The impact of uterine artery embolization of fibroids and adenomyosis in lipid profile in symptomatic and premenopausal women

Xanthoula Anthoulaki, Dorelia Deuteraiou, F Gaitatzi, I Babageogaka, Panagiotis Tsikouras
In: Geburtshilfe und Frauenheilkunde · 2018 · doi:10.1055/s-0038-1671389 · W2899337207
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This study investigated the impact of uterine artery embolization on the lipid profiles of symptomatic, premenopausal women undergoing treatment for fibroids and adenomyosis.

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This study evaluated changes in lipid and hormonal profiles among 195 symptomatic, premenopausal women aged 38 to 49 years who underwent uterine artery embolization for adenomyosis and uterine fibroids after prior treatment with gonadotropin-releasing hormone analogues. Researchers measured serum levels of FSH, AMH, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides before and after the procedure to assess physiological impacts. The results indicated a statistically significant improvement in lipid parameters, characterized by decreased total cholesterol and triglycerides alongside increased HDL-cholesterol, while no significant change occurred in LDL levels. Hormonal analysis revealed expected increases in FSH and LH during the first three postoperative months, but ovarian function remained unaffected as evidenced by stable or increasing AMH levels. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Uterine fibroids are defined as benign neoplasms that originate from smooth muscle cells. UAE is a therapeutic method for treating fibroids. The purpose of UAE is to obstruct or reduce blood flow at the level of very small arteries thus creating an irreversible ischemic damage to fibroids and the objective of this study is to research the effect of UAE on the lipid profile of patients who underwent treatment with the method of embolization.
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Materials and methods

195 patients aged 38 – 49 years with a history of adenomyosis and uterine fibroids treated with synthetic analogues of gonadotrophin releasing hormone (triptorelin) from 4 – 6 months underwent uterine artery embolization. The impact of embolization on hormone and lipid profiles of these patients was assessed by determining levels of FSH, AMH, cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides in pre- and post-treatment blood serum. The statistical method that has used was the SPSS 10 statistical packet and the x2 test usage.

Results

There was statistically noteworthy decrease in the values of triglycerides (p < 0.001) and cholesterol (p < 0.001), an increase in HDL-cholesterol (p < 0.0001), while no statistically considerable change in LDL-cholesterol levels were observed. Regarding the hormonal profile were observed a progressively statistically significant increase on of levels of FSH and LH in the first postoperative month, reaching the maximum value, the third postoperative month Exception was found in AMH levels, where increased levels were observed from the third month.

Conclusion

Lipid profile of patients improved and ovarian function was not affected.

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adenomyosis

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