Triglyceride-Glucose Index Associated With the Risk of Cardiovascular Disease: the Kailuan Study

Abstract Purpose: Triglyceride-glucose index (TyG) index, as a marker of insulin resistance, have been associated with risk of cardiovascular disease (CVD) in older adults. Nevertheless, it is unclear to whether TyG index affects risk of CVD and the subtypes of CVD in general Chinese population. Methods: A total of 96541 participants who met the criteria were included from the Kailuan Study. The TyG index was calculated as ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). The study participants were divided into 4 groups (Q1, Q2, Q3 and Q4) by quartiles of the TyG index. Incident of CVD events (myocardial infarction and stroke) during 2006-2017 were confirmed by review of medical records. The Cox proportional hazard regression models were used to assess the association TyG index with the risk of CVD and the subtypes of CVD by calculating the hazard ratios (HR) and 95% confidence interval (CI).Results: During a median 10.33 years of follow-up, we documented 6421 CVD events including 1493 myocardial infarction events and 5083 stroke events. Multivariate Cox regression analysis showed that compared with the participants in Q1 group, HR (95% CI) for CVD events were for Q2 group 1.12 (95%, 1.03-1.21), Q3 groups 1.28 (95%, 1.18-1.38), and Q4 groups 1.34 (95%, 1.23-1.45). We conducted time-dependent TyG index found compared with Q1 group, HR (95% CI) for CVD events were for Q2 group 1.09(95%, 1.02-1.18), Q3 groups 1.17(95%, 1.09-1.27), and Q4 groups 1.20 (95%, 1.11-1.30). We found similar results in myocardial infarction and stroke.Conclusions: The TyG index is an independent risk factor for CVD. The TyG index may be useful identifying individuals at high risk of developing CVD at an early stage, it can contribution to prevent and control of CVD.