nlm.nih.gov/clinvar/ ), HGMD ( http://www.hgmd.cf.ac.uk/ac/index.php ), and dbSNP ( https://www.ncbi.nlm.nih.gov/snp/ ). Results All assays were performed using DNA samples from a total of 544 cases and controls and duplicated samples for quality control. Only 40 samples (40/544; 7.35%) failed the library preparation and were excluded from the analysis. In this series, two runs led to 75% and 88% ISP loading and to the generation of total bases of 4.33 and 11.4 Gigabases for total bases of 33, 329, 31 and 84,548,378 respectively, 99% of which aligned to the reference genome (Hg19) ( Fig. 4 ). This analysis provided high analytical sensitivity and allowed detecting SNPs. Using this approach, we have generated molecular profiles of a large number of individuals and identified specific BCa variations. Among the 139 retained SNP (Table 2 ) nine minor alleles were significantly inversely associated with bladder cancer development [ rs162555 (CYP1B1*C), rs2228000 (XPC*A), rs10936599 (ACTRT3*T), rs710521 (TP63*C), rs3752645 (PRKAR2B*A), rs804276 and rs4639 (NEIL2*A and NEIL2*G), rs4881400 (AKR1C3*G) and rs288980 (ROCK1*T)]. When we used the co-dominant model (the reference group is composed of subjects with homozygous genotype for major allele) we also found a statistically significant inverse association for heterozygous genotypes of ACTRT3 (rs10936599), TP63 (rs710521), CYP3A4 ( rs2740574) , BLNK ( rs3789928) and COMT ( rs4680) (OR1 = 0.51, 0.62, 0.61, 0.55, and 0.66 respectively) or homozygous genotypes of CYP1B1 (rs162555), XPC ( rs2228000) , NEIL2 ( rs4639) , NAT2 ( rs1799930) , AKR1C3 ( rs4881400) and ROCK1 ( rs288980) (OR2 = 0.36, 0.12, 0.49, 0.38, 0.4 and 0.42 respectively) ( Table 3 ). However six minor alleles in six genes were significantly associated with increased risk of bladder cancer development: MPG (rs1013358 T > C) , GSTA4 ( rs17614751 G > A) ; GSS (rs7260770 G > A); VPS37C/ CD5 (rs7104333 G > A) ; APOBR / IL27 (rs17855750 A > C) ; and ERCC4 (rs1799801 T > C) . These aggravating effects were attributed to homozygous genotypes for VPS37C ( rs7104333 , A/A) or MPG ( rs1013358 , C/C) genes ( OR2 = 2.53 and 2.34 respectively) or to the heterozygous genotype for ARNT gene (rs1889740, rs2228099, rs2256355, rs2864873), GSTA4 (rs17614751) and APOBR/IL27 (rs17855750) with OR1 respectively estimated at 1.99, 2.00, 2.00, 1.47, 1.96 and 2.27 compared to reference group. When comparing the distribution of these unfavorable genotypes according to exposition to environmental risk factors ( Tables 4 and 5 ), we have found that non–smokers patients harboring heterozygous genotypes for ARNT/rs2864873 A > G, ARNT/ rs1889740 (C > T) or GSTA4/rs17614751 (G to A) were respectively at 2.775, 3.069 and 6.608 –folds increased risk of Bca development compared to non-smokers controls with wild genotypes. When we analyzed genotypic distribution in heavy smokers (BCa and Controls smoking more than 20PY) we found that smoker’s patients harboring ARNT CT (rs1889740), ARNT CG (rs2228099), ARNT TC (rs2864873) or ROCK1 TC genotypes were respectively associated with 2.690, 2.864, 2.779 and 3.00 fold-increased risk of BCa. In the other hand we have found that ARNT CT (rs1889740), ARNT CG (rs2228099), ARNT TC (rs2864873) and GSS GA genotypes were associated with an increased risk of BCa even in absence of professional risk factors (comparison of Non-exposed patients to Non-exposed controls). However when we compare genotypic distribution of unfavorable genotypes in exposed patients and controls according to professional risk factor, we observed that ARNT TT (rs1889740), ARNT GG (rs2228099), ARNT CC (rs2864873), ROCK1 CC/CT genotypes were respectively associated with 12.000, 12.666, 12.666, 3.976, 3.960 fold-increased risk of BCa development. Table 3 Comparison of genotypic distribution between case and control groups Dominant model (DM) Recessive model (RM) Co-dominant model (CM) Gene SNP Raisonnement/ Alleles MjAF p-value OR (95% CI) p-value OR (95% CI) p-value ¥ OR CD1 (95% CI)*1 OR CD2 (95% CI)*2 ARNT rs1889740 T C > T C 0,00 1,7 1,17 2,48 0,26 0,77 0,49 1,21 0,00 1,99 1,34 2,96 1,15 0,69 1,91 ARNT rs2228099 G C > G C 0,00 1,72 1,18 2,5 0,26 0,77 0,49 1,21 0,00 2 1,34 2,98 1,16 0,69 1,94 ARNT rs2256355 C T > C T 0,00 1,73 1,19 2,53 0,31 0,8 0,51 1,24 0,00 2 1,34 2,99 1,2 0,72 2 ARNT rs2864873 G A > G A 0,16 1,29 0,9 1,84 0,14 0,68 0,41 1,14 0,05 1,47 1,01 2,14 0,83 0,48 1,45 CYP1B1 rs162555 C T > C T 0,06 0,72 0,5 1,02 0,02 0,39 0,17 0,9 0,03 0,79 0,55 1,14 0,36 0,15 0,83 XPC rs2228000 A G > A G 0,19 0,78 0,54 1,13 0,00 0,12 0,03 0,53 0,00 0,92 0,62 1,35 0,12 0,03 0,52 ACTRT3 rs10936599 T C > T C 0,00 0,52 0,35 0,79 0,62 0,76 0,26 2,23 0,01 0,51 0,34 0,78 0,65 0,22 1,9 TP63 rs710521 C T > C T 0,01 0,64 0,44 0,91 0,89 0,95 0,44 2,06 0,04 0,62 0,42 0,89 0,79 0,36 1,74 GSTA4 rs17614751 A G > A G 0,02 2,11 1,1 4,04 0,24 NA 0 NA 0,03 1,96 1,02 3,79 NA 0 NA CYP3A4 rs2740574 C C > T T/C 0,03 0,67 0,46 0,96 0,35 1,51 0,63 3,59 0,02 0,61 0,42 0,89 1,27 0,53 3,06 NEIL2 rs804276 A G > A G 0,03 0,67 0,47 0,96 0,25 0,73 0,42 1,26 0,08 0,69 0,48 1 0,61 0,34 1,08 NEIL2 rs4639 G A > G A 0,03 0,68 0,48 0,97 0,03 0,56 0,33 0,94 0,03 0,76 0,52 1,11 0,49 0,28 0,85 NAT2 rs1799930 A G > A G 0,86 0,97 0,68 1,37 0,00 0,36 0,18 0,74 0,01 1,14 0,79 1,64 0,38 0,18 0,8 AKR1C3 rs4881400 G T > G T 0,11 0,75 0,52 1,07 0,02 0,42 0,2 0,91 0,05 0,84 0,58 1,22 0,4 0,18 0,86 BLNK rs3789928 C G > C G 0,01 0,58 0,39 0,86 0,78 0,94 0,62 1,43 0,02 0,55 0,36 0,84 0,64 0,39 1,06 VPS37C rs7104333 A G > A G 0,01 1,73 1,17 2,55 0,00 2,03 1,34 3,09 0,00 1,42 0,94 2,16 2,53 1,54 4,13 MPG rs1013358 C C > T T/C 0,09 1,36 0,95 1,92 0,00 2,2 1,26 3,84 0,01 1,15 0,79 1,68 2,34 1,31 4,19 ERCC4 rs1799801 C T > C T 0,15 1,3 0,91 1,84 0,05 1,8 1 3,22 0,09 1,18 0,81 1,71 1,95 1,05 3,59 APOBR rs17855750 C A > C A 0,01 2,36 1,16 4,79 0,49 NA 0 NA 0,02 2,27 1,11 4,63 NA 0 NA ROCK1 rs288980 T T > C C /T 0,21 0,8 0,56 1,13 0,01 0,43 0,23 0,8 0,02 0,94 0,65 1,37 0,42 0,22 0,8 GSS rs7260770 A G > A G 0,03 1,62 1,05 2,5 0,97 1,02 0,25 4,14 0,08 1,67 1,07 2,62 1,13 0,28 4,6 COMT rs4633 T C > T C 0,03 0,67 0,46 0,96 0,99 1 0,64 1,57 0,07 0,63 0,42 0,93 0,77 0,47 1,27 COMT rs4680 A G > A G 0,01 0,63 0,44 0,92 0,83 0,95 0,61 1,49 0,04 0,6 0,41 0,89 0,71 0,43 1,18 P: P value; OR: Odds ratio; 95% CI: Confidence Interval, OR CD1 : Heterozygous genotype VS Homozygous Wild genotype; OR CD2 : Mutant homozygous genotype VS Homozygous wild genotype; p-value ¥: P value for co-dominant model Table 4 Comparison of genotypes distribution of significant unfavorable SNP from “Tunisian BCHP” panel in bladder cancer patients according to tobacco status Genotypes Controls Bladder cancer Bladder cancer (NE) Vs Controls (NE) Bladder cancer (E) Vs Controls (E) Bladder cancer (E) Vs Controls (NE) BC ≥ 20PY VS Controls ≥ 20PY BC ≥ 20PY VS Controls NE Gene/Variant NE < 20PY ≥ 20PY E NE T CC 44 24 34 58 5 8 50 58 , 1* , 1* , 1* , 1* , 1* CT 43 35 23 58 15 19 91 110 0.044 3.069 (1.026–9.184) 0.009 1.896(1.169–3.075) 0.013 1.940(1.145–3.287) 0.002 2.690(1.430–5.060) 0.025 1.862(1.081–3.207) TT 30 11 11 22 7 4 27 31 0.254 2.053(0.595–7.080) 0.305 1.409(0.730–2.716) 0.453 0.783(0.414–1.481) 0.223 1.669(0.731–3.810) 0.488 0.792(0.409–1.531) ARNT rs2228099 C > G CC 43 23 34 57 5 8 48 56 , 1* , 1* , 1* , 1* , 1* CG 44 36 23 59 15 19 93 112 0.054 2.931(0.979–8.771) 0.007 1.932(1.189–3.138) 0.013 1.954(1.151–3.316) 0.001 2.864( 1.520–5.396) 0.021 1.893(1.096–3.268) GG 30 11 11 22 7 4 27 31 0.270 2.006(0.581–6.925) 0.283 1.434(0.741–2.772) 0.478 0.793(0.418–1.505) 0.190 1.738(0.760–3.976) 0.524 0.806( 0.415–1.564) ARNT rs2256355 T > C TT 30 22 33 55 5 8 46 54 , 1* , 1* , 1* , 1* , 1* TC 44 36 24 60 15 19 93 112 0.207 2.045(0.671–6.228) 0.010 1.901(1.165-3.100) 0.230 1.414(0.802–2.491) 0.001 2.779(1.475–5.237) 0.280 1.378( 0.769–2.470) CC 43 12 11 23 7 4 29 33 0.970 0.976(0.283–3.371) 0.253 1.461(0.761–2.803) 0.008 0.426(0.225–0.805) 0.130 1.891(0.828–4.318) 0.014 0.439(0.227–0.849) ARNT rs2864873 A > G AA 51 26 37 63 7 10 71 81 , 1* , 1* , 1* , 1* , 1* AG 42 36 23 59 16 17 79 96 0.040 2.775(1.044–7.377) 0.317 1.265(0.797–2.008) 0.157 1.439(0.869–2.382) 0.061 1.790(0.971–3.298) 0.255 1.351(0.803–2.270) GG 24 8 8 16 4 4 18 22 0.773 1.214(0.324–4.549) 0.855 1.069(0.5189 to 2.204) 0.111 0.577(0.293–1.135) 0.735 1.172(0.466–2.950) 0.087 0.538(0.265–1.094) CYP1B1 rs162555 (T to C) TT 63 38 36 74 18 16 106 122 , 1* , 1* , 1* , 1* , 1* TC 47 24 27 51 7 12 60 72 0.179 0.521 (50.201–1.349) 0.509 0.856 ( 0.540–1.357) 0.335 0.791 (0.491–1.274) 0.350 0.754 (0.417–1.362) 0.272 0.758 (0.4635 to 1.242) CC 7 8 5 13 2 3 2 5 1.000 1,000 (0.190–5.240) 0.007 0.233 (0.079–0.680) 0.099 0.368 ( 0.112–1.209) 0.020 0.135 (0.025–0.731) 0.030 0.169 (0.0342 to 0.842) XPC rs2228000 (G to A) GG 72 43 42 85 22 20 114 134 , 1* , 1* , 1* , 1* GA 37 19 20 39 5 11 52 63 0.127 0.442 (0.154–1.262) 0.921 1.024 ( 0.632–1.661) 0.725 0.914 (0.5567 to 1.503) 0.892 0.957 ( 0.5125 to 1.790) 0.649 0.887 (0.5306 to 1.484) AA 2 8 6 14 0 0 2 2 0.779 0.644 (0.029–13.924) 0.001 0.090 (0.020–0.408) 0.538 0.537 ( 0.074–3.894) 0.012 0.122 (0.023–0.632) 0.649 0.631 (0.0870 to 4.583) TP63, P3H2 rs710521 T/C TT 55 46 35 81 16 23 107 130 , 1* , 1* , 1* , 1* TC 56 21 28 49 9 7 53 60 0.195 0.552 (0.225–1.355) 0.257 0.763 (0.477–1.218) 0.001 0.453 (0.280–0.733) 0.115 0.619 (0.341–1.123) 0.004 0.486 (0.2960 to 0.799) CC 6 3 5 8 2 1 8 9 0.874 1.145 (0.210–6.237) 0.482 0.701 (0.259–1.890) 0.409 0.634 (0.215–1.868) 0.282 0.523 (0.160–1.704) 0.503 0.685 (0.2265 to 2.074) ACTRT3/MYNN rs10936599 (C to T) CC 76 51 44 95 18 24 135 159 , 1* , 1* , 1* , 1* CT 39 18 19 37 9 5 29 34 0.9543 0.974 (0.400-2.369) 0.026 0.549 ( 0.323–0.933) 0.001 0.416 ( 0.244–0.711) 0.041 0.497 (0.254–0.973) 0.002 0.418 (0.2399 to 0.730) TT 2 1 5 6 0 2 4 6 0.903 0.827 (0.038–17.969) 0.384 0.597 (0.187–1.905) 0.663 1.434 (0.282–7.271) 0.052 0.260 (0.067–1.014) 0.892 1.125 (0.2015 to 6.291) GSTA4 rs17614751(G to A) GG 114 63 63 126 23 31 168 199 , 1* , 1* , 1* , 1* GA 3 7 5 12 4 1 17 18 0.017 6.608 (1.385–31.530) 0.894 0.949 (0.442–2.038) 0.051 3.437 ( 0.990-11.922) 0.646 1.275 (0.451–3.601) 0.034 3.845 (1.1014 to 13.424) AA 0 0 0 0 0 0 2 2 0.431 4.872 (0.094-251.797) 0.457 3.170 ( 0.151–66.582) 0.497 2.869 (0.136–60.298) 0.683 1.884 ( 0.089–9.791) 0.431 3.397 (0.1616 to 71.433) CYP3A4 rs2740574 C > T CC 5 3 1 4 3 3 5 8 , 1* , 1* , 1* , 1* , 1* CT 46 23 28 51 2 8 50 58 0.010 0.072(0.009–0.542) 0.379 0.568(0.161-2.000) 0.693 0.788(0.241-.571) 0.358 0.357(0.039–3.211) 0.900 1.087(0.295–3.999) TT 66 44 39 83 22 20 113 133 0.445 0.555(0.122–2.516) 0.724 0.801(0.233–2.744) 0.695 1.259(0.396-4.000) 0.623 0.579(0.065–5.114) 0.408 1.712(0.477–6.134) PRKAR2B rs3752645 (G to A) GG 88 57 58 115 22 25 149 174 , 1* , 1* , 1* , 1* GA 26 10 10 20 5 6 19 25 0.629 0.769 ( 0.265–2.231) 0.554 0.826 ( 0.438–1.556) 0.019 0.486 ( 0.265–0.891) 0.472 0.739 (0.324–1.685) 0.011 0.431 (0.2259 to 0.824) AA 2 3 0 3 0 0 0 0 0.878 0.786 (0.036–16.971) 0.119 0.094 (0.004–1.847) 0.141 0.101 ( 0.004–2.135) 0.640 0.391 (0.007–19.952) 0.170 0.118 (0.0056 to 2.494) NEIL2 rs804276 G/A GG 39 37 30 67 18 17 82 99 , 1* , 1* , 1* , 1* , 1* GA 59 25 31 56 7 12 67 79 0.005 0.257 (0.098–0.672) 0.844 0.954 ( 0.601–1.515) 0.012 0.527 ( 0.319–0.870) 0.440 0.790 (0.435–1.436) 0.019 0.540( 0.321–0.906) AA 19 8 7 15 2 2 19 21 0.063 0.228 ( 0.047–1.085) 0.885 0.947 (0.455–1.969) 0.024 0.435 ( 0.211–0.897) 0.988 0.993 (0.379–2.599) 0.049 0.475( 0.226–0.998) NEIL2 rs4639 A/G AA 37 36 29 65 16 15 82 97 , 1* , 1* , 1* , 1* , 1* AG 58 23 28 51 8 13 68 81 0.017 0.319 (0.124–0.819) 0.795 1.064 (0.664–1.703) 0.014 0.532 ( 0.320–0.884) 0.625 0.858 (0.4663 to 1.581) 0.017 0.529(0.313–0.892) GG 22 11 11 22 3 3 18 21 0.091 0.315 (0.082–1.205) 0.194 0.639 ( 0.325–1.256) 0.005 0.364 (0.179–0.739) 0.213 0.578 (0.244–1.369) 0.007 0.369(0.177–0.769) NAT2 rs1799930 G > A GG 56 38 32 70 11 19 83 102 , 1* , 1* , 1* , 1* , 1* GA 46 26 28 54 14 10 78 88 0.329 1.549(0.642–3.738) 0.630 1.118(0.709–1.763) 0.842 1.050(0.647–1.702) 0.813 1.074( 0.593–1.945) 0.596 1.144(0.695–1.881) AA 15 6 8 14 2 2 7 9 0.637 0.678(0.135–3.398) 0.071 0.441(0.181–1.075) 0.014 0.329(0.135-0.800) 0.051 0.337(0.113–1.006) 0.018 0.314(0.120–0.821) AKR1C3 rs4881400 T > G TT 63 37 43 80 18 22 101 123 , 1* , 1* , 1* , 1* , 1* TG 41 28 20 48 7 9 61 70 0.291 0.597(0.229–1.556) 0.822 0.948(0.597–1.506) 0.592 0.874(0.535–1.428) 0.407 1.298(0.699–2.410) 0.772 0.928(0.559–1.538) GG 13 5 5 10 2 0 6 6 0.442 0.538(0.111–2.609) 0.079 0.390(0.136–1.115) 0.005 0.236(0.085–0.651) 0.288 0.510(0.147–1.764) 0.016 0.287(0.104–0.796) BLNK rs3789928 G/C GG 24 18 16 34 8 11 55 66 , 1* , 1* , 1* , 1* , 1* GC 59 37 42 79 17 13 70 83 0.767 0.864 (0.329–2.269) 0.019 0.541 (0.323–0.906) 0.022 0.511(0.288–0.908) 0.035 0.484 (0.246–0.952) 0.029 0.517(0.286–0.935) CC 36 15 10 25 2 7 43 50 0.031 0.166 (0.032–0.853) 0.926 1.030 ( 0.546–1.941) 0.034 0.505 ( 0.267–0.952) 0.620 1.250 ( 0.516–3.031) 0.050 0.521(0.271–1.001) VPS37C/CD5 rs7104333 G > A GG 18 14 14 28 10 11 53 64 , 1* , 1* , 1* , 1* , 1* GA 53 32 35 67 11 14 76 90 0.055 0.373(0.136–1.025) 0.056 0.587(0.340–1.013) 0.020 0.477(0.256–0.890) 0.126 0.573(0.281–1.169) 0.027 0.487(0.256–0.923) AA 46 24 19 43 6 6 49 45 0.013 0.234(0.074–0.741) 0.012 0.457(0.248–0.842) 0.000 0.275(0.141–0.535) 0.342 0.681(0.308–1.504) 0.002 0.361(0.185–0.706) MPG rs1013358 C/T CC 10 5 6 11 5 4 25 29 , 1* , 1* , 1* , 1* , 1* CT 39 34 29 62 8 13 68 81 0.184 0.410(0.110–1.529) 0.073 0.495(0.229–1.069) 0.421 0.716(0.317–1.616) 0.255 0.562(0.208–1.5167) 0.396 0.697(0.303–1.603) TT 68 31 34 65 14 14 75 89 0.153 0.411(0.121–1.391) 0.092 0.519(0.241–1.115) 0.047 0.451(0.205–0.989) 0.202 0.529(0.198–1.409) 0.045 0.441(0.197–0.985) ERCC4 rs1799801 T/C TT 58 33 34 67 10 15 70 85 , 1* , 1* , 1* , 1* TC 52 29 29 58 13 16 71 87 0.421 1.450 (0.586–3.585) 0.4768 1.182 (0.745–1.875) 0.587 1.141 ( 0.707–1.843) 0.568 1.189 (0.655–2.156) 0.628 1.131 (0.6868 to 1.863) CC 7 8 5 13 4 0 27 27 0.093 3.314 (0.817–13.438) 0.188 1.637 ( 0.784–3.414) 0.034 2.631 (1.074–6.446) 0.068 2.622 (0.928–7.409) 0.011 3.195 (1.2978 to 7.870) APOBR rs17855750 A/C AA 111 67 65 132 26 27 151 178 , 1* , 1* , 1* , 1* AC 6 3 3 6 1 4 16 20 0.757 0.711(0.082–6.167) 0.059 2.471 ( 0.965–6.326) 0.128 2.078 ( 0.809–5.335) 0.198 2.295 (0.646–8.150) 0.173 1.960 (0.7433 to 5.169) CC 0 0 0 0 0 0 1 1 0.475 4.207 ( 0.081-216.956) 0.624 2.226 ( 0.090–55.100) 0.701 1.873 (0.075–46.406) 0.874 1.297 (0.052–32.260) 0.628 2.207 (0.0891 to 54.710) ROCK1 rs288980 T/C TT 13 8 14 22 0 1 14 15 , 1* , 1* , 1* , 1* , 1* TC 42 28 22 50 12 10 66 76 0.160 7.941(0.440-143.219) 0.035 2.229(1.056–4.705) 0.289 1.568(0.681–3.606) 0.014 3.00(1.239–7.26) 0.382 1.459(0.624–3.408) CC 62 34 32 66 15 20 88 108 0.195 6.696(0.377-118.925) 0.017 2.400(1.163–4.951) 0.316 1.509(0.674–3.379) 0.018 2.750(1.182–6.396) 0.510 1.318( 0.579-.998) GSS rs7260770 G/A GG 94 61 56 117 17 24 129 153 , 1* , 1* , 1* , 1* , 1* GA 20 9 11 20 9 7 36 43 0.057 2.488 (0.970–6.377) 0.094 1.644 (0.918–2.943) 0.354 1.320 (0.732–2.381) 0.355 1.420 (0.674–2.991) 0.381 1.311 (0.7142 to 2.408) AA 3 0 1 1 1 0 3 3 0.605 1.843 (0.180-18.781) 0.474 2.294 ( 0.235–22.338) 0.555 0.614 ( 0.121–3.107) 0.820 1.302 (0.132–12.794) 0.702 0.728 (0.1439 to 3.690) COMT rs4633 C > T CC 38 19 19 38 8 9 75 84 , 1* , 1* , 1* , 1* , 1* CT 60 35 35 70 14 15 62 77 0.833 1.108(0.424–2.891) 0.006 0.497(0.301–0.821) 0.036 0.580(0.348-.967) 0.016 0.448(0.233–0.861) 0.016 0.523(0.308–0.887) TT 18 16 14 30 5 7 31 38 0.663 1.319(0.377–4.606) 0.075 0.573(0.310–1.057) 0.894 0.955(0.484–1.883) 0.160 0.561(0.250–1.257) 0.702 0.872(0.433–1.756) COMT rs4680 G > A GG 38 20 18 38 9 10 75 85 , 1* , 1* , 1* , 1* , 1* GA 62 33 35 68 14 13 63 76 0.919 0.953(0.376–2.415) 0.006 0.499(0.302–0.826) 0.020 0.548(0.329–0.911) 0.012 0.432(0.223–0.835) 0.013 0.514(0.304–0.870) AA 17 17 15 32 4 8 30 38 0.992 0.993(0.268–3.679) 0.040 0.530(0.289–0.973) 0.998 0.999(0.502–1.988) 0.074 0.480(0.214–1.074) 0.757 0.894(0.438–1.821) P: P value; OR: Odds ratio; 95% CI: Confidence Interval; NE: Non Smoker; E: Smoker Table 5 Comparison of genotypes distribution of significant unfavorable SNP from “Tunisian BCHP” panel in bladder cancer patients according to professional risk factors Controls Bladder cancer Bladder cancer (NE) Vs Controls (NE) Bladder cancer (E) Vs Controls (E) Bladder cancer (E) Vs Controls (NE) Gene/Variant Genotypes Non Exposed (NE) Exposed Non Exposed (NE) Exposed p OR (95% CI) p OR (95% CI) p OR (95% CI) (E) (E) ARNT rs1889740 C > T CC 90 12 36 19 - 1* - 1* - 1* CT 84 17 65 45 0.010 1.934(1.168–3.203) 0.269 1.671(0.670–4.166) 0.002 2.537(1.374–4.685) TT 51 1 18 19 0.710 0.882(0.455–1.710) 0.022 12.000(1.416-101.672) 0.123 1.764( 0.856–3.635) ARNT rs2228099 C > G CC 88 12 35 18 - 1* - 1* - 1* CG 86 17 66 46 0.010 1.929(1.163–3.201) 0.207 1.803(0.720–4.518) 0.002 2.615(1.405–4.864) GG 51 1 18 19 0.724 0.887(0.456–1.725) 0.020 12.666(1.491-107.602) 0.108 1.821(0.876–3.783) ARNT rs2256355 T > C TT 86 12 34 18 - 1* - 1* - 1* TC 87 17 65 46 0.014 1.889(1.133–3.149) 0.207 1.803(0.720–4.518) 0.003 2.526(1.357–4.701) CC 52 1 20 19 0.933 0.972(0.507–1.865) 0.020 12.666(1.491-107.602) 0.135 1.745(0.840–3.625) ARNT rs2864873 A > G AA 101 13 43 33 - 1* - 1* - 1* AG 85 16 62 39 0.029 1.713(1.055–2.780) 0.926 0.960(0.403–2.283) 0.222 1.404(0.813–2.424) GG 39 1 14 11 0.636 0.843(0.415–1.710) 0.180 4.333(0.507–37.030) 0.710 0.863(0.397–1.875) CYP1B1 rs162555 (T to C) TT 120 17 72 58 - 1* - 1* - 1* TC 89 9 42 25 0.315 0.786 (0.4920-.257) 0.666 0.814 (0.3199–2.072) 0.050 0.581 (0.337-1.000) CC 16 4 5 0 0.221 0.183–1.482 0.024 0.033 (0.0017–0.648) 0.054 0.062 (0.003–1.058) XPC rs2228000 (G to A) GG 146 17 79 58 - 1* - 1* - 1* GA 68 8 39 25 0.811 1.059 (0.6562–1.712) 0.858 0.915 (0.349–2.397) 0.782 0.925 (0.533–1.604) AA 11 5 1 0 0.090 0.168 (0.021–1.325 0.016 0.027 (0.001–0.516) 0.126 0.108 (0.0063–1.877) TP63, P3H2 rs710521 T/C TT 124 12 78 53 , 1* , 1* - 1* TC 89 16 36 26 0.071 0.643 (0.3980–1.038) 0.026 0.367 (0.152–0.890) 0.169 0.683 (0.397–1.175) CC 12 2 5 4 0.455 0.662 (0.2247–1.952) 0.390 0.452 (0.074–2.765) 0.678 0.779 ( 0.2405–2.529) ACTRT3/MYNN rs10936599 (C to T) CC 150 21 95 65 , 1* , 1* - 1* CT 70 6 21 16 0.007 0.473 (0.2730–0.822) 0.782 0.861 (0.298–2.485) 0.041 0.527 ( 0.284–0.976) TT 5 3 3 2 0.941 0.947 ( 0.2213–4.056) 0.104 0.215 (0.033–1.377) 0.925 0.923 (0.174–4.881) GSTA4 rs17614751(G to A) GG 213 27 107 77 , 1* , 1* - 1* GA 12 3 11 6 0.165 1.824 (0.779–4.271) 0.632 0.701 (0.163-3.000) 0.530 1.383 (0.501–3.813) AA 0 0 1 0 0.275 5.958 (0.240-147.496) 0.606 0.354 (0.006–18.319) 0.613 2.754 (0.054-140.045) CYP3A4 rs2740574 C > T CC 8 1 5 3 - 1* - 1* - 1* CT 85 12 29 21 0.320 0.545(0.165–1.802) 0.656 0.583(0.054–6.251) 0.561 0.658(0.160–2.699) TT 132 17 85 59 0.959 1.030(0.326–3.254) 0.902 1.156(0.112–11.850) 0.800 1.191(0.305–4.653) PRKAR2B rs3752645 (G to A) GG 178 25 101 75 , 1* , 1* - 1* GA 43 4 18 8 0.322 0.737 (0.4041–1.346) 0.535 0.666 (0.184–2.404) 0.045 0.441 (0.198–0.984) AA 4 1 0 0 0.275 0.195 (0.010–3.666) 0.185 0.112 (0.004–2.851) 0.371 0.262 (0.014–4.940) NEIL2 rs804276 G/A GG 93 13 64 39 , 1* , 1* - 1* GA 100 15 45 37 0.079 0.653 (0.406–1.050) 0.658 0.822 (0.345–1.959) 0.644 0.882 (0.518-1.500) AA 32 2 10 7 0.046 0.454 (0.208–0.988) 0.858 1.166 (0.214–6.336) 0.156 0.521 (0.212–1.282) NEIL2 rs4639 A/G AA 90 12 60 42 , 1* , 1* - 1* AG 94 15 48 34 0.273 0.766 ( 0.475–1.234) 0.335 0.647 (0.267–1.566) 0.352 0.775 (0.453–1.325) GG 41 3 11 7 0.016 0.402 (0.191–0.844) 0.595 0.666 (0.149–2.978) 0.025 0.365 ( 0.151–0.883) NAT2 rs1799930 G > A GG 111 15 56 42 - 1* - 1* - 1* GA 89 11 57 39 0.311 1.269(0.799–2.015) 0.603 1.2662( 0.519–3.089) 0.578 1.158(0.690–1.943) AA 25 4 6 2 0.124 0.475(0.184–1.226) 0.060 0.178(0.029–1.076) 0.040 0.211(0.048–0.932) AKR1C3 rs4881400 T > G TT 121 22 68 58 - 1* - 1* - 1* TG 85 4 45 23 0.802 0.942(0.590–1.503) 0.191 2.181( 0.677–7.025) 0.044 0.564(0.323–0.985) GG 19 4 6 2 0.241 0.561(0.214–1.474) 0.065 0.189(0.032–1.110) 0.046 0.219(0.049–0.974) BLNK rs3789928 G/C GG 50 8 39 30 , 1* , 1* - 1* GC 119 19 56 32 0.059 0.603 (0.356–1.020) 0.103 0.449 (0.171–1.178) 0.008 0.448 (0.246–0.814) CC 56 3 24 21 0.064 0.549 (0.291–1.037) 0.395 1.866 (0.442–7.873) 0.172 0.625 (0.318–1.228) VPS37C/CD5 rs7104333 G > A GG 40 6 41 21 - 1* - 1* - 1* GA 105 15 48 45 0.004 0.446(0.256–0.775) 0.779 0.857(0.291–2.522) 0.529 0.816(0.433–1.537) AA 80 9 30 17 0.001 0.365(0.199–0.669) 0.319 0.539(0.160–1.818) 0.017 0.404(0.192–0.851) MPG rs1013358 C/T CC 17 4 19 14 , 1* , 1* - 1* CT 84 17 41 36 0.031 0.436(0.205–0.927) 0.431 0.605(0.173–2.116) 0.113 0.520(0.232–1.167) TT 124 9 59 33 0.020 0.425(0.206–0.878) 0.945 1.047(0.276–3.974) 0.005 0.323(0.144–0.722) ERCC4 rs1799801 T/C TT 109 16 51 34 , 1* , 1* - 1* TC 97 13 55 35 0.422 1.211 (0.7581 to 1.937) 0.594 1.267 (0.5304 to 3.026) 0.600 1.156 (0.670–1.996) CC 19 1 13 14 0.339 1.462 (0.670–3.189) 0.080 6.588 (0.795–54.560) 0.033 2.362 (1.071–5.207) APOBR rs17855750 A/C AA 214 29 105 76 , 1* , 1* - 1* AC 11 1 14 6 0.023 2.593 (1.138–5.910) 0.452 2.289(0.264–19.849) 0.413 1.535(0.549–4.296) CC 0 0 0 1 0.723 2.033 (0.040-103.184) 0.929 1.156(0.045–29.208) 0.193 8.411(0.339-208.705) ROCK1 rs288980 T/C TT 28 7 9 4 , 1* , 1* - 1* TC 88 4 43 36 0.325 1.520(0.659–3.503) 0.020 3.976 (1.239–12.756) 0.064 2.863(0.937–8.751) CC 109 19 67 43 0.116 1.912(0.850–4.300) 0.044 3.960 (1.035–15.154) 0.071 2.761(0.914–8.341) GSS rs7260770 G/A GG 186 25 89 60 , 1* , 1* , 1* GA 35 5 28 23 0.070 1.671 (0.957–2.919) 0.235 1.916 (0.654–5.609) 0.020 2.037 (1.116–3.716) AA 4 0 2 0 0.960 1.044 (0.187–5.812) 0.667 0.421 (0.008–21.829) 0.474 0.342 (0.018–6.454) COMT rs4633 C > T CC 71 6 43 35 - 1* - 1* - 1* CT 109 21 52 31 0.352 0.787(0.476–1.302) 0.008 0.253( 0.090–0.707) 0.057 0.576(0.326–1.018) TT 45 3 24 17 0.689 0.880(0.472–1.642) 0.969 0.971(0.216–4.363) 0.449 0.766(0.384–1.526) COMT rs4680 G > A GG 69 7 45 35 - 1* - 1* - 1* GA 111 19 50 31 0.1489 0.690(0.417–1.141) 0.027 0.326( 0.121–0.880) 0.039 0.550(0.311–0.972) AA 45 4 24 17 0.525 0.817(0.439–1.522) 0.814 0.850(0.218–3.306) 0.402 0.744(0.373–1.485) P: P value for Fisher Test; OR: Odds ratio; 95% CI: Confidence Interval; NE: Non Exposed; E: Exposed Finally the decision-tree analysis produced a three major BCa class. All of these classes were characterized by an intensity of tobacco use ≥ 20 pack years (PY) and subdivided according to the genotype of the CYP1A2 C > A variation (rs762551). The first class (58/249) is defined by the presence of CYP1A2 CC or CYP1A2 CA genotype and also defined by others 8 variations: ARNT C > G (rs2228099), CYP1B1 T > C (rs162555), SOD1 T > C (rs2173962), ROCK1 T > C (rs288980), IL10 A > T (rs1800890), LY96 T > C (rs17226566), AICDA T > G (rs11046349) and MAP2K4 C > T (rs4791489). The second class of BCa group (31/249) is only defined by the intensity of tobacco use ≥ 20PY and the inheritance of the homozygous genotype for rs762551 in CYP1A2 (CYPA2 A/A), XPC GG or AG genotype (rs2228000, G > A), and MAP2K4 CC or CT genotype (rs4791489, C > T). The third class (25/249) of BCa patients was defined by rs762551 (CYP1A2 C/A or C/C genotype) and 6 other variables (ARNT rs2228099 C > G, MPO rs2333227 C > T, LY96 rs17226566 T > C, CCR2 rs391835 G > A; APOBEC3 rs1014971 C > T and CASP3 rs3087455 T > G) ( Fig. 5 ). Discussion As all complex diseases, BCa isn't one SNP/gene disorder. Rather, many SNPs with small effects may result in the impairment of key pathways involved in their pathophysiology. The identification of such SNP-signatures represents an analytical challenge requiring the appliance of novel comprehensive statistical approaches. To our knowledge, this is the first study on BCa in Tunisian population analyzing a large number of SNPs with NGS technique. Indeed, in this study, we report the development and validation of the targeted amplification-based NGS panel analyzed on the Ion Torrent Proton Platform. This panel is named BCHP (BCa Heredity Panel) and used for detecting clinically useful genetic variations associated with the development of BCa in a total of 249 patients and 255 controls. After filtration the BCHP was composed of 139 SNPs in 97 genes. These SNPs are located in many different regions: introns sites ( BCL10, GSTM4, GSTM3 ...), regulatory region ( TP63, NAT2, GSTP1, GSTP2 ), up and downstream regulation genes sequences ( GSTA4, NAT2 APOBR/IL27, CYP2D6 …), splicing sites ( CASP9)… . The encoded enzymes modulate biological processes (xenobiotic metabolic process, cellular response to xenobiotic stimulus, Base-excision repair, immunology response...) and/or affect molecular function (Damaged DNA binding, Enzyme model we found statistically significant association between some genotypes and risk of bladder cancer development. These associations were reported for gene encoding for enzymes implicated in xenobioitic and drug metabolisms [ CYP1B1 ( rs162555 ), NAT2 ( rs1799930) , CYP3A4 ( rs2740574) , COMT ( rs4680) , AKR1C3 ( rs4881400) , PRKAR2B ( rs3752645 ), ARNT ( rs1889740, rs2228099, rs2864873 ), GSS (rs7260770) , GSTA4 (rs17614751)], or in DNA repair pathway [ NEIL2 ( rs4639) , XPC ( rs2228000) , MPG (rs1013358) , ERCC4/XPF (rs1799801)] or in other molecular functions such as cell proliferation, immunology response. Xenobiotic metabolism pathway In this study, we have found that CYP1B1 C/C ( rs162555 ), NAT2 A/A ( rs1799930 ), AKR1C3 G/G ( rs4881400) genotypes and heterozygous genotypes for CYP3A4 ( rs2740574) , COMT ( rs4680) and PRKAR2B ( rs3752645 ) were associated with a decreased risk of BCa development compared to reference group. CYP1B1 encodes for the CYP1B1 enzyme which is implicated in the NADPH-dependent electron transport and xenobiotic oxidation [ 25 ]. Nevertheless, no previous study has presented conclusive results for an association between CYP1B1 rs162555 and BCa development. The CYP3A4 (Cytochrome P450 3A4) enzyme encoded by the CYP3A4 gene is expressed in adult human liver and it is responsible for the oxidative metabolism of many clinically used drugs. The CYP3A4*1B variant (rs2740574 C to T) is associated with the reduction of the expression of the activity of CYP3A4 enzyme which could explain its effect on the development of BCa [ 26 ]. These results were supported by others studies which reported a significant protective effect of homozygous wild genotype in other cancer types such as prostate cancer, breast cancer, leukemia, gastric cancer, colorectal cancer, and ovarian cancer [ 27 ]. The N-acetyltransferase 2 ( NAT2 ) gene encodes for an important phase II xenobiotic-metabolizing enzyme frequently present in liver and intestinal mucosa. It catalyzes the reaction of aromatic and heterocyclic amine carcinogens via O-acetylation and N-acetylation [ 28 – 30 ]. In our case–control study we have found an inverse association between NAT2 A/A genotype (rs1799930) and BCa development. This result concord with those of Lei Quan who reported that NAT2 A/A carriers (rs1799930) were at 50% decreased risk of bladder cancer development compared to rapid acetylator[ 31 ]. Catechol-O-methyltransferase ( COMT ) encodes a phase II enzyme mainly liable for the degradation of catecholamines, like dopamine and noradrenalinev [ 32 ]. It catalyzes the O-methylation of 2-hydroxyestradiol to yield 2-ME2 [ 32 ]. Additionally, it is involved within the inactivation of potential carcinogenic compounds that produce inflammation and catechol estrogens and thus might protect DNA from oxidative damage. Rs4680 (Ex4-12 G > A, or val158met) is the most studied COMT single nucleotide polymorphism (SNP). In our cohort we explain the significant inverse association of heterozygous genotype against BCa development by the modification of enzyme activity associated to this genotype. Indeed it has been reported that valine (val) variant enzyme is 3–4 times more active than the methionine (met) variant [ 33 , 34 ]. Moreover we observed that PRKAR2B A/A genotype (rs3752645) is inversely correlated with BCa risk. The rs3752645 G/A SNP lies within the PRKAR2B gene, which encodes a regulatory subunit for cyclic adenosine 3′, 5′-monophosphate kinase. Our result confirms previous findings of a GWAS study where the authors showed that the rs3752645 SNP had a strong inverse association with BCa risk [ 35 ]. In contrast we have found that homozygous minor genotype or heterozygous genotype for rs1889740 C/T, rs2228099 C/G, rs2256355 T/C, rs2864873 A/G in ARNT gene (Aryl hydrocarbon receptor nuclear translocator) were significantly associated to increased risk of bladder cancer. These SNPs are described for the first time in association with increased risk of BCa development. ARNT gene encodes a protein that binds to ligand-bound aryl hydrocarbon receptor and promotes the expression of genes involved in xenobiotic metabolism [ 36 ]. We also found that the inheritance of rare homozygous genotype of GSS (rs7260770) is associated with an increased risk of BCa which confirms findings reported in other studies [ 37 ]. These findings may be explained by the functional impact of this variant on the enzyme activity. Indeed it has been reported that GSS deficiency resulted in decreased GSH levels and caused dramatic metabolic consequences. However, the role of GSS in cancers has not been studied in details. Finally we showed that GSTA4 G/A genotype (rs17614751) was associated with an increased risk of BCa in our population. This result could be explained by the perturbation of enzyme activity or expression (the rs17614751 SNP is a downstream gene variant). Moreover, it has been reported that the deregulation of GSTA4 enzyme activity was implicated in cell proliferation in nasopharyngeal carcinoma, breast cancer, and liver cancer cells [ 38 ]. DNA repair pathway When considering the DNA repair pathway we have found that the minor alleles of the rs4639 and rs2228000 SNPs in NEIL 2 and XPC genes respectively were associated with a decreased risk of BCa development compared to reference groups carrying major alleles. However the minor alleles observed in the studied population for the rs1013358 and rs1799801 SNPs in respectively MPG and ERCC4/ XPF genes increased the risk of bladder cancer. The NEIL 2 (Nei-like DNA glycosylase 2) gene encodes for an enzyme implicated in the first step of the base excision repair (BER) mechanism which consists of cleaving oxidatively damaged bases and introducing a DNA strand break via the associated lyase reaction [ 39 ]. The rs4639, is located on 3′UTR of NEIL2 [ 40 ]. In our study, we found that NEIL2 G/G genotype for rs4639 was associated with 0, 49-fold decreased risk of BCa. This inverse association could be explained by the fact that the minor allele interacts with some specific miRNA, which activates the BER pathway [ 41 ]. Moreover, we have found that rs4639 and rs804276 in NEIL2 gene were in linkage disequilibrium ( p-value = 0.03). Beside NEIL2 , we found that XPC AA genotype (rs2228000) was associated with a decreased risk of BCa compared to reference group. The XPC gene is located on 3p25 and encodes for an enzyme involved in global genome repair. This enzyme represents the earliest damage detector by initiating the NER pathway and eliminating the DNA damages induced by chemical and environmental exposures such as aromatic amines and UV light [ 42 ]. Our result confirms the study of Zhu Y. et al. which demonstrates a significant association between the presence of XPC rs2228000 AA genotype and a decreased risk of BCa [ 43 ]. However, the recent study of Dai Y. et al . suggests that XPC AA genotype may be linked to an increased risk of bladder and breast cancer [ 44 ]. These conflicting results and differences in risk associations may be explained by the different etiology and mechanisms of BCa in study populations with different ethnic backgrounds [ 15 ]. On the other hand, ERCC4/XPF and MPG enzymes represent the headmaster in DNA metabolic process, DNA repair, and cellular response to DNA damage stimulus. ERCC4 (16p13.12) is a NER gene that plays a key role in DNA repair that protects against genetic instability and carcinogenesis [ 45 ]. The ERCC4 -rs1799801 is a synonymous variation (Ser835Ser). A significant association between the ERCC4 -rs1799801 polymorphisms and increased risk of Bca in Tunisian population could be explained by the effect of this variation on the enzyme activity. Indeed a previously genotype-phenotype correlation analysis indicated that the ERCC4 -rs1799801 rare homozygous C/C genotype carriers had an increased trend of ERCC4 expression levels [ 46 ]. In contradiction with our results, the meta-analysis of Shi T.Y. et al. also did not provide statistical evidence for an association between ERCC4 gene and the overall risk of several human cancers, they also report that stratification analysis showed an inverse correlation with cancer in Caucasians [ 47 ]. These conflicting results could be explained by a difference in both ethnic origins of patients and exposure to environmental risk factors. MPG, a BER gene, also plays an important role in DNA repair. Others cellular pathway In addition to xenobiotic metabolic pathway and DNA repair process we are interested in this study to investigate the impact of others variations in gene implicated in cell proliferation pathway and immunology response in the etiology of BCa. Among the analyzed variations in this panel we have found that APOBR/IL27 A/C genotype (rs17855750) was associated with 2.27 fold-increased risk of BCa. The APOBR (Apolipoprotein B Receptor)/ IL27 (Interleukin 27) encodes for a protein that has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties [ 48 ]. This significant association could be explained by the implication of encoded enzyme in the inflammatory process. In the same context, Zhou B. et al . showed a significant association between IL-27 gene polymorphisms and IL-27 plasma level and reported that rs17855750 GG (CC) genotype was associated with increased risk for muscle invasive bladder carcinoma. Moreover we found that rs7104333 in CD5/VPS37C gene. The Vacuolar protein sorting-associated protein 37C (VPS37C ) is a Component of the ESCRT-I complex, and a regulator of vesicular trafficking process. This protein may be involved in cell growth and differentiation and it is known as a negative regulator of T- and B-cell receptor signaling. Its expression has been shown to be implicated in T lymphocytes tolerance toward tumor cells [ 49 ]. In contrast we have found that genetic variations in BLNK ( rs3789928 ), TP63 ( rs710521 ), ROCK1 ( rs288980 ) and ACTRT3/MYNN ( rs10936599) were associated with a decreased risk of bladder cancer. BLNK gene encodes for a cytoplasmic linker or adaptor protein that plays a critical role in B cell development [ 50 ]. It plays an important role in the pro-B cell to pre-B cell transition and B-cell apoptosis via BCR signaling pathway and reported to have a tumor-suppressive function in various hematologic malignancies [ 51 ]. Moreover the Human Protein Atlas consortium showed that high expression of BLNK had a favorable prognosis value in urothelial cancer [ 52 ]. TP63 (3q27-28) has a homolog sequence to TP53 (tumor suppressor) and TP73 [ 53 ]. This gene encodes for an enzyme implicated in the control of cell cycle and plays an important role in apoptosis. Abnormal expression of TP63 is associated with a loss of urothelial differentiation [ 54 ]. In our study the TP63 T/C genotype (rs710521) was reported to be inversely associated with BCa ( p-value = 0.035 and an OR = 0.62; CI95% 0.42–0.89). Our results seem to agree with those of Kimeney L. et al. and Lehmann M.-L et al. who confirmed that this variant plays a role in decreasing the risk of BCa in European patients [ 55 , 56 ]. We have also found that ROCK1 TT genotype (rs288980) was associated with 0.75 fold-decreased risk of BCa. ROCK1 enzyme is a necessary effector kinase downstream of Rho GTPases, a very important pathway involved in cell migration and has been identified as a possible therapeutic target [ 57 ]. The Cancer Genome Project identified three non-synonymous mutations within the ROCK1 gene [ 58 ] but the effect of these variations in protein activity or expression was not more elucidated. Finally ACTRT3/ MYNN (Actin Related Protein T3; 3q26.2) gene is poorly described in the literature. The minor T allele of rs10936599 in ACTRT3 / MYNN has been described in the Genome-wide association study conducted by Figueroa J. et al . in 2014, to be highly associated with decreased risk of BCa [ 59 ], which was confirmed by Wang M. et al. [ 60 ]. However, the effect of rs10936599 polymorphism on the MYNN activity is not well known and more biological functional studies are needed to draw more concise conclusions regarding the underlying molecular mechanism of this variation. Interaction between genetic and environmental risk factors When we compare the distribution of unfavorable genotypes [ GSS G/A (rs7260770), ARNT A/G (rs2864873), ARNT C/T (rs1889740) ARNT C/G (rs2228099), ARNT T/C (rs2256355), GSTA4 G/A (rs17614751), ERCC4 C/C (rs1799801), MPG C/C (rs1013358), VPS37C A/A (rs7104333), APOBR/IL27 A/C (rs17855750)] between exposed bladder cancer cases and controls according to environmental risk factors we found that ARNT C/T (rs1889740), ARNT A/G ( rs2864873) and GSTA4 G/A (rs17614751 ) genotypes were associated with an increased risk of BCa even in the absence of tobacco risk factors, or professional risk factors. Moreover when we compared exposed cases to exposed controls, we have not found a significant additive effect between the majority of unfavorable genotypes and exposure to environmental risk factors (smokers’ ≥ 20PY or exposed to professional risk factors). The absence of significant additive effect between the majority of unfavorable genotypes and BCa risk could be explained by the fact that the targeted SNPs encoding enzymes were not directly implicated in the metabolism of xenobiotics. For example, the proinflammatory role of APOBR/IL27 enzyme could explain the role of rs17855750 in BCa development independently to exposition to environmental risk factors. However this additive effect reached more than 12 fold-increased risk of BCa development for ARNT rs1889740 T/T, ARNT rs2228099 G/G and ARNT rs2256355 C/C genotypes in subjects exposed to professional risk factors. This association may be explained by the fact that ARNT gene encodes a protein thats binds to ligand-bound aryl hydrocarbon receptor and promotes the expression of genes involved in xenobiotic metabolism [ 36 ]. Whether this association is caused by specific bladder carcinogens present in the work environment warrants further investigations. To conclude our analysis, a decision tree was implemented to create a disease prediction model. This tree has allowed us to define the risk groups most genetically likely to develop BCa. According to the established decision tree, we note the importance of both smoking status (≥ 20PY) and the genotype of CYP1A2 (rs762551) in the development of BCa. The decision-tree analysis produced a three major BCa class. The first major class (58/249) is defined by the presence of CYP1A2 CC or CYP1A2 CA genotype and also defined by others 8 variations: ARNT C > G (rs2228099), CYP1B1 T > C (rs162555), SOD1 T > C (rs2173962), ROCK1 T > C (rs288980), IL10 A > T (rs1800890), LY96 T > C (rs17226566), AICDA T > G (rs11046349) and MAP2K4 C > T (rs4791489). The second major class of BCa group (31/249) is only defined by the intensity of tobacco use ≥ 20PY and the inheritance of the homozygous genotype for rs762551 in CYP1A2 (CYP1A2 A/A), XPC GG or AG genotype (rs2228000, G > A), and MAP2K4 CC or CT genotype (rs4791489, C > T). This decision tree confirms the crucial role of tobacco consumption in the etiology of BCa. Indeed BCa is considered as a smoking-related cancer [ 61 ]. This risk was attributed to many compounds of tobacco such as 4-Aminobiphenyl, 3-Amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1), Toluene, Benzo[a]pyrene, Benzene… [ 62 ]. In the other hand CYP1A2 is an enzyme responsible for the metabolism of caffeine and some tobacco compounds. Rs762551 variation in CYP1A2 gene encodes for the CYP1A2*1F allele. The baseline activity of the enzyme is similar in CYP1A2*1F allele carriers and non-carriers. Moreover it has been reported that he presence of rs762551 (A) codes for the "high inducibility" form the CYP1A2 enzyme, characterized by higher enzyme activity in the presence of an inducer such as smoking or heavy coffee consumption[ 63 ]. To explain our result we have reanalyzed the CYP1A2 C > A genotype distribution between cases and controls and according to tobacco status. As result we have found that the inheritance of CYP1A2 (CC) or CYP1 A2 (CA) genotype were respectively associated with 6.89 and 9.04 –fold increased risk of BCa in only heavy smokers patients (≥ 20PY) compared to heavy smokers controls. However we have not data about coffee consumption. Conclusion We have conducted the first study in Tunisian population to evaluate systematically the association between genetic variations in BCa and environmental factors. We also determined the effect of studied pathway SNPs in comparison with environmental exposition. Once validated, these findings may provide urologists additional genetic information that may help for clinical assessment and treatment decisions. Nevertheless, the underlying mechanisms through which these genes or SNPs affect the clinical behavior of BCas require further studies. Future investigations in our populations and detailed functional characterization are needed to establish predictive or prognostic markers for BCa. Abbreviations ACTRT3 Actin Related Protein T3; 3q26.2 APOBR Apolipoprotein B Receptor ARNT Aryl hydrocarbon receptor nuclear translocator BCa Bladder cancer BER base excision repair BLNK B cell linker COMT Catechol-O-methyltransferase CYP1B1 cytochrome P450 family 1 subfamily B member 1 CYP3A4 Cytochrome P450 3A4 dbSNP database of single nucleotide polymorphisms DNA deoxyribonucleic acid DRC DNA Repair Capacity DSBR double-strand break repair EDTA ethylene diamine tetra-acetic acid ERCC4 Excision Repair Cross-Complementation group 4 GSTM1 Glutathione-s-transferase M1 GWAS Genome-Wide Association Study GSS Glutathione Synthase GSTA4 Glutathione S-transferase Alpha 4 HG High-Grade IARC International Agency for Research on Cancer IL27 Interleukin 27 KEGG Kyoto Encyclopedia of Genes and Genomes LG Low-Grade MIBC muscle-invasive BCa MMR mismatch repair MPG N-methylpurine DNA glycosylase NEIL2 Nei-like DNA glycosylase 2 NAT2 N-acetyltransferase 2 NER nucleotide excision repair NGS Next-Generation Sequencing NMIBC non-muscle-invasive BCa PRKAR2B Protein Kinase cAMP-dependent type II regulatory subunit beta ROCK1 Rho associated coiled-coil containing protein kinase 1 SNP nucleotide polymorphisms TCR transcription-coupled repair TP63 Tumor Protein p63 VPS37C vacuolar protein sorting-associated protein 37C WHO World Health Organization XPC Xeroderma Pigmentosum, Complementation group C XPF excision repair cross-complementing rodent repair deficiency, complementation group 4 Declarations Ethics approval and consent to participate - This trial protocol and recruitment were approved and carried out after the agreement of the ethics committee of the Charles Nicolle Hospital and approved by an Ethics Committee (IEC Project No. 17-35) and an MTA (MATERIAL TRANSFER AGREEMENT MTA/ 2017 / IMP / GCS)/ 0356) from IARC. -Informed consent was obtained from all participants (in both languages: Arabic/French) prior to enrollment and participation in this study.. - All samples are coded and no patient names appear in the study. All data whether clinical or personal remains anonymous and secret. Consent for publication Not applicable. This study did not use identifying images and any clinical and personal details despite written informed consent for publication of their clinical details and/or clinical Availability of data and material The dataset is available upon reasonable request to the corresponding author Competing interests The authors declare that they have no competing interests Funding “No funding was obtained for this study” Authors' contributions IH: Collecting clinical samples and data, designed the panel, molecular analysis, drafted the manuscript and bioinformatics analyzes. SB, HD and FH: Help in Bioinformatics and statistical analyzes. GD and CV: Technical assistance for NGS analyzes. HA: Clinical characterization of the studied population. SZ, ZN and MA: help in collecting samples. MC and JM: designed the study and revised the manuscript. FL: drafted and revised the manuscript. SO: designed the study, performed the statistical analysis and drafted and revised the manuscript. All authors read and approved the final version of the manuscript. Acknowledgements The authors thank all patients for participating in this study. We greatly thank also the Urology department, Charles Nicolle hospital, Tunis, Tunisia, Biochemistry Department, Charles Nicolle Hospital, Tunis and the International Agency for Research on Cancer IARC ; Lyon. France. References Antoni S, Ferlay J, Soerjomataram I, et al (2017) Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends. European Urology 71:96–108. https://doi.org/10.1016/j.eururo.2016.06.010 Wong MCS, Fung FDH, Leung C, et al (2018) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projection. Scientific Reports 8:. https://doi.org/10.1038/s41598-018-19199-z Cancer today. http://gco.iarc.fr/today/home. 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Faculte des Sciences de Tunis","correspondingAuthor":false,"prefix":"","firstName":"SAMI","middleName":"","lastName":"BOUSETTA","suffix":""},{"id":48711395,"identity":"eaf46fb3-32fd-4b17-a1ee-e682d94f3082","order_by":2,"name":"Hamza Dallali","email":"","orcid":"","institution":"IPT: Institut Pasteur de Tunis","correspondingAuthor":false,"prefix":"","firstName":"Hamza","middleName":"","lastName":"Dallali","suffix":""},{"id":48711396,"identity":"897b9a96-e58f-4bfb-b7b7-3d31fe4b0b5d","order_by":3,"name":"Faycel Hellal","email":"","orcid":"","institution":"INSAT: Institut National des Sciences Appliquees et de Technologie","correspondingAuthor":false,"prefix":"","firstName":"Faycel","middleName":"","lastName":"Hellal","suffix":""},{"id":48711397,"identity":"eb06c522-7cb4-416f-b448-dd90fc19dc56","order_by":4,"name":"Geoffroy Durand","email":"","orcid":"","institution":"CIRC: International Agency for Research on Cancer","correspondingAuthor":false,"prefix":"","firstName":"Geoffroy","middleName":"","lastName":"Durand","suffix":""},{"id":48711398,"identity":"0ab40cb8-417e-4c5f-ab46-bbbd5c23f54d","order_by":5,"name":"Catherine Voegele","email":"","orcid":"","institution":"CIRC: International Agency for Research on Cancer","correspondingAuthor":false,"prefix":"","firstName":"Catherine","middleName":"","lastName":"Voegele","suffix":""},{"id":48711399,"identity":"e6a73473-249b-403a-8f24-5fc7e5d409e4","order_by":6,"name":"Haroun AYED","email":"","orcid":"","institution":"Charles Nicolle Hospital: Hopital Charles Nicolle","correspondingAuthor":false,"prefix":"","firstName":"Haroun","middleName":"","lastName":"AYED","suffix":""},{"id":48711400,"identity":"d7657b76-0bb9-41f6-b727-b98df016534b","order_by":7,"name":"Selim Zaghbib","email":"","orcid":"","institution":"Charles Nicolle Hospital: Hopital Charles Nicolle","correspondingAuthor":false,"prefix":"","firstName":"Selim","middleName":"","lastName":"Zaghbib","suffix":""},{"id":48711401,"identity":"e68103d7-ce09-489f-9d27-72f0909f5591","order_by":8,"name":"Zeineb Naimi","email":"","orcid":"","institution":"Institut Salah-Azaïz: Institut Salah-Azaiz","correspondingAuthor":false,"prefix":"","firstName":"Zeineb","middleName":"","lastName":"Naimi","suffix":""},{"id":48711402,"identity":"339e4d38-9295-4405-96be-c7cc048a6410","order_by":9,"name":"Mouna Ayadi","email":"","orcid":"","institution":"Institut Salah-Azaïz: Institut Salah-Azaiz","correspondingAuthor":false,"prefix":"","firstName":"Mouna","middleName":"","lastName":"Ayadi","suffix":""},{"id":48711403,"identity":"9cc0618c-a1c4-46cd-bd70-df0bef6fd092","order_by":10,"name":"Mohamed Chebil","email":"","orcid":"","institution":"Charles Nicolle Hospital: Hopital Charles Nicolle","correspondingAuthor":false,"prefix":"","firstName":"Mohamed","middleName":"","lastName":"Chebil","suffix":""},{"id":48711404,"identity":"9f9f23fb-a547-4323-af12-6f30e83f042e","order_by":11,"name":"James Mckay","email":"","orcid":"","institution":"IARC: International Agency for Research on Cancer","correspondingAuthor":false,"prefix":"","firstName":"James","middleName":"","lastName":"Mckay","suffix":""},{"id":48711405,"identity":"f65b9a23-0589-46a8-a934-fd6842ab0fa5","order_by":12,"name":"Florence Le Calvez-Klem","email":"","orcid":"","institution":"IARC: International Agency for Research on Cancer","correspondingAuthor":false,"prefix":"","firstName":"Florence","middleName":"Le","lastName":"Calvez-Klem","suffix":""},{"id":48711406,"identity":"b1530d9e-c1c5-4ff7-a259-c141385d15ba","order_by":13,"name":"Slah Ouerhani","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2klEQVRIie3PsQrCMBCA4SuR69Lg2iLaV4gEWsTisyhCJ2dnQWgn38UpOBayCs5udekmOBUERa8I4tTWTTD/kMuQjyQAJtMvZgNWQwBjGVgr2tKsj70JTl+EZksCjmhH/DUrcmsRydB2Sve6iwaAPK8lQmMoLBUHozVX3mYfS0Bb1BMGgWspHQnNlcsTPVv5SdPD7JLIg4hTePeKINYT0E51SxYQwR5vQ+jkkshc0qfkuJ/EEpuIn6aKyGS4PejT8ZxEg27jwyh2e82OW60twAe9fHPaZDKZ/qcnmM051IiwpmEAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-3651-4690","institution":"laboratoire ingénierie des protéines et des molécules recombinantes. Institut National des Sciences Appliquees et de Technologie de Tunis","correspondingAuthor":true,"prefix":"","firstName":"Slah","middleName":"","lastName":"Ouerhani","suffix":""}],"badges":[],"createdAt":"2021-08-23 14:07:55","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-840773/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-840773/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":12913323,"identity":"42004338-b04a-4264-9226-11ad749f8a0e","added_by":"auto","created_at":"2021-08-30 22:43:15","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":37569,"visible":true,"origin":"","legend":"Overview of data analysis workflow","description":"","filename":"fig1.png","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/9671773f72c7bd2927614da2.png"},{"id":12913102,"identity":"d5980dc4-a3cc-40d7-92d8-f5409cbcd56b","added_by":"auto","created_at":"2021-08-30 22:40:15","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":5456223,"visible":true,"origin":"","legend":"BCHP protein–protein interaction networks using a STRING server\na: Overall BCHP panel\nb: Xenobiotic metabolic process \nc: Base-excision repair \nd: Response to drug","description":"","filename":"fig2.png","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/8616385bc928aa07af67e453.png"},{"id":12913097,"identity":"2c472777-66a4-4952-95b5-ff23f8bb6533","added_by":"auto","created_at":"2021-08-30 22:40:15","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":43502,"visible":true,"origin":"","legend":"Proton experiment workflow","description":"","filename":"fig3.png","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/d0365333736b2d6292341edd.png"},{"id":12913100,"identity":"f1ca6581-10e3-4790-a63e-aa7ee6722737","added_by":"auto","created_at":"2021-08-30 22:40:15","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":169591,"visible":true,"origin":"","legend":"Run2 Report for Auto user CIRC-PROTON-121-TERT Imen2 100418 299","description":"","filename":"fig4.png","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/3fae3aa8dabc253e761b6fdb.png"},{"id":12913101,"identity":"2902756a-577d-4a64-b53a-58c79929e8f8","added_by":"auto","created_at":"2021-08-30 22:40:15","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":594777,"visible":true,"origin":"","legend":"Decision Tree of predictive profiles of Patients and Controls\nV: Variable","description":"","filename":"fig5.png","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/117f3ea750fc054b965773a0.png"},{"id":13711986,"identity":"8249a5b7-50c6-4115-81ef-ccc14bf5a32c","added_by":"auto","created_at":"2021-09-17 14:25:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2507901,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/a04746e4-9c48-4c3c-bff9-056af8dcbe17.pdf"},{"id":12913098,"identity":"b52f6c1f-d4f4-41e5-9a07-f6beaf003356","added_by":"auto","created_at":"2021-08-30 22:40:15","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":17398,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryFile.docx","url":"https://assets-eu.researchsquare.com/files/rs-840773/v1/821eedd53972ebbd94666c54.docx"}],"financialInterests":"","formattedTitle":"\u003cp\u003eDevelopment of a Custom NGS Panel for the Determination of Bladder Cancer Risk\u003c/p\u003e","fulltext":[{"header":"Highlight","content":"\u003cp\u003eIn this study we determined the effect of studied pathway SNPs in comparison with environmental exposition using Next-Generation Sequencing (NGS). We have found that homozygous minor genotype or heterozygous genotype for rs1889740 C/T, rs2228099 C/G, rs2256355 T/C, rs2864873 A/G in ARNT gene (Aryl hydrocarbon receptor nuclear translocator) were significantly associated to increased risk of bladder cancer even in the absence of tobacco risk factors, or professional risk factors. Finally we noticed the importance of tobacco status and the CYP1A2 (rs762551) genotype in the stratification of Tunisian BCa patients.\u003c/p\u003e"},{"header":"Background","content":"\u003cp\u003eBladder cancer (BCa) is a common malignancy of the urinary tract and the ninth most frequent cancer in the world, affecting nearly 3.4\u0026nbsp;million people with 430 000 new cases diagnosed in 2012 and 165 000 deaths per year (2% of all the cases)[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. In the few last years, the incidence of BCa was higher in developed countries and some African countries, with an increase in the aggressiveness of the disease and the mortality rate [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. According to the Cancer Registry of the north of Tunisia (1999\u0026ndash;2003), BCa is the most frequent urological cancer in Tunisia in men and in 2018 it became the second malignant tumor with an age-standardized incidence rates of 17.7 and 2.0 per 100 000 in men in women respectively[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. In 2018, the number of new BCa cases was 1323 [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. The mean age at diagnosis is 65.9 years, without sex significant difference. At the time of diagnosis, non-muscle-invasive BCa (NMIBC) represents the majority of BCa whereas muscle-invasive BCa (MIBC) represents around 25% of bladder tumors with a 5-year survival rate ranging from 35\u0026ndash;70%. NMIBC is usually associated with a favorable prognosis but it is characterized by a variable rate of recurrence and progression depending on tumor characteristics. MIBC is, however, initially aggressive and given the associated high risk of developing a metastatic disease requires a radical treatment when still localized[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eBCa is a heterogeneous disease associated with many risk factors. The most known risk factor is tobacco smoking, which accounts for the occurrence of up 50% of BCa [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. Occupational exposure to chemicals, genetic factors, and other environmental factors such as dietary factors, lifestyle, medical condition, fluid intake, also contribute to BCa carcinogenesis, although the evidence of the role of some of these risk factors is still inconclusive [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Most carcinogens undergo activation by Phase I enzymes, mostly through oxidation reactions, and detoxification by Phase II enzymes, which is the case for aromatic and heterocyclic amines, well-known BCa carcinogens present in smoking and occupational exposure [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Therefore, early studies evaluated whether candidate genetic variants in such metabolic pathways could modify the risk of BCa induced by the above-mentioned carcinogens. For example, the deletion of xenobiotic metabolism gene \"\u003cem\u003eGSTM1\u003c/em\u003e and/or \u003cem\u003eGSTT1\u003c/em\u003e\" characterized as \u003cem\u003eGSTM1-\u003c/em\u003e and \u003cem\u003eGSTT1-null\u003c/em\u003e genotypes have been shown to be BCa susceptibility loci in several studies [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]. Moreover, N-acetyltransferase 2 (\u003cem\u003eNAT2\u003c/em\u003e) and Glutathione-s-transferase M1 (GSTM1) variants were the first described genes showing a gene-smoking interaction associated with increased risk of BCa[\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Hypothetically the deficiency in xenobiotic metabolizing pathway could result in the accumulation of somatic mutations which should be corrected by DNA-repair pathways. There are five major important DNA-repair pathways consisting of more than 130 genes: nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), double-strand break repair (DSBR) and transcription-coupled repair (TCR) [\u003cspan additionalcitationids=\"CR13\" citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. Among these pathways, NER is the most important DNA repair mechanism responsible for various types of DNA damage consisting of oxidative DNA damage, bulky adducts cross-links, alkylating damage, and thymidine dimmers[\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. Deficient DNA repair capacity is known to be a cancer-predisposing factor. Indeed the presence of some single nucleotide polymorphisms (SNP) in DNA repair genes can impair the function of the repair enzymes, thus reducing DNA Repair Capacity (DRC) and inducing genetic instability [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. In addition others studies have reported a significant association between variations in gene encoded for cell cycle and/or inflammatory response proteins and bladder development and/or prognosis[\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eAll of this reported information highlights the complexity of the mechanisms implicated in the etiology of BCa which warrants further investigation. The goal of this case-control study was to evaluate the implication a selected SNP panel in BCa development of the Tunisian population. We developed an amplification-based targeted Next-Generation Sequencing (NGS) assay to simultaneously genotype 139 polymorphisms in 97 genes, selected according to their eventual implications in the etiology and the prognosis BCa such as those located in genes encoded for enzymes implicated in xenobiotic metabolism, DNA repair, treatment response, and inflammatory reaction process. The design of the panel was done, after consulting published data and available databases (dbSNP, UCSC Genome Browser, and GWAS).\u003c/p\u003e"},{"header":"Methods","content":"\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\n\u003ch2\u003eStudy population\u003c/h2\u003e\n\u003cp\u003eA case-control study was conducted in the Urology department of Charles Nicolle Hospital in Tunis (Tunisia) and the Laboratory of Protein Engineering and Bioactive Molecules (LIP-MB 11ES24) of the National Institute of Applied Sciences and Technology of Tunis (INSAT), in collaboration with the Genetic Cancer Susceptibility group (GCS group) of the International Agency for Research on Cancer in Lyon (IARC/WHO). Recruitment was carried out after the agreement of the ethics committee of the Charles Nicolle Hospital and approved by an Ethics Committee (IEC Project No. 17\u0026ndash;35) and an MTA (MATERIAL TRANSFER AGREEMENT MTA/ 2017 / IMP / GCS)/ 0356) from IARC.\u003c/p\u003e\n\u003cp\u003eThis study was performed on a cohort of 504 cases (249 BCa patients and 255 controls). A total of 255 control cases, randomly selected from healthy volunteer cases enrolled in the Biochemistry Department, were matched to those of the BCa patients group according to the age range (64.28\u0026thinsp;\u0026plusmn;\u0026thinsp;11.54), sex, and geographic origin. Epidemiological, clinical and anatomopathological data of BCa patients were collected from the medical records of the urology department and the histological reports from the pathology department of the Charles Nicolle Hospital in Tunis \u003cstrong\u003e(\u003c/strong\u003eTable\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e\u003cstrong\u003e).\u003c/strong\u003e Epidemiological data (age, sex, smoking status) and pathological data (grade, stage, histological type, type, and follow-up of treatment) were recorded and made available for the study \u003cstrong\u003e(\u003c/strong\u003eTable\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e\u003cstrong\u003e)\u003c/strong\u003e. Histological reviews of the tumors were performed confirmed by a trained pathologist in urological oncology. The BCa tumors of the 249 patients were classified as 45 Specimens of High-Grade (HG) NMIBC, 119 specimens of Low-Grade (LG) NMIBC, and 66 specimens of MIBC.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1: \u003c/strong\u003eClinical and Epidemiological characteristics of bladder cancer patients\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\n\u003ctable id=\"Tabb\" border=\"1\"\u003e\u003ccolgroup\u003e\u003c/colgroup\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eClinical and epidemiological parameters\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eBladder cancer patients\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eControls\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSamples sizes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMale\u003c/p\u003e\n\u003cp\u003eFemale\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e249\u003c/p\u003e\n\u003cp\u003e224 (89.96%)\u003c/p\u003e\n\u003cp\u003e25 (10.04%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e255\u003c/p\u003e\n\u003cp\u003e196 (76.86%)\u003c/p\u003e\n\u003cp\u003e59 (23.14%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMean Age at diagnosis (years)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e68.18\u0026thinsp;\u0026plusmn;\u0026thinsp;12.80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e64.28\u0026thinsp;\u0026plusmn;\u0026thinsp;11.54\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSmoking status\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eSmokers\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e199 (79.91%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e138 (54.12%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNon smokers\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e27 (10.84%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e117 (45.88%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eND\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e23 (9.25%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0 (00.00%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNumber of pack/years\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026lt;\u0026thinsp;20 PY\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e31 (15.58%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e70 (50.72%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026ge; 20 PY\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e168 (84.42%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e68 (49.28%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eExposure to professional risk factors (farmer, painter, building, chemical factory\u0026hellip;)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNot exposed\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e119 (47.80%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e225 (88.24%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eExposed\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e83 (33.33%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e30 (11.76%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eND\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e47 (18.87%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0 (00.00%)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTNM classification\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eLG NMIBC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e119 (47.80%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eHG NMIBC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45 (18.07%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eMIBC\u003c/p\u003e\n\u003cp\u003eND\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e66 (27.50%)\u003c/p\u003e\n\u003cp\u003e19 (07.63%)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003ctfoot\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"3\"\u003eND: Not Determined; PY: Packet per Year; LG: Low Grade; HG: Haut Grade; MIBC: Muscle Invasive Bladder Cancer; NMIBC: Non-Muscle Invasive Bladder Cancer\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tfoot\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003c/div\u003e\n\u003ch2\u003eBiological Samples And Dna Extraction\u003c/h2\u003e\n\u003cp\u003ePeripheral blood samples were collected into tubes with ethylene diamine tetra-acetic acid EDTA (PH 8). Genomic DNA was extracted from leukocytes using a phenol /chloroform procedure. First, the integrity of the genomic DNA was visualized by electrophoresis on a 1% agarose gel stained with ethidium bromide. In a second step, DNA samples were quantified by Nanodrop and Qubit (High Sensitivity HS / Broad Rang BR) and were dried with the speedvac (Eppendorf\u0026trade; Vacufuge\u0026trade; Concentrator) to be normalized into 6*96-well plates.\u003c/p\u003e\n\u003ch2\u003ePanel Design\u003c/h2\u003e\n\u003cp\u003eWe have selected a panel of 139 polymorphisms from 97 genes. These SNP were selected according to their eventual implications in poor-prognosis BCa such as those affecting the xenobiotic metabolism, DNA repair, treatment response, and inflammatory reaction. The design of the panel was done, after consulting published data and available databases (dbSNP, UCSC Genome Browser, and GWAS).\u003c/p\u003e\n\u003cp\u003eIn a second step, the implication of the SNPs selected in our SNP panel in BCa susceptibility was confirmed by the following tools: Kyoto Encyclopedia of Genes and Genomes (KEGG) available on the website \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.genome.jp/kegg/pathway.html\u003c/span\u003e\u003c/span\u003e [\u003cspan class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e19\u003c/span\u003e], Panther classification system available on the website (\u003c/p\u003e\n\u003cp\u003e\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://pantherdb.org/tools/gxIdsList.do?list=upload_1\u0026amp;organism=Homo%20sapiens\u003c/span\u003e\u003c/span\u003e)[\u003cspan class=\"CitationRef\"\u003e20\u003c/span\u003e], STRING database available on the website \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://string-db.org/\u003c/span\u003e\u003c/span\u003e ,AmiGO2[\u003cspan class=\"CitationRef\"\u003e21\u003c/span\u003e], Reactome Pathway Database[\u003cspan class=\"CitationRef\"\u003e22\u003c/span\u003e] and GWAS [\u003cspan class=\"CitationRef\"\u003e23\u003c/span\u003e].In addition, we constructed candidate pathways based on our defined panel consisting of 97 genes. The pathways were defined according to the STRING protein\u0026ndash;protein interaction networks. A complete list of the studied variants was summarized in Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e. Pathways and protein-protein interaction, in which the studied genes were implicated, were presented and described in Fig. \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\n\u003ctable id=\"Tab2\" border=\"1\"\u003e\u003ccaption\u003e\n\u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\n\u003cdiv class=\"CaptionContent\"\u003e\n\u003cp\u003eA comprehensive list of all regions targeted by the Tunisian bladder cancer hereditary panel and Allelic Association (BCHP panel)\u003c/p\u003e\n\u003c/div\u003e\n\u003c/caption\u003e\u003ccolgroup\u003e\u003c/colgroup\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eCHR\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eSNP\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eGENES\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eVARIATION\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eReference variant\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eMutated variant\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eMajor allele /Minor allele\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eMajor.allele.freq\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"3\" align=\"left\"\u003e\n\u003cp\u003eAllelic Association\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ep-value.log-additive\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e95% CI\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2020902\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCASP9\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esplice_region_variant,intron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e82,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,873\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.7\u0026ndash;1.35\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2647396\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBCL10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e65,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,685\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.81\u0026ndash;1.37\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers560018\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTM4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e82,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,938\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.72\u0026ndash;1.36\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers11101992\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTM5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant,non_coding_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e65,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,596\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u0026thinsp;\u0026minus;\u0026thinsp;1,39\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4970774\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTM5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant,non_coding_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e50,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,754\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;1,33\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4970776\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTM5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant,non_coding_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e53,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,87\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u0026thinsp;\u0026minus;\u0026thinsp;1,3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1571858\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTM3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e75,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,888\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,37\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers15864\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEPS8L3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e81,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,947\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,71\u0026thinsp;\u0026minus;\u0026thinsp;1,37\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3136701\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCD2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,23\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1889740\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e57,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,207\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u0026thinsp;\u0026minus;\u0026thinsp;1,5\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2228099\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e57,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,203\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u0026thinsp;\u0026minus;\u0026thinsp;1,51\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1027699\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e64,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,937\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u0026thinsp;\u0026minus;\u0026thinsp;1,3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2256355\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e56,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,181\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u0026thinsp;\u0026minus;\u0026thinsp;1,52\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2864873\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e64,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u0026thinsp;\u0026minus;\u0026thinsp;1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers763110\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eFASLG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e58,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,998\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u0026thinsp;\u0026minus;\u0026thinsp;1,28\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers228001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eASTN1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant,non_coding_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,937\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,54\u0026thinsp;\u0026minus;\u0026thinsp;1,96\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1800890\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,886\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u0026thinsp;\u0026minus;\u0026thinsp;1,3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2854461\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEPHX1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e73,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,223\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u0026thinsp;\u0026minus;\u0026thinsp;1,57\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1051740\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEPHX1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e72,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;1,4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2260863\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEPHX1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e64,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u0026thinsp;\u0026minus;\u0026thinsp;1,3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1805410\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePARP1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e82,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,432\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,65\u0026thinsp;\u0026minus;\u0026thinsp;1,2\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers391835\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAC012593.1/CCR2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant,non_coding_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eA/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e53,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,26\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1056836\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1B1/RMDN2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e56,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,618\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,84\u0026thinsp;\u0026minus;\u0026thinsp;1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers162555\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1B1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e76,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,017\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,52\u0026thinsp;\u0026minus;\u0026thinsp;0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3771171\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL18R1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,165\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,59\u0026thinsp;\u0026minus;\u0026thinsp;1,1\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers11892031\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eUGT1A10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e90,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,213\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,51\u0026thinsp;\u0026minus;\u0026thinsp;1,17\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2228000\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eXPC\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e81,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,024\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,5\u0026thinsp;\u0026minus;\u0026thinsp;0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1050450\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eRHOA\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,953\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;1,25\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers10936599\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eACTRT3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e85,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,004\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u0026thinsp;\u0026minus;\u0026thinsp;0,85\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers710459\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMASP1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e71,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,968\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,29\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers710521\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTP63\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eregulatory_region_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e76,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,035\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,54\u0026thinsp;\u0026minus;\u0026thinsp;0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers798766\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTACC3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,836\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,24\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4073\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e55,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,23\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2227306\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e68,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,428\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,7\u0026thinsp;\u0026minus;\u0026thinsp;1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3804099\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTLR2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,259\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,87\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u0026thinsp;\u0026minus;\u0026thinsp;1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3087455\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCASP3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u0026thinsp;\u0026minus;\u0026thinsp;1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers34847072\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAHRR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e82,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,106\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,56\u0026thinsp;\u0026minus;\u0026thinsp;1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers401681\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTERT/CLPTM1L\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e53,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,415\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u0026thinsp;\u0026minus;\u0026thinsp;1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2070874\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e80,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,455\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,82\u0026thinsp;\u0026minus;\u0026thinsp;1,55\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4510656\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCDKAL1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e61,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,103\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u0026thinsp;\u0026minus;\u0026thinsp;1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers451774\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGPX5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e60,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,377\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u0026thinsp;\u0026minus;\u0026thinsp;1,15\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers8193036\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL17A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2275913\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL17A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e79,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,207\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u0026thinsp;\u0026minus;\u0026thinsp;1,64\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2180314\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e54,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,398\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,7\u0026thinsp;\u0026minus;\u0026thinsp;1,15\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2144698\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e79,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,679\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u0026thinsp;\u0026minus;\u0026thinsp;1,43\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers17614751\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e95,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,029\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,14\u0026thinsp;\u0026minus;\u0026thinsp;3,99\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers367836\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e59,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,764\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;1,32\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers150126\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMAP3K7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,999\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,31\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4880\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSOD2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,406\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,87\u0026thinsp;\u0026minus;\u0026thinsp;1,4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1062492\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSNX8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e79,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,234\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u0026thinsp;\u0026minus;\u0026thinsp;1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2017000\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEGFR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,139\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,82\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u0026thinsp;\u0026minus;\u0026thinsp;1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1140475\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEGFR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e92,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u0026thinsp;\u0026minus;\u0026thinsp;1,73\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2293347\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEGFR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,698\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u0026thinsp;\u0026minus;\u0026thinsp;2,09\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1045642\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eABCB1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,95\u0026thinsp;\u0026minus;\u0026thinsp;1,62\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1858923\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eABCB1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e61,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,611\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,82\u0026thinsp;\u0026minus;\u0026thinsp;1,39\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2740574\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP3A4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e79,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,129\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,58\u0026thinsp;\u0026minus;\u0026thinsp;1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers11773597\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP3A4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e92,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,247\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;2,04\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e7\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3752645\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePRKAR2B\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e90,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,023\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,39\u0026thinsp;\u0026minus;\u0026thinsp;0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers804276\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e67,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,58\u0026thinsp;\u0026minus;\u0026thinsp;0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers8191604\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,409\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u0026thinsp;\u0026minus;\u0026thinsp;1,44\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1874546\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e85,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,769\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,66\u0026thinsp;\u0026minus;\u0026thinsp;1,35\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4639\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e65,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,009\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,56\u0026thinsp;\u0026minus;\u0026thinsp;0,92\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1961456\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e76,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,952\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,75\u0026thinsp;\u0026minus;\u0026thinsp;1,36\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799929\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e54,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,374\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u0026thinsp;\u0026minus;\u0026thinsp;1,42\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799930\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e70,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,82\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u0026thinsp;\u0026minus;\u0026thinsp;1,09\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799931\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e97,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,814\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,54\u0026thinsp;\u0026minus;\u0026thinsp;2,19\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers12674710\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e89,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,538\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,58\u0026thinsp;\u0026minus;\u0026thinsp;1,33\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1495741\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eregulatory_region_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eA/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e79,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,509\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,82\u0026thinsp;\u0026minus;\u0026thinsp;1,51\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers13278062\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTNFRSF10A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e55,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,633\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u0026thinsp;\u0026minus;\u0026thinsp;1,2\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1126452\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEPHX2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,325\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u0026thinsp;\u0026minus;\u0026thinsp;1,49\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3136717\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePOLB\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e71,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,439\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u0026thinsp;\u0026minus;\u0026thinsp;1,45\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers17226566\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eLY96\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e84,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,611\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,66\u0026thinsp;\u0026minus;\u0026thinsp;1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers9642880\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCASC11\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant,non_coding_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e50,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,405\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,87\u0026thinsp;\u0026minus;\u0026thinsp;1,43\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e8\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2294008\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePSCA\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e54,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,426\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,7\u0026thinsp;\u0026minus;\u0026thinsp;1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1937845\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,886\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,25\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3763676\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,289\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u0026thinsp;\u0026minus;\u0026thinsp;1,52\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers12529\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,886\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,25\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1937843\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,289\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u0026thinsp;\u0026minus;\u0026thinsp;1,52\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4881400\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e76,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,029\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,55\u0026thinsp;\u0026minus;\u0026thinsp;0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers12775701\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e59,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,665\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u0026thinsp;\u0026minus;\u0026thinsp;1,35\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2475377\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP2C9\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintergenic_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e87,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,283\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u0026thinsp;\u0026minus;\u0026thinsp;1,76\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers9332197\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP2C9\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e98,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,132\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u0026thinsp;\u0026minus;\u0026thinsp;5,69\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers12357751\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBLNK\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e73,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;1,41\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3789928\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBLNK\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,057\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u0026thinsp;\u0026minus;\u0026thinsp;1,01\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2031920\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP2E1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e97,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,249\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,58\u0026thinsp;\u0026minus;\u0026thinsp;3,13\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e10\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers915908\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP2E1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e84,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,869\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u0026thinsp;\u0026minus;\u0026thinsp;1,46\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e11\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7104333\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eVPS37C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,24\u0026thinsp;\u0026minus;\u0026thinsp;2,02\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e11\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers625978\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTP1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eregulatory_region_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e61,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u0026thinsp;\u0026minus;\u0026thinsp;1,23\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e11\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1695\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTP1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e62,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,376\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u0026thinsp;\u0026minus;\u0026thinsp;1,15\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3213427\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCD4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e64,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,761\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,75\u0026thinsp;\u0026minus;\u0026thinsp;1,24\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers11046349\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAICDA\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e73,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,283\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,88\u0026thinsp;\u0026minus;\u0026thinsp;1,54\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers10878176\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTBK1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e71,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,807\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u0026thinsp;\u0026minus;\u0026thinsp;1,26\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1866074\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTDG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e59,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,247\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,67\u0026thinsp;\u0026minus;\u0026thinsp;1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3890995\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eUNG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e81,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,796\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,43\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e12\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4765621\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSCARB1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e51,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,155\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,65\u0026thinsp;\u0026minus;\u0026thinsp;1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1050112\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePARP4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e50,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,164\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u0026thinsp;\u0026minus;\u0026thinsp;1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers13428\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePARP4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e58,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,131\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u0026thinsp;\u0026minus;\u0026thinsp;1,05\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e13\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers17655\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eERCC5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e67,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,887\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,75\u0026thinsp;\u0026minus;\u0026thinsp;1,28\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2228026\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTEP1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e94,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,475\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,49\u0026thinsp;\u0026minus;\u0026thinsp;1,4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1130409\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOSGEP\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e53,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,978\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u0026thinsp;\u0026minus;\u0026thinsp;1,26\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers696\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNFKBIA\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,236\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,91\u0026thinsp;\u0026minus;\u0026thinsp;1,49\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers10133290\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCHURC1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e72,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,797\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u0026thinsp;\u0026minus;\u0026thinsp;1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7101\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eFOS\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e81,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,698\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u0026thinsp;\u0026minus;\u0026thinsp;1,29\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e14\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers861539\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eKLC1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e60,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,985\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u0026thinsp;\u0026minus;\u0026thinsp;1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1048943\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1A1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e96,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,587\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,44\u0026thinsp;\u0026minus;\u0026thinsp;1,68\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2472299\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1A1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintergenic_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e58,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,601\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,72\u0026thinsp;\u0026minus;\u0026thinsp;1,21\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers762551\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1A2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eA/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e57,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,901\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u0026thinsp;\u0026minus;\u0026thinsp;1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e15\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers976072\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePOLG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e71,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,393\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u0026thinsp;\u0026minus;\u0026thinsp;1,47\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1013358\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMPG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e68,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,08\u0026thinsp;\u0026minus;\u0026thinsp;1,81\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799801\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eERCC4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e67,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,044\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,01\u0026ndash;1,71\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers17855750\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAPOBR/IL27\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e96,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,021\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,18\u0026thinsp;\u0026minus;\u0026thinsp;4,74\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers153109\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL27\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e75,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,632\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u0026thinsp;\u0026minus;\u0026thinsp;1,4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1800566\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNQO1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e73,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,507\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u0026thinsp;\u0026minus;\u0026thinsp;1,46\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers689452\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNQO1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eG/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e86,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,56\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e16\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers899729\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eIL17C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e67,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,598\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u0026thinsp;\u0026minus;\u0026thinsp;1,39\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4791489\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMAP2K4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,251\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,64\u0026thinsp;\u0026minus;\u0026thinsp;1,12\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4796030\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eLIG3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e52,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,525\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u0026thinsp;\u0026minus;\u0026thinsp;1,18\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2333227\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMPO\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e68,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,275\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,66\u0026thinsp;\u0026minus;\u0026thinsp;1,12\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7209435\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMAP3K3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e64,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u0026thinsp;\u0026minus;\u0026thinsp;1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e17\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers11655650\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBIRC5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e56,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,485\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u0026thinsp;\u0026minus;\u0026thinsp;1,39\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers288980\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eROCK1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e71,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,57\u0026thinsp;\u0026minus;\u0026thinsp;0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers10775480\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSLC14A1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,363\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,87\u0026thinsp;\u0026minus;\u0026thinsp;1,46\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers10853535\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSLC14A1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e61,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,479\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u0026thinsp;\u0026minus;\u0026thinsp;1,43\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e18\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers723279\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSOCS6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,963\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u0026thinsp;\u0026minus;\u0026thinsp;1,31\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3746162\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSBNO2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e77,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,392\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u0026thinsp;\u0026minus;\u0026thinsp;1,51\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers5498\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eICAM5\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e62,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,664\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u0026thinsp;\u0026minus;\u0026thinsp;1,23\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers25487\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eXRCC1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e56,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,969\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u0026thinsp;\u0026minus;\u0026thinsp;1,2\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799782\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eXRCC1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e94,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,765\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,56\u0026thinsp;\u0026minus;\u0026thinsp;1,53\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e19\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers13181\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eERCC2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e65,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,092\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u0026thinsp;\u0026minus;\u0026thinsp;1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7265992\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSS\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e90,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,148\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,49\u0026thinsp;\u0026minus;\u0026thinsp;1,12\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers6088662\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSS\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eupstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,091\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u0026thinsp;\u0026minus;\u0026thinsp;1,04\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e20\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7260770\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSS\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintergenic_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e88,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,046\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u0026ndash;2,19\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e21\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2173962\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAP000253.1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e96,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,943\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,51\u0026thinsp;\u0026minus;\u0026thinsp;2,06\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e21\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2839488\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTFF1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eintron_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e50,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,904\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u0026thinsp;\u0026minus;\u0026thinsp;1,29\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4633\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003esynonymous_variant,NMD_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC/T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e57,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,152\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,65\u0026thinsp;\u0026minus;\u0026thinsp;1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4680\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003emissense_variant,NMD_transcript_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,081\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u0026thinsp;\u0026minus;\u0026thinsp;1,03\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1006771\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eDDTL\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3_prime_UTR_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e74,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,177\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,91\u0026thinsp;\u0026minus;\u0026thinsp;1,64\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1014971\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eregulatory_region_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e69,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,526\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,7\u0026thinsp;\u0026minus;\u0026thinsp;1,2\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e22\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers5751222\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP2D6\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003edownstream_gene_variant\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT/A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\"\u003e\n\u003cp\u003e87,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,823\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u0026thinsp;\u0026minus;\u0026thinsp;1,36\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003ctfoot\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"11\"\u003eChr: Chromosome; SNP: Single Nucleotide Polymorphism ; P: P value for Fisher Test; OR: Odds ratio; 95% CI: Confidence Interval\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tfoot\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ch2\u003eSnp Genotyping\u003c/h2\u003e\n\u003cp\u003eSNP genotyping was performed by NGS on the Ion Torrent Proton sequencer (Life Technologies, Ion Torrent technology). The GeneRead DNAseq Panel PCR Kit V2 (Qiagen) was used for the amplification of the targeted SNPs. The Gene Readprimers provided in different three pools. The samples were all re-quantified by Picogreen (using Fluoroscan) and normalized to 5ng/ul and 20 ng of each sample was plated into 3 daughter plates for the analysis of each group of primers. A validated in-house protocol was used to perform multiplex PCRs in 10 \u0026micro;L reaction volumes, containing 20 ng DNA, 60 nM of each primer pool and 0.73 \u0026micro;L of HotStarTaq enzyme. Amplification was carried out in a 96-well format plates using the standard conditions recommended by Qiagen: 15 min at 95\u0026deg;C and 22 cycles of 15 s at 95\u0026deg;C and 4 min at 60\u0026deg;C and 10 min at 72\u0026deg;C. Amplification products from the same sample were pooled purified using paramagnetic Serapure beads at 1.8X and quantified with the Qubit DNA high-sensitivity assay kit (Invitrogen Corporation). Barcoded libraries were prepared from 10ul of purified products and as previously described [\u003cspan class=\"CitationRef\"\u003e24\u003c/span\u003e]. For template preparation, the barcoded libraries were pooled in equimolar concentrations and 7 \u0026micro;L of 100 pM was subsequently used for emulsion PCR (emPCR) using the Ion Torrent Template Ion PI Hi-Q OT2 200 kit on the Ion OneTouch2 Instrument (Thermo Fisher Scientific). The sequencing reaction was performed on an Ion Proton System using Life Technologies' Ion PI\u0026trade; Chip Kit v3 and Ion PI\u0026trade; Hi-Q\u0026trade; Sequencing 200 Kit (Thermoscience Fisher Scientific) \u003cstrong\u003e(\u003c/strong\u003eFig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e\u003cstrong\u003e).\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ch2\u003eBioinformatics Analyses\u003c/h2\u003e\n\u003cp\u003ePrimary analyses were done using the Torrent_Suite 5.6.0 and included signal processing, base calling, reads alignment to the human genome reference 19 (Genome Reference Consortium GRCh37), quality control of mapping and coverage analysis, and variant calling. Subsequently, a list of detected sequence variants, including SNPs and small insertions/deletions, was imported into (Thermo Fisher Scientific) for annotation. The GeneRead data analysis workflow runs the GATK Variant Annotator program using the TVC output to populate the INFO field in the VCF file with the parameters necessary for downstream filtering. The INFO field of the GATK Unified Genotyper output already contains all the necessary parameters. Alignments were visually verified with the Integrative Genomics Viewer (IGV) v2.3. A combination of SnpEff v4.3, SnpSift v4.3 were used for annotation and filtration, and PLINK and in-house algorithms (R packages \u0026hellip;) were used for analysis. QC filtered variants were then merged, annotated, and filtered using various databases including, ClinVar (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://www.ncbi.nlm.nih.gov/clinvar/\u003c/span\u003e\u003c/span\u003e), HGMD (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttp://www.hgmd.cf.ac.uk/ac/index.php\u003c/span\u003e\u003c/span\u003e), and dbSNP (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.ncbi.nlm.nih.gov/snp/\u003c/span\u003e\u003c/span\u003e).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eAll assays were performed using DNA samples from a total of 544 cases and controls and duplicated samples for quality control. Only 40 samples (40/544; 7.35%) failed the library preparation and were excluded from the analysis. In this series, two runs led to 75% and 88% ISP loading and to the generation of total bases of 4.33 and 11.4 Gigabases for total bases of 33, 329, 31 and 84,548,378 respectively, 99% of which aligned to the reference genome (Hg19) \u003cstrong\u003e(\u003c/strong\u003eFig. \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e\u003cstrong\u003e).\u003c/strong\u003e This analysis provided high analytical sensitivity and allowed detecting SNPs. Using this approach, we have generated molecular profiles of a large number of individuals and identified specific BCa variations.\u003c/p\u003e\n\u003cp\u003eAmong the 139 retained SNP (Table \u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e\u003cstrong\u003e)\u003c/strong\u003e nine minor alleles were significantly inversely associated with bladder cancer development [\u003cstrong\u003ers162555\u003c/strong\u003e (CYP1B1*C), \u003cstrong\u003ers2228000\u003c/strong\u003e (XPC*A), \u003cstrong\u003ers10936599\u003c/strong\u003e (ACTRT3*T), \u003cstrong\u003ers710521\u003c/strong\u003e (TP63*C), \u003cstrong\u003ers3752645\u003c/strong\u003e (PRKAR2B*A), \u003cstrong\u003ers804276\u003c/strong\u003e and \u003cstrong\u003ers4639\u003c/strong\u003e (NEIL2*A and NEIL2*G), \u003cstrong\u003ers4881400\u003c/strong\u003e (AKR1C3*G) and \u003cstrong\u003ers288980\u003c/strong\u003e (ROCK1*T)]. When we used the co-dominant model (the reference group is composed of subjects with homozygous genotype for major allele) we also found a statistically significant inverse association for heterozygous genotypes of \u003cem\u003eACTRT3\u003c/em\u003e (rs10936599), \u003cem\u003eTP63\u003c/em\u003e (rs710521), \u003cem\u003eCYP3A4\u003c/em\u003e (\u003cstrong\u003ers2740574)\u003c/strong\u003e, \u003cem\u003eBLNK\u003c/em\u003e (\u003cstrong\u003ers3789928)\u003c/strong\u003e and \u003cem\u003eCOMT\u003c/em\u003e (\u003cstrong\u003ers4680)\u003c/strong\u003e (OR1\u0026thinsp;=\u0026thinsp;0.51, 0.62, 0.61, 0.55, and 0.66 respectively) or homozygous genotypes of \u003cem\u003eCYP1B1\u003c/em\u003e (rs162555), \u003cem\u003eXPC\u003c/em\u003e (\u003cstrong\u003ers2228000)\u003c/strong\u003e, \u003cem\u003eNEIL2\u003c/em\u003e (\u003cstrong\u003ers4639)\u003c/strong\u003e, \u003cem\u003eNAT2\u003c/em\u003e (\u003cstrong\u003ers1799930)\u003c/strong\u003e, \u003cem\u003eAKR1C3\u003c/em\u003e (\u003cstrong\u003ers4881400)\u003c/strong\u003e and \u003cem\u003eROCK1\u003c/em\u003e (\u003cstrong\u003ers288980)\u003c/strong\u003e (OR2\u0026thinsp;=\u0026thinsp;0.36, 0.12, 0.49, 0.38, 0.4 and 0.42 respectively) \u003cstrong\u003e(\u003c/strong\u003eTable \u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003e\u003cstrong\u003e).\u003c/strong\u003e However six minor alleles in six genes were significantly associated with increased risk of bladder cancer development: \u003cem\u003eMPG\u003c/em\u003e \u003cstrong\u003e(rs1013358 T\u0026thinsp;\u0026gt;\u0026thinsp;C)\u003c/strong\u003e, \u003cem\u003eGSTA4\u003c/em\u003e (\u003cstrong\u003ers17614751 G\u0026thinsp;\u0026gt;\u0026thinsp;A)\u003c/strong\u003e; \u003cem\u003eGSS\u003c/em\u003e \u003cstrong\u003e(rs7260770 G\u0026thinsp;\u0026gt;\u0026thinsp;A);\u003c/strong\u003e \u003cem\u003eVPS37C/\u003c/em\u003eCD5 \u003cstrong\u003e(rs7104333 G\u0026thinsp;\u0026gt;\u0026thinsp;A)\u003c/strong\u003e; \u003cem\u003eAPOBR\u003c/em\u003e/\u003cem\u003eIL27\u003c/em\u003e \u003cstrong\u003e(rs17855750 A\u0026thinsp;\u0026gt;\u0026thinsp;C)\u003c/strong\u003e; and \u003cem\u003eERCC4\u003c/em\u003e \u003cstrong\u003e(rs1799801 T\u0026thinsp;\u0026gt;\u0026thinsp;C)\u003c/strong\u003e. These aggravating effects were attributed to homozygous genotypes for \u003cem\u003eVPS37C\u003c/em\u003e (\u003cstrong\u003ers7104333\u003c/strong\u003e, A/A) or MPG (\u003cstrong\u003ers1013358\u003c/strong\u003e, C/C) genes \u003cstrong\u003e(\u003c/strong\u003eOR2\u0026thinsp;=\u0026thinsp;2.53 and 2.34 respectively) or to the heterozygous genotype for ARNT gene (rs1889740, rs2228099, rs2256355, rs2864873), GSTA4 (rs17614751) and APOBR/IL27 (rs17855750) with OR1 respectively estimated at 1.99, 2.00, 2.00, 1.47, 1.96 and 2.27 compared to reference group. When comparing the distribution of these unfavorable genotypes according to exposition to environmental risk factors \u003cstrong\u003e(\u003c/strong\u003eTables \u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003e and \u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e), we have found that non\u0026ndash;smokers patients harboring heterozygous genotypes for ARNT/rs2864873 A\u0026thinsp;\u0026gt;\u0026thinsp;G, ARNT/ rs1889740 (C\u0026thinsp;\u0026gt;\u0026thinsp;T) or GSTA4/rs17614751 (G to A) were respectively at 2.775, 3.069 and 6.608 \u0026ndash;folds increased risk of Bca development compared to non-smokers controls with wild genotypes. When we analyzed genotypic distribution in heavy smokers (BCa and Controls smoking more than 20PY) we found that smoker\u0026rsquo;s patients harboring \u003cem\u003eARNT\u003c/em\u003e CT (rs1889740), \u003cem\u003eARNT\u003c/em\u003e CG (rs2228099), \u003cem\u003eARNT\u003c/em\u003e TC (rs2864873) or \u003cem\u003eROCK1\u003c/em\u003e TC genotypes were respectively associated with 2.690, 2.864, 2.779 and 3.00 fold-increased risk of BCa. In the other hand we have found that \u003cem\u003eARNT\u003c/em\u003e CT (rs1889740), \u003cem\u003eARNT\u003c/em\u003e CG (rs2228099), \u003cem\u003eARNT\u003c/em\u003e TC (rs2864873) and \u003cem\u003eGSS\u003c/em\u003e GA genotypes were associated with an increased risk of BCa even in absence of professional risk factors (comparison of Non-exposed patients to Non-exposed controls). However when we compare genotypic distribution of unfavorable genotypes in exposed patients and controls according to professional risk factor, we observed that \u003cem\u003eARNT\u003c/em\u003e TT (rs1889740), \u003cem\u003eARNT\u003c/em\u003e GG (rs2228099), \u003cem\u003eARNT\u003c/em\u003e CC (rs2864873), \u003cem\u003eROCK1\u003c/em\u003e CC/CT genotypes were respectively associated with 12.000, 12.666, 12.666, 3.976, 3.960 fold-increased risk of BCa development.\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n\u003ctable id=\"Tab3\" border=\"1\"\u003e\u003ccaption\u003e\n\u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\n\u003cdiv class=\"CaptionContent\"\u003e\n\u003cp\u003eComparison of genotypic distribution between case and control groups\u003c/p\u003e\n\u003c/div\u003e\n\u003c/caption\u003e\u003ccolgroup\u003e\u003c/colgroup\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth colspan=\"4\" align=\"left\"\u003e\n\u003cp\u003eDominant model (DM)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"4\" align=\"left\"\u003e\n\u003cp\u003eRecessive model (RM)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth colspan=\"6\" align=\"left\"\u003e\n\u003cp\u003eCo-dominant model (CM)\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGene\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSNP\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eRaisonnement/\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAlleles\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMjAF\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e(95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e(95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ep-value \u0026yen;\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR\u003c/strong\u003e\u003csub\u003e\u003cstrong\u003eCD1\u003c/strong\u003e\u003c/sub\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e(95% CI)*1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR\u003c/strong\u003e \u003csub\u003e\u003cstrong\u003eCD2\u003c/strong\u003e\u003c/sub\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e(95% CI)*2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1889740\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,91\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2228099\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,98\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,94\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2256355\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,73\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2864873\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,47\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,45\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1B1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers162555\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eXPC\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2228000\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,54\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,52\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eACTRT3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers10936599\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,9\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTP63\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers710521\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,91\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,06\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,74\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers17614751\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP3A4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers2740574\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,06\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers804276\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,47\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,73\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,08\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,69\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,08\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4639\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,85\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799930\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,74\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4881400\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,91\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBLNK\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers3789928\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,78\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,06\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eVPS37C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7104333\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,73\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,54\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,13\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMPG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1013358\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,92\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,00\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,19\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eERCC4\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers1799801\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,91\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,09\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,81\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,71\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3,59\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAPOBR\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers17855750\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNA\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eROCK1\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers288980\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eT\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eC /T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,8\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSS\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers7260770\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,05\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,02\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,08\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2,62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4,6\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4633\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,03\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,57\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,07\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,47\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,27\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ers4680\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,01\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,92\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,04\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,71\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0,43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1,18\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003ctfoot\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"20\"\u003eP: P value; OR: Odds ratio; 95% CI: Confidence Interval, OR\u003csub\u003eCD1\u003c/sub\u003e: Heterozygous genotype VS Homozygous Wild genotype; OR\u003csub\u003eCD2\u003c/sub\u003e: Mutant homozygous genotype VS Homozygous wild genotype; p-value \u0026yen;: P value for co-dominant model\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tfoot\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n\u003ctable id=\"Tab4\" style=\"width: 1151px;\" border=\"1\"\u003e\u003ccaption\u003e\n\u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\n\u003cdiv class=\"CaptionContent\"\u003e\n\u003cp\u003eComparison of genotypes distribution of significant unfavorable SNP from \u0026ldquo;Tunisian BCHP\u0026rdquo; panel in bladder cancer patients according to tobacco status\u003c/p\u003e\n\u003c/div\u003e\n\u003c/caption\u003e\u003ccolgroup\u003e\u003c/colgroup\u003e\n\u003cthead\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003cth style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 66px; height: 83px;\" rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eGenotypes\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 106px; height: 83px;\" colspan=\"4\" rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eControls\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 102px; height: 83px;\" colspan=\"4\" rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 115px; height: 48px;\" colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer (NE) Vs Controls (NE)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 115px; height: 48px;\" colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer (E) Vs Controls (E)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 136px; height: 48px;\" colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer (E) Vs Controls (NE)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 108px; height: 48px;\" colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBC\u0026thinsp;\u0026ge;\u0026thinsp;20PY VS Controls\u0026thinsp;\u0026ge;\u0026thinsp;20PY\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 108px; height: 48px;\" colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBC\u0026thinsp;\u0026ge;\u0026thinsp;20PY VS Controls NE\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003cth style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGene/Variant\u003c/strong\u003e\u003c/p\u003e\n\u003c/th\u003e\n\u003cth style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNE\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;20PY\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026ge;\u0026thinsp;20PY\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eE\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNE\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;20PY\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026ge;\u0026thinsp;20PY\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eE\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eP\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eP\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eP\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eOR (95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs1889740 C\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCC\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e91\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e110\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.044\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3.069 (1.026\u0026ndash;9.184)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.009\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.896(1.169\u0026ndash;3.075)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.013\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.940(1.145\u0026ndash;3.287)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.690(1.430\u0026ndash;5.060)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.025\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.862(1.081\u0026ndash;3.207)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.254\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.053(0.595\u0026ndash;7.080)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.305\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.409(0.730\u0026ndash;2.716)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.453\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.783(0.414\u0026ndash;1.481)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.223\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.669(0.731\u0026ndash;3.810)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.488\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.792(0.409\u0026ndash;1.531)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs2228099 C\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCC\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e57\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e112\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.054\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.931(0.979\u0026ndash;8.771)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.007\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.932(1.189\u0026ndash;3.138)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.013\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.954(1.151\u0026ndash;3.316)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.864( 1.520\u0026ndash;5.396)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.021\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.893(1.096\u0026ndash;3.268)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.270\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.006(0.581\u0026ndash;6.925)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.283\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.434(0.741\u0026ndash;2.772)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.478\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.793(0.418\u0026ndash;1.505)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.190\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.738(0.760\u0026ndash;3.976)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.524\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.806( 0.415\u0026ndash;1.564)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs2256355 T\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTT\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e54\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTC\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e112\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.207\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.045(0.671\u0026ndash;6.228)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.010\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.901(1.165-3.100)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.230\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.414(0.802\u0026ndash;2.491)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.779(1.475\u0026ndash;5.237)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.280\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.378( 0.769\u0026ndash;2.470)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCC\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.970\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.976(0.283\u0026ndash;3.371)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.253\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.461(0.761\u0026ndash;2.803)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.008\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.426(0.225\u0026ndash;0.805)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.130\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.891(0.828\u0026ndash;4.318)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.014\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.439(0.227\u0026ndash;0.849)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs2864873 A\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAA\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e71\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e81\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e96\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.040\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.775(1.044\u0026ndash;7.377)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.317\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.265(0.797\u0026ndash;2.008)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.157\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.439(0.869\u0026ndash;2.382)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.061\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.790(0.971\u0026ndash;3.298)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.255\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.351(0.803\u0026ndash;2.270)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGG\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.773\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.214(0.324\u0026ndash;4.549)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.855\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.069(0.5189 to 2.204)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.111\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.577(0.293\u0026ndash;1.135)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.735\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.172(0.466\u0026ndash;2.950)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.087\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.538(0.265\u0026ndash;1.094)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1B1 rs162555 (T to C)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e74\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e106\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e122\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e47\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.179\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.521 (50.201\u0026ndash;1.349)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.509\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.856 ( 0.540\u0026ndash;1.357)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.335\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.791 (0.491\u0026ndash;1.274)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.350\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.754 (0.417\u0026ndash;1.362)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.272\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.758 (0.4635 to 1.242)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.000\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1,000 (0.190\u0026ndash;5.240)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.007\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.233 (0.079\u0026ndash;0.680)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.099\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.368 ( 0.112\u0026ndash;1.209)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.135 (0.025\u0026ndash;0.731)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.030\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.169 (0.0342 to 0.842)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eXPC rs2228000 (G to A)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e114\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e134\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.127\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.442 (0.154\u0026ndash;1.262)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.921\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.024 ( 0.632\u0026ndash;1.661)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.725\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.914 (0.5567 to 1.503)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.892\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.957 ( 0.5125 to 1.790)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.649\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.887 (0.5306 to 1.484)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.779\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.644 (0.029\u0026ndash;13.924)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.090 (0.020\u0026ndash;0.408)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.538\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.537 ( 0.074\u0026ndash;3.894)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.012\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.122 (0.023\u0026ndash;0.632)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.649\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.631 (0.0870 to 4.583)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTP63,\u0026nbsp;P3H2 rs710521 T/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e81\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e107\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e130\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.195\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.552 (0.225\u0026ndash;1.355)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.257\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.763 (0.477\u0026ndash;1.218)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.453 (0.280\u0026ndash;0.733)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.115\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.619 (0.341\u0026ndash;1.123)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.004\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.486 (0.2960 to 0.799)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.874\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.145 (0.210\u0026ndash;6.237)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.482\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.701 (0.259\u0026ndash;1.890)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.409\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.634 (0.215\u0026ndash;1.868)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.282\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.523 (0.160\u0026ndash;1.704)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.503\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.685 (0.2265 to 2.074)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eACTRT3/MYNN rs10936599 (C to T)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e135\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e159\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.9543\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.974 (0.400-2.369)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.026\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.549 ( 0.323\u0026ndash;0.933)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.416 ( 0.244\u0026ndash;0.711)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.041\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.497 (0.254\u0026ndash;0.973)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.418 (0.2399 to 0.730)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.903\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.827 (0.038\u0026ndash;17.969)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.384\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.597 (0.187\u0026ndash;1.905)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.663\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.434 (0.282\u0026ndash;7.271)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.052\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.260 (0.067\u0026ndash;1.014)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.892\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.125 (0.2015 to 6.291)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA4 rs17614751(G to A)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e114\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e126\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e168\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e199\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.017\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6.608 (1.385\u0026ndash;31.530)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.894\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.949 (0.442\u0026ndash;2.038)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.051\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3.437 ( 0.990-11.922)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.646\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.275 (0.451\u0026ndash;3.601)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.034\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3.845 (1.1014 to 13.424)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.431\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e4.872 (0.094-251.797)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.457\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e3.170 ( 0.151\u0026ndash;66.582)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.497\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e2.869 (0.136\u0026ndash;60.298)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.683\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1.884 ( 0.089\u0026ndash;9.791)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.431\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e3.397 (0.1616 to 71.433)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP3A4 rs2740574 C\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.010\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.072(0.009\u0026ndash;0.542)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.379\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.568(0.161-2.000)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.693\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.788(0.241-.571)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.358\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.357(0.039\u0026ndash;3.211)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.900\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.087(0.295\u0026ndash;3.999)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e44\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e113\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e133\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.445\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.555(0.122\u0026ndash;2.516)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.724\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.801(0.233\u0026ndash;2.744)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.695\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.259(0.396-4.000)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.623\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.579(0.065\u0026ndash;5.114)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.408\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.712(0.477\u0026ndash;6.134)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePRKAR2B rs3752645 (G to A)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e57\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e115\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e149\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e174\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.629\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.769 ( 0.265\u0026ndash;2.231)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.554\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.826 ( 0.438\u0026ndash;1.556)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.019\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.486 ( 0.265\u0026ndash;0.891)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.472\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.739 (0.324\u0026ndash;1.685)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.011\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.431 (0.2259 to 0.824)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.878\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.786 (0.036\u0026ndash;16.971)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.119\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.094 (0.004\u0026ndash;1.847)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.141\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.101 ( 0.004\u0026ndash;2.135)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.640\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.391 (0.007\u0026ndash;19.952)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.170\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.118 (0.0056 to 2.494)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2 rs804276 G/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e82\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e99\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.005\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.257 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height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.540( 0.321\u0026ndash;0.906)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.063\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.228 ( 0.047\u0026ndash;1.085)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.885\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.947 (0.455\u0026ndash;1.969)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.024\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.435 ( 0.211\u0026ndash;0.897)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.988\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.993 (0.379\u0026ndash;2.599)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.049\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.475( 0.226\u0026ndash;0.998)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2 rs4639 A/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e82\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e81\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.017\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.319 (0.124\u0026ndash;0.819)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.795\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.064 (0.664\u0026ndash;1.703)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.014\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.532 ( 0.320\u0026ndash;0.884)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.625\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.858 (0.4663 to 1.581)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.017\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.529(0.313\u0026ndash;0.892)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.091\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.315 (0.082\u0026ndash;1.205)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.194\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.639 ( 0.325\u0026ndash;1.256)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.005\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.364 (0.179\u0026ndash;0.739)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.213\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.578 (0.244\u0026ndash;1.369)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.007\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.369(0.177\u0026ndash;0.769)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2 rs1799930 G\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e32\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e102\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e54\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e78\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.329\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.549(0.642\u0026ndash;3.738)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.630\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.118(0.709\u0026ndash;1.763)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.842\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.050(0.647\u0026ndash;1.702)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.813\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.074( 0.593\u0026ndash;1.945)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.596\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.144(0.695\u0026ndash;1.881)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.637\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.678(0.135\u0026ndash;3.398)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.071\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.441(0.181\u0026ndash;1.075)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.014\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.329(0.135-0.800)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.051\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.337(0.113\u0026ndash;1.006)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.018\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.314(0.120\u0026ndash;0.821)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3 rs4881400 T\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e101\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e123\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.291\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.597(0.229\u0026ndash;1.556)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.822\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.948(0.597\u0026ndash;1.506)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.592\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.874(0.535\u0026ndash;1.428)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.407\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.298(0.699\u0026ndash;2.410)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.772\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.928(0.559\u0026ndash;1.538)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.442\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.538(0.111\u0026ndash;2.609)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.079\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.390(0.136\u0026ndash;1.115)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.005\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.236(0.085\u0026ndash;0.651)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.288\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.510(0.147\u0026ndash;1.764)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.016\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.287(0.104\u0026ndash;0.796)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBLNK rs3789928 G/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e83\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.767\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.864 (0.329\u0026ndash;2.269)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.019\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.541 (0.323\u0026ndash;0.906)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.022\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.511(0.288\u0026ndash;0.908)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.035\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.484 (0.246\u0026ndash;0.952)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.029\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.517(0.286\u0026ndash;0.935)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.031\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.166 (0.032\u0026ndash;0.853)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.926\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.030 ( 0.546\u0026ndash;1.941)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.034\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.505 ( 0.267\u0026ndash;0.952)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.620\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.250 ( 0.516\u0026ndash;3.031)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.050\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.521(0.271\u0026ndash;1.001)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 159px; height: 48px;\" colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eVPS37C/CD5 rs7104333 G\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e32\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e90\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.055\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.373(0.136\u0026ndash;1.025)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.056\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.587(0.340\u0026ndash;1.013)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.477(0.256\u0026ndash;0.890)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.126\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.573(0.281\u0026ndash;1.169)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.027\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.487(0.256\u0026ndash;0.923)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e49\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.013\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.234(0.074\u0026ndash;0.741)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.012\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.457(0.248\u0026ndash;0.842)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.000\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.275(0.141\u0026ndash;0.535)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.342\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.681(0.308\u0026ndash;1.504)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.361(0.185\u0026ndash;0.706)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMPG rs1013358 C/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e81\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.184\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.410(0.110\u0026ndash;1.529)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.073\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.495(0.229\u0026ndash;1.069)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.421\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.716(0.317\u0026ndash;1.616)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.255\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.562(0.208\u0026ndash;1.5167)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.396\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.697(0.303\u0026ndash;1.603)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.153\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.411(0.121\u0026ndash;1.391)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.092\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.519(0.241\u0026ndash;1.115)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.047\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.451(0.205\u0026ndash;0.989)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.202\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.529(0.198\u0026ndash;1.409)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.045\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.441(0.197\u0026ndash;0.985)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eERCC4 rs1799801 T/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e71\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e87\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.421\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.450 (0.586\u0026ndash;3.585)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.4768\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.182 (0.745\u0026ndash;1.875)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.587\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.141 ( 0.707\u0026ndash;1.843)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.568\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.189 (0.655\u0026ndash;2.156)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.628\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.131 (0.6868 to 1.863)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.093\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3.314 (0.817\u0026ndash;13.438)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.188\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.637 ( 0.784\u0026ndash;3.414)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.034\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.631 (1.074\u0026ndash;6.446)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.068\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.622 (0.928\u0026ndash;7.409)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.011\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3.195 (1.2978 to 7.870)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAPOBR rs17855750 A/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e111\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e132\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e151\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e178\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.757\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.711(0.082\u0026ndash;6.167)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.059\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.471 ( 0.965\u0026ndash;6.326)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.128\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.078 ( 0.809\u0026ndash;5.335)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.198\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.295 (0.646\u0026ndash;8.150)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.173\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.960 (0.7433 to 5.169)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.475\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e4.207 ( 0.081-216.956)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.624\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e2.226 ( 0.090\u0026ndash;55.100)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.701\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1.873 (0.075\u0026ndash;46.406)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.874\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1.297 (0.052\u0026ndash;32.260)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.628\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e2.207 (0.0891 to 54.710)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eROCK1 rs288980 T/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.160\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7.941(0.440-143.219)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.035\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.229(1.056\u0026ndash;4.705)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.289\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.568(0.681\u0026ndash;3.606)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.014\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e3.00(1.239\u0026ndash;7.26)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.382\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.459(0.624\u0026ndash;3.408)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e32\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e108\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.195\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e6.696(0.377-118.925)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.017\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.400(1.163\u0026ndash;4.951)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.316\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.509(0.674\u0026ndash;3.379)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.018\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.750(1.182\u0026ndash;6.396)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.510\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.318( 0.579-.998)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSS rs7260770 G/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e61\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e117\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e129\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e153\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.057\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e2.488 (0.970\u0026ndash;6.377)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.094\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.644 (0.918\u0026ndash;2.943)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.354\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.320 (0.732\u0026ndash;2.381)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.355\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.420 (0.674\u0026ndash;2.991)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.381\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.311 (0.7142 to 2.408)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 61px;\"\u003e\n\u003ctd style=\"width: 93px; height: 61px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.605\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1.843 (0.180-18.781)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.474\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e2.294 ( 0.235\u0026ndash;22.338)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.555\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.614 ( 0.121\u0026ndash;3.107)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.820\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e1.302 (0.132\u0026ndash;12.794)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.702\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 61px;\" align=\"left\"\u003e\n\u003cp\u003e0.728 (0.1439 to 3.690)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT rs4633 C\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.833\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.108(0.424\u0026ndash;2.891)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.006\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.497(0.301\u0026ndash;0.821)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.036\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.580(0.348-.967)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.016\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.448(0.233\u0026ndash;0.861)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.016\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.523(0.308\u0026ndash;0.887)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.663\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e1.319(0.377\u0026ndash;4.606)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.075\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.573(0.310\u0026ndash;1.057)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.894\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.955(0.484\u0026ndash;1.883)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.160\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.561(0.250\u0026ndash;1.257)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.702\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.872(0.433\u0026ndash;1.756)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT rs4680 G\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 35px;\"\u003e\n\u003ctd style=\"width: 93px; height: 35px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 35px;\" align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e63\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.919\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.953(0.376\u0026ndash;2.415)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.006\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.499(0.302\u0026ndash;0.826)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.548(0.329\u0026ndash;0.911)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.012\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.432(0.223\u0026ndash;0.835)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.013\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.514(0.304\u0026ndash;0.870)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 48px;\"\u003e\n\u003ctd style=\"width: 93px; height: 48px;\" align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd style=\"width: 66px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e32\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 21px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e38\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.992\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.993(0.268\u0026ndash;3.679)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 39px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.040\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.530(0.289\u0026ndash;0.973)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.998\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 104px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.999(0.502\u0026ndash;1.988)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.074\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.480(0.214\u0026ndash;1.074)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.757\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76px; height: 48px;\" align=\"left\"\u003e\n\u003cp\u003e0.894(0.438\u0026ndash;1.821)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003ctfoot\u003e\n\u003ctr style=\"height: 13px;\"\u003e\n\u003ctd style=\"width: 987px; height: 13px;\" colspan=\"20\"\u003eP: P value; OR: Odds ratio; 95% CI: Confidence Interval; NE: Non Smoker; E: Smoker\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tfoot\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cdiv class=\"gridtable\"\u003e\u0026nbsp;\n\u003ctable id=\"Tab5\" border=\"1\"\u003e\u003ccaption\u003e\n\u003cdiv class=\"CaptionNumber\"\u003eTable 5\u003c/div\u003e\n\u003cdiv class=\"CaptionContent\"\u003e\n\u003cp\u003eComparison of genotypes distribution of significant unfavorable SNP from \u0026ldquo;Tunisian BCHP\u0026rdquo; panel in bladder cancer patients according to professional risk factors\u003c/p\u003e\n\u003c/div\u003e\n\u003c/caption\u003e\u003ccolgroup\u003e\u003c/colgroup\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eControls\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer (NE) Vs Controls (NE)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer (E) Vs Controls (E)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eBladder cancer (E) Vs Controls (NE)\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGene/Variant\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGenotypes\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNon Exposed (NE)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eExposed\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNon Exposed (NE)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eExposed\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003ep\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eOR \u003cstrong\u003e(95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003ep\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eOR \u003cstrong\u003e(95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003ep\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eOR \u003cstrong\u003e(95% CI)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e(E)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003e(E)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs1889740 C\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e90\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.010\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.934(1.168\u0026ndash;3.203)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.269\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.671(0.670\u0026ndash;4.166)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.537(1.374\u0026ndash;4.685)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.710\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.882(0.455\u0026ndash;1.710)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.022\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12.000(1.416-101.672)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.123\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.764( 0.856\u0026ndash;3.635)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs2228099 C\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e66\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.010\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.929(1.163\u0026ndash;3.201)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.207\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.803(0.720\u0026ndash;4.518)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.002\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.615(1.405\u0026ndash;4.864)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.724\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.887(0.456\u0026ndash;1.725)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12.666(1.491-107.602)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.108\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.821(0.876\u0026ndash;3.783)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs2256355 T\u0026thinsp;\u0026gt;\u0026thinsp;C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e86\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e87\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e46\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.014\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.889(1.133\u0026ndash;3.149)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.207\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.803(0.720\u0026ndash;4.518)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.003\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.526(1.357\u0026ndash;4.701)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e20\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.933\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.972(0.507\u0026ndash;1.865)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12.666(1.491-107.602)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.135\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.745(0.840\u0026ndash;3.625)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eARNT rs2864873 A\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e101\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e62\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.029\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.713(1.055\u0026ndash;2.780)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.926\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.960(0.403\u0026ndash;2.283)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.222\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.404(0.813\u0026ndash;2.424)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.636\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.843(0.415\u0026ndash;1.710)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.180\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4.333(0.507\u0026ndash;37.030)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.710\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.863(0.397\u0026ndash;1.875)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP1B1 rs162555 (T to C)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e120\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e72\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.315\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.786 (0.4920-.257)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.666\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.814 (0.3199\u0026ndash;2.072)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.050\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.581 (0.337-1.000)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.221\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.183\u0026ndash;1.482\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.024\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.033 (0.0017\u0026ndash;0.648)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.054\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.062 (0.003\u0026ndash;1.058)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eXPC rs2228000 (G to A)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e146\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e79\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.811\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.059 (0.6562\u0026ndash;1.712)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.858\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.915 (0.349\u0026ndash;2.397)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.782\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.925 (0.533\u0026ndash;1.604)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.090\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.168 (0.021\u0026ndash;1.325\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.016\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.027 (0.001\u0026ndash;0.516)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.126\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.108 (0.0063\u0026ndash;1.877)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eTP63,\u0026nbsp;P3H2 rs710521 T/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e124\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e78\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e26\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.071\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.643 (0.3980\u0026ndash;1.038)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.026\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.367 (0.152\u0026ndash;0.890)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.169\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.683 (0.397\u0026ndash;1.175)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.455\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.662 (0.2247\u0026ndash;1.952)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.390\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.452 (0.074\u0026ndash;2.765)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.678\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.779 ( 0.2405\u0026ndash;2.529)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eACTRT3/MYNN rs10936599 (C to T)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e150\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e95\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e65\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e70\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.007\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.473 (0.2730\u0026ndash;0.822)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.782\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.861 (0.298\u0026ndash;2.485)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.041\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.527 ( 0.284\u0026ndash;0.976)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.941\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.947 ( 0.2213\u0026ndash;4.056)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.104\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.215 (0.033\u0026ndash;1.377)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.925\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.923 (0.174\u0026ndash;4.881)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSTA4 rs17614751(G to A)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e213\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e27\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e107\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e77\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.165\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.824 (0.779\u0026ndash;4.271)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.632\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.701 (0.163-3.000)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.530\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.383 (0.501\u0026ndash;3.813)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.275\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5.958 (0.240-147.496)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.606\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.354 (0.006\u0026ndash;18.319)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.613\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.754 (0.054-140.045)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCYP3A4 rs2740574 C\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.320\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.545(0.165\u0026ndash;1.802)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.656\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.583(0.054\u0026ndash;6.251)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.561\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.658(0.160\u0026ndash;2.699)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e132\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.959\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.030(0.326\u0026ndash;3.254)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.902\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.156(0.112\u0026ndash;11.850)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.800\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.191(0.305\u0026ndash;4.653)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePRKAR2B rs3752645 (G to A)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e178\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e101\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e18\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.322\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.737 (0.4041\u0026ndash;1.346)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.535\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.666 (0.184\u0026ndash;2.404)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.045\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.441 (0.198\u0026ndash;0.984)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.275\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.195 (0.010\u0026ndash;3.666)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.185\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.112 (0.004\u0026ndash;2.851)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.371\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.262 (0.014\u0026ndash;4.940)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2 rs804276 G/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e93\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e64\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e100\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e37\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.079\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.653 (0.406\u0026ndash;1.050)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.658\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.822 (0.345\u0026ndash;1.959)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.644\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.882 (0.518-1.500)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e32\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e10\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.046\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.454 (0.208\u0026ndash;0.988)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.858\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.166 (0.214\u0026ndash;6.336)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.156\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.521 (0.212\u0026ndash;1.282)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNEIL2 rs4639 A/G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e90\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e94\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.273\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.766 ( 0.475\u0026ndash;1.234)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.335\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.647 (0.267\u0026ndash;1.566)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.352\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.775 (0.453\u0026ndash;1.325)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.016\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.402 (0.191\u0026ndash;0.844)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.595\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.666 (0.149\u0026ndash;2.978)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.025\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.365 ( 0.151\u0026ndash;0.883)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNAT2 rs1799930 G\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e111\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e42\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e57\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.311\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.269(0.799\u0026ndash;2.015)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.603\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.2662( 0.519\u0026ndash;3.089)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.578\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.158(0.690\u0026ndash;1.943)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.124\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.475(0.184\u0026ndash;1.226)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.060\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.178(0.029\u0026ndash;1.076)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.040\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.211(0.048\u0026ndash;0.932)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAKR1C3 rs4881400 T\u0026thinsp;\u0026gt;\u0026thinsp;G\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e121\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e22\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e68\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e58\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e85\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.802\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.942(0.590\u0026ndash;1.503)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.191\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.181( 0.677\u0026ndash;7.025)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.044\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.564(0.323\u0026ndash;0.985)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.241\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.561(0.214\u0026ndash;1.474)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.065\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.189(0.032\u0026ndash;1.110)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.046\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.219(0.049\u0026ndash;0.974)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eBLNK rs3789928 G/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e8\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e119\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e32\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.059\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.603 (0.356\u0026ndash;1.020)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.103\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.449 (0.171\u0026ndash;1.178)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.008\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.448 (0.246\u0026ndash;0.814)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.064\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.549 (0.291\u0026ndash;1.037)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.395\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.866 (0.442\u0026ndash;7.873)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.172\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.625 (0.318\u0026ndash;1.228)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eVPS37C/CD5 rs7104333 G\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e40\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e105\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e15\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e48\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.004\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.446(0.256\u0026ndash;0.775)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.779\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.857(0.291\u0026ndash;2.522)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.529\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.816(0.433\u0026ndash;1.537)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.001\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.365(0.199\u0026ndash;0.669)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.319\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.539(0.160\u0026ndash;1.818)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.017\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.404(0.192\u0026ndash;0.851)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eMPG rs1013358 C/T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e84\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e41\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.031\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.436(0.205\u0026ndash;0.927)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.431\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.605(0.173\u0026ndash;2.116)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.113\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.520(0.232\u0026ndash;1.167)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e124\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e59\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e33\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.425(0.206\u0026ndash;0.878)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.945\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.047(0.276\u0026ndash;3.974)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.005\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.323(0.144\u0026ndash;0.722)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eERCC4 rs1799801 T/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e109\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e51\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e34\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e97\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e55\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.422\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.211 (0.7581 to 1.937)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.594\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.267 (0.5304 to 3.026)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.600\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.156 (0.670\u0026ndash;1.996)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.339\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.462 (0.670\u0026ndash;3.189)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.080\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6.588 (0.795\u0026ndash;54.560)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.033\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.362 (1.071\u0026ndash;5.207)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAPOBR rs17855750 A/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e214\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e29\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e105\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e76\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e14\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.023\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.593 (1.138\u0026ndash;5.910)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.452\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.289(0.264\u0026ndash;19.849)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.413\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.535(0.549\u0026ndash;4.296)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.723\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.033 (0.040-103.184)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.929\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.156(0.045\u0026ndash;29.208)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.193\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e8.411(0.339-208.705)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eROCK1 rs288980 T/C\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e9\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e88\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e36\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.325\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.520(0.659\u0026ndash;3.503)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3.976 (1.239\u0026ndash;12.756)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.064\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.863(0.937\u0026ndash;8.751)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e109\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.116\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.912(0.850\u0026ndash;4.300)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.044\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3.960 (1.035\u0026ndash;15.154)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.071\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.761(0.914\u0026ndash;8.341)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eGSS rs7260770 G/A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e186\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e89\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e,\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e28\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e23\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.070\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.671 (0.957\u0026ndash;2.919)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.235\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.916 (0.654\u0026ndash;5.609)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.020\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.037 (1.116\u0026ndash;3.716)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.960\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.044 (0.187\u0026ndash;5.812)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.667\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.421 (0.008\u0026ndash;21.829)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.474\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.342 (0.018\u0026ndash;6.454)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT rs4633 C\u0026thinsp;\u0026gt;\u0026thinsp;T\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCC\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e71\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e43\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eCT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e109\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e52\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.352\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.787(0.476\u0026ndash;1.302)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.008\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.253( 0.090\u0026ndash;0.707)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.057\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.576(0.326\u0026ndash;1.018)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eTT\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.689\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.880(0.472\u0026ndash;1.642)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.969\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.971(0.216\u0026ndash;4.363)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.449\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.766(0.384\u0026ndash;1.526)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eCOMT rs4680 G\u0026thinsp;\u0026gt;\u0026thinsp;A\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGG\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e69\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e7\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eGA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e111\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e19\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e50\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e31\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.1489\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.690(0.417\u0026ndash;1.141)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.027\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.326( 0.121\u0026ndash;0.880)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.039\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.550(0.311\u0026ndash;0.972)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAA\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e45\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e17\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.525\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.817(0.439\u0026ndash;1.522)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.814\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.850(0.218\u0026ndash;3.306)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.402\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.744(0.373\u0026ndash;1.485)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003ctfoot\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"12\"\u003eP: P value for Fisher Test; OR: Odds ratio; 95% CI: Confidence Interval; NE: Non Exposed; E: Exposed\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tfoot\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFinally the decision-tree analysis produced a three major BCa class. All of these classes were characterized by an intensity of tobacco use\u0026thinsp;\u0026ge;\u0026thinsp;20 pack years (PY) and subdivided according to the genotype of the CYP1A2 C\u0026thinsp;\u0026gt;\u0026thinsp;A variation (rs762551). The first class (58/249) is defined by the presence of CYP1A2 CC or CYP1A2 CA genotype and also defined by others 8 variations: ARNT C\u0026thinsp;\u0026gt;\u0026thinsp;G (rs2228099), CYP1B1 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs162555), SOD1 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs2173962), ROCK1 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs288980), IL10 A\u0026thinsp;\u0026gt;\u0026thinsp;T (rs1800890), LY96 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs17226566), AICDA T\u0026thinsp;\u0026gt;\u0026thinsp;G (rs11046349) and MAP2K4 C\u0026thinsp;\u0026gt;\u0026thinsp;T (rs4791489). The second class of BCa group (31/249) is only defined by the intensity of tobacco use\u0026thinsp;\u0026ge;\u0026thinsp;20PY and the inheritance of the \u003cstrong\u003ehomozygous genotype for\u003c/strong\u003e rs762551 in CYP1A2 (CYPA2 A/A), XPC GG or AG genotype (rs2228000, G\u0026thinsp;\u0026gt;\u0026thinsp;A), and MAP2K4 CC or CT genotype (rs4791489, C\u0026thinsp;\u0026gt;\u0026thinsp;T). The third class (25/249) of BCa patients was defined by rs762551 (CYP1A2 C/A or C/C genotype) and 6 other variables (ARNT rs2228099 C\u0026thinsp;\u0026gt;\u0026thinsp;G, MPO rs2333227 C\u0026thinsp;\u0026gt;\u0026thinsp;T, LY96 rs17226566 T\u0026thinsp;\u0026gt;\u0026thinsp;C, CCR2 rs391835 G\u0026thinsp;\u0026gt;\u0026thinsp;A; APOBEC3 rs1014971 C\u0026thinsp;\u0026gt;\u0026thinsp;T and CASP3 rs3087455 T\u0026thinsp;\u0026gt;\u0026thinsp;G) \u003cstrong\u003e(\u003c/strong\u003eFig. \u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e\u003cstrong\u003e).\u003c/strong\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eAs all complex diseases, BCa isn't one SNP/gene disorder. Rather, many SNPs with small effects may result in the impairment of key pathways involved in their pathophysiology. The identification of such SNP-signatures represents an analytical challenge requiring the appliance of novel comprehensive statistical approaches. To our knowledge, this is the first study on BCa in Tunisian population analyzing a large number of SNPs with NGS technique. Indeed, in this study, we report the development and validation of the targeted amplification-based NGS panel analyzed on the Ion Torrent Proton Platform. This panel is named BCHP (BCa Heredity Panel) and used for detecting clinically useful genetic variations associated with the development of BCa in a total of 249 patients and 255 controls. After filtration the BCHP was composed of 139 SNPs in 97 genes. These SNPs are located in many different regions: introns sites (\u003cem\u003eBCL10, GSTM4, GSTM3\u003c/em\u003e...), regulatory region (\u003cem\u003eTP63, NAT2, GSTP1, GSTP2\u003c/em\u003e), up and downstream regulation genes sequences (\u003cem\u003eGSTA4, NAT2 APOBR/IL27, CYP2D6\u003c/em\u003e\u0026hellip;), splicing sites (\u003cem\u003eCASP9)\u0026hellip;\u003c/em\u003e. The encoded enzymes modulate biological processes (xenobiotic metabolic process, cellular response to xenobiotic stimulus, Base-excision repair, immunology response...) and/or affect molecular function (Damaged DNA binding, Enzyme model we found statistically significant association between some genotypes and risk of bladder cancer development. These associations were reported for gene encoding for enzymes implicated in xenobioitic and drug metabolisms [\u003cem\u003eCYP1B1\u003c/em\u003e (\u003cb\u003ers162555\u003c/b\u003e), \u003cem\u003eNAT2\u003c/em\u003e (\u003cb\u003ers1799930)\u003c/b\u003e, \u003cem\u003eCYP3A4\u003c/em\u003e (\u003cb\u003ers2740574)\u003c/b\u003e, \u003cem\u003eCOMT\u003c/em\u003e (\u003cb\u003ers4680)\u003c/b\u003e, \u003cem\u003eAKR1C3\u003c/em\u003e (\u003cb\u003ers4881400)\u003c/b\u003e, \u003cem\u003ePRKAR2B\u003c/em\u003e (\u003cb\u003ers3752645\u003c/b\u003e), \u003cem\u003eARNT\u003c/em\u003e (\u003cb\u003ers1889740, rs2228099, rs2864873\u003c/b\u003e), GSS \u003cb\u003e(rs7260770)\u003c/b\u003e, \u003cem\u003eGSTA4\u003c/em\u003e (rs17614751)], or in DNA repair pathway [\u003cem\u003eNEIL2\u003c/em\u003e (\u003cb\u003ers4639)\u003c/b\u003e, \u003cem\u003eXPC\u003c/em\u003e (\u003cb\u003ers2228000)\u003c/b\u003e, \u003cem\u003eMPG\u003c/em\u003e \u003cb\u003e(rs1013358)\u003c/b\u003e, \u003cem\u003eERCC4/XPF\u003c/em\u003e \u003cb\u003e(rs1799801)]\u003c/b\u003e or in other molecular functions such as cell proliferation, immunology response.\u003c/p\u003e \u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003eXenobiotic metabolism pathway\u003c/h2\u003e \u003cp\u003eIn this study, we have found that \u003cem\u003eCYP1B1\u003c/em\u003e C/C (\u003cb\u003ers162555\u003c/b\u003e), NAT2 A/A (\u003cb\u003ers1799930\u003c/b\u003e), \u003cem\u003eAKR1C3\u003c/em\u003e G/G (\u003cb\u003ers4881400)\u003c/b\u003e genotypes and heterozygous genotypes for \u003cem\u003eCYP3A4\u003c/em\u003e (\u003cb\u003ers2740574)\u003c/b\u003e, \u003cem\u003eCOMT\u003c/em\u003e (\u003cb\u003ers4680)\u003c/b\u003e and \u003cem\u003ePRKAR2B\u003c/em\u003e (\u003cb\u003ers3752645\u003c/b\u003e) were associated with a decreased risk of BCa development compared to reference group. \u003cem\u003eCYP1B1\u003c/em\u003e encodes for the CYP1B1 enzyme which is implicated in the NADPH-dependent electron transport and xenobiotic oxidation [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Nevertheless, no previous study has presented conclusive results for an association between \u003cem\u003eCYP1B1\u003c/em\u003e rs162555 and BCa development. The CYP3A4 (Cytochrome P450 3A4) enzyme encoded by the \u003cem\u003eCYP3A4\u003c/em\u003e gene is expressed in adult human liver and it is responsible for the oxidative metabolism of many clinically used drugs. The \u003cem\u003eCYP3A4*1B\u003c/em\u003e variant (rs2740574 C to T) is associated with the reduction of the expression of the activity of CYP3A4 enzyme which could explain its effect on the development of BCa [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. These results were supported by others studies which reported a significant protective effect of homozygous wild genotype in other cancer types such as prostate cancer, breast cancer, leukemia, gastric cancer, colorectal cancer, and ovarian cancer [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe N-acetyltransferase 2 (\u003cem\u003eNAT2\u003c/em\u003e) gene encodes for an important phase II xenobiotic-metabolizing enzyme frequently present in liver and intestinal mucosa. It catalyzes the reaction of aromatic and heterocyclic amine carcinogens via O-acetylation and N-acetylation [\u003cspan additionalcitationids=\"CR29\" citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. In our case\u0026ndash;control study we have found an inverse association between \u003cem\u003eNAT2 A/A\u003c/em\u003e genotype (rs1799930) and BCa development. This result concord with those of Lei Quan who reported that \u003cem\u003eNAT2 A/A\u003c/em\u003e carriers (rs1799930) were at 50% decreased risk of bladder cancer development compared to rapid acetylator[\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e]. Catechol-O-methyltransferase (\u003cem\u003eCOMT\u003c/em\u003e) encodes a phase II enzyme mainly liable for the degradation of catecholamines, like dopamine and noradrenalinev [\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]. It catalyzes the O-methylation of 2-hydroxyestradiol to yield 2-ME2 [\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]. Additionally, it is involved within the inactivation of potential carcinogenic compounds that produce inflammation and catechol estrogens and thus might protect DNA from oxidative damage. Rs4680 (Ex4-12 G\u0026thinsp;\u0026gt;\u0026thinsp;A, or val158met) is the most studied \u003cem\u003eCOMT\u003c/em\u003e single nucleotide polymorphism (SNP). In our cohort we explain the significant inverse association of heterozygous genotype against BCa development by the modification of enzyme activity associated to this genotype. Indeed it has been reported that valine (val) variant enzyme is 3\u0026ndash;4 times more active than the methionine (met) variant [\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e, \u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e]. Moreover we observed that \u003cem\u003ePRKAR2B\u003c/em\u003e A/A genotype (rs3752645) is inversely correlated with BCa risk. The rs3752645 G/A SNP lies within the \u003cem\u003ePRKAR2B\u003c/em\u003e gene, which encodes a regulatory subunit for cyclic adenosine 3\u0026prime;, 5\u0026prime;-monophosphate kinase. Our result confirms previous findings of a GWAS study where the authors showed that the rs3752645 SNP had a strong inverse association with BCa risk [\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIn contrast we have found that homozygous minor genotype or heterozygous genotype for rs1889740 C/T, rs2228099 C/G, rs2256355 T/C, rs2864873 A/G in ARNT gene (Aryl hydrocarbon receptor nuclear translocator) were significantly associated to increased risk of bladder cancer. These SNPs are described for the first time in association with increased risk of BCa development. \u003cem\u003eARNT gene\u003c/em\u003e encodes a protein that binds to ligand-bound aryl hydrocarbon receptor and promotes the expression of genes involved in xenobiotic metabolism [\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e]. We also found that the inheritance of rare homozygous genotype of \u003cem\u003eGSS\u003c/em\u003e \u003cb\u003e(rs7260770)\u003c/b\u003e is associated with an increased risk of BCa which confirms findings reported in other studies [\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e]. These findings may be explained by the functional impact of this variant on the enzyme activity. Indeed it has been reported that GSS deficiency resulted in decreased GSH levels and caused dramatic metabolic consequences. However, the role of \u003cem\u003eGSS\u003c/em\u003e in cancers has not been studied in details. Finally we showed that \u003cem\u003eGSTA4\u003c/em\u003e G/A genotype (rs17614751) was associated with an increased risk of BCa in our population. This result could be explained by the perturbation of enzyme activity or expression (the rs17614751 SNP is a downstream gene variant). Moreover, it has been reported that the deregulation of GSTA4 enzyme activity was implicated in cell proliferation in nasopharyngeal carcinoma, breast cancer, and liver cancer cells [\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e].\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec12\" class=\"Section2\"\u003e \u003ch2\u003eDNA repair pathway\u003c/h2\u003e \u003cp\u003eWhen considering the DNA repair pathway we have found that the minor alleles of the \u003cb\u003ers4639 and rs2228000\u003c/b\u003e SNPs in \u003cem\u003eNEIL\u003c/em\u003e2 and \u003cem\u003eXPC\u003c/em\u003e genes respectively were associated with a decreased risk of BCa development compared to reference groups carrying major alleles. However the minor alleles observed in the studied population for the \u003cb\u003ers1013358 and rs1799801 SNPs\u003c/b\u003e in respectively \u003cem\u003eMPG\u003c/em\u003e and \u003cem\u003eERCC4/ XPF\u003c/em\u003e genes increased the risk of bladder cancer.\u003c/p\u003e \u003cp\u003eThe \u003cem\u003eNEIL\u003c/em\u003e2 (Nei-like DNA glycosylase 2) gene encodes for an enzyme implicated in the first step of the base excision repair (BER) mechanism which consists of cleaving oxidatively damaged bases and introducing a DNA strand break via the associated lyase reaction [\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e]. The rs4639, is located on 3\u0026prime;UTR of \u003cem\u003eNEIL2\u003c/em\u003e[\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e]. In our study, we found that \u003cem\u003eNEIL2 G/G\u003c/em\u003e genotype for rs4639 was associated with 0, 49-fold decreased risk of BCa. This inverse association could be explained by the fact that the minor allele interacts with some specific miRNA, which activates the BER pathway [\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e]. Moreover, we have found that rs4639 and rs804276 in \u003cem\u003eNEIL2\u003c/em\u003e gene were in linkage disequilibrium (\u003cem\u003ep-value\u0026thinsp;=\u003c/em\u003e\u0026thinsp;0.03). Beside \u003cem\u003eNEIL2\u003c/em\u003e, we found that \u003cem\u003eXPC\u003c/em\u003e AA genotype (rs2228000) was associated with a decreased risk of BCa compared to reference group. The \u003cem\u003eXPC\u003c/em\u003e gene is located on 3p25 and encodes for an enzyme involved in global genome repair. This enzyme represents the earliest damage detector by initiating the NER pathway and eliminating the DNA damages induced by chemical and environmental exposures such as aromatic amines and UV light [\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. Our result confirms the study of Zhu Y. \u003cem\u003eet al.\u003c/em\u003e which demonstrates a significant association between the presence of \u003cem\u003eXPC\u003c/em\u003e rs2228000 AA genotype and a decreased risk of BCa [\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e]. However, the recent study of Dai Y. \u003cem\u003eet al\u003c/em\u003e. suggests that \u003cem\u003eXPC\u003c/em\u003e AA genotype may be linked to an increased risk of bladder and breast cancer [\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e]. These conflicting results and differences in risk associations may be explained by the different etiology and mechanisms of BCa in study populations with different ethnic backgrounds [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eOn the other hand, ERCC4/XPF and MPG enzymes represent the headmaster in DNA metabolic process, DNA repair, and cellular response to DNA damage stimulus. \u003cem\u003eERCC4\u003c/em\u003e (16p13.12) is a NER gene that plays a key role in DNA repair that protects against genetic instability and carcinogenesis [\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e]. The \u003cem\u003eERCC4\u003c/em\u003e-rs1799801 is a synonymous variation (Ser835Ser). A significant association between the \u003cem\u003eERCC4\u003c/em\u003e-rs1799801 polymorphisms and increased risk of Bca in Tunisian population could be explained by the effect of this variation on the enzyme activity. Indeed a previously genotype-phenotype correlation analysis indicated that the \u003cem\u003eERCC4\u003c/em\u003e-rs1799801 rare homozygous C/C genotype carriers had an increased trend of \u003cem\u003eERCC4\u003c/em\u003e expression levels [\u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e]. In contradiction with our results, the meta-analysis of Shi T.Y. \u003cem\u003eet al.\u003c/em\u003e also did not provide statistical evidence for an association between \u003cem\u003eERCC4\u003c/em\u003e gene and the overall risk of several human cancers, they also report that stratification analysis showed an inverse correlation with cancer in Caucasians [\u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e]. These conflicting results could be explained by a difference in both ethnic origins of patients and exposure to environmental risk factors. MPG, a BER gene, also plays an important role in DNA repair.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003eOthers cellular pathway\u003c/h2\u003e \u003cp\u003eIn addition to xenobiotic metabolic pathway and DNA repair process we are interested in this study to investigate the impact of others variations in gene implicated in cell proliferation pathway and immunology response in the etiology of BCa. Among the analyzed variations in this panel we have found that \u003cem\u003eAPOBR/IL27\u003c/em\u003e A/C genotype \u003cb\u003e(rs17855750)\u003c/b\u003e was associated with 2.27 fold-increased risk of BCa. The APOBR (Apolipoprotein B Receptor)/ \u003cem\u003eIL27\u003c/em\u003e (Interleukin 27) encodes for a protein that has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties [\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e]. This significant association could be explained by the implication of encoded enzyme in the inflammatory process. In the same context, Zhou B. \u003cem\u003eet al\u003c/em\u003e. showed a significant association between \u003cem\u003eIL-27\u003c/em\u003e gene polymorphisms and \u003cem\u003eIL-27\u003c/em\u003eplasma level and reported that rs17855750 GG (CC) genotype was associated with increased risk for muscle invasive bladder carcinoma. Moreover we found that rs7104333 in \u003cem\u003eCD5/VPS37C\u003c/em\u003e gene. The Vacuolar protein sorting-associated protein 37C (VPS37C\u003cem\u003e)\u003c/em\u003e is a Component of the ESCRT-I complex, and a regulator of vesicular trafficking process. This protein may be involved in cell growth and differentiation and it is known as a negative regulator of T- and B-cell receptor signaling. Its expression has been shown to be implicated in T lymphocytes tolerance toward tumor cells [\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e]. In contrast we have found that genetic variations in \u003cem\u003eBLNK\u003c/em\u003e (\u003cb\u003ers3789928\u003c/b\u003e), \u003cem\u003eTP63 (\u003c/em\u003e\u003cb\u003ers710521\u003c/b\u003e), \u003cem\u003eROCK1\u003c/em\u003e (\u003cb\u003ers288980\u003c/b\u003e) and \u003cem\u003eACTRT3/MYNN\u003c/em\u003e (\u003cb\u003ers10936599)\u003c/b\u003e were associated with a decreased risk of bladder cancer. \u003cem\u003eBLNK\u003c/em\u003e gene encodes for a cytoplasmic linker or adaptor protein that plays a critical role in B cell development [\u003cspan citationid=\"CR50\" class=\"CitationRef\"\u003e50\u003c/span\u003e]. It plays an important role in the pro-B cell to pre-B cell transition and B-cell apoptosis via BCR signaling pathway and reported to have a tumor-suppressive function in various hematologic malignancies [\u003cspan citationid=\"CR51\" class=\"CitationRef\"\u003e51\u003c/span\u003e]. Moreover the Human Protein Atlas consortium showed that high expression of BLNK had a favorable prognosis value in urothelial cancer [\u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e52\u003c/span\u003e]. \u003cem\u003eTP63\u003c/em\u003e (3q27-28) has a homolog sequence to \u003cem\u003eTP53\u003c/em\u003e (tumor suppressor) and \u003cem\u003eTP73\u003c/em\u003e[\u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e53\u003c/span\u003e]. This gene encodes for an enzyme implicated in the control of cell cycle and plays an important role in apoptosis. Abnormal expression of TP63 is associated with a loss of urothelial differentiation [\u003cspan citationid=\"CR54\" class=\"CitationRef\"\u003e54\u003c/span\u003e]. In our study the TP63 T/C genotype (rs710521) was reported to be inversely associated with BCa (\u003cem\u003ep-value\u0026thinsp;=\u003c/em\u003e\u0026thinsp;0.035 and an OR\u0026thinsp;=\u0026thinsp;0.62; CI95% 0.42\u0026ndash;0.89). Our results seem to agree with those of Kimeney L. \u003cem\u003eet al.\u003c/em\u003e and Lehmann M.-L \u003cem\u003eet al.\u003c/em\u003e who confirmed that this variant plays a role in decreasing the risk of BCa in European patients [\u003cspan citationid=\"CR55\" class=\"CitationRef\"\u003e55\u003c/span\u003e, \u003cspan citationid=\"CR56\" class=\"CitationRef\"\u003e56\u003c/span\u003e]. We have also found that \u003cem\u003eROCK1\u003c/em\u003e TT genotype (rs288980) was associated with 0.75 fold-decreased risk of BCa. \u003cem\u003eROCK1\u003c/em\u003e enzyme is a necessary effector kinase downstream of Rho GTPases, a very important pathway involved in cell migration and has been identified as a possible therapeutic target [\u003cspan citationid=\"CR57\" class=\"CitationRef\"\u003e57\u003c/span\u003e]. The Cancer Genome Project identified three non-synonymous mutations within the \u003cem\u003eROCK1\u003c/em\u003e gene [\u003cspan citationid=\"CR58\" class=\"CitationRef\"\u003e58\u003c/span\u003e] but the effect of these variations in protein activity or expression was not more elucidated. Finally \u003cem\u003eACTRT3/ MYNN\u003c/em\u003e (Actin Related Protein T3; 3q26.2) gene is poorly described in the literature. The minor T allele of rs10936599 in \u003cem\u003eACTRT3\u003c/em\u003e/ \u003cem\u003eMYNN\u003c/em\u003e has been described in the Genome-wide association study conducted by Figueroa J. \u003cem\u003eet al\u003c/em\u003e. in 2014, to be highly associated with decreased risk of BCa [\u003cspan citationid=\"CR59\" class=\"CitationRef\"\u003e59\u003c/span\u003e], which was confirmed by Wang M. \u003cem\u003eet al.\u003c/em\u003e [\u003cspan citationid=\"CR60\" class=\"CitationRef\"\u003e60\u003c/span\u003e]. However, the effect of rs10936599 polymorphism on the \u003cem\u003eMYNN\u003c/em\u003e activity is not well known and more biological functional studies are needed to draw more concise conclusions regarding the underlying molecular mechanism of this variation.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec14\" class=\"Section2\"\u003e \u003ch2\u003eInteraction between genetic and environmental risk factors\u003c/h2\u003e \u003cp\u003eWhen we compare the distribution of unfavorable genotypes [\u003cem\u003eGSS G/A\u003c/em\u003e (rs7260770), ARNT A/G (rs2864873), ARNT C/T (rs1889740) ARNT C/G (rs2228099), ARNT T/C (rs2256355), GSTA4 G/A (rs17614751), \u003cem\u003eERCC4\u003c/em\u003e C/C (rs1799801), MPG C/C (rs1013358), \u003cem\u003eVPS37C\u003c/em\u003e A/A (rs7104333), APOBR/IL27 A/C (rs17855750)] between exposed bladder cancer cases and controls according to environmental risk factors we found that \u003cem\u003eARNT\u003c/em\u003e C/T (rs1889740), \u003cem\u003eARNT\u003c/em\u003e A/G \u003cem\u003e(\u003c/em\u003ers2864873) and \u003cem\u003eGSTA4\u003c/em\u003e G/A (rs17614751\u003cem\u003e)\u003c/em\u003e genotypes were associated with an increased risk of BCa even in the absence of tobacco risk factors, or professional risk factors. Moreover when we compared exposed cases to exposed controls, we have not found a significant additive effect between the majority of unfavorable genotypes and exposure to environmental risk factors (smokers\u0026rsquo; \u0026ge; 20PY or exposed to professional risk factors). The absence of significant additive effect between the majority of unfavorable genotypes and BCa risk could be explained by the fact that the targeted SNPs encoding enzymes were not directly implicated in the metabolism of xenobiotics. For example, the proinflammatory role of APOBR/IL27 enzyme could explain the role of rs17855750 in BCa development independently to exposition to environmental risk factors. However this additive effect reached more than 12 fold-increased risk of BCa development for \u003cem\u003eARNT\u003c/em\u003e rs1889740 T/T, \u003cem\u003eARNT\u003c/em\u003e rs2228099 G/G and \u003cem\u003eARNT\u003c/em\u003e rs2256355 C/C genotypes in subjects exposed to professional risk factors. This association may be explained by the fact that \u003cem\u003eARNT gene\u003c/em\u003e encodes a protein thats binds to ligand-bound aryl hydrocarbon receptor and promotes the expression of genes involved in xenobiotic metabolism [\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e]. Whether this association is caused by specific bladder carcinogens present in the work environment warrants further investigations. To conclude our analysis, a decision tree was implemented to create a disease prediction model. This tree has allowed us to define the risk groups most genetically likely to develop BCa. According to the established decision tree, we note the importance of both smoking status (\u0026ge;\u0026thinsp;20PY) and the genotype of CYP1A2 (rs762551) in the development of BCa. The decision-tree analysis produced a three major BCa class. The first major class (58/249) is defined by the presence of CYP1A2 CC or CYP1A2 CA genotype and also defined by others 8 variations: ARNT C\u0026thinsp;\u0026gt;\u0026thinsp;G (rs2228099), CYP1B1 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs162555), SOD1 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs2173962), ROCK1 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs288980), IL10 A\u0026thinsp;\u0026gt;\u0026thinsp;T (rs1800890), LY96 T\u0026thinsp;\u0026gt;\u0026thinsp;C (rs17226566), AICDA T\u0026thinsp;\u0026gt;\u0026thinsp;G (rs11046349) and MAP2K4 C\u0026thinsp;\u0026gt;\u0026thinsp;T (rs4791489). The second major class of BCa group (31/249) is only defined by the intensity of tobacco use\u0026thinsp;\u0026ge;\u0026thinsp;20PY and the inheritance of the \u003cb\u003ehomozygous genotype for\u003c/b\u003e rs762551 in CYP1A2 (CYP1A2 A/A), XPC GG or AG genotype (rs2228000, G\u0026thinsp;\u0026gt;\u0026thinsp;A), and MAP2K4 CC or CT genotype (rs4791489, C\u0026thinsp;\u0026gt;\u0026thinsp;T). This decision tree confirms the crucial role of tobacco consumption in the etiology of BCa. Indeed BCa is considered as a smoking-related cancer [\u003cspan citationid=\"CR61\" class=\"CitationRef\"\u003e61\u003c/span\u003e]. This risk was attributed to many compounds of tobacco such as 4-Aminobiphenyl, 3-Amino-1,4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1), Toluene, Benzo[a]pyrene, Benzene\u0026hellip; [\u003cspan citationid=\"CR62\" class=\"CitationRef\"\u003e62\u003c/span\u003e]. In the other hand CYP1A2 is an enzyme responsible for the metabolism of caffeine and some tobacco compounds. Rs762551 variation in \u003cem\u003eCYP1A2\u003c/em\u003e gene encodes for the CYP1A2*1F allele. The baseline activity of the enzyme is similar in CYP1A2*1F allele carriers and non-carriers. Moreover it has been reported that he presence of rs762551 (A) codes for the \"high inducibility\" form the CYP1A2 enzyme, characterized by higher enzyme activity in the presence of an inducer such as smoking or heavy coffee consumption[\u003cspan citationid=\"CR63\" class=\"CitationRef\"\u003e63\u003c/span\u003e]. To explain our result we have reanalyzed the CYP1A2 C\u0026thinsp;\u0026gt;\u0026thinsp;A genotype distribution between cases and controls and according to tobacco status. As result we have found that the inheritance of CYP1A2 (CC) or CYP1 A2 (CA) genotype were respectively associated with 6.89 and 9.04 \u0026ndash;fold increased risk of BCa in only heavy smokers patients (\u0026ge;\u0026thinsp;20PY) compared to heavy smokers controls. However we have not data about coffee consumption.\u003c/p\u003e \u003c/div\u003e"},{"header":"Conclusion","content":"\u003cp\u003eWe have conducted the first study in Tunisian population to evaluate systematically the association between genetic variations in BCa and environmental factors. We also determined the effect of studied pathway SNPs in comparison with environmental exposition. Once validated, these findings may provide urologists additional genetic information that may help for clinical assessment and treatment decisions. Nevertheless, the underlying mechanisms through which these genes or SNPs affect the clinical behavior of BCas require further studies. Future investigations in our populations and detailed functional characterization are needed to establish predictive or prognostic markers for BCa.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cdiv class=\"DefinitionList\"\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eACTRT3\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eActin Related Protein T3; 3q26.2\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eAPOBR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eApolipoprotein B Receptor\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eARNT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eAryl hydrocarbon receptor nuclear translocator\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eBCa\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eBladder cancer\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eBER\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ebase excision repair\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eBLNK\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eB cell linker\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCOMT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCatechol-O-methyltransferase\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCYP1B1\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ecytochrome P450 family 1 subfamily B member 1\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCYP3A4\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCytochrome P450 3A4\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003edbSNP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003edatabase of single nucleotide polymorphisms\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eDNA\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003edeoxyribonucleic acid\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eDRC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eDNA Repair Capacity\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eDSBR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003edouble-strand break repair\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eEDTA\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eethylene diamine tetra-acetic acid\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eERCC4\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eExcision Repair Cross-Complementation group 4\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eGSTM1\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eGlutathione-s-transferase M1\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eGWAS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eGenome-Wide Association Study\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eGSS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eGlutathione Synthase\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eGSTA4\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eGlutathione S-transferase Alpha 4\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eHG\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eHigh-Grade\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eIARC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eInternational Agency for Research on Cancer\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eIL27\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eInterleukin 27\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eKEGG\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eKyoto Encyclopedia of Genes and Genomes\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLG\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eLow-Grade\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eMIBC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003emuscle-invasive BCa\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eMMR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003emismatch repair\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eMPG\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eN-methylpurine DNA glycosylase\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNEIL2\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eNei-like DNA glycosylase 2\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNAT2\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eN-acetyltransferase 2\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNER\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003enucleotide excision repair\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNGS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eNext-Generation Sequencing\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNMIBC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003enon-muscle-invasive BCa\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePRKAR2B\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eProtein Kinase cAMP-dependent type II regulatory subunit beta\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eROCK1\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eRho associated coiled-coil containing protein kinase 1\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eSNP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003enucleotide polymorphisms\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eTCR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003etranscription-coupled repair\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eTP63\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eTumor Protein p63\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eVPS37C\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003evacuolar protein sorting-associated protein 37C\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eWHO\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eWorld Health Organization\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eXPC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eXeroderma Pigmentosum, Complementation group C\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eXPF\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eexcision repair cross-complementing rodent repair deficiency, complementation group 4\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003c/div\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e- This trial protocol and recruitment were approved and carried out after the agreement of the ethics committee of the Charles Nicolle Hospital and approved by an Ethics Committee (IEC Project No. 17-35) and an MTA (MATERIAL TRANSFER AGREEMENT MTA/ 2017 / IMP / GCS)/ 0356) from IARC.\u003c/p\u003e\n\u003cp\u003e-Informed consent was obtained from all participants (in both languages: Arabic/French) prior to enrollment and participation in this study..\u003c/p\u003e\n\u003cp\u003e- All samples are coded and no patient names appear in the study. All data whether clinical or personal remains anonymous and secret.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable. This study did not use identifying images and any clinical and personal details despite written informed consent for publication of their clinical details and/or clinical\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe dataset is available upon reasonable request to the corresponding author\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u0026ldquo;No funding was obtained for this study\u0026rdquo;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIH: Collecting clinical samples and data, designed the panel, molecular analysis, drafted the manuscript and bioinformatics analyzes. SB, HD and FH: Help in Bioinformatics and statistical analyzes. GD and CV: Technical assistance for NGS analyzes. HA: Clinical characterization of the studied population. SZ, ZN and MA: help in collecting samples. MC and JM: designed the study and revised the manuscript. FL: drafted and revised the manuscript. SO: designed the study, performed the statistical analysis and drafted and revised the manuscript. All authors read and approved the final version of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank all patients for participating in this study. We greatly thank also the Urology department, Charles Nicolle hospital, Tunis, Tunisia, Biochemistry Department, Charles Nicolle Hospital, Tunis and the International Agency for Research on Cancer IARC\u0026nbsp;; Lyon. France.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eAntoni S, Ferlay J, Soerjomataram I, et al (2017) Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends. European Urology 71:96\u0026ndash;108. https://doi.org/10.1016/j.eururo.2016.06.010\u003c/li\u003e\n\u003cli\u003eWong MCS, Fung FDH, Leung C, et al (2018) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projection. Scientific Reports 8:. https://doi.org/10.1038/s41598-018-19199-z\u003c/li\u003e\n\u003cli\u003eCancer today. http://gco.iarc.fr/today/home. Accessed 15 Jun 2020\u003c/li\u003e\n\u003cli\u003eBray F, Ferlay J, Soerjomataram I, et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 68:394\u0026ndash;424. https://doi.org/10.3322/caac.21492\u003c/li\u003e\n\u003cli\u003eCassell A, Yunusa B, Jalloh M, et al (2019) Non-Muscle Invasive Bladder Cancer: A Review of the Current Trend in Africa. World J Oncol 10:123\u0026ndash;131. https://doi.org/10.14740/wjon1210\u003c/li\u003e\n\u003cli\u003eBurger M, Catto JWF, Dalbagni G, et al (2013) Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 63:234\u0026ndash;241. https://doi.org/10.1016/j.eururo.2012.07.033\u003c/li\u003e\n\u003cli\u003eColin P, Koenig P, Ouzzane A, et al (2009) Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract. BJU International 104:1436\u0026ndash;1440. https://doi.org/10.1111/j.1464-410X.2009.08838.x\u003c/li\u003e\n\u003cli\u003eSkipper PL, Kim MY, Sun H-LP, et al (2010) Monocyclic aromatic amines as potential human carcinogens: old is new again. Carcinogenesis 31:50\u0026ndash;58. https://doi.org/10.1093/carcin/bgp267\u003c/li\u003e\n\u003cli\u003eRouissi K, Ouerhani S, Hamrita B, et al (2011) Smoking and Polymorphisms in Xenobiotic Metabolism and DNA Repair Genes are Additive Risk Factors Affecting Bladder Cancer in Northern Tunisia. Pathol Oncol Res 17:879. https://doi.org/10.1007/s12253-011-9398-3\u003c/li\u003e\n\u003cli\u003eMatic M, Pekmezovic T, Djukic T, et al (2013) GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: A case-control study. Urologic Oncology: Seminars and Original Investigations 31:1184\u0026ndash;1192. https://doi.org/10.1016/j.urolonc.2011.08.005\u003c/li\u003e\n\u003cli\u003eGarc\u0026iacute;a-Closas M, Malats N, Silverman D, et al (2005) NAT2 slow acetylation and GSTM1 null genotypes increase bladder cancer risk: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 366:649\u0026ndash;659. https://doi.org/10.1016/S0140-6736(05)67137-1\u003c/li\u003e\n\u003cli\u003eKumar N, Moreno NC, Feltes BC, et al (2020) Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins. Genetics and Molecular Biology 43:. https://doi.org/10.1590/1678-4685-gmb-2019-0104\u003c/li\u003e\n\u003cli\u003eGreenman C, Stephens P, Smith R, et al (2007) Patterns of somatic mutation in human cancer genomes. Nature 446:153\u0026ndash;158. https://doi.org/10.1038/nature05610\u003c/li\u003e\n\u003cli\u003ePleasance ED, Cheetham RK, Stephens PJ, et al (2010) A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463:191\u0026ndash;196. https://doi.org/10.1038/nature08658\u003c/li\u003e\n\u003cli\u003eHe J, Shi T-Y, Zhu M-L, et al (2013) Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: A meta-analysis. International Journal of Cancer 133:1765\u0026ndash;1775. https://doi.org/10.1002/ijc.28089\u003c/li\u003e\n\u003cli\u003eRouissi K, Bahria IB, Bougatef K, et al (2011) The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development. BMC Cancer 11:101. https://doi.org/10.1186/1471-2407-11-101\u003c/li\u003e\n\u003cli\u003eLeibovici D, Grossman HB, Dinney CP, et al (2005) Polymorphisms in Inflammation Genes and Bladder Cancer: From Initiation to Recurrence, Progression, and Survival. JCO 23:5746\u0026ndash;5756. https://doi.org/10.1200/JCO.2005.01.598\u003c/li\u003e\n\u003cli\u003eKanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27\u0026ndash;30. https://doi.org/10.1093/nar/28.1.27\u003c/li\u003e\n\u003cli\u003eKanehisa M, Sato Y, Furumichi M, et al (2019) New approach for understanding genome variations in KEGG. Nucleic Acids Res 47:D590\u0026ndash;D595. https://doi.org/10.1093/nar/gky962\u003c/li\u003e\n\u003cli\u003ePANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323939/. Accessed 30 Sep 2020\u003c/li\u003e\n\u003cli\u003eAshburner M, Ball CA, Blake JA, et al (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25:25\u0026ndash;29. https://doi.org/10.1038/75556\u003c/li\u003e\n\u003cli\u003eJassal B, Matthews L, Viteri G, et al (2020) The reactome pathway knowledgebase. Nucleic Acids Res 48:D498\u0026ndash;D503. https://doi.org/10.1093/nar/gkz1031\u003c/li\u003e\n\u003cli\u003eSelinski S (2017) Discovering urinary bladder cancer risk variants: Status quo after almost ten years of genome-wide association studies. EXCLI J 16:1288\u0026ndash;1296. https://doi.org/10.17179/excli2017-1000\u003c/li\u003e\n\u003cli\u003eCalvez-Kelm FL, Foll M, Wozniak MB, et al (2016) KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control. Oncotarget 7:78827\u0026ndash;78840. https://doi.org/10.18632/oncotarget.12386\u003c/li\u003e\n\u003cli\u003eWang M, Wang M, Zhang W, et al (2009) Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population. Carcinogenesis 30:991\u0026ndash;996. https://doi.org/10.1093/carcin/bgp091\u003c/li\u003e\n\u003cli\u003eDally H, Edler L, J??ger B, et al (2003) The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose. Pharmacogenetics 13:607\u0026ndash;618. https://doi.org/10.1097/00008571-200310000-00004\u003c/li\u003e\n\u003cli\u003eBožina N, Bradamante V, Lovrić M (2009) Genetic Polymorphism of Metabolic Enzymes P450 (CYP) as a Susceptibility Factor for Drug Response, Toxicity, and Cancer Risk. Archives of Industrial Hygiene and Toxicology 60:217\u0026ndash;242. https://doi.org/10.2478/10004-1254-60-2009-1885\u003c/li\u003e\n\u003cli\u003eWindmill KF, Gaedigk A, Hall PM, et al (2000) Localization of N-acetyltransferases NAT1 and NAT2 in human tissues. Toxicol Sci 54:19\u0026ndash;29. https://doi.org/10.1093/toxsci/54.1.19\u003c/li\u003e\n\u003cli\u003eYamada S, Tang M, Richardson K, et al (2009) Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population. Pharmacogenomics 10:1433\u0026ndash;1445. https://doi.org/10.2217/pgs.09.66\u003c/li\u003e\n\u003cli\u003ePande JN, Pande A, Singh SPN (2003) Acetylator status, drug metabolism and disease. 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Am J Hum Genet 75:807\u0026ndash;821\u003c/li\u003e\n\u003cli\u003eLachman HM, Papolos DF, Saito T, et al (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6:243\u0026ndash;250. https://doi.org/10.1097/00008571-199606000-00007\u003c/li\u003e\n\u003cli\u003eFigueroa JD, Han SS, Garcia-Closas M, et al (2014) Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis 35:1737\u0026ndash;1744. https://doi.org/10.1093/carcin/bgu064\u003c/li\u003e\n\u003cli\u003eARNT Gene - GeneCards | ARNT Protein | ARNT Antibody. https://www.genecards.org/cgi-bin/carddisp.pl?gene=ARNT. 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Basic \u0026amp; Clinical Pharmacology \u0026amp; Toxicology 112:257\u0026ndash;263. https://doi.org/10.1111/bcpt.12038\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"molecular-biology-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mole","sideBox":"Learn more about [Molecular Biology Reports](https://www.springer.com/journal/11033)","snPcode":"11033","submissionUrl":"https://submission.nature.com/new-submission/11033/3","title":"Molecular Biology Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Bladder cancer, NGS, Panel, SNP, tobacco, Tunisia","lastPublishedDoi":"10.21203/rs.3.rs-840773/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-840773/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackgound\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eBladder cancer (BCa) is a heterogeneous disease caused by the interaction between environmental and genetic risk factors. The objective of this study was to design a panel that evaluates the role of some selected variants in BCa susceptibility. We are also interested in studying the interaction between environmental and genetic risk factors.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eThe case/controls cohort was composed with 249 BCa cases and 255 controls. The designed Bladder cancer hereditary panel (BCHP) is composed of 139 selected variants. These variants were genotyped by an amplification-based targeted Next-Generation Sequencing (NGS) on the Ion Torrent Proton sequencer (Life Technologies, Ion Torrent technology). \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eWe have found that rs162555, rs2228000, rs10936599, rs710521, rs3752645, rs804276, rs4639, rs4881400 and rs288980 were significantly associated with decreased risk of bladder cancer. However the homozygous genotypes for \u003cem\u003eVPS37C\u003c/em\u003e (rs7104333, A/A), MPG (rs1013358, C/C) genes or the heterozygous genotype for ARNT gene (rs1889740, rs2228099, rs2256355, rs2864873), GSTA4 (rs17614751) and APOBR/IL27 (rs17855750) were significantly associated with increased risk of bladder cancer development compared to reference group (OR=2.53, 2.34, 1.99, 2.00, 2.00, 1.47, 1.96 and 2.27 respectively). We have also found that non–smokers patients harboring heterozygous genotypes for ARNT/rs2864873 (A\u0026gt;G),\u0026nbsp;ARNT/ rs1889740 (C\u0026gt;T) or GSTA4/rs17614751 (G to A) were respectively at 2.775, 3.069 and 6.608 –folds increased risk of Bca development compared to non-smokers controls with wild genotypes. Moreover the \u003cem\u003eARNT\u003c/em\u003e CT (rs1889740), \u003cem\u003eARNT\u003c/em\u003e CG (rs2228099), \u003cem\u003eARNT\u003c/em\u003e TC (rs2864873) and \u003cem\u003eGSS \u003c/em\u003eGA genotypes were associated with an increased risk of BCa even in absence of professional risk factors. Finally the decision-tree analysis produced a three major BCa class. These three classes were essentially characterized by an intensity of tobacco use more than 20 pack years (PY) and the CYP1A2 (rs762551) genotype. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eThe determined association between genetic variations in BCa and environmental factors, as well as the effect of studied pathway SNPs in comparison with environmental exposition may provide urologists additional genetic information that may help for clinical assessment and treatment decisions. Nevertheless, the underlying mechanisms through which these genes or SNPs affect the clinical behavior of BCas require further studies.\u003c/p\u003e\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","manuscriptTitle":"Development of a Custom NGS Panel for the Determination of Bladder Cancer Risk","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-08-30 22:40:13","doi":"10.21203/rs.3.rs-840773/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2021-08-29T10:50:48+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-08-27T13:13:51+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2021-08-24T09:13:53+00:00","index":"","fulltext":""},{"type":"submitted","content":"Molecular Biology Reports","date":"2021-08-23T10:07:28+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"molecular-biology-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"mole","sideBox":"Learn more about [Molecular Biology Reports](https://www.springer.com/journal/11033)","snPcode":"11033","submissionUrl":"https://submission.nature.com/new-submission/11033/3","title":"Molecular Biology Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"7bfa09b7-d545-4821-881e-c4558c441956","owner":[],"postedDate":"August 30th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":6816008,"name":"Molecular Biology"}],"tags":[],"updatedAt":"2021-11-09T15:53:16+00:00","versionOfRecord":[],"versionCreatedAt":"2021-08-30 22:40:13","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-840773","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-840773","identity":"rs-840773","version":["v1"]},"buildId":"J0_U0BvcaRcwD8yVFaRlm","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}