Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort

Mary Anne Rossing, Brooke L. Fridley, Malcolm C. Pike, Andrew Berchuck, Patricia G. Moorman, Claire Templeman, Robert A. Vierkant, Allison F. Vitonis, Georgia Chenevix‐Trench, Julie M. Cunningham, Aleksandra Gentry‐Maharaj, Kathryn L. Terry, Celeste Leigh Pearce, Joellen M. Schildkraut, Rachel T. Palmieri, Anna H. Wu, Roberta B. Ness, Aimee M. Near, Penelope M. Webb, Susanne K. Kjær, Jennifer A. Doherty, Usha Menon, Estrid Høgdall, Daniel W. Cramer, Susan J. Ramus, Ellen L. Goode, Simon A. Gayther, Kirsten B. Moysich, David J. Van Den Berg
2020 · doi:10.17615/bbtw-kf09 · W4299119401
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study investigated the association between progesterone receptor gene polymorphisms, specifically the +331C/T SNP and the PROGINS allele, and self-reported endometriosis in an international collaborative effort.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

This international collaborative study examined associations between progesterone receptor gene polymorphisms and endometriosis risk using genetic and epidemiologic data pooled across multiple populations. The main finding was that specific progesterone receptor variants were not uniformly associated with endometriosis risk, and the overall results did not show strong, consistent genetic effects across the studied polymorphisms. The authors emphasize limitations including reliance on genetic association design and the need for sufficiently powered, well-characterized samples to detect modest effects, along with potential heterogeneity across study cohorts. This paper is centrally about endometriosis — it specifically tests progesterone receptor gene polymorphisms as genetic risk factors for endometriosis.

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Abstract

To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism (SNP) and the PROGINS allele.
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MLA Near, Aimee M, et al. Progesterone Receptor Gene Polymorphisms and Risk of Endometriosis: Results From an International Collaborative Effort. 2011. https://doi.org/10.17615/bbtw-kf09 APA Near, A., Wu, A., Templeman, C., Van Den Berg, D., Doherty, J., Rossing, M., Goode, E., Cunningham, J., Vierkant, R., Fridley, B., Chenevix Trench, G., Webb, P., Kjær, S., Hogdall, E., Gayther, S., Ramus, S., Menon, U., Gentry Maharaj, A., Schildkraut, J., Moorman, P., Palmieri, R., Ness, R., Moysich, K., Cramer, D., Terry, K., Vitonis, A., Pike, M., Berchuck, A., & Pearce, C. (2011). Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort. https://doi.org/10.17615/bbtw-kf09 Chicago Near, Aimee M., Anna H Wu, Claire Templeman, David J Van Den Berg, Jennifer A Doherty, Mary Anne Rossing, Ellen L Goode et al. 2011. Progesterone Receptor Gene Polymorphisms and Risk of Endometriosis: Results From an International Collaborative Effort. https://doi.org/10.17615/bbtw-kf09

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endometriosis

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