Propagation and blocking of bistable waves by variable diffusion

preprint OA: closed
Full text JSON View at publisher
AI-generated deep summary by claude@2026-07, 2026-07-04 · read from full text

The paper studies how reaction–diffusion systems with bistable states (two stable regimes separated by an interface) propagate or become blocked when diffusion varies depending on the location between departure and arrival points, considering neutral, repulsive, and attractive transitions. Using singular limit analysis, it derives an interface equation and an expression for wave propagation speed when transition probability depends on the “dividing point” ratio between departure and arrival points, reporting that in one-dimensional space the transition between propagation and conditional blocking occurs when the dividing-point ratio is 3:1. It further applies the framework to the Aliev–Panfilov model to examine mechanisms for generating spiral patterns. The paper is a mathematical preprint and does not state experimental or clinical validation. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Abstract Biological diffusion processes are often influenced by environmental factors. In this study, we investigate the effects of variable diffusion, which depend on the point between the departure and the arrival points, on the propagation of bistable waves. This process includes neutral, repulsive, and attractive transitions. Using singular limit analysis, we derive the equation for the interface between two stable states and examine the relationship between wave propagation and variable diffusion. In particular, when the transition probability depends on the environment at the dividing point between the departure and the arrival points, we derived an expression for the wave propagation speed that includes this dividing point ratio. More specifically, the threshold between wave propagation and conditional blocking in a one-dimensional space occurs when the transition probability is determined by a dividing point ratio of 3:1 between the departure and the arrival points. Furthermore, as an application of this concept, we consider the Aliev-Panfilov model to explore the mechanism for generating spiral patterns.
Full text 10,058 characters · extracted from preprint-html · click to expand
Propagation and blocking of bistable waves by variable diffusion | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Propagation and blocking of bistable waves by variable diffusion Hirokazu Ninomiya, Keita Nakajima This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5457898/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Biological diffusion processes are often influenced by environmental factors. In this study, we investigate the effects of variable diffusion, which depend on the point between the departure and the arrival points, on the propagation of bistable waves. This process includes neutral, repulsive, and attractive transitions. Using singular limit analysis, we derive the equation for the interface between two stable states and examine the relationship between wave propagation and variable diffusion. In particular, when the transition probability depends on the environment at the dividing point between the departure and the arrival points, we derived an expression for the wave propagation speed that includes this dividing point ratio. More specifically, the threshold between wave propagation and conditional blocking in a one-dimensional space occurs when the transition probability is determined by a dividing point ratio of 3:1 between the departure and the arrival points. Furthermore, as an application of this concept, we consider the Aliev-Panfilov model to explore the mechanism for generating spiral patterns. Mathematical and Theoretical Biology Applied Mathematics reaction-diffusion equations propagation variable diffusion singular limit problem transition probability Full Text Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5457898","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":378602583,"identity":"e6fb1951-d53d-4ea3-afea-b6e5badf5583","order_by":0,"name":"Hirokazu Ninomiya","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDElEQVRIiWNgGAWjYBACA2YGBsYGMBNMSTAwsINoAwtStPAcAIlL4NbCANcCAxIJDBC9OIA5O+/DhzNq6hIbpJvbHnzMsUjsn/n86oYfBRIM/O3dCdi0WDazGxtuOMaW2CBzsN1w5jaJxBm3c8pu9gAdJnHm7AasDjvMxib5gI0nsUEisU2aF6il4XZO2g0eoBYDiVw8Wv5JILTMv3km7eYfQlo2thkgtGy4wX7sNgFbmA1n9iUYtwG1SAL9YrzxTA7bbRkDCR6cfjl/jPFhz7c62X6J9GcSH7fVyc47fvzZzTd/bOT423uxaoEDNijt2MDAA4osBh68ypGBPTDFPCBa9SgYBaNgFIwIAACbg2JCmwHqqwAAAABJRU5ErkJggg==","orcid":"","institution":"Meiji University","correspondingAuthor":true,"prefix":"","firstName":"Hirokazu","middleName":"","lastName":"Ninomiya","suffix":""},{"id":378602584,"identity":"37d67f05-523d-427c-9668-f9d80d180eee","order_by":1,"name":"Keita Nakajima","email":"","orcid":"","institution":"Meiji University","correspondingAuthor":false,"prefix":"","firstName":"Keita","middleName":"","lastName":"Nakajima","suffix":""}],"badges":[],"createdAt":"2024-11-15 05:56:05","currentVersionCode":1,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-5457898/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5457898/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":69200017,"identity":"c0d866d1-3a7e-40b5-aba6-7b127052c08f","added_by":"auto","created_at":"2024-11-18 02:34:14","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1567820,"visible":true,"origin":"","legend":"","description":"","filename":"NakajimaNinomiyasubmitfinalpreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5457898/v1_covered_ff8518fc-ef96-4c3e-bc78-5300f6366c98.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003ePropagation and blocking of bistable waves by variable diffusion\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"reaction-diffusion equations, propagation, variable diffusion, singular limit problem, transition probability","lastPublishedDoi":"10.21203/rs.3.rs-5457898/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5457898/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBiological diffusion processes are often influenced by environmental factors. In this study, we investigate the effects of variable diffusion, which depend on the point between the departure and the arrival points, on the propagation of bistable waves. This process includes neutral, repulsive, and attractive transitions. Using singular limit analysis, we derive the equation for the interface between two stable states and examine the relationship between wave propagation and variable diffusion. In particular, when the transition probability depends on the environment at the dividing point between the departure and the arrival points, we derived an expression for the wave propagation speed that includes this dividing point ratio. More specifically, the threshold between wave propagation and conditional blocking in a one-dimensional space occurs when the transition probability is determined by a dividing point ratio of 3:1 between the departure and the arrival points. Furthermore, as an application of this concept, we consider the Aliev-Panfilov model to explore the mechanism for generating spiral patterns.\u003c/p\u003e","manuscriptTitle":"Propagation and blocking of bistable waves by variable diffusion","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-11-18 02:26:04","doi":"10.21203/rs.3.rs-5457898/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ae39225e-d12e-4e99-8b70-6262bc49532c","owner":[],"postedDate":"November 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":40321228,"name":"Mathematical and Theoretical Biology"},{"id":40321229,"name":"Applied Mathematics"}],"tags":[],"updatedAt":"2024-11-18T02:26:04+00:00","versionOfRecord":[],"versionCreatedAt":"2024-11-18 02:26:04","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5457898","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5457898","identity":"rs-5457898","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: preprint-html

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

europepmc
last seen: 2026-05-20T01:45:00.602351+00:00