Comparative Study of Midterm Outcomes between Roux-en-Y Gastric Bypass (RYGB), Diverted One-Anastomosis Gastric Bypass (D-OAGB), and One Anastomosis Gastric Bypass (OAGB)

Comparative Study of Midterm Outcomes between Roux-en-Y Gastric Bypass (RYGB), Diverted One-Anastomosis Gastric Bypass (D-OAGB), and One Anastomosis Gastric Bypass (OAGB) | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Short Report Comparative Study of Midterm Outcomes between Roux-en-Y Gastric Bypass (RYGB), Diverted One-Anastomosis Gastric Bypass (D-OAGB), and One Anastomosis Gastric Bypass (OAGB) Mohamed El Masry, Islam Abdul Rahman, Mohamed Elshal, Ahmed Maher This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4868843/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 09 Nov, 2024 Read the published version in Langenbeck's Archives of Surgery → Version 1 posted 9 You are reading this latest preprint version Abstract Purpose Diverted one anastomosis gastric bypass (D-OAGB) is a new procedure that entails performing Roux-en-Y diversion during OAGB to preclude post-OAGB bile reflux. This study aimed to compare the mid-term outcomes of Roux-en-Y gastric bypass (RYGB) and OAGB versus D-OAGB. Methods This is a retrospective study that encompassed the analysis of data from patients undergoing bypass surgeries from 2015 to May 2021. The patients’ data until 2 years of follow-up were compared. Results This study included 140 patients who underwent OAGB (n = 64), RYGB (n = 24), and D-OAGB (n = 52). In the OAGB, RYGB, and D-OAGB groups, complication rates were 3.1%, 8.3%, and 5.8%, respectively. At the 3-month and 6-month follow-ups, the OAGB and D-OAGB groups showed statistically significant higher percentage of excess weight loss (EWL%). Otherwise, the weight measures and weight loss outcome were comparable among the three groups in the other follow-up visits (p > 0.05). There was a significantly lower number of gastroesophageal reflux disease (GERD) remission cases and a higher number of de novo GERD cases in the OAGB group. Conclusion D-OAGB demonstrated favorable outcomes, including lower early adverse events and superior weight loss results in the first 6 months post-surgery when compared to RYGB. The D-OAGB group also showed higher rates of GERD remission and lower de novo GERD occurrence than OAGB. Further research is warranted to validate these findings and expand our understanding of this innovative surgical approach. One anastomosis gastric bypass (OAGB) diverted OAGB Roux-en-Y gastric bypass (RYGB) weight loss gastroesophageal reflux Introduction Obesity has become a pandemic, impacting people’s health worldwide [ 1 ]. Currently, metabolic/bariatric surgery is the most definitive solution for obesity and its associated medical conditions [ 2 ]. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have been recognized as the gold standard bariatric procedures. However, Roux-en-Y gastric bypass has shown a more evident metabolic effect and remission of obesity-associated conditions due to the bypass component of the surgery [ 3 ]. One anastomosis gastric bypass (OAGB) is another bypass procedure that was first described by Rutledge and published in 2001 [ 4 ]. Since then, it has gained wide popularity and acceptance, being a relatively simple procedure compared to RYGB and maintaining its effectiveness in weight loss and resolution of obesity-associated medical conditions. It has even been reported that OAGB has weight loss and metabolic benefits exceeding those of RYGB due to the more malabsorptive effect driven by the longer biliopancreatic limb [ 5 ]. One anastomosis gastric bypass has risen to become the third most frequently conducted bariatric surgery, trailing only sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) [ 6 ]. In addition, it gained recognition as a mainstream bariatric technique by the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) in 2018 [ 7 ]. However, there is still a controversial OAGB-related clinical concern, which is the biliary reflux that is responsible for surgery revision in a number of patients [ 8 ]. Diverted One-Anastomosis Gastric Bypass (D-OAGB) is a new procedure that entails performing Roux-en-Y diversion during OAGB to preclude the post-OAGB bile reflux and associated marginal ulcers seen with OAGB [ 9 ]. It has been noted as a less complex approach compared to RYGBP, as it circumvents the necessity of positioning the small bowel up to the gastroesophageal junction, thereby reducing tension on the anastomosis [ 9 ]. This study aimed to compare the mid-term outcomes of RYGB and OAGB versus D-OAGB. Patients and Methods This is a retrospective study that entailed the analysis of prospectively collected data. The study was conducted on consecutively recruited patients who were planned for bariatric bypass surgery at our institutions during the period from December 2015 to May 2021. The study was initiated after getting the approval of the Research Ethics Committee and adhering to the Declaration of Helsinki. The patient's eligibility for bariatric surgery was judged per the IFSO guidelines [ 10 , 11 ]. Patients recruited for bypass surgeries (OAGB, RYGB, or D-OAGB) during the study period were included in the study. The selection of either procedure was based on the preference of each patient after a discussion with the surgeon that included a dedicated description of each choice’s advantages and possible shortcomings. The study patients underwent routine workups that included detailed history-taking, multidisciplinary clinical evaluation, and laboratory investigations. Patients with incomplete follow-up data until 2 years after surgery were excluded from the study. Written informed consent was obtained from each patient before surgery. Operative procedure The surgical procedures were conducted as established. In summary, the surgery was performed under general anesthesia. In a diamond-shaped pattern, five trocar insertions were done after the induction of pneumoperitoneum. In patients who underwent OAGB, the gastric pouch was fashioned over a 36-French bougie, and after determining the Treitz ligament, a bilio-pancreatic limb (BPL) of 200 cm length was created. A 3-cm side-to-side gastrojejunal anastomosis was formulated to be vertical or slightly oblique, ante-colic, and isoperistaltic. In patients who were subjected to the RYGB group, the BPL was created at a length of 45 cm and anastomosed side-to-side with the gastric pouch, and a 120 cm alimentary limb (AL) was performed along the mesenteric border. In patients undergoing D-OAGB, steps were followed the same as in OAGB. The stomach was vertically divided using a stapling device over a 36-French bougie to create a long and narrow gastric pouch. From the ligament of Treitz, which marks the start of the jejunum, 200 cm of the small intestine is measured. This section was designated as the BPL. An additional segment, measuring 60 cm distally, was marked as the alimentary limb, the end of which was surgically connected to the lower part of the gastric pouch, forming a direct path for the food to bypass a large portion of the stomach and the initial segment of the small intestine. This connection is known as the gastrojejunal anastomosis. One of the distinguishing steps of the D-OAGB is the creation of the entero-enterostomy, a secondary connection in the small intestine. To achieve this, antimesenteric holes are fashioned both in the previously identified BPL and near the terminus of the alimentary limb. These holes allow for the establishment of the secondary connection, diverting the bile and pancreatic fluids to join the food contents further downstream. As a result of the procedure, the intestine takes on a Roux-en-Y configuration. This design ensures that food bypasses the initial section of the intestines, promoting malabsorption, while also facilitating the diversion of bile and pancreatic fluids, thus reducing the chance of bile reflux into the stomach [ 9 , 12 ]. In the three groups, an intraoperative methylene blue test was employed to examine for the presence of any anastomotic leakage. Drain usage was determined selectively based on the presence of any bleeding spots and tissue conditions. Study outcomes The study outcomes were the differences among the three groups in the perioperative events, weight loss outcome, associated medical condition improvement, and the GERD condition. The percentages of total weight loss (TWL%) and excess body weight loss (EWL%) were calculated as previously described [ 13 ]. Improvement of hypertension, diabetes mellitus, and dyslipidemia was considered if one or more medications’ dosage was reduced or cessated [ 14 ]. Patients were diagnosed to have GERD if they had typical symptoms and/or were using medical treatment such as proton pump inhibitors (PPIs) after the prescribed 3-month postoperative use, according to the described guidelines [ 15 ]. GERD improvement was considered in cases of symptom relief or cessation of treatment. Statistical analysis The patients' data were analyzed using version 28 of the SPSS statistical software (IBM Corp., Armonk, NY, USA). After normality testing, the numerical data of the three groups were compared using the ANOVA test. Qualitative data were presented as counts and percentages, and the chi-square test was used for comparison. A P-value less than 0.05 was considered statistically significant. Results The present study included 140 patients who were recruited for the OAGB (n = 64), RYGB (n = 24), or D-OAGB (n = 52). The age of the included patients ranged from 19 to 59 years, with a mean of 37.7 ± 9.9 years. Females constituted the majority of patients (n = 103, 73.6%). The mean preoperative weight was 123.56 ± 22.59 kg, and the mean BMI was 44.87 ± 7.37 kg/m 2 . The patients’ main associated medical conditions were hypertension (n = 39, 27.9%), diabetes mellitus (n = 42, 30.0%), and dyslipidemia (n = 68, 48.6%). Gastroesophageal reflux symptoms were found in 34 patients (24.3%). The patients in the three groups were comparable in the baseline criteria, apart from the GERD rate, which was significantly lower in the OAGB group (Table 1 ). Table 1 Baseline demographic data of the study patients The OAGB group (n = 64) The RYGB group (n = 24) The D-OAGB group (n = 52) p-value Mean ± SD Mean ± SD Mean ± SD Age (year) 37.5 ± 10.3 35.3 ± 10.2 39.04 ± 9.2 0.304 Preoperative weight (Kg) 124.97 ± 23.96 120.83 ± 17.69 123.08 ± 23.04 0.735 Preoperative BMI (Kg/m 2 ) 45.1 ± 6.8 46.5 ± 8.7 43.8 ± 7.3 0.330 Count (%) Count (%) Count (%) Sex Male 13 (20.3) 5 (20.8) 19 (36.5) 0.114 Female 51 (79.7) 19 (79.2) 33 (63.5) Comorbidities Hypertension 17 (26.6) 9 (37.5) 13 (25) 0.29 Type 2 diabetes mellitus 18 (28.1) 9 (37.5) 15 (28.8) 0.468 Dyslipidemia 28 (43.8) 13 (54.2) 27 (51.9) 0.568 GERD 7 (1.1) 9 (37.5) 18 (34.6) 0.003* *: statistically significant Operative and early postoperative events A lower mean surgery time was found in the OAGB group. However, without statistical significance (110.47 ± 29.33 minutes in the OAGB group, 121.04 ± 36.71 minutes in the RYGB group, and 119.9 ± 33.95 minutes in the D-OAGB group, p = 0.206), no intraoperative adverse events were experienced. Early postoperative complications occurred in 7 patients (5.0%), and surgical intervention was required in 4 of them (2.9%). In the OAGB group, complications were recorded in 2 patients (3.1%), including one case of septicemia managed conservatively and one case of intra-abdominal bleeding necessitating exploration. The RYGB group exhibited a higher complication rate at 8.3% (n = 2), with two cases of leakage that required re-intervention and stent placement. In the D-OAGB group, complications were noted in 3 cases (5.8%), consisting of one case of intra-abdominal bleeding necessitating exploration and drainage, another bleeding case managed conservatively, and one leakage case treated conservatively (Table 2 ). Table 2 Operative and early postoperative events and weight loss outcomes Parameter OAGB (n = 64) RYGB (n = 24) D-OAGB (n = 52) p-value Mean Surgery Time (mins) 110.47 ± 29.33 121.04 ± 36.71 119.9 ± 33.95 0.206 Early Postoperative Complications (%) 2 (3.1%) 2 (8.3%) 3 (5.8%) 0.528 BMI (kg/m^2) 3 month 34.2 ± 6.25 37.15 ± 5.84 33.76 ± 4.98 0.049* 6 month 31.9 ± 4.2 33.3 ± 4.5 30.5 ± 5.7 0.346 1 year 29.7 ± 47 32.8 ± 4.3 29.4 ± 4 0.088 2 year 27.02 ± 5.1 28.4 ± 5 26.9 ± 4 0.670 EWL% 3 month 43.68 ± 8.15 37.21 ± 11.85 42.4 ± 9.34 0.016* 6 month 67.33 ± 9.35 61.4 ± 13.17 66.11 ± 8.15 0.040* 1 year 79.92 ± 17.8 67.83 ± 11.7 81.94 ± 22.1 0.084 2 year 93.01 ± 18.8 87.83 ± 21.8 94.08 ± 35.9 0.805 TWL% 3 month 17.7 ± 5.5 17.4 ± 5.9 18.9 ± 4.4 0.427 6 month 26 ± 8.9 24.1 ± 6.7 26.3 ± 4.5 0.365 1 year 31.7 ± 7.9 31.5 ± 5.6 34 ± 7.6 0.385 2 year 33.9 ± 8.7 34.5 ± 6.6 35.6 ± 7.8 0.520 1-year comorbidities remission rate Hypertension 34/39 (87.2%) 7/9 (77.8%) 12/13 (92.3%) 0.596 Diabetes Mellitus 14/18 (77.8%) 6/9 (66.7%) 8/10 (80.0%) 0.743 Dyslipidemia 27/28 (96.4%) 11/13 (84.6%) 25/27 (92.6%) 0.403 *: statistically significant Weight loss outcome At the 3-month follow-up, the OAGB and D-OAGB groups showed statistically significant lower weight (93.2 ± 19.19 kg and 92.97 ± 18.67 kg vs. 105.71 ± 18.26 kg in the RYGB group, p = 0.033), lower BMI (34.2 ± 6.25 kg/m 2 and 33.76 ± 4.98 kg/m 2 vs. 37.15 ± 5.84 kg/m 2 in the RYGB group, p = 0.049), and higher EWL% (43.68 ± 8.15 and 42.4 ± 9.34 vs. 37.21 ± 11.85 in the RYGB group, p = 0.016). No statistically significant differences were noted in the TWL% (p = 0.427) (Table 2 ). At the 6-month follow-up, similar significant differences were noted in the weight (79.5 ± 11.23 kg and 80.2 ± 12.31 kg vs. 86.5 ± 11.81 kg in the RYGB group, p = 0.042) and EWL% (67.33 ± 9.35 and 66.11 ± 8.15 vs. 61.4 ± 13.17 in the RYGB group, p = 0.040) (Table 2 ). Otherwise, the weight measures and weight loss outcome were comparable among the three groups in the other follow-up visits (p > 0.05) (Table 2 ). Associated medical conditions The three groups showed significant improvement in the associated medical conditions (Table). At the 1-year postoperative follow-up, remission occurred in 34/39 patients (87.2%) with hypertension (88.2% of the OAGB group, 92.3% of the D-OAGB group, and 77.8% of the RYGB group, p = 0.596), 32/42 patients (76.2%) with diabetes mellitus (77.8% of the OAGB group, 80% of the D-OAGB group, and 66.7% of the RYGB group, p = 0.743), and 63/68 patients (92.6%) with dyslipidemia (96.4% of the OAGB group, 92.6% of the D-OAGB group, and 84.6% of the RYGB group, p = 0.403) (Table 2 ). At 6 months, relief of symptoms occurred in 23/34 patients (67.6%) with GERD (14.3% of the OAGB group, 83.3% of the D-OAGB group, and 77.8% of the RYGB group, p = 0.003), and worsening occurred in 2/34 patients (5.9%), both of whom were in the OAGB. De novo GERD symptoms were experienced by 2 patients (in the OAGB). At the one-year and 2-year follow-ups, the number of denovo cases reached 4 patients (3 in the OAGB group and 1 in the D-OAGB group). Discussion The very new procedure, diverted one anastomosis gastric bypass, also named long pouch Roux-en-Y bypass (LPRYGB), was performed in 2013 and published in 2018. First, it has been implemented by Ribeiro and coworkers as a revisional procedure for patients who have failed OAGB due to reflux symptoms. After that, the procedure was performed as a primary procedure. Its first name, diverted one anastomosis gastric bypass, has been grounded in being typical of OAGB, with adding a second entero-enterostomy aiming at diversion of the bile away from the stomach to preclude postoperative bile reflux and GERD [ 9 ]. The second name, long pouch Roux-en-Y gastric bypass, has been mentioned in their article published in 2019, since they considered the added entero-enterostomy as a Roux-en-Y diversion [ 12 ]. The foundation of our understanding and subsequent practice of this procedure is attributed to scientific meetings with the surgery innovators during 2014 and 2015, where they extensively discussed and demonstrated the technique. Encouraged by the promise it showed, we began implementing this procedure by the end of 2015. As for the best of our knowledge, this is the first study reporting practicing this procedure after being introduced by Ribeiro et al. [ 9 , 12 ]. In our study, for the first time, we compared the outcome of this procedure to the most established bypass surgeries (RYGB and OAGB). Overall, OAGB and D-OAGB showed outperformance in terms of lower early postoperative adverse events. However, the difference did not reach the level of statistical significance, likely due to the relatively small sample size. This result aligns with the previously reported fewer OAGB-associated adverse events compared to RYGB, which has been attributed to the only anastomosis and the more straightforward anatomical construction found in OAGB [ 16 ]. In spite of the presence of a second anastomotic site in the D-OAGB, the surgery doesn’t entail bringing up an intestinal loop up to the gastroesophageal junction, which likely makes up less tension on the site of anastomosis [ 17 ]. It is worthy to note that this D-OAGB-associated lower rate of early adverse events, compared to RYGB, comes in the early learning curve of the procedure, with likely lower rates as the learning curve progresses. The present study showed another point of OAGB and D-OAGB superiority, which was the significantly better weight loss outcome during the first year after surgery. This is consistent with a meta-analysis encompassing 16 studies and 12,445 patients that found that OAGB was associated with a higher postoperative EWL% compared to RYGB [ 18 ]. This was explained by the longer BPL in both surgeries compared to that of RYGB. Notably, a significantly lower number of GERD remissions and a higher number of denovo GERD cases were found in the OAGB group. This is in line with the still-debatable association between OAGB and biliary reflux [ 19 – 22 ]. The bile reflux-associated Barrett’s esophagus and gastric cancer have been described [ 23 , 24 ], which makes it a non-negligible surgery consequence. For this reason, RYGB has long been regarded as the best therapeutic choice for GERD patients [ 25 – 27 ]. The newly adopted procedure could now be another solution for patients with GERD. It offers efficiency in GERD remission and early weight loss, along with a lower rate of adverse events and denovo GERD occurrence, making it an excellent choice for patients seeking bariatric surgery, especially those with GERD, or risky for GERD and Barrett’s esophagus. Overall, our work emphasizes the new procedure-associated promising outcome that was reported by Ribeiro et al. [ 9 , 12 ]. The study is limited by the small sample size. D-OAGB is a new and non-popular procedure, thus limiting the patient’s acceptability of the procedure. The study is also limited by the retrospective design, short-term assessment, and non-objective assessment of GERD. However, we present our experience in a very new procedure that needs to be unveiled by more comparative studies. Conclusion In conclusion, D-OAGB, also known as LPRYGB, demonstrated favorable outcomes, including lower early adverse events and superior weight loss results in the first year when compared to RYGB, with GERD remission and reduced de novo GERD occurrence when compared to OAGB. Further research is warranted to validate these findings and expand our understanding of this innovative surgical approach. Declarations Acknowledgements: None. Funding: None. Statement for informed consent: Informed consent was obtained from all individual participants included in the study. Statement for conflict of interest: The authors declare that they have no conflict of interest. Ethical approval: This study has been approved by the appropriate institutional research ethics committee. Study conception and design was constructed by Dr. Mohamed Abdul Moneim El Masry Acquisition of data was done by Dr. Mohamed Fathy Mahmoud Elshal Analysis and interpretation of data was done by Drs. 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Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 09 Nov, 2024 Read the published version in Langenbeck's Archives of Surgery → Version 1 posted Editorial decision: Revision requested 12 Oct, 2024 Reviews received at journal 07 Oct, 2024 Reviewers agreed at journal 27 Sep, 2024 Reviews received at journal 06 Sep, 2024 Reviewers agreed at journal 04 Sep, 2024 Reviewers invited by journal 04 Sep, 2024 Editor assigned by journal 11 Aug, 2024 Submission checks completed at journal 09 Aug, 2024 First submitted to journal 06 Aug, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4868843","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Short Report","associatedPublications":[],"authors":[{"id":349473971,"identity":"9ec1cc5d-e83b-447c-95a5-57dba8914b28","order_by":0,"name":"Mohamed El Masry","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA5ElEQVRIiWNgGAWjYPACm3rG9gYQg5loLWkJzD0HSNNyOIF9RgKRWnSnHX78ubKNOY935uNnEgwV1okN7O0X8Goxu51mJnm2ja1YcnaamQTDmfTEBp4zBQS0JJgxNrbxMG6cncMmwdh2OLFBIieBgJb0zx8b2yQY9988A9TyD6hF/g0hLTkGko1tBomNM3iAWhpAtrAfIKSlTLLhXIIxY0+asUXCsXTjNp4cvDpADtv8saHsvxxj++GHNz7UWMv2sx9/gF8PCDCyQRkgT7Ax8BgQ1sLwB4XHToQto2AUjIJRMJIAAGWtSbpN0U5VAAAAAElFTkSuQmCC","orcid":"","institution":"Cairo University","correspondingAuthor":true,"prefix":"","firstName":"Mohamed","middleName":"El","lastName":"Masry","suffix":""},{"id":349473972,"identity":"34c518c3-69c5-4ee2-9bfa-8d79a7eb5170","order_by":1,"name":"Islam Abdul Rahman","email":"","orcid":"","institution":"Military Production Specialized Medical Centre","correspondingAuthor":false,"prefix":"","firstName":"Islam","middleName":"Abdul","lastName":"Rahman","suffix":""},{"id":349473973,"identity":"a63f56b4-da19-4040-90f7-914836ecfaec","order_by":2,"name":"Mohamed Elshal","email":"","orcid":"","institution":"Cairo University","correspondingAuthor":false,"prefix":"","firstName":"Mohamed","middleName":"","lastName":"Elshal","suffix":""},{"id":349473974,"identity":"35de61b7-3989-48dc-90f7-ab31529beed4","order_by":3,"name":"Ahmed Maher","email":"","orcid":"","institution":"Cairo University","correspondingAuthor":false,"prefix":"","firstName":"Ahmed","middleName":"","lastName":"Maher","suffix":""}],"badges":[],"createdAt":"2024-08-06 13:29:39","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4868843/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4868843/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s00423-024-03525-3","type":"published","date":"2024-11-09T15:58:01+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":68750002,"identity":"6182ea43-24eb-4a07-964c-8d48db7370db","added_by":"auto","created_at":"2024-11-11 16:08:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":554353,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4868843/v1/7177f87c-52b9-4b7c-a927-1307eb97a198.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Comparative Study of Midterm Outcomes between Roux-en-Y Gastric Bypass (RYGB), Diverted One-Anastomosis Gastric Bypass (D-OAGB), and One Anastomosis Gastric Bypass (OAGB)","fulltext":[{"header":"Introduction","content":"\u003cp\u003eObesity has become a pandemic, impacting people\u0026rsquo;s health worldwide [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Currently, metabolic/bariatric surgery is the most definitive solution for obesity and its associated medical conditions [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) have been recognized as the gold standard bariatric procedures. However, Roux-en-Y gastric bypass has shown a more evident metabolic effect and remission of obesity-associated conditions due to the bypass component of the surgery [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eOne anastomosis gastric bypass (OAGB) is another bypass procedure that was first described by Rutledge and published in 2001 [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Since then, it has gained wide popularity and acceptance, being a relatively simple procedure compared to RYGB and maintaining its effectiveness in weight loss and resolution of obesity-associated medical conditions. It has even been reported that OAGB has weight loss and metabolic benefits exceeding those of RYGB due to the more malabsorptive effect driven by the longer biliopancreatic limb [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. One anastomosis gastric bypass has risen to become the third most frequently conducted bariatric surgery, trailing only sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. In addition, it gained recognition as a mainstream bariatric technique by the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) in 2018 [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eHowever, there is still a controversial OAGB-related clinical concern, which is the biliary reflux that is responsible for surgery revision in a number of patients [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Diverted One-Anastomosis Gastric Bypass (D-OAGB) is a new procedure that entails performing Roux-en-Y diversion during OAGB to preclude the post-OAGB bile reflux and associated marginal ulcers seen with OAGB [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. It has been noted as a less complex approach compared to RYGBP, as it circumvents the necessity of positioning the small bowel up to the gastroesophageal junction, thereby reducing tension on the anastomosis [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. This study aimed to compare the mid-term outcomes of RYGB and OAGB versus D-OAGB.\u003c/p\u003e"},{"header":"Patients and Methods","content":"\u003cp\u003eThis is a retrospective study that entailed the analysis of prospectively collected data. The study was conducted on consecutively recruited patients who were planned for bariatric bypass surgery at our institutions during the period from December 2015 to May 2021. The study was initiated after getting the approval of the Research Ethics Committee and adhering to the Declaration of Helsinki.\u003c/p\u003e \u003cp\u003eThe patient's eligibility for bariatric surgery was judged per the IFSO guidelines [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Patients recruited for bypass surgeries (OAGB, RYGB, or D-OAGB) during the study period were included in the study. The selection of either procedure was based on the preference of each patient after a discussion with the surgeon that included a dedicated description of each choice\u0026rsquo;s advantages and possible shortcomings. The study patients underwent routine workups that included detailed history-taking, multidisciplinary clinical evaluation, and laboratory investigations. Patients with incomplete follow-up data until 2 years after surgery were excluded from the study. Written informed consent was obtained from each patient before surgery.\u003c/p\u003e \u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eOperative procedure\u003c/h2\u003e \u003cp\u003eThe surgical procedures were conducted as established. In summary, the surgery was performed under general anesthesia. In a diamond-shaped pattern, five trocar insertions were done after the induction of pneumoperitoneum.\u003c/p\u003e \u003cp\u003eIn patients who underwent OAGB, the gastric pouch was fashioned over a 36-French bougie, and after determining the Treitz ligament, a bilio-pancreatic limb (BPL) of 200 cm length was created. A 3-cm side-to-side gastrojejunal anastomosis was formulated to be vertical or slightly oblique, ante-colic, and isoperistaltic.\u003c/p\u003e \u003cp\u003eIn patients who were subjected to the RYGB group, the BPL was created at a length of 45 cm and anastomosed side-to-side with the gastric pouch, and a 120 cm alimentary limb (AL) was performed along the mesenteric border.\u003c/p\u003e \u003cp\u003eIn patients undergoing D-OAGB, steps were followed the same as in OAGB. The stomach was vertically divided using a stapling device over a 36-French bougie to create a long and narrow gastric pouch. From the ligament of Treitz, which marks the start of the jejunum, 200 cm of the small intestine is measured. This section was designated as the BPL. An additional segment, measuring 60 cm distally, was marked as the alimentary limb, the end of which was surgically connected to the lower part of the gastric pouch, forming a direct path for the food to bypass a large portion of the stomach and the initial segment of the small intestine. This connection is known as the gastrojejunal anastomosis. One of the distinguishing steps of the D-OAGB is the creation of the entero-enterostomy, a secondary connection in the small intestine. To achieve this, antimesenteric holes are fashioned both in the previously identified BPL and near the terminus of the alimentary limb. These holes allow for the establishment of the secondary connection, diverting the bile and pancreatic fluids to join the food contents further downstream. As a result of the procedure, the intestine takes on a Roux-en-Y configuration. This design ensures that food bypasses the initial section of the intestines, promoting malabsorption, while also facilitating the diversion of bile and pancreatic fluids, thus reducing the chance of bile reflux into the stomach [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIn the three groups, an intraoperative methylene blue test was employed to examine for the presence of any anastomotic leakage. Drain usage was determined selectively based on the presence of any bleeding spots and tissue conditions.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eStudy outcomes\u003c/h2\u003e \u003cp\u003eThe study outcomes were the differences among the three groups in the perioperative events, weight loss outcome, associated medical condition improvement, and the GERD condition.\u003c/p\u003e \u003cp\u003eThe percentages of total weight loss (TWL%) and excess body weight loss (EWL%) were calculated as previously described [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e]. Improvement of hypertension, diabetes mellitus, and dyslipidemia was considered if one or more medications\u0026rsquo; dosage was reduced or cessated [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. Patients were diagnosed to have GERD if they had typical symptoms and/or were using medical treatment such as proton pump inhibitors (PPIs) after the prescribed 3-month postoperative use, according to the described guidelines [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. GERD improvement was considered in cases of symptom relief or cessation of treatment.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003eStatistical analysis\u003c/h2\u003e \u003cp\u003eThe patients' data were analyzed using version 28 of the SPSS statistical software (IBM Corp., Armonk, NY, USA). After normality testing, the numerical data of the three groups were compared using the ANOVA test. Qualitative data were presented as counts and percentages, and the chi-square test was used for comparison. A P-value less than 0.05 was considered statistically significant.\u003c/p\u003e \u003c/div\u003e"},{"header":"Results","content":"\u003cp\u003eThe present study included 140 patients who were recruited for the OAGB (n\u0026thinsp;=\u0026thinsp;64), RYGB (n\u0026thinsp;=\u0026thinsp;24), or D-OAGB (n\u0026thinsp;=\u0026thinsp;52). The age of the included patients ranged from 19 to 59 years, with a mean of 37.7\u0026thinsp;\u0026plusmn;\u0026thinsp;9.9 years. Females constituted the majority of patients (n\u0026thinsp;=\u0026thinsp;103, 73.6%). The mean preoperative weight was 123.56\u0026thinsp;\u0026plusmn;\u0026thinsp;22.59 kg, and the mean BMI was 44.87\u0026thinsp;\u0026plusmn;\u0026thinsp;7.37 kg/m\u003csup\u003e2\u003c/sup\u003e.\u003c/p\u003e \u003cp\u003eThe patients\u0026rsquo; main associated medical conditions were hypertension (n\u0026thinsp;=\u0026thinsp;39, 27.9%), diabetes mellitus (n\u0026thinsp;=\u0026thinsp;42, 30.0%), and dyslipidemia (n\u0026thinsp;=\u0026thinsp;68, 48.6%). Gastroesophageal reflux symptoms were found in 34 patients (24.3%). The patients in the three groups were comparable in the baseline criteria, apart from the GERD rate, which was significantly lower in the OAGB group (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eBaseline demographic data of the study patients\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"6\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eThe OAGB group (n\u0026thinsp;=\u0026thinsp;64)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eThe RYGB group\u003c/p\u003e \u003cp\u003e(n\u0026thinsp;=\u0026thinsp;24)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eThe D-OAGB group\u003c/p\u003e \u003cp\u003e(n\u0026thinsp;=\u0026thinsp;52)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e \u003cp\u003ep-value\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eMean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eMean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eMean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eAge (year)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e37.5\u0026thinsp;\u0026plusmn;\u0026thinsp;10.3\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e35.3\u0026thinsp;\u0026plusmn;\u0026thinsp;10.2\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e39.04\u0026thinsp;\u0026plusmn;\u0026thinsp;9.2\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.304\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003ePreoperative weight (Kg)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e124.97\u0026thinsp;\u0026plusmn;\u0026thinsp;23.96\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e120.83\u0026thinsp;\u0026plusmn;\u0026thinsp;17.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e123.08\u0026thinsp;\u0026plusmn;\u0026thinsp;23.04\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.735\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003ePreoperative BMI (Kg/m\u003c/b\u003e\u003csup\u003e\u003cb\u003e2\u003c/b\u003e\u003c/sup\u003e\u003cb\u003e)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e45.1\u0026thinsp;\u0026plusmn;\u0026thinsp;6.8\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e46.5\u0026thinsp;\u0026plusmn;\u0026thinsp;8.7\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e43.8\u0026thinsp;\u0026plusmn;\u0026thinsp;7.3\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.330\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e\u003cb\u003eCount (%)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e\u003cb\u003eCount (%)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e\u003cb\u003eCount (%)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e\u0026nbsp;\u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003e\u003cb\u003eSex\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003eMale\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e13 (20.3)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e5 (20.8)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e19 (36.5)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003e0.114\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003eFemale\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e51 (79.7)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e19 (79.2)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e33 (63.5)\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eComorbidities\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eHypertension\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e17 (26.6)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e9 (37.5)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e13 (25)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.29\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eType 2 diabetes mellitus\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e18 (28.1)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e9 (37.5)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e15 (28.8)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.468\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eDyslipidemia\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e28 (43.8)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e13 (54.2)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e27 (51.9)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.568\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eGERD\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e7 (1.1)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e9 (37.5)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e18 (34.6)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.003*\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003ctfoot\u003e \u003ctr\u003e\u003ctd colspan=\"6\"\u003e*: statistically significant\u003c/td\u003e\u003c/tr\u003e \u003c/tfoot\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cdiv id=\"Sec7\" class=\"Section2\"\u003e \u003ch2\u003eOperative and early postoperative events\u003c/h2\u003e \u003cp\u003eA lower mean surgery time was found in the OAGB group. However, without statistical significance (110.47\u0026thinsp;\u0026plusmn;\u0026thinsp;29.33 minutes in the OAGB group, 121.04\u0026thinsp;\u0026plusmn;\u0026thinsp;36.71 minutes in the RYGB group, and 119.9\u0026thinsp;\u0026plusmn;\u0026thinsp;33.95 minutes in the D-OAGB group, p\u0026thinsp;=\u0026thinsp;0.206), no intraoperative adverse events were experienced. Early postoperative complications occurred in 7 patients (5.0%), and surgical intervention was required in 4 of them (2.9%). In the OAGB group, complications were recorded in 2 patients (3.1%), including one case of septicemia managed conservatively and one case of intra-abdominal bleeding necessitating exploration. The RYGB group exhibited a higher complication rate at 8.3% (n\u0026thinsp;=\u0026thinsp;2), with two cases of leakage that required re-intervention and stent placement. In the D-OAGB group, complications were noted in 3 cases (5.8%), consisting of one case of intra-abdominal bleeding necessitating exploration and drainage, another bleeding case managed conservatively, and one leakage case treated conservatively (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eOperative and early postoperative events and weight loss outcomes\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"6\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003eParameter\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eOAGB\u003c/p\u003e \u003cp\u003e(n\u0026thinsp;=\u0026thinsp;64)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003eRYGB\u003c/p\u003e \u003cp\u003e(n\u0026thinsp;=\u0026thinsp;24)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003eD-OAGB\u003c/p\u003e \u003cp\u003e(n\u0026thinsp;=\u0026thinsp;52)\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e \u003cp\u003ep-value\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eMean Surgery Time (mins)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e110.47\u0026thinsp;\u0026plusmn;\u0026thinsp;29.33\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e121.04\u0026thinsp;\u0026plusmn;\u0026thinsp;36.71\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e119.9\u0026thinsp;\u0026plusmn;\u0026thinsp;33.95\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.206\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eEarly Postoperative Complications (%)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e2 (3.1%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e2 (8.3%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e3 (5.8%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.528\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003e\u003cb\u003eBMI (kg/m^2)\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e3 month\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e34.2\u0026thinsp;\u0026plusmn;\u0026thinsp;6.25\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e37.15\u0026thinsp;\u0026plusmn;\u0026thinsp;5.84\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e33.76\u0026thinsp;\u0026plusmn;\u0026thinsp;4.98\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.049*\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e6 month\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e31.9\u0026thinsp;\u0026plusmn;\u0026thinsp;4.2\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e33.3\u0026thinsp;\u0026plusmn;\u0026thinsp;4.5\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e30.5\u0026thinsp;\u0026plusmn;\u0026thinsp;5.7\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.346\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e1 year\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e29.7\u0026thinsp;\u0026plusmn;\u0026thinsp;47\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e32.8\u0026thinsp;\u0026plusmn;\u0026thinsp;4.3\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e29.4\u0026thinsp;\u0026plusmn;\u0026thinsp;4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.088\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e2 year\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e27.02\u0026thinsp;\u0026plusmn;\u0026thinsp;5.1\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e28.4\u0026thinsp;\u0026plusmn;\u0026thinsp;5\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e26.9\u0026thinsp;\u0026plusmn;\u0026thinsp;4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.670\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003e\u003cb\u003eEWL%\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e3 month\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e43.68\u0026thinsp;\u0026plusmn;\u0026thinsp;8.15\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e37.21\u0026thinsp;\u0026plusmn;\u0026thinsp;11.85\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e42.4\u0026thinsp;\u0026plusmn;\u0026thinsp;9.34\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.016*\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e6 month\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e67.33\u0026thinsp;\u0026plusmn;\u0026thinsp;9.35\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e61.4\u0026thinsp;\u0026plusmn;\u0026thinsp;13.17\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e66.11\u0026thinsp;\u0026plusmn;\u0026thinsp;8.15\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.040*\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e1 year\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e79.92\u0026thinsp;\u0026plusmn;\u0026thinsp;17.8\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e67.83\u0026thinsp;\u0026plusmn;\u0026thinsp;11.7\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e81.94\u0026thinsp;\u0026plusmn;\u0026thinsp;22.1\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.084\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e2 year\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e93.01\u0026thinsp;\u0026plusmn;\u0026thinsp;18.8\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e87.83\u0026thinsp;\u0026plusmn;\u0026thinsp;21.8\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e94.08\u0026thinsp;\u0026plusmn;\u0026thinsp;35.9\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.805\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"3\" rowspan=\"4\"\u003e \u003cp\u003e\u003cb\u003eTWL%\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e3 month\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e17.7\u0026thinsp;\u0026plusmn;\u0026thinsp;5.5\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e17.4\u0026thinsp;\u0026plusmn;\u0026thinsp;5.9\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e18.9\u0026thinsp;\u0026plusmn;\u0026thinsp;4.4\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.427\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e6 month\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e26\u0026thinsp;\u0026plusmn;\u0026thinsp;8.9\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e24.1\u0026thinsp;\u0026plusmn;\u0026thinsp;6.7\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e26.3\u0026thinsp;\u0026plusmn;\u0026thinsp;4.5\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.365\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e1 year\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e31.7\u0026thinsp;\u0026plusmn;\u0026thinsp;7.9\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e31.5\u0026thinsp;\u0026plusmn;\u0026thinsp;5.6\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e34\u0026thinsp;\u0026plusmn;\u0026thinsp;7.6\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.385\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003e\u003cb\u003e2 year\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e33.9\u0026thinsp;\u0026plusmn;\u0026thinsp;8.7\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e34.5\u0026thinsp;\u0026plusmn;\u0026thinsp;6.6\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e35.6\u0026thinsp;\u0026plusmn;\u0026thinsp;7.8\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.520\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"6\" nameend=\"c6\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003e1-year comorbidities remission rate\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eHypertension\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e34/39 (87.2%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e7/9 (77.8%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e12/13 (92.3%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.596\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eDiabetes Mellitus\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e14/18 (77.8%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e6/9 (66.7%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e8/10 (80.0%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.743\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e \u003cp\u003e\u003cb\u003eDyslipidemia\u003c/b\u003e\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c3\"\u003e \u003cp\u003e27/28 (96.4%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c4\"\u003e \u003cp\u003e11/13 (84.6%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c5\"\u003e \u003cp\u003e25/27 (92.6%)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003e0.403\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003ctfoot\u003e \u003ctr\u003e\u003ctd colspan=\"6\"\u003e*: statistically significant\u003c/td\u003e\u003c/tr\u003e \u003c/tfoot\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003eWeight loss outcome\u003c/h2\u003e \u003cp\u003eAt the 3-month follow-up, the OAGB and D-OAGB groups showed statistically significant lower weight (93.2\u0026thinsp;\u0026plusmn;\u0026thinsp;19.19 kg and 92.97\u0026thinsp;\u0026plusmn;\u0026thinsp;18.67 kg vs. 105.71\u0026thinsp;\u0026plusmn;\u0026thinsp;18.26 kg in the RYGB group, p\u0026thinsp;=\u0026thinsp;0.033), lower BMI (34.2\u0026thinsp;\u0026plusmn;\u0026thinsp;6.25 kg/m\u003csup\u003e2\u003c/sup\u003e and 33.76\u0026thinsp;\u0026plusmn;\u0026thinsp;4.98 kg/m\u003csup\u003e2\u003c/sup\u003e vs. 37.15\u0026thinsp;\u0026plusmn;\u0026thinsp;5.84 kg/m\u003csup\u003e2\u003c/sup\u003e in the RYGB group, p\u0026thinsp;=\u0026thinsp;0.049), and higher EWL% (43.68\u0026thinsp;\u0026plusmn;\u0026thinsp;8.15 and 42.4\u0026thinsp;\u0026plusmn;\u0026thinsp;9.34 vs. 37.21\u0026thinsp;\u0026plusmn;\u0026thinsp;11.85 in the RYGB group, p\u0026thinsp;=\u0026thinsp;0.016). No statistically significant differences were noted in the TWL% (p\u0026thinsp;=\u0026thinsp;0.427) (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eAt the 6-month follow-up, similar significant differences were noted in the weight (79.5\u0026thinsp;\u0026plusmn;\u0026thinsp;11.23 kg and 80.2\u0026thinsp;\u0026plusmn;\u0026thinsp;12.31 kg vs. 86.5\u0026thinsp;\u0026plusmn;\u0026thinsp;11.81 kg in the RYGB group, p\u0026thinsp;=\u0026thinsp;0.042) and EWL% (67.33\u0026thinsp;\u0026plusmn;\u0026thinsp;9.35 and 66.11\u0026thinsp;\u0026plusmn;\u0026thinsp;8.15 vs. 61.4\u0026thinsp;\u0026plusmn;\u0026thinsp;13.17 in the RYGB group, p\u0026thinsp;=\u0026thinsp;0.040) (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eOtherwise, the weight measures and weight loss outcome were comparable among the three groups in the other follow-up visits (p\u0026thinsp;\u0026gt;\u0026thinsp;0.05) (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003eAssociated medical conditions\u003c/h2\u003e \u003cp\u003eThe three groups showed significant improvement in the associated medical conditions (Table). At the 1-year postoperative follow-up, remission occurred in 34/39 patients (87.2%) with hypertension (88.2% of the OAGB group, 92.3% of the D-OAGB group, and 77.8% of the RYGB group, p\u0026thinsp;=\u0026thinsp;0.596), 32/42 patients (76.2%) with diabetes mellitus (77.8% of the OAGB group, 80% of the D-OAGB group, and 66.7% of the RYGB group, p\u0026thinsp;=\u0026thinsp;0.743), and 63/68 patients (92.6%) with dyslipidemia (96.4% of the OAGB group, 92.6% of the D-OAGB group, and 84.6% of the RYGB group, p\u0026thinsp;=\u0026thinsp;0.403) (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eAt 6 months, relief of symptoms occurred in 23/34 patients (67.6%) with GERD (14.3% of the OAGB group, 83.3% of the D-OAGB group, and 77.8% of the RYGB group, p\u0026thinsp;=\u0026thinsp;0.003), and worsening occurred in 2/34 patients (5.9%), both of whom were in the OAGB. De novo GERD symptoms were experienced by 2 patients (in the OAGB). At the one-year and 2-year follow-ups, the number of denovo cases reached 4 patients (3 in the OAGB group and 1 in the D-OAGB group).\u003c/p\u003e \u003c/div\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe very new procedure, diverted one anastomosis gastric bypass, also named long pouch Roux-en-Y bypass (LPRYGB), was performed in 2013 and published in 2018. First, it has been implemented by Ribeiro and coworkers as a revisional procedure for patients who have failed OAGB due to reflux symptoms. After that, the procedure was performed as a primary procedure. Its first name, diverted one anastomosis gastric bypass, has been grounded in being typical of OAGB, with adding a second entero-enterostomy aiming at diversion of the bile away from the stomach to preclude postoperative bile reflux and GERD [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e]. The second name, long pouch Roux-en-Y gastric bypass, has been mentioned in their article published in 2019, since they considered the added entero-enterostomy as a Roux-en-Y diversion [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe foundation of our understanding and subsequent practice of this procedure is attributed to scientific meetings with the surgery innovators during 2014 and 2015, where they extensively discussed and demonstrated the technique. Encouraged by the promise it showed, we began implementing this procedure by the end of 2015.\u003c/p\u003e \u003cp\u003eAs for the best of our knowledge, this is the first study reporting practicing this procedure after being introduced by Ribeiro et al. [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. In our study, for the first time, we compared the outcome of this procedure to the most established bypass surgeries (RYGB and OAGB).\u003c/p\u003e \u003cp\u003eOverall, OAGB and D-OAGB showed outperformance in terms of lower early postoperative adverse events. However, the difference did not reach the level of statistical significance, likely due to the relatively small sample size. This result aligns with the previously reported fewer OAGB-associated adverse events compared to RYGB, which has been attributed to the only anastomosis and the more straightforward anatomical construction found in OAGB [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. In spite of the presence of a second anastomotic site in the D-OAGB, the surgery doesn\u0026rsquo;t entail bringing up an intestinal loop up to the gastroesophageal junction, which likely makes up less tension on the site of anastomosis [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. It is worthy to note that this D-OAGB-associated lower rate of early adverse events, compared to RYGB, comes in the early learning curve of the procedure, with likely lower rates as the learning curve progresses.\u003c/p\u003e \u003cp\u003eThe present study showed another point of OAGB and D-OAGB superiority, which was the significantly better weight loss outcome during the first year after surgery. This is consistent with a meta-analysis encompassing 16 studies and 12,445 patients that found that OAGB was associated with a higher postoperative EWL% compared to RYGB [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. This was explained by the longer BPL in both surgeries compared to that of RYGB.\u003c/p\u003e \u003cp\u003eNotably, a significantly lower number of GERD remissions and a higher number of denovo GERD cases were found in the OAGB group. This is in line with the still-debatable association between OAGB and biliary reflux [\u003cspan additionalcitationids=\"CR20 CR21\" citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. The bile reflux-associated Barrett\u0026rsquo;s esophagus and gastric cancer have been described [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e], which makes it a non-negligible surgery consequence. For this reason, RYGB has long been regarded as the best therapeutic choice for GERD patients [\u003cspan additionalcitationids=\"CR26\" citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e]. The newly adopted procedure could now be another solution for patients with GERD. It offers efficiency in GERD remission and early weight loss, along with a lower rate of adverse events and denovo GERD occurrence, making it an excellent choice for patients seeking bariatric surgery, especially those with GERD, or risky for GERD and Barrett\u0026rsquo;s esophagus.\u003c/p\u003e \u003cp\u003eOverall, our work emphasizes the new procedure-associated promising outcome that was reported by Ribeiro et al. [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. The study is limited by the small sample size. D-OAGB is a new and non-popular procedure, thus limiting the patient\u0026rsquo;s acceptability of the procedure. The study is also limited by the retrospective design, short-term assessment, and non-objective assessment of GERD. However, we present our experience in a very new procedure that needs to be unveiled by more comparative studies.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eIn conclusion, D-OAGB, also known as LPRYGB, demonstrated favorable outcomes, including lower early adverse events and superior weight loss results in the first year when compared to RYGB, with GERD remission and reduced de novo GERD occurrence when compared to OAGB. Further research is warranted to validate these findings and expand our understanding of this innovative surgical approach.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements:\u003c/strong\u003e None.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e None.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatement for informed consent:\u003c/strong\u003e Informed consent was obtained from all individual participants included in the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatement for conflict of interest:\u003c/strong\u003e The authors declare that they have no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical approval:\u003c/strong\u003e This study has been approved by the appropriate institutional research ethics committee.\u003c/p\u003e\n\u003cul\u003e\n \u003cli\u003eStudy conception and design was constructed by Dr. Mohamed Abdul Moneim El Masry\u0026nbsp;\u003c/li\u003e\n \u003cli\u003eAcquisition of data was done by Dr. Mohamed Fathy Mahmoud Elshal\u003c/li\u003e\n \u003cli\u003eAnalysis and interpretation of data was done by Drs. Mohamed Abdul Moneim El Masry and Ahmed Maher Abdul Moneim\u003c/li\u003e\n \u003cli\u003eDrafting of manuscript was performed by Dr. Islam Abdul Rahman\u003c/li\u003e\n \u003cli\u003eCritical revision of manuscript was done by Dr. Mohamed Abdul Moneim El Masry\u0026nbsp;\u003c/li\u003e\n\u003c/ul\u003e"},{"header":"References","content":"\u003col start=\"1\" type=\"1\"\u003e\n\u003cli\u003eGBD 2015 Obesity Collaborators; Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, et al. (2017) Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med, 377(1):13-27.\u003c/li\u003e\n\u003cli\u003eWelbourn R, Hollyman M, Kinsman R, Dixon J, Liem R, Ottosson J, et al. (2019) Bariatric Surgery Worldwide: Baseline Demographic Description and One-Year Outcomes from the Fourth IFSO Global Registry Report 2018. Obes Surg, 29(3):782-795.\u003c/li\u003e\n\u003cli\u003eASMBS, American Society for Metabolic and Bariatric Surgery. (2021) Bariatric Surgery Procedures. 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Obes Surg, 27(2):545\u0026ndash;547.\u003c/li\u003e\n\u003cli\u003eRibeiro R, Guerra A, Viveiros O. (Chapter) Diverted MGB: a new procedure. In: Deitel M, editor. Essentials of mini \u0026ndash; one anastomosis gastric bypass. New York: Springer; 2018. p. 327\u0026ndash;342.\u003c/li\u003e\n\u003cli\u003eFried M, Yumuk V, Oppert JM, Scopinaro N, Torres AJ, Weiner R, et al; European Association for the Study of Obesity; International Federation for the Surgery of Obesity - European Chapter. (2013) Interdisciplinary European Guidelines on metabolic and bariatric surgery. Obes Facts, 6(5):449-468.\u003c/li\u003e\n\u003cli\u003eDi Lorenzo N, Antoniou SA, Batterham RL, Busetto L, Godoroja D, Iossa A, et al. (2020) Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP. 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(2007) Gastric fluid bile concentrations and risk of Barrett\u0026apos;s esophagus. Interact Cardiovasc Thorac Surg, 6(3):304-307.\u003c/li\u003e\n\u003cli\u003eWang S, Kuang J, Zhang H, Chen W, Zheng X, Wang J, et al. (2022) Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis. Adv Sci (Weinh), 9(16):e2200263.\u003c/li\u003e\n\u003cli\u003eFelsenreich DM, Steinlechner K, Langer FB, Vock N, Eichelter J, Bichler C, Jedamzik J, Mairinger M, Kristo I, Prager G. (2022) Outcome of Sleeve Gastrectomy Converted to Roux-en-Y Gastric Bypass and One-Anastomosis Gastric Bypass. Obes Surg, 32(3):643-651.\u003c/li\u003e\n\u003cli\u003eRayman S, Assaf D, Azran C, Sroka G, Assalia A, Beglaibter N, Elazary R, Eldar SM, Romano-Zelekha O, Goitein D. (2021) Sleeve Gastrectomy Failure-Revision to Laparoscopic One-Anastomosis Gastric Bypass or Roux-n-Y Gastric Bypass: a Multicenter Study. Obes Surg, 31(7):2927-2934.\u003c/li\u003e\n\u003cli\u003eParmar CD, Mahawar KK, Boyle M, Schroeder, N, Balupuri S, Small PK. (2017) Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass is Effective for Gastro-Oesophageal Reflux Disease but not for Further Weight Loss. Obes Surg, 27(7):1651-1658.\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"langenbecks-archives-of-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"laos","sideBox":"Learn more about [Langenbeck's Archives of Surgery](http://link.springer.com/journal/423)","snPcode":"423","submissionUrl":"https://submission.nature.com/new-submission/423/3","title":"Langenbeck's Archives of Surgery","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"One anastomosis gastric bypass (OAGB), diverted OAGB, Roux-en-Y gastric bypass (RYGB), weight loss, gastroesophageal reflux","lastPublishedDoi":"10.21203/rs.3.rs-4868843/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4868843/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e \u003cp\u003eDiverted one anastomosis gastric bypass (D-OAGB) is a new procedure that entails performing Roux-en-Y diversion during OAGB to preclude post-OAGB bile reflux. This study aimed to compare the mid-term outcomes of Roux-en-Y gastric bypass (RYGB) and OAGB versus D-OAGB.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eThis is a retrospective study that encompassed the analysis of data from patients undergoing bypass surgeries from 2015 to May 2021. The patients\u0026rsquo; data until 2 years of follow-up were compared.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThis study included 140 patients who underwent OAGB (n\u0026thinsp;=\u0026thinsp;64), RYGB (n\u0026thinsp;=\u0026thinsp;24), and D-OAGB (n\u0026thinsp;=\u0026thinsp;52). In the OAGB, RYGB, and D-OAGB groups, complication rates were 3.1%, 8.3%, and 5.8%, respectively. At the 3-month and 6-month follow-ups, the OAGB and D-OAGB groups showed statistically significant higher percentage of excess weight loss (EWL%). Otherwise, the weight measures and weight loss outcome were comparable among the three groups in the other follow-up visits (p\u0026thinsp;\u0026gt;\u0026thinsp;0.05). There was a significantly lower number of gastroesophageal reflux disease (GERD) remission cases and a higher number of de novo GERD cases in the OAGB group.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eD-OAGB demonstrated favorable outcomes, including lower early adverse events and superior weight loss results in the first 6 months post-surgery when compared to RYGB. The D-OAGB group also showed higher rates of GERD remission and lower de novo GERD occurrence than OAGB. Further research is warranted to validate these findings and expand our understanding of this innovative surgical approach.\u003c/p\u003e","manuscriptTitle":"Comparative Study of Midterm Outcomes between Roux-en-Y Gastric Bypass (RYGB), Diverted One-Anastomosis Gastric Bypass (D-OAGB), and One Anastomosis Gastric Bypass (OAGB)","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-09-06 09:17:50","doi":"10.21203/rs.3.rs-4868843/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-10-12T08:27:27+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-10-07T10:12:44+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"251048911712113499514575389469143560417","date":"2024-09-27T11:52:56+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-09-06T16:08:37+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"133467661277707350613507993570210999505","date":"2024-09-04T11:53:47+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-09-04T11:48:27+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-08-12T03:37:19+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-08-09T15:57:56+00:00","index":"","fulltext":""},{"type":"submitted","content":"Langenbeck's Archives of Surgery","date":"2024-08-06T13:28:23+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"langenbecks-archives-of-surgery","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"laos","sideBox":"Learn more about [Langenbeck's Archives of Surgery](http://link.springer.com/journal/423)","snPcode":"423","submissionUrl":"https://submission.nature.com/new-submission/423/3","title":"Langenbeck's Archives of Surgery","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"329bbcbb-575a-4f6b-8764-2c53bb296e65","owner":[],"postedDate":"September 6th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2024-11-11T16:03:03+00:00","versionOfRecord":{"articleIdentity":"rs-4868843","link":"https://doi.org/10.1007/s00423-024-03525-3","journal":{"identity":"langenbecks-archives-of-surgery","isVorOnly":false,"title":"Langenbeck's Archives of Surgery"},"publishedOn":"2024-11-09 15:58:01","publishedOnDateReadable":"November 9th, 2024"},"versionCreatedAt":"2024-09-06 09:17:50","video":"","vorDoi":"10.1007/s00423-024-03525-3","vorDoiUrl":"https://doi.org/10.1007/s00423-024-03525-3","workflowStages":[]},"version":"v1","identity":"rs-4868843","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4868843","identity":"rs-4868843","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}