Primary Pulmonary Paraganglioma, Case Report and Review of the Literature

Primary Pulmonary Paraganglioma, Case Report and Review of the Literature | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Primary Pulmonary Paraganglioma, Case Report and Review of the Literature Ledi Bardhi, Margherita Vannucchi, Roberto Corzani, Angela Galgano, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2361854/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Primary pulmonary paraganglioma (PPPG) is an extremely rare neuroendocrine tumor, counting less than 1% of all paragangliomas (PGs). The incidence of PGs ranges between 2–8 per million in a year. Generally, pulmonary PGs are nonfunctional. The majority of the patients develop respiratory symptoms, such as a cough, chest pain, or dyspnea, as in our case. The average size of the neoplasm is about 7 cm. There seems to be no difference in incidence between the right and left lungs; however, the lower lobe appears to be the most affected. On gross examination, the neoplasm was well-demarcated with a white-brown cut surface and solid consistency. The tumor cells appear in a typical nested pattern supported by a thin vascular framework producing the classic ‘zellballen’ or the basket pattern. Immunohistochemical staining showed positive for CgA, Syn, and S100. PPPGs are rare entities, and their differential diagnosis with carcinoid tumors, more typical for this site, is not always easy and lies in subtle morphological and immunophenotypic differences. A correct diagnosis is decisive since mutations in tumor susceptibility genes have been reported in 50% of the patients. Thus genetic testing and counseling should be considered. Primary pulmonary paragangliomas “Substentacular” cells Immunohisto-chemical Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Introduction PGs are uncommon neural crest neoplasms usually considered as an extra-adrenal analog of pheochromocytoma which shares the cells of origin (the chromaffin cells), morphology, and immunophenotype. It can occur in patients of all ages, with peak incidence during the fourth through sixth decades of life. There is a slight female predominance. Tumors arising in children are frequently bilateral and/or multifocal and associated with the familial disease. Usually, paragangliomas follow a benign course, particularly in the sporadic setting and with complete resection, with an overall recurrence rate of < 10% 1 . PGs originate from the sympathetic and parasympathetic ganglia distributed along the prevertebral and paravertebral chains and nerve fibers and, although rare, have been described in almost every organ. A primary intrapulmonary PG can arise when paraganglia-like structures appear in the periarterial pulmonary interstitium. Indeed, over 50 years ago, Blessing and Hora demonstrated the presence of paraganglia in the lung in close proximity to the pulmonary artery 2 . They hypothesized that these paraganglia functioned as chemoreceptors and regulators of breathing and pulmonary blood flow 2 . PPPGs are often asymptomatic and discovered incidentally with chest CT. For these reasons, the histopathological evaluation of the lesion is fundamental for a correct diagnosis 3 . Here, we report a case of primary pulmonary paraganglioma in a 71-year-old woman without previous history of neuroendocrine tumors or familial disease. A 71-year-old woman presented at our hospital with a persistent cough and not responding to the usual therapy. Active smoker of 56 p/y, her medical history consisted of a myocardial infarction treated by PTCA and stenting in 2014, anxious-depressive syndrome, hypertension, diabetes, obesity (BMI 37.3), and Hashimoto thyroiditis. The chest radiography revealed a rounded opacity of the middle lobe. The CT scan showed a 2.6 cm solid lesion, oval in shape and with regular margins, located in the medial segment of the middle lobe. Neither enlarged hilar and mediastinal lymph nodes nor alteration in other organs was detected. The pulmonary lesion showed intense hypermetabolism on the PET scan (SUV max 8.1), Figure 1. A bronchoscopic evaluation was carried out, which did not show any endobronchial mass. The case was discussed in a multidisciplinary team meeting where it was decided the patient would undergo surgery, a middle lobectomy with hilar-mediastinal lymphadenectomy, Figure 2. On gross examination, a well-demarcated neoplasm, measuring 2.5 x 1.5 x 1.5 cm with a white-brown cut surface and solid consistency was found in the medial segment of the middle pulmonary lobe 4 . Under low power, the microscopic examination revealed a well-circumscribed epithelial proliferation in close relation with a bronchus and its pulmonary artery branch 5 . At higher magnification, the lesion consisted mostly of epithelioid round cells, relatively uniform in size, mixed with spindle-shaped cells, with poor eosinophilic cytoplasm, round-to-ovoid nuclei, and blind cytology 6,7 . The tumor cells appear to be arranged in a typical alveolar or nested pattern surrounded by a delicate and richly vascular network producing the classic ‘zellballen’ or basket pattern. No necrosis was found, and the mitotic index was <1 mitosis for ten high-magnification fields. There was no metastasis in the dissected lymph nodes 8,9 , Figure 3. Immunohistochemical staining of the tumor showed a diffuse, strong, reactivity for chromogranin and synaptophysin and a weak, patchy positivity for anti-CK7 and anti-TTF1 antibodies. The proliferation index evaluated with Ki67 staining was lower than 1%. Notably, S100 immunostaining revealed the presence of the classic supporting or sustentacular cells at the periphery of the neoplastic cell’s nets 10,11 , Figures 4 and 5. Results PPPGs are extremely rare, counting less than 1% of all PGs. The first case of PPPG was published by Heppleston in 1958 12 . To the best of our knowledge, only about 26 case studies have been described in the English literature. The median age of onset is 44 years, and there is no significance based on sex. Generally, pulmonary PGs are nonfunctional. The majority of the patients are asymptomatic, except for some cases where they presented with dry cough, expectoration, and cervical lymphadenopathy. Dyspnea or chest pain can be observed. Furthermore, 5/26 patients described in the literature had hypertension. The average size of the neoplasm is about 7 cm. There seems to be no difference in incidence between the right and left lungs; however, the lower lobe appears to be the most affected. On gross examination all pulmonary PGs were well circumscribed, presenting in some cases a well-formed fibrous capsule 13 , Table 1 and 2. Table 1 . Primary pulmonary paraganglioma. Author Male Female Age Location Symptoms Size (cm) Kaplan et al. 14 x 56 inferior lobe, left lung 6.5 Africa et al. 15 x 58 right lung, upper lobe Saeki et al. 16 x 38 left lower lobe chest pain on exertion 13 x 12 x 7 Mazzucco et al. 17 x 49 right lower lobe asymptomatic (dry cough worsening in supine position) 3.4 x 2.6 Dahir et al. 18 x 39 lingula hypertension, weight gain, easy bruising, hyperpigmentation, depression 1.3 x 1 x 1.7 Kim et al. 19 x 34 right lower lobe manic episode 3 x 2.8 x 1.7 Hangartner et al. 8 x 49 right upper lobe pleuritic pain, cough with white sputum, breathlessness 7 Hagemeyera et al. 20 x 36 left upper lung truncal obesity, abdominal striae, borderline hypertension, edema, myopathy, diabetes mellitus 1 Tobón et al. 21 x 70 left lower lobe chronic cough with sputum, hypertension, anxiety disorder 3.3 x 3.2 Huang et al. (2021) 22 x 49 left lower lobe cough, intermittent chest pain, dyspnea 1.5 x 1.2 x 1 Zhang et al. 23 x 38 left lower lobe chest pain, paroxysmal cough with little sputum 2.6 x 3.5 x 3.7 & 1.6 x 1.6 x 3.5 Fiorentino et al. 24 x 63 middle right lobe cough, intermittent palpitations, dyspnea 2.4 Asa et al. 3 X 69 middle right lobe cough, dyspnea 1 x 1 x 0.5 Skizidt et al. 25 X 33 right lower lobe coughing with expectoration 4 x 3 x 3 & 1.5 x 1.2 x 1 Aubertine et al. 11 x 40 left lobe recurrent obstructive pneumonia 0.9 Huang et al. 7 X 37 right middle lobe asymptomatic 4 x 3 x 3 da Silvaa et al. 9 X 60 right lower lobe asymptomatic 1.2 Singh et al. 5 X 63 lingula hypertension 4.5 Shibahara et al. 10 X 55 left lower lobe hypertension, occasional headaches, 3.5 Yüksel et al. 4 x 15 left lower lobe cough, weakness, hemoptysis, hypertension, tachycardia 3 Yüksel et al. 4 x 32 left main bronchus dyspnea 1.3 Kavakli et al. 26 x 21 left lower lobe left cervical lymphadenopathy 3 x 3 Gan et al. 27 X 49 right middle lobe asymptomatic 2.2 x 2.1 Hsu and Tsou 28 x 46 right lower lobe cough, yellowish sputum 4.5 x 4 x 4.5 Geoffrion et al. 29 x 10 left lobe hemoptysis, worsening symptoms of asthma 1.7 Kim et al. 19 X 37 left hilum exertional dyspnea, cough, 1 episode of hemoptysis 7 x 3 Table 2 . Immunohistochemical investigations. References TTF1 Ki-67 CgA SYP CD56 CK CK5/6 S100 NSE GATA 3 AE1+AE3 Da Silva et al. 9 (-) (+) (+) (-) (+) (+) (-) Yüksel et al. 4 (-) (+) (+) (+) (-) (+) (+) Hsu and Tsou 28 (-) (+) (+) (-) (+) Mazzucco et al. 17 (+) (+) (-) (+/-) Huang et al. 7 (-) 2% (+) (+) (+) (-) (-) (+) Fiorentino et al. 24 (+) (+) (-) (+) (+) Geoffrion et al. 29 (-) (+) (+) (+) (-) (+) Hangartner et al. 8 (+) (+) (-) (+) (+) Tobón et al. 21 (-) 2% (+) (+) (+) (-) (-) (+) (+/-) Gan et al. 27 (+) (+) (+) (+) Shibahara et al. 10 (+) (+) (+) (-) (+) Dahir et al. 18 (+) (+) (+) (-) (+) Aubertine and Flieder et al. 11 (+) (+) (+) (-) Kim et al. 19 (+) (+) (+/-) (+) (+) (+/-) Zhang et al. 23 (+) Skødt et al. 13 (-) (+) (+) (-) (+) (+) Saeki et al. 16 (+) (+) (+) Kaplan R et al. 14 (+) (+) (-) (+) (+) (+) Africa et al. 15 (-) LOW (+) (+) (+/-) (-) (+) (+) Histologically, PPPGs demonstrated the characteristic zellballen pattern consisting of small nets of polygonal cells surrounded by sustentacular cells, clearly evident with S-100 immunostaining and separated by a delicate fibrovascular stroma. Neoplastic cells showed positivity for neuroendocrine markers (Chromogranin and Synaptofisin) in almost all cases described, while immunohistochemical markers for cytokeratins and TFF1 were negative in most cases. Additionally, PPPGs have a characteristically low mitotic index with a Ki-67 usually < 5%. Surgery was the treatment choice in all the cases described in literature and no local recurrence have been reported expect for one case presented with lymphnode metastasis. Discussion PGs are uncommon neural crest neoplasms derived from paraganglion cells of the autonomic nervous system from both the sympathetic and parasympathetic systems. PGs can appear as multiple small tumors or a solitary mass. Most PGs are benign. But they may also present as malignant tumors with lymph node metastases. According to the literature, the total number of PG cases published is less than 50. Pulmonary nonfunctional PGs are usually incidentally detected by CT as hypervascular nodules presenting typical features: isodensity or slightly low density as well as a homogeneous and intense enhancement – except in the necrotic areas that show scarce enhancement. By CT, pulmonary PGs can resemble carcinoid tumors. Indeed, there are no specific radiologic features that can differentiate explicitly between carcinoid tumors and pulmonary PG diagnosis 19 . Notably, carcinoid tumors may have this same organoid nesting pattern. The PG tumor cells show vesicular or hyperchromatic round-to-oval nuclei with moderate pleomorphism. The cytoplasm is pale, homogeneous, or vacuolated. Tumor cells may appear syncytial since their cytoplasmic borders are poorly defined. There may be interdigitation of adjoining cells or cell processes, which gives the appearance of cells embracing one another. From the literature, we see that most cases are benign except for 1/26 cases with lymph node metastases but no evidence of distant metastases or any primary extrapulmonary lesion 16 . As the histological similarity between PGs and the carcinoid tumor’s morphology is quite stark, the following criteria have been proposed to facilitate the differential diagnosis between the two entities: A diffuse zellballen pattern throughout the tumor, Absence of the histologic features distinctive of carcinoid tumors (trabecular pattern, pseudo glandular acini, ossification, perivascular pseudorosettes, oncocytic change, spindle cells), Presence of features distinctive of PGs (cytoplasmic vacuoles, cell in-cell embracing phenomenon), and Absence of immunohistochemical staining for keratin favors PG. Up to 80 percent of carcinoids stain with keratin, while PGs are virtually always keratin negative. S-100 protein-positive sustentacular cells can be found in carcinoids and PGs; however, not to the same extent. On the other hand, neuroendocrine markers such as chromogranin are positive in both tumor cells 30 . Complete resection is the first treatment option for solitary PPPG 31 . Some authors proposed that PG is sensitive to radiation therapy and without serious side effects 32 . Given the high local control rates and few complications, some authors consider radiotherapy a first-choice treatment for PG. In addition, they evaluated the effects of external beam radiation therapy (EBRT). However, EBRT can only be considered when the local disease progresses 33 . The use of the chemotherapy regimen is not unanimously approved. In some metastasis cases, sorafenib use has been reported with a good response 34 . Conclusion The diagnosis of PPPG requires the exclusion of an extrapulmonary PG or a pheochromocytoma. PPPGs are rare entities, and their differential diagnosis with carcinoid tumors is not always easy for this site and lies in subtle morphological and immunophenotypic differences. In neuroendocrine tumor diagnosis the importance of keratins, which are available in almost every pathology laboratory, should be emphasized. However, one should not forget that pulmonary gangliocytic PGs can also show CK positivity 35 . Tyrosine hydroxylase and GATA3 are new markers that help differentiate diagnosis 11 . PPPG should be considered in the differential diagnosis of endo- and peri-bronchial neoplasms. A correct diagnosis is important since mutations in tumor susceptibility genes have been reported in one in two patients. Thus, genetic testing and counseling are recommended for these patients. References 1. World Health Organization (WHO). Thoracic Tumours, 5th ed.; Organisation mondiale de la santé, Centre international de recherche sur le cancer, Eds.; World Health Organization classification of tumours; International agency for research on cancer: Lyon, 2021. 2. Blessing, M. & Hora, B. Glomera in der Lunge des Menschen [Glomera in the human lung]. Z Zellforsch Mikrosk Anat. 87 , 562–570 (1968). 3. Asa, S. L., Ezzat, S. & Mete, O. The diagnosis and clinical significance of paragangliomas in unusual locations. J Clin Med 7 , (2018). 4. Yüksel, C. et al. Primary pulmonary paraganglioma: Two cases. Turkish Journal of Thoracic and Cardiovascular Surgery 28 , 394–398 (2020). 5. Singh, G., Lee, R. E. & Brooks, D. H. Primary pulmonary paraganglioma: report of a case and review of the literature. Cancer 40 , 2286–2289 (1977). 6. Tobón, A. et al. Pathologic features and clinical course of a non-functioning primary pulmonary paraganglioma: A case report. Annals of Medicine and Surgery 55 , 185–189 (2020). 7. Huang, X. et al. Primary Pulmonary Paraganglioma: A Case Report and Review of Literature. Medicine 94 , (2015). 8. Hangartner, J. R., Loosemore, T. M., Burke, M. & Pepper, J. R. Malignant primary pulmonary paraganglioma. Thorax 44 , 154 (1989). 9. Afonso Da Silva, R., Gross, J. L., Haddad, F. J., Toledo, C. A. B. & Younes, R. N. LETTER TO THE EDITORS PRIMARY PULMONARY PARAGANGLIOMA: CASE REPORT AND LITERATURE REVIEW. Clinics 61 , 83–89 (2006). 10. Shibahara, J. et al. Primary Pulmonary Paraganglioma Report of a Functioning Case With Immunohistochemical and Ultrastructural Study. Am J Surg Pathol 28 , 825–829 (2004). 11. Aubertine, C. L. & Flieder, D. B. Primary paraganglioma of the lung. Ann Diagn Pathol 8 , 237–241 (2004). 12. Heppleston, A. G. A CAROTID-BODY-LIKE TUMOC-R IN THE LUNG. J. PATH. BACT. LXXV , 461–466 (1958). 13. SKØDT, V., JACOBSEN, G. K. & HELSTED, M. Primary paraganglioma of the lung Report of two cases and review of the literature. APMIS 103 , 597–603 (1995). 14. Kaplan, R. et al. Paraganglioma pulmonar primario como tumor incidental [Primary lung paraganglioma. A case report]. Rev Fac Cien Med Univ Nac Cordoba 67 , 118–122 (2010). 15. Africa, G., Plutino, F. M. & Filotico, M. A rare neurendocrine tumor of the lung: Sclerosing paraganglioma. A neoplasm that is difficult to diagnose and a source of dangerous pitfalls. A case report and literature review. Pathologica 112 , 191–194 (2020). 16. Saeki, T. et al. An Extremely Large Solitary Primary Paraganglioma of the Lung: Report of a Case. Surg Today Jpn J Surg 29 , 1195–1200 (1999). 17. Mazzucco, A. et al. An Unusual Histology for a Lung Nodule: A Case Report of Primary Pulmonary Paraganglioma. Front Surg 8 , (2021). 18. Dahir, K. M. et al. Ectopic Adrenocorticotropic Hormone Hypersecretion Due To A Primary Pulmonary Paraganglioma. Endocrine Practice 10 , 424–428 (2004). 19. Ki, N. K., Lee, K. N., Mee, S. R., Pil, J. C. & Doo, K. Y. Pulmonary paraganglioma manifesting as an endobronchial mass. Korean J Radiol 9 , 87–90 (2008). 20. Hagemeyera, O., Cabinsb, H. J., Kaysera, K. & Words, K. Paraganglioma of the Lung-Developed after Exposure to Nuclear Radiation by the Tschernobyl Atomic Reactor Accident? 21. Tobón, A. et al. Pathologic features and clinical course of a non-functioning primary pulmonary paraganglioma: A case report. Annals of Medicine and Surgery 55 , 185–189 (2020). 22. Huang, X. J., Wu, C. & Chen, X. Y. Primary endobronchial paraganglioma with lymph node metastasis: a case report. Journal of International Medical Research 49 , (2021). 23. Zhang, J.-J., Liu, T. & Peng, F. Primary Paraganglioma of the Lung: a Case Report and Literature Review. J Int Med Res 40 , 1617–1626 (2012). 24. Fiorentino, G., Annunziata, A. & de Rosa, N. Primary paraganglioma of the lung: A case report. J Med Case Rep 9 , (2015). 25. Skizidt, V., Krag Jacobsen, G., Helsted, M., Primary paraganglioma, M. & Sksdt, V. Primary paraganglioma of the lung Report of two cases and review of the literature. APMIS 103 , 597403 (1995). 26. Kavakli M.; Ongoru O.; Gürkök S.; Genc O., K. ; O. Primary Pulmonary Paraganglioma with Hodgkin’s Lymphoma. Thorac Cardiovasc Surg 57 , 375–377 (2009). 27. Gan, F., Xia, L. & Liu, L. Primary pulmonary paraganglioma. QJM 111 , 901–902 (2018). 28. Hsu, L.-H. & Tsou, M.-H. Article in Zhonghua yi xue za zhi = Chinese medical journal. Chinese Medical Journal 65 , 446–449 (2002). 29. Geoffrion, T. R. et al. Pulmonary paraganglioma in a 10-year-old: a case report and review of the literature. J Surg Case Rep 2018 , 1–4 (2018). 30. William D. Travis, Andrew G. Nicholson, Kim R. Geisinger & Elisabeth Brambilla. Tumors of the Lower Respiratory Tract (AFIP Atlas of Tumor Pathology, Series 4,) . AFIP ATLAS OF TUMOR PATHOLOGY (American Registry of Pathology, 2019). 31. Chung, J. H. et al. Uniportal video-assisted thoracoscopic lobectomy: An alternative to conventional thoracoscopic lobectomy in lung cancer surgery? Interact Cardiovasc Thorac Surg 20 , 813–819 (2015). 32. Elshaikh, M. A. et al. RECURRENT HEAD-AND-NECK CHEMODECTOMAS: A COMPARISON OF SURGICAL AND RADIOTHERAPEUTIC RESULTS. Int. J. Radiation Oncology Biol. Phys. 52 , 953–956 (2002). 33. Smee, R. I., Jayasekara, J., Williams, J. R. & Hanna, C. Paragangliomas: Presentation and management by radiotherapy at the Prince of Wales Hospital. J Med Imaging Radiat Oncol 59 , 229–235 (2015). 34. Gunaldi, M. et al. A New Approach to the Treatment of Metastatic Paraganglioma: Sorafenib. Cancer Res Treat 46 , 411–414 (2014). 35. Ayala-Ramirez, M. et al. Clinical benefits of systemic chemotherapy for patients with metastatic pheochromocytomas or sympathetic extra-adrenal paragangliomas: Insights from the largest single-institutional experience. Cancer 118 , 2804–2812 (2012). Declarations Acknowledgments The authors would like to thank the patient for allowing for this case to be presented and Dr. Ornela Bardhi for proofreading. Author Contributions LB drafted the manuscript and figures. LB, AG, and LADN collected and reviewed the population data.LB, MV, and CB did the conceptualization of the study. MV, RC, AG, LADN, PP, and CB reviewed the manuscript. All authors read and approved the final manuscript. Corresponding author: Professor Cristiana Bellan. Funding Not applicable. Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request. Ethics approval and consent to participate This study was approved by and conducted in accordance with the ethical standards and requirements of the University Hospital of Siena Ethical Board (Siena, Italy). Consent for publication Written informed consent was obtained from the patient for publication of this case report and any accompanying images. Competing interests The authors declare that they have no competing interests. Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2361854","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":165022766,"identity":"9b454043-b35e-4a56-9eda-442010cdc03e","order_by":0,"name":"Ledi Bardhi","email":"","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":false,"prefix":"","firstName":"Ledi","middleName":"","lastName":"Bardhi","suffix":""},{"id":165022768,"identity":"9b0a1d56-7e72-48c0-86b1-13d8258bfd7e","order_by":1,"name":"Margherita Vannucchi","email":"","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":false,"prefix":"","firstName":"Margherita","middleName":"","lastName":"Vannucchi","suffix":""},{"id":165022769,"identity":"f936a27a-caba-4ab8-8cff-766ff685d5e3","order_by":2,"name":"Roberto Corzani","email":"","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":false,"prefix":"","firstName":"Roberto","middleName":"","lastName":"Corzani","suffix":""},{"id":165022772,"identity":"d314ff21-f484-49aa-bb7a-20fb05fd7e89","order_by":3,"name":"Angela Galgano","email":"","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":false,"prefix":"","firstName":"Angela","middleName":"","lastName":"Galgano","suffix":""},{"id":165022773,"identity":"ee644c5d-bc32-4ff6-855c-94af670537e4","order_by":4,"name":"Libero Antonio Nicola","email":"","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":false,"prefix":"","firstName":"Libero","middleName":"Antonio","lastName":"Nicola","suffix":""},{"id":165022774,"identity":"947cf31a-4aab-4f07-91d3-21f9341e6ec9","order_by":5,"name":"Piero Paladini","email":"","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":false,"prefix":"","firstName":"Piero","middleName":"","lastName":"Paladini","suffix":""},{"id":165022775,"identity":"6492b934-968c-41ec-8973-c376071ba9d1","order_by":6,"name":"Cristiana Bellan","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAtUlEQVRIiWNgGAWjYBACAwbmxgMMDDYMDMwMDAeAXGK0MDYAtaTBtBChB6rlMIJPEJizNzYc+LnjfOJ2dvaHBxgK/hDWYtlzsOFg75nbiTubeQyIdNiNxIYDvG23Ezcc5iHWL/cfNhz823YOqIX9AbG2MDYc5m07ANTCQKTDLHsSGw7LtiUbAx1mcCDBwJiwFnP2wwcfvm2zk91w/vjjDx/+yBHWggoSSNUwCkbBKBgFowA7AAA9nkGn+1v1CQAAAABJRU5ErkJggg==","orcid":"","institution":"University Hospital of Siena","correspondingAuthor":true,"prefix":"","firstName":"Cristiana","middleName":"","lastName":"Bellan","suffix":""}],"badges":[],"createdAt":"2022-12-09 13:44:20","currentVersionCode":2,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-2361854/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-2361854/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":50122834,"identity":"92eb655c-f971-47bb-870b-9c94816f2e2b","added_by":"auto","created_at":"2024-01-24 20:10:08","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":263352,"visible":true,"origin":"","legend":"\u003cp\u003eThe pulmonary lesion showed intense hypermetabolism on the PET scan (SUV max 8.1).\u003c/p\u003e","description":"","filename":"Figure1.png","url":"https://assets-eu.researchsquare.com/files/rs-2361854/v2/0bd8f8cb00a19dc3e0952e2a.png"},{"id":50122837,"identity":"5b951533-922f-4567-a882-fe9f10eefed5","added_by":"auto","created_at":"2024-01-24 20:10:08","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":614252,"visible":true,"origin":"","legend":"\u003cp\u003eThe specimen after middle lobectomy with hilar-mediastinal lymphadenectomy was performed.\u003c/p\u003e","description":"","filename":"Figure2.png","url":"https://assets-eu.researchsquare.com/files/rs-2361854/v2/63b0282c5f1023da571c2dd8.png"},{"id":50122836,"identity":"851fc9f3-7f3e-41ac-984a-03a247e2d9b1","added_by":"auto","created_at":"2024-01-24 20:10:08","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":1654920,"visible":true,"origin":"","legend":"\u003cp\u003e(a) the tumor consisted of nests of epithelioid cells surrounded by delicate, richly vascular stroma. (Hematoxylin-eosin, 10x). (b) at higher magnification, rounded polyhedral cells arranged in sheets and nests separated by thin strands of connective tissue (Zellballen) and vascular channels are noticeable (Hematoxylin-eosin, 20x). (c) The tumor is in close proximity to a bronchus and its artery (Hematoxylin-eosin staining, 10x).\u003c/p\u003e","description":"","filename":"Figure3.png","url":"https://assets-eu.researchsquare.com/files/rs-2361854/v2/b7738d00734b53a608bb5508.png"},{"id":50122835,"identity":"6a736b7c-4758-48fc-92aa-cbc90299802b","added_by":"auto","created_at":"2024-01-24 20:10:08","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":1921444,"visible":true,"origin":"","legend":"\u003cp\u003e(a) sustentacular cells surrounding nests of tumor are highlighted with anti-S100-anti- body (20x). (b) Tumor cells were strongly and diffusely positive for chromogranin (chromogranin 10x). (c,d) Patchy positivity for anti-CK7 and anti-TTF1 antibodies (anti-CK7, anti-TTF1 antibodies, 20x)\u003c/p\u003e","description":"","filename":"Figure4.png","url":"https://assets-eu.researchsquare.com/files/rs-2361854/v2/5dbda06da5abd11a628a9df3.png"},{"id":50122838,"identity":"635d5965-01df-448c-b97b-ba38223b4324","added_by":"auto","created_at":"2024-01-24 20:10:08","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":902650,"visible":true,"origin":"","legend":"\u003cp\u003e(a) silver stain shows the Zellballen architecture (Silver stain 20x). (b) The mitotic index was \u0026lt;1 mitosis for 10 high-magnification fields (10x).\u003c/p\u003e","description":"","filename":"Figure5.png","url":"https://assets-eu.researchsquare.com/files/rs-2361854/v2/819c9ed7d411939b353f1b7b.png"},{"id":50123007,"identity":"c5d31e21-7e1f-44a2-94c7-216d6705eaac","added_by":"auto","created_at":"2024-01-24 20:18:13","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":5028424,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2361854/v2/64f009d0-b2bd-47bc-8bdf-ce52994fde53.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003ePrimary Pulmonary Paraganglioma, Case Report and Review of the Literature\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePGs are uncommon neural crest neoplasms usually considered as an extra-adrenal analog of pheochromocytoma which shares the cells of origin (the chromaffin cells), morphology, and immunophenotype.\u003c/p\u003e\n\u003cp\u003eIt can occur in patients of all ages, with peak incidence during the fourth through sixth decades of life. There is a slight female predominance. Tumors arising in children are frequently bilateral and/or multifocal and associated with the familial disease. Usually, paragangliomas follow a benign course, particularly in the sporadic setting and with complete resection, with an overall recurrence rate of \u0026lt; 10% \u003csup\u003e1\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003ePGs originate from the sympathetic and parasympathetic ganglia distributed along the prevertebral and paravertebral chains and nerve fibers and, although rare, have been described in almost every organ.\u003c/p\u003e\n\u003cp\u003eA primary intrapulmonary PG can arise when paraganglia-like structures appear in the periarterial pulmonary interstitium. Indeed, over 50 years ago, Blessing and Hora demonstrated the presence of paraganglia in the lung in close proximity to the pulmonary artery\u003csup\u003e2\u003c/sup\u003e. They hypothesized that these paraganglia functioned as chemoreceptors and regulators of breathing and pulmonary blood flow\u003csup\u003e2\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003ePPPGs are often asymptomatic and discovered incidentally with chest CT. For these reasons, the histopathological evaluation of the lesion is fundamental for a correct diagnosis\u003csup\u003e3\u003c/sup\u003e. Here, we report a case of primary pulmonary paraganglioma in a 71-year-old woman without previous history of neuroendocrine tumors or familial disease.\u003c/p\u003e\n\u003cp\u003eA 71-year-old woman presented at our hospital with a persistent cough and not responding to the usual therapy. Active smoker of 56 p/y, her medical history consisted of a myocardial infarction treated by PTCA and stenting in 2014, anxious-depressive syndrome, hypertension, diabetes, obesity (BMI 37.3), and Hashimoto thyroiditis.\u003c/p\u003e\n\u003cp\u003eThe chest radiography revealed a rounded opacity of the middle lobe. The CT scan showed a 2.6 cm solid lesion, oval in shape and with regular margins, located in the medial segment of the middle lobe.\u003c/p\u003e\n\u003cp\u003eNeither enlarged hilar and mediastinal lymph nodes nor alteration in other organs was detected. The pulmonary lesion showed intense hypermetabolism on the PET scan (SUV max 8.1), Figure 1. A bronchoscopic evaluation was carried out, which did not show any endobronchial mass.\u003c/p\u003e\n\u003cp\u003eThe case was discussed in a multidisciplinary team meeting where it was decided the patient would undergo surgery, a middle lobectomy with hilar-mediastinal lymphadenectomy, Figure 2.\u003c/p\u003e\n\u003cp\u003eOn gross examination, a well-demarcated neoplasm, measuring 2.5 x 1.5 x 1.5 cm with a white-brown cut surface and solid consistency was found in the medial segment of the middle pulmonary lobe\u003csup\u003e4\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eUnder low power, the microscopic examination revealed a well-circumscribed epithelial proliferation in close relation with a bronchus and its pulmonary artery branch\u003csup\u003e5\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eAt higher magnification, the lesion consisted mostly of epithelioid round cells, relatively uniform in size, mixed with spindle-shaped cells, with poor eosinophilic cytoplasm, round-to-ovoid nuclei, and blind cytology\u003csup\u003e6,7\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eThe tumor cells appear to be arranged in a typical alveolar or nested pattern surrounded by a delicate and richly vascular network producing the classic \u0026lsquo;zellballen\u0026rsquo; or basket pattern. No necrosis was found, and the mitotic index was \u0026lt;1 mitosis for ten high-magnification fields. There was no metastasis in the dissected lymph nodes\u003csup\u003e8,9\u003c/sup\u003e, Figure 3.\u003c/p\u003e\n\u003cp\u003eImmunohistochemical staining of the tumor showed a diffuse, strong, reactivity for chromogranin and synaptophysin and a weak, patchy positivity for anti-CK7 and anti-TTF1 antibodies. The proliferation index evaluated with Ki67 staining was lower than 1%. Notably, S100 immunostaining revealed the presence of the classic supporting or sustentacular cells at the periphery of the neoplastic cell\u0026rsquo;s nets\u003csup\u003e10,11\u003c/sup\u003e, Figures 4 and 5.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003ePPPGs are extremely rare, counting less than 1% of all PGs.\u0026nbsp;The first case of PPPG was published by Heppleston\u0026nbsp;in 1958\u003csup\u003e12\u003c/sup\u003e. To the best of our knowledge, only about 26 case studies have been described in the English literature.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe median age of onset is 44 years, and there is no significance based on sex. Generally, pulmonary PGs are nonfunctional. The majority of the patients are asymptomatic, except for some cases where they presented with dry cough, expectoration, and cervical lymphadenopathy. Dyspnea or chest pain can be observed. Furthermore, 5/26 patients described in the literature had hypertension. The average size of the neoplasm is about 7 cm. There seems to be no difference in incidence between the right and left lungs; however, the lower lobe appears to be the most affected. On gross examination all pulmonary PGs were well circumscribed, presenting in some cases a well-formed fibrous capsule\u003csup\u003e13\u003c/sup\u003e, Table 1 and 2.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;font-size:12px;font-family:\"Calibri\",sans-serif;color:#44546A;font-style:italic;line-height:150%;'\u003e\u003cspan style=\"font-size:15px;line-height:150%;\"\u003eTable\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:15px;line-height:150%;\"\u003e1\u003c/span\u003e\u003cspan style=\"font-size:15px;line-height:150%;\"\u003e.\u003c/span\u003e \u003cspan style=\"font-size:15px;line-height:150%;\"\u003ePrimary pulmonary paraganglioma.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.3e+2pt;border: none;margin-left:-35.45pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eAuthor\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-1.65pt;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eMale\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.2pt;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eFemale\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eAge\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eLocation\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eSymptoms\u0026nbsp;\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eSize (cm)\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eKaplan et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e14\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e56\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003einferior lobe, left lung\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e6.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eAfrica et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e15\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright lung, upper lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eSaeki et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e16\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e38\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003echest pain on exertion\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e13 x 12 x 7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eMazzucco et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e17\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003easymptomatic (dry cough worsening\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ein supine position)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.4 x 2.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eDahir et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e18\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e39\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003elingula\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ehypertension, weight gain, easy bruising, hyperpigmentation, depression\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.3 x 1 x 1.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eKim et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e19\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003emanic episode\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3 x 2.8 x 1.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHangartner et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e8\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright upper lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003epleuritic pain, cough with white sputum,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ebreathlessness\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHagemeyera et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e20\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft upper lung\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003etruncal obesity, abdominal striae, borderline hypertension, edema, myopathy, diabetes mellitus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eTob\u0026oacute;n et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e21\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003echronic cough with sputum, hypertension,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eanxiety disorder\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.3 x 3.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHuang et al. (2021)\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e22\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ecough, intermittent chest pain, dyspnea\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.5 x 1.2 x 1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eZhang et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e23\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e38\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003echest pain, paroxysmal cough with\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003elittle sputum\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.6 x 3.5 x 3.7 \u0026amp; 1.6 x 1.6 x 3.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eFiorentino et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e24\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e63\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003emiddle right lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ecough, intermittent palpitations, dyspnea\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eAsa et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e3\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003emiddle right lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ecough, dyspnea\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1 x 1 x 0.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eSkizidt et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e25\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ecoughing with expectoration\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4 x 3 x 3 \u0026amp; 1.5 x 1.2 x 1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eAubertine et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e11\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003erecurrent obstructive pneumonia\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHuang et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e7\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright middle lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003easymptomatic\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4 x 3 x 3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.6pt;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; da Silvaa et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e9\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003easymptomatic\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.6pt;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Singh et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e5\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e63\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003elingula\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ehypertension\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eShibahara et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e10\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ehypertension, occasional headaches,\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom: 0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eY\u0026uuml;ksel et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e4\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e15\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ecough, weakness, hemoptysis,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ehypertension, tachycardia\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eY\u0026uuml;ksel et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e4\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e32\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft main bronchus\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003edyspnea\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eKavakli et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e26\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e21\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft cervical lymphadenopathy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e3 x 3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eGan et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e27\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright middle lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003easymptomatic\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.2 x 2.1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eHsu and Tsou \u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e28\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eright lower lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ecough, yellowish sputum\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e4.5 x 4 x 4.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eGeoffrion et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e29\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003ex\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003e10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft lobe\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003ehemoptysis, worsening symptoms\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eof asthma\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eKim et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e19\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eX\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 28.2pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e37\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 74.1pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-2.9pt;margin-bottom:0in;margin-left:-7.25pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eleft hilum\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 188.35pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eexertional dyspnea, cough,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin-top:0in;margin-right:-5.15pt;margin-bottom:0in;margin-left:-7.9pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1 episode of hemoptysis\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 64.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:-5.25pt;margin-bottom:0in;margin-left:-5.65pt;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:center;line-height:normal;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7 x 3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:justify;line-height:150%;'\u003e\u003cspan style='font-size:16px;line-height:150%;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:10.0pt;margin-left:0in;font-size:12px;font-family:\"Calibri\",sans-serif;color:#44546A;font-style:italic;line-height:150%;'\u003e\u003cspan style=\"font-size:15px;line-height:150%;\"\u003eTable\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:15px;line-height:150%;\"\u003e2\u003c/span\u003e\u003cspan style=\"font-size:15px;line-height:150%;\"\u003e. Immunohistochemical investigations.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 5.2e+2pt;border: none;margin-left:-28.35pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eReferences\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eTTF1\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eKi-67\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eCgA\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eSYP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eCD56\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eCK\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eCK5/6\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eS100\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eNSE\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eGATA 3\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-width: medium medium 1pt;border-style: none none solid;border-color: currentcolor currentcolor rgb(127, 127, 127);border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eAE1+AE3\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eDa Silva et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e9\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eY\u0026uuml;ksel et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e4\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eHsu and Tsou \u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e28\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eMazzucco et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e17\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+/-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eHuang et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e7\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e2%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eFiorentino et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e24\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eGeoffrion et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e29\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eHangartner et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e8\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eTob\u0026oacute;n et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e21\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e2%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+/-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eGan et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e27\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eShibahara et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e10\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eDahir et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e18\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eAubertine and Flieder et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e11\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eKim et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e19\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+/-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+/-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eZhang et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e23\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eSk\u0026oslash;dt et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e13\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eSaeki et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e16\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eKaplan R et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e14\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 85.05pt;border-width: medium 1pt medium medium;border-style: none solid none none;border-color: currentcolor rgb(127, 127, 127) currentcolor currentcolor;border-image: none;background: white;padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;text-align:right;line-height:normal;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eAfrica et al.\u003csup\u003e\u003cspan style=\"font-style:normal;\"\u003e15\u003c/span\u003e\u003c/sup\u003e\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 36.75pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003eLOW\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 34.15pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.4pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+/-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(-)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.45pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e(+)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;background: rgb(242, 242, 242);padding: 0in 5.4pt;height: 0.2in;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;font-size:11.0pt;font-family:\"Calibri\",sans-serif;line-height:normal;'\u003e\u003cspan style='font-size:13px;font-family:\"Times New Roman\",serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eHistologically, PPPGs demonstrated the characteristic zellballen pattern consisting of small nets of polygonal cells surrounded by sustentacular cells, clearly evident with S-100 immunostaining and separated by a delicate fibrovascular stroma.\u0026nbsp;Neoplastic cells showed positivity for neuroendocrine markers (Chromogranin and Synaptofisin) in almost all cases described, while immunohistochemical markers for cytokeratins and TFF1 were negative in most cases. Additionally, PPPGs have a characteristically low mitotic index with a Ki-67 usually \u0026lt; 5%.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eSurgery was the treatment choice in all the cases described in literature and no local recurrence have been reported expect for one case presented with lymphnode metastasis.\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003ePGs are uncommon neural crest neoplasms derived from paraganglion cells of the autonomic nervous system from both the sympathetic and parasympathetic systems. PGs can appear as multiple small tumors or a solitary mass. Most PGs are benign. But they may also present as malignant tumors with lymph node metastases. According to the literature, the total number of PG cases published is less than 50.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePulmonary nonfunctional PGs are usually incidentally detected by CT as hypervascular nodules presenting typical features: isodensity or slightly low density as well as a homogeneous and intense enhancement \u0026ndash; except in the necrotic areas that show scarce enhancement. By CT, pulmonary PGs can resemble carcinoid tumors. Indeed, there are no specific radiologic features that can differentiate explicitly between carcinoid tumors and pulmonary PG diagnosis\u003csup\u003e19\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eNotably, carcinoid tumors may have this same organoid nesting pattern. The PG tumor cells show vesicular or hyperchromatic round-to-oval nuclei with moderate pleomorphism. The cytoplasm is pale, homogeneous, or vacuolated. Tumor cells may appear syncytial since their cytoplasmic borders are poorly defined. There may be interdigitation of adjoining cells or cell processes, which gives the appearance of cells embracing one another. From the literature, we see that most cases are benign except for 1/26 cases with lymph node metastases but no evidence of distant metastases or any primary extrapulmonary lesion\u003csup\u003e16\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eAs the histological similarity between PGs and the carcinoid tumor\u0026rsquo;s morphology is quite stark, the following criteria have been proposed to facilitate the differential diagnosis between the two entities:\u003c/p\u003e\n\u003cul\u003e\n \u003cli\u003eA diffuse zellballen pattern throughout the tumor,\u0026nbsp;\u003c/li\u003e\n \u003cli\u003eAbsence of the histologic features distinctive of carcinoid tumors (trabecular pattern, pseudo glandular acini, ossification, perivascular pseudorosettes, oncocytic change, spindle cells),\u003c/li\u003e\n \u003cli\u003ePresence of features distinctive of PGs (cytoplasmic vacuoles, cell in-cell embracing phenomenon), and\u0026nbsp;\u003c/li\u003e\n \u003cli\u003eAbsence of immunohistochemical staining for keratin favors PG.\u0026nbsp;\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003eUp to 80 percent of carcinoids stain with keratin, while PGs are virtually always keratin negative. S-100 protein-positive sustentacular cells can be found in carcinoids and PGs; however, not to the same extent. On the other hand, neuroendocrine markers such as chromogranin are positive in both tumor cells\u003csup\u003e30\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eComplete resection is the first treatment option for solitary PPPG\u003csup\u003e31\u003c/sup\u003e. Some authors proposed that PG is sensitive to radiation therapy and without serious side effects\u003csup\u003e32\u003c/sup\u003e. Given the high local control rates and few complications, some authors consider radiotherapy a first-choice treatment for PG. In addition, they evaluated the effects of external beam radiation therapy (EBRT). However, EBRT can only be considered when the local disease progresses\u003csup\u003e33\u003c/sup\u003e. The use of the chemotherapy regimen is not unanimously approved. In some metastasis cases, sorafenib use has been reported with a good response\u003csup\u003e34\u003c/sup\u003e.\u0026nbsp;\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThe diagnosis of PPPG requires the exclusion of an extrapulmonary PG or a pheochromocytoma. PPPGs are rare entities, and their differential diagnosis with carcinoid tumors is not always easy for this site and lies in subtle morphological and immunophenotypic differences. In neuroendocrine tumor diagnosis the importance of keratins, which are available in almost every pathology laboratory, should be emphasized. However, one should not forget that pulmonary gangliocytic PGs can also show CK positivity\u003csup\u003e35\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eTyrosine hydroxylase and GATA3 are new markers that help differentiate diagnosis\u003csup\u003e11\u003c/sup\u003e. PPPG should be considered in the differential diagnosis of endo- and peri-bronchial neoplasms. A correct diagnosis is important since mutations in tumor susceptibility genes have been reported in one in two patients. Thus, genetic testing and counseling are recommended for these patients.\u003c/p\u003e"},{"header":"References","content":"\u003cp\u003e1.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;World Health Organization (WHO). Thoracic Tumours, 5th ed.; Organisation mondiale de la sant\u0026eacute;, Centre international de recherche sur le cancer, Eds.; World Health Organization classification of tumours; International agency for research on cancer: Lyon, 2021.\u003c/p\u003e\n\u003cp\u003e2.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Blessing, M. \u0026amp; Hora, B. Glomera in der Lunge des Menschen [Glomera in the human lung]. \u003cem\u003eZ Zellforsch Mikrosk Anat.\u003c/em\u003e \u003cstrong\u003e87\u003c/strong\u003e, 562\u0026ndash;570 (1968).\u003c/p\u003e\n\u003cp\u003e3.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Asa, S. L., Ezzat, S. \u0026amp; Mete, O. The diagnosis and clinical significance of paragangliomas in unusual locations. \u003cem\u003eJ Clin Med\u003c/em\u003e \u003cstrong\u003e7\u003c/strong\u003e, (2018).\u003c/p\u003e\n\u003cp\u003e4.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Y\u0026uuml;ksel, C. \u003cem\u003eet al.\u003c/em\u003e Primary pulmonary paraganglioma: Two cases. \u003cem\u003eTurkish Journal of Thoracic and Cardiovascular Surgery\u003c/em\u003e \u003cstrong\u003e28\u003c/strong\u003e, 394\u0026ndash;398 (2020).\u003c/p\u003e\n\u003cp\u003e5.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Singh, G., Lee, R. E. \u0026amp; Brooks, D. H. Primary pulmonary paraganglioma: report of a case and review of the literature. \u003cem\u003eCancer\u003c/em\u003e \u003cstrong\u003e40\u003c/strong\u003e, 2286\u0026ndash;2289 (1977).\u003c/p\u003e\n\u003cp\u003e6.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Tob\u0026oacute;n, A. \u003cem\u003eet al.\u003c/em\u003e Pathologic features and clinical course of a non-functioning primary pulmonary paraganglioma: A case report. \u003cem\u003eAnnals of Medicine and Surgery\u003c/em\u003e \u003cstrong\u003e55\u003c/strong\u003e, 185\u0026ndash;189 (2020).\u003c/p\u003e\n\u003cp\u003e7.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Huang, X. \u003cem\u003eet al.\u003c/em\u003e Primary Pulmonary Paraganglioma: A Case Report and Review of Literature. \u003cem\u003eMedicine\u003c/em\u003e \u003cstrong\u003e94\u003c/strong\u003e, (2015).\u003c/p\u003e\n\u003cp\u003e8.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Hangartner, J. R., Loosemore, T. M., Burke, M. \u0026amp; Pepper, J. R. Malignant primary pulmonary paraganglioma. \u003cem\u003eThorax\u003c/em\u003e \u003cstrong\u003e44\u003c/strong\u003e, 154 (1989).\u003c/p\u003e\n\u003cp\u003e9.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Afonso Da Silva, R., Gross, J. L., Haddad, F. J., Toledo, C. A. B. \u0026amp; Younes, R. N. LETTER TO THE EDITORS PRIMARY PULMONARY PARAGANGLIOMA: CASE REPORT AND LITERATURE REVIEW. \u003cem\u003eClinics\u003c/em\u003e \u003cstrong\u003e61\u003c/strong\u003e, 83\u0026ndash;89 (2006).\u003c/p\u003e\n\u003cp\u003e10.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Shibahara, J. \u003cem\u003eet al.\u003c/em\u003e Primary Pulmonary Paraganglioma Report of a Functioning Case With Immunohistochemical and Ultrastructural Study. \u003cem\u003eAm J Surg Pathol\u003c/em\u003e \u003cstrong\u003e28\u003c/strong\u003e, 825\u0026ndash;829 (2004).\u003c/p\u003e\n\u003cp\u003e11.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Aubertine, C. L. \u0026amp; Flieder, D. B. Primary paraganglioma of the lung. \u003cem\u003eAnn Diagn Pathol\u003c/em\u003e \u003cstrong\u003e8\u003c/strong\u003e, 237\u0026ndash;241 (2004).\u003c/p\u003e\n\u003cp\u003e12.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Heppleston, A. G. A CAROTID-BODY-LIKE TUMOC-R IN THE LUNG. \u003cem\u003eJ. PATH. BACT.\u003c/em\u003e \u003cstrong\u003eLXXV\u003c/strong\u003e, 461\u0026ndash;466 (1958).\u003c/p\u003e\n\u003cp\u003e13.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;SK\u0026Oslash;DT, V., JACOBSEN, G. K. \u0026amp; HELSTED, M. Primary paraganglioma of the lung Report of two cases and review of the literature.\u0026nbsp;\u003cem\u003eAPMIS\u003c/em\u003e \u003cstrong\u003e103\u003c/strong\u003e, 597\u0026ndash;603 (1995).\u003c/p\u003e\n\u003cp\u003e14.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Kaplan, R. \u003cem\u003eet al.\u003c/em\u003e Paraganglioma pulmonar primario como tumor incidental [Primary lung paraganglioma.\u0026nbsp;A case report]. \u003cem\u003eRev Fac Cien Med Univ Nac Cordoba\u003c/em\u003e \u003cstrong\u003e67\u003c/strong\u003e, 118\u0026ndash;122 (2010).\u003c/p\u003e\n\u003cp\u003e15.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Africa, G., Plutino, F. M. \u0026amp; Filotico, M. A rare neurendocrine tumor of the lung: Sclerosing paraganglioma. A neoplasm that is difficult to diagnose and a source of dangerous pitfalls. A case report and literature review. \u003cem\u003ePathologica\u003c/em\u003e \u003cstrong\u003e112\u003c/strong\u003e, 191\u0026ndash;194 (2020).\u003c/p\u003e\n\u003cp\u003e16.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Saeki, T. \u003cem\u003eet al.\u003c/em\u003e An Extremely Large Solitary Primary Paraganglioma of the Lung: Report of a Case. \u003cem\u003eSurg Today Jpn J Surg\u003c/em\u003e \u003cstrong\u003e29\u003c/strong\u003e, 1195\u0026ndash;1200 (1999).\u003c/p\u003e\n\u003cp\u003e17.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Mazzucco, A. \u003cem\u003eet al.\u003c/em\u003e An Unusual Histology for a Lung Nodule: A Case Report of Primary Pulmonary Paraganglioma. \u003cem\u003eFront Surg\u003c/em\u003e \u003cstrong\u003e8\u003c/strong\u003e, (2021).\u003c/p\u003e\n\u003cp\u003e18.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Dahir, K. M. \u003cem\u003eet al.\u003c/em\u003e Ectopic Adrenocorticotropic Hormone Hypersecretion Due To A Primary Pulmonary Paraganglioma. \u003cem\u003eEndocrine Practice\u003c/em\u003e \u003cstrong\u003e10\u003c/strong\u003e, 424\u0026ndash;428 (2004).\u003c/p\u003e\n\u003cp\u003e19.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Ki, N. K., Lee, K. N., Mee, S. R., Pil, J. C. \u0026amp; Doo, K. Y. Pulmonary paraganglioma manifesting as an endobronchial mass. \u003cem\u003eKorean J Radiol\u003c/em\u003e \u003cstrong\u003e9\u003c/strong\u003e, 87\u0026ndash;90 (2008).\u003c/p\u003e\n\u003cp\u003e20.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Hagemeyera, O., Cabinsb, H. J., Kaysera, K. \u0026amp; Words, K. Paraganglioma of the Lung-Developed after Exposure to Nuclear Radiation by the Tschernobyl Atomic Reactor Accident?\u003c/p\u003e\n\u003cp\u003e21.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Tob\u0026oacute;n, A. \u003cem\u003eet al.\u003c/em\u003e Pathologic features and clinical course of a non-functioning primary pulmonary paraganglioma: A case report. \u003cem\u003eAnnals of Medicine and Surgery\u003c/em\u003e \u003cstrong\u003e55\u003c/strong\u003e, 185\u0026ndash;189 (2020).\u003c/p\u003e\n\u003cp\u003e22.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Huang, X. J., Wu, C. \u0026amp; Chen, X. Y. Primary endobronchial paraganglioma with lymph node metastasis: a case report. \u003cem\u003eJournal of International Medical Research\u003c/em\u003e \u003cstrong\u003e49\u003c/strong\u003e, (2021).\u003c/p\u003e\n\u003cp\u003e23.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Zhang, J.-J., Liu, T. \u0026amp; Peng, F. Primary Paraganglioma of the Lung: a Case Report and Literature Review. \u003cem\u003eJ Int Med Res\u003c/em\u003e \u003cstrong\u003e40\u003c/strong\u003e, 1617\u0026ndash;1626 (2012).\u003c/p\u003e\n\u003cp\u003e24.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Fiorentino, G., Annunziata, A. \u0026amp; de Rosa, N. Primary paraganglioma of the lung: A case report. \u003cem\u003eJ Med Case Rep\u003c/em\u003e \u003cstrong\u003e9\u003c/strong\u003e, (2015).\u003c/p\u003e\n\u003cp\u003e25.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Skizidt, V., Krag Jacobsen, G., Helsted, M., Primary paraganglioma, M. \u0026amp; Sksdt, V. Primary paraganglioma of the lung Report of two cases and review of the literature. \u003cem\u003eAPMIS\u003c/em\u003e \u003cstrong\u003e103\u003c/strong\u003e, 597403 (1995).\u003c/p\u003e\n\u003cp\u003e26.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Kavakli M.; Ongoru O.; G\u0026uuml;rk\u0026ouml;k S.; Genc O., K. ; O. Primary Pulmonary Paraganglioma with Hodgkin\u0026rsquo;s Lymphoma. \u003cem\u003eThorac Cardiovasc Surg\u003c/em\u003e \u003cstrong\u003e57\u003c/strong\u003e, 375\u0026ndash;377 (2009).\u003c/p\u003e\n\u003cp\u003e27.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Gan, F., Xia, L. \u0026amp; Liu, L. Primary pulmonary paraganglioma. \u003cem\u003eQJM\u003c/em\u003e \u003cstrong\u003e111\u003c/strong\u003e, 901\u0026ndash;902 (2018).\u003c/p\u003e\n\u003cp\u003e28.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Hsu, L.-H. \u0026amp; Tsou, M.-H. Article in Zhonghua yi xue za zhi = Chinese medical journal. \u003cem\u003eChinese Medical Journal\u0026nbsp;\u003c/em\u003e\u003cstrong\u003e65\u003c/strong\u003e, 446\u0026ndash;449 (2002).\u003c/p\u003e\n\u003cp\u003e29.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Geoffrion, T. R. \u003cem\u003eet al.\u003c/em\u003e Pulmonary paraganglioma in a 10-year-old: a case report and review of the literature. \u003cem\u003eJ Surg Case Rep\u003c/em\u003e \u003cstrong\u003e2018\u003c/strong\u003e, 1\u0026ndash;4 (2018).\u003c/p\u003e\n\u003cp\u003e30.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;William D. Travis, Andrew G. Nicholson, Kim R. Geisinger \u0026amp; Elisabeth Brambilla. \u003cem\u003eTumors of the Lower Respiratory Tract (AFIP Atlas of Tumor Pathology, Series 4,)\u003c/em\u003e. \u003cem\u003eAFIP ATLAS OF TUMOR PATHOLOGY\u003c/em\u003e (American Registry of Pathology, 2019).\u003c/p\u003e\n\u003cp\u003e31.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Chung, J. H. \u003cem\u003eet al.\u003c/em\u003e Uniportal video-assisted thoracoscopic lobectomy: An alternative to conventional thoracoscopic lobectomy in lung cancer surgery? \u003cem\u003eInteract Cardiovasc Thorac Surg\u003c/em\u003e \u003cstrong\u003e20\u003c/strong\u003e, 813\u0026ndash;819 (2015).\u003c/p\u003e\n\u003cp\u003e32.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Elshaikh, M. A. \u003cem\u003eet al.\u003c/em\u003e RECURRENT HEAD-AND-NECK CHEMODECTOMAS: A COMPARISON OF SURGICAL AND RADIOTHERAPEUTIC RESULTS. \u003cem\u003eInt. J. Radiation Oncology Biol. Phys.\u003c/em\u003e \u003cstrong\u003e52\u003c/strong\u003e, 953\u0026ndash;956 (2002).\u003c/p\u003e\n\u003cp\u003e33.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Smee, R. I., Jayasekara, J., Williams, J. R. \u0026amp; Hanna, C. Paragangliomas: Presentation and management by radiotherapy at the Prince of Wales Hospital. \u003cem\u003eJ Med Imaging Radiat Oncol\u003c/em\u003e \u003cstrong\u003e59\u003c/strong\u003e, 229\u0026ndash;235 (2015).\u003c/p\u003e\n\u003cp\u003e34.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Gunaldi, M. \u003cem\u003eet al.\u003c/em\u003e A New Approach to the Treatment of Metastatic Paraganglioma: Sorafenib. \u003cem\u003eCancer Res Treat\u003c/em\u003e \u003cstrong\u003e46\u003c/strong\u003e, 411\u0026ndash;414 (2014).\u003c/p\u003e\n\u003cp\u003e35.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;Ayala-Ramirez, M. \u003cem\u003eet al.\u003c/em\u003e Clinical benefits of systemic chemotherapy for patients with metastatic pheochromocytomas or sympathetic extra-adrenal paragangliomas: Insights from the largest single-institutional experience. \u003cem\u003eCancer\u003c/em\u003e \u003cstrong\u003e118\u003c/strong\u003e, 2804\u0026ndash;2812 (2012).\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank the patient for allowing for this case to be presented and Dr. Ornela Bardhi for proofreading.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eLB drafted the manuscript and figures. LB, AG, and LADN collected and reviewed the population data.LB, MV, and CB did the conceptualization of the study. MV, RC, AG, LADN, PP, and CB reviewed the manuscript. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003eCorresponding author: Professor Cristiana Bellan.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by and conducted in accordance with the ethical standards and requirements of the University Hospital of Siena Ethical Board (Siena, Italy).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWritten informed consent was obtained from the patient for publication of this case report and any accompanying images.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Primary pulmonary paragangliomas, “Substentacular” cells, Immunohisto-chemical","lastPublishedDoi":"10.21203/rs.3.rs-2361854/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-2361854/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003ePrimary pulmonary paraganglioma (PPPG) is an extremely rare neuroendocrine tumor, counting less than 1% of all paragangliomas (PGs). The incidence of PGs ranges between 2–8 per million in a year. Generally, pulmonary PGs are nonfunctional. The majority of the patients develop respiratory symptoms, such as a cough, chest pain, or dyspnea, as in our case. The average size of the neoplasm is about 7 cm. There seems to be no difference in incidence between the right and left lungs; however, the lower lobe appears to be the most affected.\u003c/p\u003e\n\u003cp\u003eOn gross examination, the neoplasm was well-demarcated with a white-brown cut surface and solid consistency. The tumor cells appear in a typical nested pattern supported by a thin vascular framework producing the classic ‘zellballen’ or the basket pattern. Immunohistochemical staining showed positive for CgA, Syn, and S100.\u003c/p\u003e\n\u003cp\u003ePPPGs are rare entities, and their differential diagnosis with carcinoid tumors, more typical for this site, is not always easy and lies in subtle morphological and immunophenotypic differences. A correct diagnosis is decisive since mutations in tumor susceptibility genes have been reported in 50% of the patients. Thus genetic testing and counseling should be considered.\u003c/p\u003e","manuscriptTitle":"Primary Pulmonary Paraganglioma, Case Report and Review of the Literature","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2024-01-24 20:10:03","doi":"10.21203/rs.3.rs-2361854/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2023-01-04 15:35:39","doi":"10.21203/rs.3.rs-2361854/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6159a773-14da-442c-abc1-726c4e824d90","owner":[],"postedDate":"January 24th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-01-04T15:35:42+00:00","versionOfRecord":[],"versionCreatedAt":"2024-01-24 20:10:03","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-2361854","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-2361854","identity":"rs-2361854","version":["v2"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}