Clinical and Functional Outcomes After Laparoscopic IPOM Repair: A Comparison Between Hybrid Biosynthetic and Conventional Meshes

Clinical and Functional Outcomes After Laparoscopic IPOM Repair: A Comparison Between Hybrid Biosynthetic and Conventional Meshes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Clinical and Functional Outcomes After Laparoscopic IPOM Repair: A Comparison Between Hybrid Biosynthetic and Conventional Meshes Alessandro Verbo, Mattia Angelo Bez, Danilo Di Giorgio, Iacopo Verbo This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8656937/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Laparoscopic IPOM repair is widely used for ventral hernia treatment. Hybrid biosynthetic meshes have been developed to improve tissue integration and functional recovery; however, comparative clinical evidence remains limited. Methods This was a single-center retrospective study conducted at a tertiary care institution between 2020 and 2025 including 95 consecutive patients undergoing laparoscopic IPOM repair. Forty-two patients received a hybrid biosynthetic mesh (SINECOR®) and 53 a conventional synthetic mesh. Demographic, clinical and surgical variables were analyzed, including defect size, mesh surface, operative time, complications, length of stay, functional and occupational recovery time, and quality of life (EuraHS-QoL). Hernia defects were classified as small (≤20 cm²), medium (21–100 cm²) and large (>100 cm²). Mesh size was categorized as small (≤150 cm²), medium (151–400 cm²) and large (>400 cm²). Delayed functional recovery was defined as occupational recovery >30 days. Multivariable logistic regression was performed to identify independent predictors of delayed recovery. Results Hybrid mesh was associated with significantly shorter operative time, reduced length of stay, faster functional and occupational recovery, and higher quality-of-life scores. Overall complication rates were comparable between groups. Recurrence was less frequent in the hybrid group, although follow-up was shorter. On multivariable analysis, hybrid biosynthetic mesh remained the only independent predictor of faster functional recovery. Conclusions Hybrid biosynthetic mesh was associated with improved functional recovery and quality of life for small-to-medium defects, with a safety profile comparable to conventional meshes. Larger prospective studies are warranted. Surgery General Surgery Gastrointestinal Surgery Ventral hernia IPOM hybrid biosynthetic mesh quality of life hernia repair Full Text Additional Declarations The authors declare no competing interests. Ethics statement for preprint submission The study was conducted in accordance with the Declaration of Helsinki and was approved by the local Institutional Review Board / Ethics Committee of Mater Olbia Hospital. Given the retrospective monocentric design of the study, the requirement for informed consent was waived by the Ethics Committee. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8656937","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":577944494,"identity":"1a845bea-cbbe-4919-857d-d51c7b7147f3","order_by":0,"name":"Alessandro Verbo","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDklEQVRIie3RsUoDMRjA8RyB3JKSNUfp+QqRwD1PuzhVn6DIycF1qZ0z+BCCoItDwgd16QPccINSuMnBQygZSvF6Zx30oqtD/kOy5MeXEIR8vv9Y2G1B2u0asXY9hB0EfydR2hLBEXaYH0R0IxriGMMyDLWdlaOHeUp4/VjGsjg32s52lyhkuo9wIGdDuqrkzVqTSFWVTIqLsVmsfrkY0AQjAhPFx1hSDZP7YioAETc5AfZe2/0n2TXkTh3I3k0EUMQHeUuCDWrILW9IkLvJKZBkOFiCVNRcvSx0Jfn6VZjrpYxyjEUfiZ+yTW23MFJhprXVZczmU/lmtzFjzDz3v/+r49ccI3+c9/l8Pp+7D1LEYwk/IC/CAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0003-4993-6638","institution":"Chatolic University of Sacred Heart","correspondingAuthor":true,"prefix":"","firstName":"Alessandro","middleName":"","lastName":"Verbo","suffix":""},{"id":577944646,"identity":"f1c3587c-667c-48fa-b097-e0f83059efed","order_by":1,"name":"Mattia Angelo Bez","email":"","orcid":"","institution":"Mater Olbia Hospital","correspondingAuthor":false,"prefix":"","firstName":"Mattia","middleName":"Angelo","lastName":"Bez","suffix":""},{"id":577944647,"identity":"54529d51-2b2d-4507-a710-ddcc2fc5d296","order_by":2,"name":"Danilo Di Giorgio","email":"","orcid":"","institution":"Mater Olbia Hospital","correspondingAuthor":false,"prefix":"","firstName":"Danilo","middleName":"Di","lastName":"Giorgio","suffix":""},{"id":577944648,"identity":"23bae88d-9f82-4ac6-9a9f-d56bf5566036","order_by":3,"name":"Iacopo Verbo","email":"","orcid":"","institution":"Università La Sapienza Roma","correspondingAuthor":false,"prefix":"","firstName":"Iacopo","middleName":"","lastName":"Verbo","suffix":""}],"badges":[],"createdAt":"2026-01-21 08:15:13","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-8656937/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-8656937/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":100842781,"identity":"2fe77815-857e-4a81-8948-8d133faa3253","added_by":"auto","created_at":"2026-01-22 03:15:10","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":393243,"visible":true,"origin":"","legend":"","description":"","filename":"IPOMHybridvsConventionalMeshPreprint.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8656937/v1_covered_386b0fb1-b2e8-4e27-b194-db1020ab2bc8.pdf"}],"financialInterests":"\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e\n\u003cp\u003eEthics statement for preprint submission\u003c/p\u003e\n\u003cp\u003eThe study was conducted in accordance with the Declaration of Helsinki and was approved by the local Institutional Review Board / Ethics Committee of Mater Olbia Hospital. Given the retrospective monocentric design of the study, the requirement for informed consent was waived by the Ethics Committee.\u003c/p\u003e","formattedTitle":"\u003cp\u003e\u003cstrong\u003eClinical and Functional Outcomes After Laparoscopic IPOM Repair:\u003cbr\u003e\nA Comparison Between Hybrid Biosynthetic and Conventional Meshes\u003c/strong\u003e\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Mater Olbia Hospital, Olbia, Italy","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Ventral hernia, IPOM, hybrid biosynthetic mesh, quality of life, hernia repair","lastPublishedDoi":"10.21203/rs.3.rs-8656937/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8656937/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eLaparoscopic IPOM repair is widely used for ventral hernia treatment. Hybrid biosynthetic meshes have been developed to improve tissue integration and functional recovery; however, comparative clinical evidence remains limited.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis was a single-center retrospective study conducted at a tertiary care institution between 2020 and 2025 including 95 consecutive patients undergoing laparoscopic IPOM repair. Forty-two patients received a hybrid biosynthetic mesh (SINECOR®) and 53 a conventional synthetic mesh. Demographic, clinical and surgical variables were analyzed, including defect size, mesh surface, operative time, complications, length of stay, functional and occupational recovery time, and quality of life (EuraHS-QoL). Hernia defects were classified as small (≤20 cm²), medium (21–100 cm²) and large (\u0026gt;100 cm²). Mesh size was categorized as small (≤150 cm²), medium (151–400 cm²) and large (\u0026gt;400 cm²). Delayed functional recovery was defined as occupational recovery \u0026gt;30 days. Multivariable logistic regression was performed to identify independent predictors of delayed recovery.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eHybrid mesh was associated with significantly shorter operative time, reduced length of stay, faster functional and occupational recovery, and higher quality-of-life scores. Overall complication rates were comparable between groups. Recurrence was less frequent in the hybrid group, although follow-up was shorter. On multivariable analysis, hybrid biosynthetic mesh remained the only independent predictor of faster functional recovery.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eHybrid biosynthetic mesh was associated with improved functional recovery and quality of life for small-to-medium defects, with a safety profile comparable to conventional meshes. Larger prospective studies are warranted.\u003c/p\u003e","manuscriptTitle":"Clinical and Functional Outcomes After Laparoscopic IPOM Repair:\nA Comparison Between Hybrid Biosynthetic and Conventional Meshes","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-22 03:15:04","doi":"10.21203/rs.3.rs-8656937/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"14e45e4e-2963-4320-b4f9-25cb740537de","owner":[],"postedDate":"January 22nd, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":61489817,"name":"Surgery"},{"id":61489818,"name":"General Surgery"},{"id":61489819,"name":"Gastrointestinal Surgery"}],"tags":[],"updatedAt":"2026-01-22T03:15:04+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-22 03:15:04","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8656937","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8656937","identity":"rs-8656937","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}