STUDY TO ASSESS ASSOCIATION OF C-REACTIVE PROTEIN WITH NEPHROPATHY IN PEOPLE LIVING WITH TYPE 2 DIABETES MELLITUS

Introduction Diabetes mellitus (DM) is a metabolic disorder with inappropriate hyperglycemia either due to an absolute or relative deficiency of insulin secretion or reduction in the biologic effectiveness of insulin or both. An inflammatory basis for Diabetes & its complications has attracted interest. Among several markers of inflammation, C reactive protein (CRP) is found to be significant in people with diabetes. Diabetic nephropathy may be associated with abnormally high levels of CRP. Materials & Methods This study was performed for 1 year over 100 type 2 diabetic patients (n=100) aged 30-70 years in Calcutta National Medical College & Hospital. Necessary clinical & Diabetes related laboratory investigations were done as the routine procedure. Results Among 100 study population, all macro-albuminuria patients were found to have high CRP. 63% of Stage 3 chronic kidney disease (CKD) patients were having high CRP in our study. High CRP values were also found among patients with higher spot urine ACR (329.50±259.40 mg/gram).(P<0.05) Conclusion CRP is a marker which increased in inflammatory reactions. Low grade inflammation as indicated by high CRP was an important predictor of diabetic nephropathy.