Effect of oral hyoscine-N-butyl bromide on pain perception during hysterosalpingography: A randomized, double-blind, placebo controlled trial

Ahmed M. Abbas, Nahed A. Abo-Elela, Ehab M. Mosa
In: Middle East Fertility Society Journal · 2017 · vol. 23(1) , pp. 57–62 · doi:10.1016/j.mefs.2017.08.004 · W2753404266
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Oral hyoscine-N-butyl bromide administered 30 minutes prior to hysterosalpingography provided no benefit in reducing pain perception during or after the procedure, but increased side effects.

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Abstract

Objectives: The current study aims to investigate the analgesic effect of oral hyoscine-N-butyl bromide (HBB) for alleviating pain during hysterosalpingography (HSG). Study design: Randomized, double-blind, placebo-controlled study. Study setting: Assiut University Hospital, Egypt. Materials and methods: The study was conducted between March and May 2016. Infertile women scheduled for HSG were randomized (1:1) to HBB or Placebo group. All women received oral 20 mg HBB or placebo tablets 30 min before the procedure. The primary outcome was the participant's self-rated pain perception utilizing a 10-cm Visual Analogue Scale (VAS) with 0 = no pain, and 10 = worst imaginable pain during the HSG procedure. Results: Ninety-four women were enrolled (n = 47 in each group). No difference in the baseline characteristics. Oral HBB does not reduce the median VAS pain scores during injection of the dye (3.75 vs. 4.5, p = 0.195), immediately post-procedure (3 vs. 3, p = 0.102) and 30 min post-procedure (2 vs. 2.5, P = 0.745). No significant differences in women satisfaction score (p = 0.302). The rate of side effects was higher in the HBB group especially nausea (14.9%) and dizziness (10.6%) (p = 0.0001). Conclusion: Utility of oral HBB 30 min before HSG has no benefit in alleviating the induced pain during and 30 min after the HSG procedure.

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